| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
|---|
| | Pseudomonas putida KT2440 | PP_2139 | | DNA topoisomerase I | no data | 100 | 100 |
| o | Pseudomonas sp. BP01 | JOY50_RS25050 | topA | type I DNA topoisomerase | no data | 99 | 100 |
| o | Pseudomonas sp. RS175 | PFR28_01113 | | DNA topoisomerase 1 | strong | 91 | 100 |
| o | Pseudomonas sp. SVBP6 | COO64_RS09410 | topA | type I DNA topoisomerase | strong | 94 | 100 |
| o | Pseudomonas simiae WCS417 | PS417_07590 | | DNA topoisomerase I | no data | 92 | 100 |
| o | Pseudomonas fluorescens SBW25 | PFLU_RS07665 | | type I DNA topoisomerase | strong | 92 | 100 |
| o | Pseudomonas fluorescens SBW25-INTG | PFLU_RS07665 | | type I DNA topoisomerase | strong | 92 | 100 |
| o | Pseudomonas orientalis W4I3 | QF045_RS10230 | | type I DNA topoisomerase | no data | 91 | 100 |
| o | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2287 | | DNA topoisomerase I (EC 5.99.1.2) | no data | 91 | 100 |
| o | Pseudomonas lactucae CFBP13502 | GEMAOFIL_01650 | | DNA topoisomerase 1 | no data | 92 | 100 |
| o | Pseudomonas fluorescens FW300-N2C3 | AO356_02315 | | DNA topoisomerase I | strong | 91 | 100 |
| o | Pseudomonas aeruginosa MRSN321 | DY961_RS01910 | topA;go_component=cytoplasm|0005737||IEA;go_function=DNA | type I DNA topoisomerase | no data | 90 | 100 |
| o | Pseudomonas aeruginosa PA14 | IKLFDK_15320 | | type I DNA topoisomerase | no data | 90 | 100 |
| o | Pseudomonas aeruginosa PUPa3 | DQ20_RS33670 | topA;go_component=cytoplasm|0005737||IEA;go_function=DNA | type I DNA topoisomerase | no data | 90 | 100 |
| o | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4038 | | DNA topoisomerase I (EC 5.99.1.2) | strong | 91 | 100 |
| o | Pseudomonas sp. DMC3 | GFF1274 | | DNA topoisomerase 1 | no data | 91 | 100 |
| o | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_3906 | | DNA topoisomerase I (EC 5.99.1.2) | strong | 91 | 100 |
| o | Pseudomonas fluorescens FW300-N2E3 | AO353_00495 | | DNA topoisomerase I | strong | 91 | 100 |
| o | Pseudomonas syringae pv. syringae B728a | Psyr_3287 | | DNA topoisomerase I | strong | 90 | 100 |
| o | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3287 | | DNA topoisomerase I | no data | 90 | 100 |
| o | Pseudomonas stutzeri RCH2 | Psest_2651 | | DNA topoisomerase I, bacterial | strong | 89 | 100 |
| o | Pseudomonas segetis P6 | ACVTMO_RS14820 | topA | type I DNA topoisomerase | no data | 89 | 100 |
| o | Pseudomonas sp. S08-1 | OH686_21940 | | DNA topoisomerase I | no data | 88 | 100 |
| o | Marinobacter adhaerens HP15 | HP15_1514 | | DNA topoisomerase I | no data | 70 | 100 |
| o | Shewanella sp. ANA-3 | Shewana3_1729 | | DNA topoisomerase I (RefSeq) | no data | 67 | 100 |
| o | Shewanella amazonensis SB2B | Sama_1322 | | DNA topoisomerase I (RefSeq) | no data | 66 | 100 |
| o | Shewanella oneidensis MR-1 | SO2705 | topA | DNA topoisomerase I (NCBI ptt file) | no data | 66 | 100 |
| o | Escherichia coli BL21 | ECD_01250 | | DNA topoisomerase I, omega subunit | strong | 66 | 100 |
| o | Escherichia coli ECOR27 | NOLOHH_20270 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECOR38 | HEPCGN_25595 | | type I DNA topoisomerase | strong | 66 | 100 |
| o | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_02410 | | DNA topoisomerase 1 | strong | 66 | 100 |
| o | Escherichia coli BW25113 | b1274 | topA | DNA topoisomerase I (NCBI) | no data | 66 | 100 |
| o | Escherichia fergusonii Becca | EFB2_02653 | | DNA topoisomerase 1 | strong | 66 | 100 |
| o | Escherichia coli ECRC100 | OKFHMN_02605 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECRC101 | MCAODC_15660 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECRC102 | NIAGMN_26775 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECRC98 | JDDGAC_05150 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECRC99 | KEDOAH_26160 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Escherichia coli ECRC62 | BNILDI_18420 | | type I DNA topoisomerase | insig. | 66 | 100 |
| o | Escherichia coli Nissle 1917 | ECOLIN_RS07675 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Shewanella loihica PV-4 | Shew_2224 | | DNA topoisomerase I (RefSeq) | no data | 67 | 100 |
| o | Alteromonas macleodii MIT1002 | MIT1002_01705 | | DNA topoisomerase 1 | no data | 66 | 99 |
| o | Kangiella aquimarina DSM 16071 | B158DRAFT_2227 | | DNA topoisomerase I, bacterial | strong | 66 | 99 |
| o | Vibrio cholerae E7946 ATCC 55056 | CSW01_08695 | | DNA topoisomerase 1 | no data | 66 | 100 |
| o | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2714 | | DNA topoisomerase I (EC 5.99.1.2) | no data | 66 | 100 |
| o | Klebsiella michiganensis M5al | BWI76_RS11925 | | DNA topoisomerase I | no data | 66 | 99 |
| o | Klebsiella pneumoniae MKP103 | KDGMDA_19615 | | type I DNA topoisomerase | strong | 66 | 99 |
| o | Klebsiella pneumoniae MRSN742743 | KFA93_RS20105 | topA;go_component=cytoplasm|0005737||IEA;go_function=DNA | type I DNA topoisomerase | no data | 66 | 99 |
| o | Rahnella sp. WP5 | EX31_RS09895 | | type I DNA topoisomerase | cofit | 67 | 100 |
| o | Pantoea sp. MT58 | IAI47_09235 | | type I DNA topoisomerase | insig. | 65 | 100 |
| o | Dickeya dadantii 3937 | DDA3937_RS10535 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS06950 | | type I DNA topoisomerase | no data | 65 | 99 |
| o | Serratia liquefaciens MT49 | IAI46_13970 | | type I DNA topoisomerase | strong | 66 | 100 |
| o | Enterobacter sp. TBS_079 | MPMX20_02502 | | DNA topoisomerase 1 | no data | 65 | 100 |
| o | Enterobacter asburiae PDN3 | EX28DRAFT_0945 | | DNA topoisomerase I, bacterial | no data | 65 | 100 |
| o | Dickeya dianthicola 67-19 | HGI48_RS10535 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Dickeya dianthicola ME23 | DZA65_RS11015 | | type I DNA topoisomerase | no data | 66 | 100 |
| o | Erwinia amylovora T8 | OLJFJH_13525 | | type I DNA topoisomerase | no data | 65 | 100 |
| o | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_23715 | | type I DNA topoisomerase | no data | 64 | 100 |
| o | Erwinia tracheiphila SCR3 | LU632_RS12555 | topA | type I DNA topoisomerase | no data | 64 | 100 |
| o | Pectobacterium carotovorum WPP14 | HER17_RS10875 | | type I DNA topoisomerase | no data | 65 | 100 |
| o | Acinetobacter baumannii LAC-4 | RR41_RS16785 | | type I DNA topoisomerase | no data | 65 | 99 |
| o | Acinetobacter radioresistens SK82 | MPMX26_00365 | | DNA topoisomerase 1 | no data | 65 | 99 |
| o | Desulfovibrio vulgaris Hildenborough JW710 | DVU3389 | topA | DNA topoisomerase I (TIGR) | no data | 40 | 85 |
| o | Desulfovibrio vulgaris Miyazaki F | DvMF_2069 | | DNA topoisomerase I (RefSeq) | no data | 40 | 85 |
| | Cellulophaga baltica 18 | M666_RS02295 | | type I DNA topoisomerase | no data | 43 | 72 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_3133 | | DNA topoisomerase I, bacterial | no data | 42 | 71 |
| | Methylophilus sp. DMC18 | GFF1540 | | DNA topoisomerase 1 | no data | 42 | 72 |
| | Dinoroseobacter shibae DFL-12 | Dshi_1137 | | DNA topoisomerase I (RefSeq) | no data | 42 | 72 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_07630 | | DNA topoisomerase I | no data | 42 | 68 |
| | Azospirillum sp. SherDot2 | MPMX19_01509 | | DNA topoisomerase 1 | no data | 40 | 75 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.4752.1 | | DNA topoisomerase I (EC 5.99.1.2) | insig. | 44 | 68 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c06220 | | DNA topoisomerase TopA | no data | 41 | 72 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_13765 | topA | DNA topoisomerase I | no data | 43 | 71 |
| | Azospirillum brasilense Sp245 | AZOBR_RS15890 | | DNA topoisomerase I | strong | 40 | 75 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS12100 | | type I DNA topoisomerase | no data | 41 | 71 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS04700 | | type I DNA topoisomerase | strong | 41 | 71 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS05015 | | type I DNA topoisomerase | no data | 39 | 71 |
| | Fusobacterium nucleatum SB010 | HUW76_06805 | | type I DNA topoisomerase | no data | 35 | 86 |
| | Rhodospirillum rubrum S1H | Rru_A3202 | | DNA topoisomerase (NCBI) | strong | 39 | 73 |
| | Rhodopseudomonas palustris CGA009 | TX73_016155 | | type I DNA topoisomerase | strong | 40 | 72 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS09790 | | DNA topoisomerase I | no data | 42 | 71 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10150 | | DNA topoisomerase I | strong | 42 | 71 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS08530 | | type I DNA topoisomerase | no data | 44 | 66 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS07115 | | DNA topoisomerase I | no data | 41 | 67 |
| | Rhizobium sp. OAE497 | ABIE40_RS07355 | | type I DNA topoisomerase | sig. | 39 | 75 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS03505 | | type I DNA topoisomerase | no data | 42 | 72 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS02930 | | DNA topoisomerase I | no data | 42 | 71 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS01095 | | type I DNA topoisomerase | strong | 39 | 73 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS13865 | | DNA topoisomerase I | sig. | 42 | 71 |
| | Lysobacter sp. OAE881 | ABIE51_RS02220 | | DNA topoisomerase I | strong | 41 | 71 |
| | Sinorhizobium meliloti 1021 | SMc01364 | | DNA topoisomerase I | insig. | 38 | 75 |
| | Mycobacterium tuberculosis H37Rv | Rv3646c | | DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I) | no data | 41 | 74 |
| | Caulobacter crescentus NA1000 | CCNA_02535 | | DNA topoisomerase I | insig. | 39 | 74 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02535 | | DNA topoisomerase I | no data | 39 | 74 |
| | Agrobacterium fabrum C58 | Atu1304 | | DNA topoisomerase I | no data | 38 | 75 |
| | Sphingobium sp. HT1-2 | GFF115 | | DNA topoisomerase I (EC 5.99.1.2) | no data | 39 | 76 |
| | Bosea sp. OAE506 | ABIE41_RS17240 | | type I DNA topoisomerase | no data | 40 | 75 |
| | Xanthobacter sp. DMC5 | GFF934 | | DNA topoisomerase 1 | no data | 40 | 72 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS04230 | | type I DNA topoisomerase | no data | 39 | 72 |
| | Bifidobacterium breve UCC2003 | BBR_RS11185 | | type I DNA topoisomerase | sig. | 39 | 71 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2827 | | DNA topoisomerase I (NCBI ptt file) | no data | 39 | 71 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_2450 | | DNA topoisomerase I, bacterial | no data | 41 | 72 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02074 | | DNA topoisomerase I | cofit | 40 | 66 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS11640 | | type I DNA topoisomerase | no data | 39 | 71 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1416 | topA | DNA topoisomerase I | no data | 39 | 73 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_01245 | | type I DNA topoisomerase | insig. | 35 | 72 |
| | Methanococcus maripaludis S2 | MMP_RS04955 | | DNA topoisomerase I | strong | 29 | 81 |
| | Methanococcus maripaludis JJ | MMJJ_RS00180 | | DNA topoisomerase I | strong | 29 | 81 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS23620 | | DNA topoisomerase III | no data | 27 | 70 |
| | Ralstonia solanacearum GMI1000 | RS_RS00330 | | DNA topoisomerase III | no data | 27 | 70 |
| | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS09745 | | DNA topoisomerase III | no data | 26 | 70 |
| | Ralstonia solanacearum UW163 | UW163_RS03835 | | DNA topoisomerase III | no data | 26 | 70 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS20490 | | DNA topoisomerase III | no data | 27 | 70 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS23390 | | DNA topoisomerase III | no data | 26 | 70 |
| | Dechlorosoma suillum PS | Dsui_2608 | | topoisomerase IA | cofit | 26 | 91 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_00120 | | DNA topoisomerase III | insig. | 26 | 63 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS00140 | | DNA topoisomerase III | no data | 27 | 70 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS04995 | | DNA topoisomerase III | strong | 27 | 70 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_972 | | DNA topoisomerase III (EC 5.99.1.2) in PFGI-1-like cluster | insig. | 27 | 64 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS09715 | | DNA topoisomerase III | insig. | 27 | 63 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS09715 | | DNA topoisomerase III | insig. | 27 | 63 |
| | Paraburkholderia graminis OAS925 | ABIE53_000384 | | DNA topoisomerase-3 | no data | 27 | 70 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1268 | | DNA topoisomerase III, Burkholderia type (EC 5.99.1.2) | insig. | 26 | 70 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_02205 | | DNA topoisomerase 3 | cofit | 27 | 70 |
| | Dechlorosoma suillum PS | Dsui_0821 | | DNA topoisomerase III | no data | 27 | 70 |
| | Pseudomonas simiae WCS417 | PS417_10550 | | DNA topoisomerase III | insig. | 26 | 70 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS01440 | | DNA topoisomerase III | no data | 26 | 70 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02244 | | DNA topoisomerase-3 | no data | 26 | 70 |
| | Pseudomonas orientalis W4I3 | QF045_RS12525 | | DNA topoisomerase III | cofit | 26 | 68 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_21700 | | DNA topoisomerase III | insig. | 27 | 65 |
| | Pseudomonas sp. RS175 | PFR28_01342 | | DNA topoisomerase 3 | insig. | 27 | 65 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS24470 | | hypothetical protein | insig. | 27 | 60 |
| | Pseudomonas putida KT2440 | PP_4019 | | DNA topoisomerase III | insig. | 26 | 68 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS12290 | | DNA topoisomerase III | no data | 26 | 70 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_07605 | topB | DNA topoisomerase III | no data | 28 | 62 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS10610 | | DNA topoisomerase III | cofit | 27 | 70 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS10610 | | DNA topoisomerase III | insig. | 27 | 70 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2495 | | DNA topoisomerase III, Burkholderia type (EC 5.99.1.2) | strong | 26 | 70 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2100 | | DNA topoisomerase III (EC 5.99.1.2) | insig. | 26 | 65 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1473 | | DNA topoisomerase III | insig. | 28 | 64 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1473 | | DNA topoisomerase III | insig. | 28 | 64 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS16120 | | type IA DNA topoisomerase | insig. | 29 | 60 |
| | Pseudomonas sp. BP01 | JOY50_RS06610 | | DNA topoisomerase III | insig. | 26 | 68 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_26780 | | DNA topoisomerase III | insig. | 26 | 65 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT0105 | | DNA topoisomerase I (Omega-protein) (NCBI ptt file) | sig. | 26 | 64 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_3176 | | DNA topoisomerase III (RefSeq) | insig. | 26 | 65 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS11415 | | type IA DNA topoisomerase | insig. | 25 | 69 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS14305 | | DNA topoisomerase 3 | insig. | 26 | 68 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.2568.1 | | DNA topoisomerase III (EC 5.99.1.2) in PFGI-1-like cluster | insig. | 26 | 74 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS09935 | | DNA topoisomerase 3 | cofit | 25 | 71 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_4446 | | DNA topoisomerase III (EC 5.99.1.2) | insig. | 27 | 65 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03290 | | DNA topoisomerase | insig. | 26 | 68 |
| | Pseudomonas sp. SVBP6 | COO64_RS23235 | | DNA topoisomerase III | insig. | 26 | 67 |
| | Pseudomonas sp. DMC3 | GFF1711 | | DNA topoisomerase 3 | insig. | 26 | 65 |
| | Erwinia amylovora T8 | OLJFJH_02895 | | DNA topoisomerase III | insig. | 27 | 62 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2089 | | DNA topoisomerase III (NCBI ptt file) | no data | 25 | 68 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_3568 | | DNA topoisomerase III (EC 5.99.1.2) | insig. | 26 | 65 |
| | Pseudomonas stutzeri RCH2 | Psest_1383 | | DNA topoisomerase III, bacteria and conjugative plasmid | insig. | 26 | 68 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08375 | | DNA topoisomerase 3 | no data | 26 | 62 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2324 | | DNA topoisomerase III (NCBI ptt file) | insig. | 27 | 54 |
| | Marinobacter adhaerens HP15 | HP15_1186 | | DNA topoisomerase III | insig. | 26 | 70 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU2316 | topB | DNA topoisomerase III (TIGR) | insig. | 30 | 33 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS01110 | | DNA topoisomerase 3 | cofit | 26 | 65 |
| | Variovorax sp. SCN45 | GFF5383 | | DNA topoisomerase III, Burkholderia type (EC 5.99.1.2) | cofit | 25 | 71 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_2244 | | DNA topoisomerase III | insig. | 26 | 68 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_2244 | | DNA topoisomerase III | insig. | 26 | 68 |
| | Variovorax sp. OAS795 | ABID97_RS02310 | | DNA topoisomerase III | no data | 25 | 70 |
| | Azospirillum brasilense Sp245 | AZOBR_RS10830 | | DNA topoisomerase III | sig. | 28 | 53 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS09915 | | type IA DNA topoisomerase | insig. | 27 | 54 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS08865 | | type IA DNA topoisomerase | insig. | 25 | 70 |
| | Azospirillum sp. SherDot2 | MPMX19_01540 | | DNA topoisomerase 3 | insig. | 26 | 65 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_1977 | | DNA topoisomerase III (EC 5.99.1.2) in PFGI-1-like cluster | insig. | 32 | 41 |
| | Dickeya dianthicola ME23 | DZA65_RS04865 | | DNA topoisomerase III | insig. | 26 | 62 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_3808 | | DNA topoisomerase III, bacteria and conjugative plasmid | insig. | 24 | 72 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_02650 | | DNA topoisomerase III | sig. | 25 | 65 |
| | Cellulophaga baltica 18 | M666_RS01325 | | DNA topoisomerase 3 | insig. | 25 | 54 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS07650 | | DNA topoisomerase III | sig. | 25 | 57 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS08715 | | type IA DNA topoisomerase | insig. | 25 | 64 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_3239 | | Topoisomerase IA | insig. | 24 | 70 |
| | Marinobacter adhaerens HP15 | HP15_p42g25 | | DNA topoisomerase III | insig. | 26 | 63 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS09790 | | type IA DNA topoisomerase | sig. | 25 | 64 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS08935 | | type IA DNA topoisomerase | insig. | 25 | 64 |
| | Klebsiella michiganensis M5al | BWI76_RS11605 | | DNA topoisomerase III | insig. | 24 | 57 |
| | Shewanella loihica PV-4 | Shew_2299 | | DNA topoisomerase III (RefSeq) | insig. | 26 | 54 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS09010 | | DNA topoisomerase III | insig. | 25 | 64 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_19285 | | DNA topoisomerase III | insig. | 24 | 57 |
| | Escherichia coli ECOR27 | NOLOHH_00255 | topB | DNA topoisomerase III | insig. | 25 | 71 |
| | Klebsiella pneumoniae MRSN742743 | KFA93_RS19790 | | DNA topoisomerase III | insig. | 23 | 57 |
| | Escherichia coli ECOR38 | HEPCGN_00150 | topB | DNA topoisomerase III | insig. | 24 | 71 |
| | Dickeya dianthicola 67-19 | HGI48_RS10310 | | DNA topoisomerase III | insig. | 24 | 57 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3486 | | DNA topoisomerase III (EC 5.99.1.2) | insig. | 23 | 57 |
| | Shewanella sp. ANA-3 | Shewana3_1486 | | DNA topoisomerase III (RefSeq) | insig. | 24 | 56 |
| | Pectobacterium carotovorum WPP14 | HER17_RS11095 | | DNA topoisomerase III | insig. | 23 | 57 |
| | Escherichia coli BL21 | ECD_01732 | | DNA topoisomerase III | cofit | 23 | 67 |
| | Escherichia coli ECOR38 | HEPCGN_05200 | topB | DNA topoisomerase III | insig. | 23 | 67 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_01969 | | DNA topoisomerase 3 | insig. | 23 | 67 |
| | Escherichia coli BW25113 | b1763 | topB | DNA topoisomerase III (NCBI) | strong | 23 | 67 |
| | Dickeya dianthicola ME23 | DZA65_RS10785 | | DNA topoisomerase III | insig. | 24 | 57 |
| | Escherichia coli ECOR27 | NOLOHH_17340 | topB | DNA topoisomerase III | insig. | 23 | 67 |
| | Escherichia coli ECRC62 | BNILDI_16125 | topB | DNA topoisomerase III | insig. | 23 | 67 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS09830 | | DNA topoisomerase III | no data | 23 | 67 |
| | Dickeya dadantii 3937 | DDA3937_RS10300 | | DNA topoisomerase III | insig. | 23 | 57 |
| | Escherichia fergusonii Becca | EFB2_02231 | | DNA topoisomerase 3 | insig. | 23 | 67 |
| | Serratia liquefaciens MT49 | IAI46_14305 | | DNA topoisomerase III | insig. | 22 | 68 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_22650 | topB | DNA topoisomerase III | no data | 25 | 55 |
| | Erwinia tracheiphila SCR3 | LU632_RS12960 | | DNA topoisomerase III | insig. | 25 | 55 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS02815 | | DNA topoisomerase III | cofit | 25 | 51 |
| | Shewanella oneidensis MR-1 | SO3061 | topB | DNA topoisomerase III (NCBI ptt file) | insig. | 24 | 56 |
| | Escherichia coli ECRC99 | KEDOAH_01280 | topB | DNA topoisomerase III | no data | 23 | 67 |
| | Escherichia coli ECRC100 | OKFHMN_26830 | topB | DNA topoisomerase III | cofit | 23 | 67 |
| | Escherichia coli ECRC101 | MCAODC_18580 | topB | DNA topoisomerase III | insig. | 23 | 67 |
| | Escherichia coli ECRC102 | NIAGMN_01235 | topB | DNA topoisomerase III | cofit | 23 | 67 |
| | Escherichia coli ECRC98 | JDDGAC_01405 | topB | DNA topoisomerase III | cofit | 23 | 67 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_10220 | | DNA topoisomerase III | cofit | 27 | 56 |
| | Enterobacter sp. TBS_079 | MPMX20_01853 | | DNA topoisomerase 3 | insig. | 23 | 57 |
| | Pantoea sp. MT58 | IAI47_08980 | | DNA topoisomerase III | insig. | 25 | 51 |
| | Shewanella amazonensis SB2B | Sama_2145 | | DNA topoisomerase III (RefSeq) | sig. | 25 | 56 |
| | Erwinia amylovora T8 | OLJFJH_13255 | | DNA topoisomerase III | insig. | 22 | 67 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_1764 | | DNA topoisomerase III, bacteria and conjugative plasmid | insig. | 23 | 57 |
| | Rhodopseudomonas palustris CGA009 | TX73_021440 | | DNA topoisomerase | insig. | 28 | 30 |
| | Rahnella sp. WP5 | EX31_RS06315 | | DNA topoisomerase III | insig. | 22 | 67 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_03765 | | DNA topoisomerase | insig. | 26 | 50 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01501 | | DNA topoisomerase | insig. | 25 | 57 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2644 | | DNA topoisomerase I (NCBI ptt file) | insig. | 24 | 52 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU2316 | topB | DNA topoisomerase III (TIGR) | insig. | 26 | 28 |
| | Bifidobacterium breve UCC2003 | BBR_RS16225 | | type IA DNA topoisomerase | insig. | 26 | 27 |
| | Alteromonas macleodii MIT1002 | MIT1002_00024 | | DNA topoisomerase 1 | cofit | 29 | 17 |
| | Marinobacter adhaerens HP15 | HP15_1186 | | DNA topoisomerase III | insig. | 37 | 9 |
| | Rahnella sp. WP5 | EX31_RS15960 | | hypothetical protein | insig. | 33 | 9 |
| | Serratia liquefaciens MT49 | IAI46_23250 | | topoisomerase DNA-binding C4 zinc finger domain-containing protein | insig. | 35 | 9 |
| | Escherichia coli ECOR27 | NOLOHH_09345 | yrdD | Uncharacterized protein YrdD | insig. | 33 | 9 |
| | Escherichia fergusonii Becca | EFB2_00540 | | DNA topoisomerase 1 | cofit | 33 | 9 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS18850 | | type I DNA topoisomerase | insig. | 33 | 9 |
| | Escherichia coli ECOR38 | HEPCGN_16375 | yrdD | Uncharacterized protein YrdD | sig. | 33 | 9 |
| | Escherichia coli ECRC62 | BNILDI_02175 | yrdD | Uncharacterized protein YrdD | cofit | 33 | 9 |
| | Dickeya dianthicola 67-19 | HGI48_RS19200 | | topoisomerase DNA-binding C4 zinc finger domain-containing protein | insig. | 32 | 16 |
| | Erwinia tracheiphila SCR3 | LU632_RS22455 | | topoisomerase DNA-binding C4 zinc finger domain-containing protein | insig. | 30 | 9 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2395 | | Similar to C-terminal Zn-finger domain of DNA topoisomerase I | insig. | 30 | 9 |
| | Bifidobacterium breve UCC2003 | BBR_RS16225 | | type IA DNA topoisomerase | insig. | 28 | 17 |
| | Escherichia coli BL21 | ECD_03134 | | ssDNA-binding protein, function unknown | strong | 31 | 9 |
| | Escherichia coli ECRC100 | OKFHMN_17555 | yrdD | Uncharacterized protein YrdD | cofit | 31 | 9 |
| | Escherichia coli ECRC101 | MCAODC_08075 | yrdD | Uncharacterized protein YrdD | insig. | 31 | 9 |
| | Escherichia coli ECRC102 | NIAGMN_15315 | yrdD | Uncharacterized protein YrdD | insig. | 31 | 9 |
| | Escherichia coli ECRC98 | JDDGAC_21175 | yrdD | Uncharacterized protein YrdD | insig. | 31 | 9 |
| | Escherichia coli ECRC99 | KEDOAH_10595 | yrdD | Uncharacterized protein YrdD | no data | 31 | 9 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_00420 | | DNA topoisomerase 1 | insig. | 31 | 9 |
| | Escherichia coli BW25113 | b3283 | yrdD | predicted DNA topoisomerase (NCBI) | sig. | 31 | 9 |
| | Dickeya dadantii 3937 | DDA3937_RS22495 | | topoisomerase DNA-binding C4 zinc finger domain-containing protein | insig. | 29 | 10 |
| | Dickeya dianthicola ME23 | DZA65_RS20325 | | hypothetical protein | insig. | 32 | 16 |