| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_02810 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 100 | 100 |
| o | Dickeya dadantii 3937 | DDA3937_RS16895 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 72 | 99 |
| o | Dickeya dianthicola 67-19 | HGI48_RS16965 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Rahnella sp. WP5 | EX31_RS07850 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 72 | 99 |
| o | Dickeya dianthicola ME23 | DZA65_RS18040 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Serratia liquefaciens MT49 | IAI46_03760 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Pantoea sp. MT58 | IAI47_04210 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 100 |
| o | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS16755 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Erwinia amylovora T8 | OLJFJH_09355 | | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 72 | 99 |
| o | Pectobacterium carotovorum WPP14 | HER17_RS04330 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Shewanella amazonensis SB2B | Sama_1039 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (RefSeq) | no data | 68 | 99 |
| o | Alteromonas macleodii MIT1002 | MIT1002_00630 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 71 | 99 |
| o | Shewanella loihica PV-4 | Shew_1208 | | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (RefSeq) | no data | 70 | 99 |
| o | Shewanella oneidensis MR-1 | SO3437 | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (NCBI ptt file) | no data | 70 | 99 |
| o | Shewanella sp. ANA-3 | Shewana3_1119 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (RefSeq) | no data | 69 | 99 |
| o | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_17475 | ispF | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 70 | 99 |
| o | Erwinia tracheiphila SCR3 | LU632_RS06455 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 70 | 99 |
| o | Klebsiella pneumoniae MKP103 | KDGMDA_03245 | | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 76 | 99 |
| o | Klebsiella michiganensis M5al | BWI76_RS22670 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Pseudomonas sp. S08-1 | OH686_18160 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 69 | 99 |
| o | Enterobacter asburiae PDN3 | EX28DRAFT_2842 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 75 | 99 |
| o | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF4794 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 75 | 99 |
| o | Escherichia coli BL21 | ECD_02596 | | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECOR27 | NOLOHH_12285 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECOR38 | HEPCGN_19650 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC100 | OKFHMN_20470 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC101 | MCAODC_10995 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC102 | NIAGMN_18240 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC62 | BNILDI_10835 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC98 | JDDGAC_24135 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli ECRC99 | KEDOAH_07670 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_00987 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli BW25113 | b2746 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (NCBI) | no data | 75 | 99 |
| o | Escherichia fergusonii Becca | EFB2_01164 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Escherichia coli Nissle 1917 | ECOLIN_RS15355 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Pseudomonas stutzeri RCH2 | Psest_2812 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 69 | 97 |
| o | Enterobacter sp. TBS_079 | MPMX20_03632 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 75 | 99 |
| o | Kangiella aquimarina DSM 16071 | B158DRAFT_2294 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 66 | 99 |
| o | Pseudomonas putida KT2440 | PP_1618 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 66 | 99 |
| o | Pseudomonas sp. BP01 | JOY50_RS23730 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 66 | 99 |
| o | Pseudomonas aeruginosa PA14 | IKLFDK_18520 | | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 66 | 97 |
| o | Pseudomonas simiae WCS417 | PS417_06340 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 65 | 99 |
| o | Pseudomonas aeruginosa MRSN321 | DY961_RS14840 | ispF;go_function=2-C-methyl-D-erythritol | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 66 | 97 |
| o | Pseudomonas aeruginosa PUPa3 | DQ20_RS42285 | ispF;go_function=2-C-methyl-D-erythritol | 2-C-methyl-D-erythritol 2 4-cyclodiphosphate synthase | no data | 66 | 97 |
| o | Pseudomonas fluorescens SBW25 | PFLU_RS06405 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas fluorescens SBW25-INTG | PFLU_RS06405 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas orientalis W4I3 | QF045_RS09185 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4680 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 64 | 99 |
| o | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_3110 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 64 | 99 |
| o | Pseudomonas syringae pv. syringae B728a | Psyr_1369 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 65 | 99 |
| o | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1369 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 65 | 99 |
| o | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_3042 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 64 | 99 |
| o | Pseudomonas fluorescens FW300-N2C3 | AO356_05910 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas sp. DMC3 | GFF2079 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas lactucae CFBP13502 | GEMAOFIL_01438 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas fluorescens FW300-N2E3 | AO353_16590 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 63 | 99 |
| o | Pseudomonas sp. SVBP6 | COO64_RS19770 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 99 |
| o | Pseudomonas sp. RS175 | PFR28_00422 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 63 | 99 |
| o | Pseudomonas segetis P6 | MPMX49_03434 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 66 | 99 |
| o | Rhodanobacter sp. FW510-T8 | OKGIIK_08140 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 57 | 99 |
| o | Rhodanobacter denitrificans MT42 | LRK55_RS16355 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 99 |
| o | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS16630 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 99 |
| o | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS12290 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 56 | 99 |
| o | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS06615 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 97 |
| o | Herbaspirillum seropedicae SmR1 | HSERO_RS15190 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 59 | 99 |
| o | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_00882 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 59 | 99 |
| o | Burkholderia phytofirmans PsJN | BPHYT_RS09300 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 58 | 99 |
| o | Acinetobacter baumannii LAC-4 | RR41_RS08000 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 59 | 97 |
| o | Methylophilus sp. DMC18 | GFF2 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 58 | 96 |
| o | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4932 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 58 | 99 |
| o | Cupriavidus basilensis FW507-4G11 | RR42_RS07855 | | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | no data | 57 | 99 |
| o | Lysobacter sp. OAE881 | ABIE51_RS06465 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 54 | 99 |
| o | Paraburkholderia sabiae LMG 24235 | QEN71_RS22050 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 56 | 99 |
| o | Paraburkholderia graminis OAS925 | ABIE53_002097 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 58 | 99 |
| o | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS01435 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 56 | 99 |
| o | Ralstonia solanacearum UW163 | UW163_RS14745 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 56 | 99 |
| o | Ralstonia sp. UNC404CL21Col | ABZR87_RS13230 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 99 |
| o | Ralstonia solanacearum GMI1000 | RS_RS08285 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 99 |
| o | Ralstonia solanacearum PSI07 | RPSI07_RS16050 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 54 | 99 |
| o | Variovorax sp. OAS795 | ABID97_RS17275 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 53 | 99 |
| o | Dechlorosoma suillum PS | Dsui_2391 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 53 | 99 |
| | Azospirillum sp. SherDot2 | MPMX19_01108 | | Bifunctional enzyme IspD/IspF | no data | 52 | 98 |
| o | Marinobacter adhaerens HP15 | HP15_1277 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 64 | 98 |
| o | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3138.1 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 52 | 99 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS04805 | | bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 55 | 95 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14410 | | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | no data | 52 | 98 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c14760 | | bifunctional enzyme IspDF | insig. | 47 | 99 |
| o | Synechocystis sp000284455 PCC 6803 | SGL_RS06450 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 51 | 99 |
| o | Acinetobacter radioresistens SK82 | MPMX26_01675 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 60 | 97 |
| o | Fusobacterium nucleatum SB010 | HUW76_00790 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 50 | 99 |
| | Rhodospirillum rubrum S1H | Rru_A1674 | | bifunctional enzyme, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C- methyl-D-erythritol synthase (NCBI) | no data | 51 | 97 |
| | Bosea sp. OAE506 | ABIE41_RS16800 | | bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 51 | 99 |
| | Caulobacter crescentus NA1000 | CCNA_01812 | | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 52 | 97 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_01812 | | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 52 | 97 |
| | Xanthobacter sp. DMC5 | GFF851 | | Bifunctional enzyme IspD/IspF | no data | 52 | 98 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_0144 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 51 | 97 |
| | Rhodopseudomonas palustris CGA009 | TX73_013405 | | bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 52 | 98 |
| o | Variovorax sp. SCN45 | GFF410 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) | no data | 53 | 99 |
| o | Synechococcus elongatus PCC 7942 | Synpcc7942_1170 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 49 | 97 |
| o | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS04815 | | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | no data | 51 | 99 |