| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Agrobacterium fabrum C58 | Atu2826 | | protease heat shock protein | insig. | 100 | 100 |
| o | Sinorhizobium meliloti 1021 | SMc04091 | | heat shock protein HtpX | sig. | 81 | 100 |
| o | Rhizobium sp. OAE497 | ABIE40_RS19145 | | zinc metalloprotease HtpX | insig. | 81 | 100 |
| o | Xanthobacter sp. DMC5 | GFF3853 | | Protease HtpX | insig. | 69 | 93 |
| o | Rhodospirillum rubrum S1H | Rru_A3579 | | Peptidase M48, Ste24p (NCBI) | insig. | 71 | 87 |
| o | Azospirillum brasilense Sp245 | AZOBR_RS00250 | | heat shock protein HtpX | insig. | 66 | 88 |
| o | Rhodopseudomonas palustris CGA009 | TX73_004060 | | zinc metalloprotease HtpX | insig. | 62 | 95 |
| o | Sphingobium sp. HT1-2 | GFF3270 | | Protease HtpX homolog | insig. | 63 | 89 |
| o | Azospirillum sp. SherDot2 | MPMX19_00488 | | Protease HtpX | insig. | 59 | 99 |
| o | Caulobacter crescentus NA1000 | CCNA_02594 | | heat shock endopeptidase HtpX | cofit | 58 | 100 |
| o | Caulobacter crescentus NA1000 Δfur | CCNA_02594 | | heat shock endopeptidase HtpX | cofit | 58 | 100 |
| o | Sphingomonas koreensis DSMZ 15582 | Ga0059261_2238 | | Zn-dependent protease with chaperone function | insig. | 62 | 88 |
| o | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS14650 | | zinc metalloprotease HtpX | insig. | 61 | 92 |
| o | Paraburkholderia sabiae LMG 24235 | QEN71_RS00170 | | zinc metalloprotease HtpX | sig. | 59 | 87 |
| o | Paraburkholderia graminis OAS925 | ABIE53_000391 | | heat shock protein HtpX | strong | 59 | 87 |
| o | Burkholderia phytofirmans PsJN | BPHYT_RS01470 | | protease HtpX homolog | no data | 59 | 87 |
| o | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02238 | | Heat shock protein. Metallo peptidase. MEROPS family M48B | insig. | 58 | 87 |
| o | Bosea sp. OAE506 | ABIE41_RS05110 | | zinc metalloprotease HtpX | insig. | 62 | 87 |
| o | Cupriavidus basilensis FW507-4G11 | RR42_RS20455 | | protease HtpX | insig. | 59 | 87 |
| o | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS09785 | | protease | insig. | 60 | 87 |
| o | Ralstonia solanacearum UW163 | UW163_RS03795 | | protease | insig. | 60 | 87 |
| o | Ralstonia solanacearum PSI07 | RPSI07_RS23580 | | zinc metalloprotease HtpX | insig. | 60 | 87 |
| o | Ralstonia sp. UNC404CL21Col | ABZR87_RS04955 | | zinc metalloprotease HtpX | insig. | 59 | 87 |
| o | Ralstonia solanacearum GMI1000 | RS_RS00370 | | protease HtpX | sig. | 59 | 87 |
| o | Dechlorosoma suillum PS | Dsui_0815 | | Zn-dependent protease with chaperone function | cofit | 56 | 87 |
| o | Methylophilus sp. DMC18 | GFF1498 | | Protease HtpX | insig. | 54 | 88 |
| o | Desulfovibrio vulgaris Miyazaki F | DvMF_0946 | | peptidase M48 Ste24p (RefSeq) | insig. | 46 | 87 |
| o | Desulfovibrio vulgaris Hildenborough JW710 | DVU2494 | | peptidase, M48 family (TIGR) | sig. | 47 | 87 |
| o | Mycobacterium tuberculosis H37Rv | Rv0563 | | Probable protease transmembrane protein heat shock protein HtpX | sig. | 46 | 87 |
| o | Methanococcus maripaludis JJ | MMJJ_RS03175 | | zinc metalloprotease HtpX | sig. | 43 | 87 |
| o | Methanococcus maripaludis S2 | MMP_RS02130 | | zinc metalloprotease HtpX | strong | 43 | 87 |
| o | Bifidobacterium breve UCC2003 | BBR_RS10735 | | zinc metalloprotease HtpX | strong | 44 | 87 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03977 | | peptidase, M48 family | insig. | 34 | 73 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS01380 | | M48 family metallopeptidase | insig. | 31 | 84 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS09810 | | heat shock protein HtpX | insig. | 34 | 84 |
| | Rhodopseudomonas palustris CGA009 | TX73_023340 | | M48 family metallopeptidase | insig. | 30 | 87 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1199 | | putative protease (NCBI ptt file) | sig. | 34 | 73 |
| | Azospirillum sp. SherDot2 | MPMX19_06400 | | Protease HtpX | insig. | 30 | 85 |
| | Dechlorosoma suillum PS | Dsui_1149 | | Zn-dependent protease with chaperone function | cofit | 33 | 83 |
| | Acinetobacter radioresistens SK82 | MPMX26_00808 | | Protease HtpX | no data | 33 | 85 |
| | Azospirillum brasilense Sp245 | AZOBR_RS21965 | | peptidase M48 Ste24p | insig. | 33 | 85 |
| | Acinetobacter baumannii LAC-4 | RR41_RS04305 | | protease HtpX | sig. | 33 | 86 |
| | Bosea sp. OAE506 | ABIE41_RS00330 | | M48 family metallopeptidase | insig. | 33 | 73 |
| | Escherichia coli BL21 | ECD_01800 | | putative endopeptidase | insig. | 33 | 85 |
| | Escherichia fergusonii Becca | EFB2_02172 | | Protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECOR27 | NOLOHH_16980 | htpX | protease HtpX | no data | 33 | 85 |
| | Escherichia coli ECOR38 | HEPCGN_04870 | htpX | protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECRC100 | OKFHMN_26470 | htpX | protease HtpX | cofit | 33 | 85 |
| | Escherichia coli ECRC101 | MCAODC_18935 | htpX | protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECRC102 | NIAGMN_01590 | htpX | protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECRC62 | BNILDI_15775 | htpX | protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECRC98 | JDDGAC_01045 | htpX | protease HtpX | insig. | 33 | 85 |
| | Escherichia coli ECRC99 | KEDOAH_01635 | htpX | protease HtpX | no data | 33 | 85 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_01902 | | Protease HtpX | sig. | 33 | 85 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS10185 | | protease HtpX | no data | 33 | 85 |
| | Pseudomonas stutzeri RCH2 | Psest_1770 | | Zn-dependent protease with chaperone function | no data | 32 | 84 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2844 | | Probable protease HtpX (EC 3.4.24.-) | no data | 33 | 86 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS14825 | | protease HtpX | strong | 32 | 79 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS19940 | | heat-shock protein HtpX | insig. | 33 | 85 |
| | Dechlorosoma suillum PS | Dsui_1503 | | Zn-dependent protease with chaperone function | insig. | 32 | 87 |
| | Escherichia coli BW25113 | b1829 | htpX | heat shock protein HtpX (NCBI) | strong | 32 | 85 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.2262.1 | | Probable protease htpX homolog (EC 3.4.24.-) | insig. | 37 | 64 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1965 | | Heat shock protease | insig. | 35 | 82 |
| | Enterobacter sp. TBS_079 | MPMX20_02736 | | Protease HtpX | sig. | 33 | 86 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_25240 | | protease HtpX | cofit | 32 | 86 |
| | Klebsiella pneumoniae MRSN742743 | KFA93_RS07815 | htpX;go_function=metalloendopeptidase | protease HtpX | cofit | 32 | 86 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_03645 | htpX | protease HtpX | strong | 32 | 79 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS14540 | | protease HtpX | strong | 32 | 79 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS00580 | | protease HtpX | strong | 34 | 78 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_0727 | | Zn-dependent protease with chaperone function | insig. | 33 | 86 |
| | Klebsiella michiganensis M5al | BWI76_RS17970 | | zinc metalloprotease HtpX | insig. | 32 | 86 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS13770 | | protease HtpX | insig. | 33 | 79 |
| | Fusobacterium nucleatum SB010 | HUW76_05515 | | M48 family metalloprotease | cofit | 34 | 76 |
| | Dickeya dianthicola ME23 | DZA65_RS11840 | | protease HtpX | sig. | 31 | 86 |
| | Serratia liquefaciens MT49 | IAI46_10810 | | protease HtpX | no data | 32 | 86 |
| | Dickeya dianthicola 67-19 | HGI48_RS11505 | | protease HtpX | insig. | 31 | 86 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS02845 | htpX;go_function=metalloendopeptidase | protease HtpX | strong | 33 | 79 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_14375 | | protease HtpX | strong | 33 | 79 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS32750 | htpX;go_function=metalloendopeptidase | protease HtpX | strong | 33 | 79 |
| | Pseudomonas sp. SVBP6 | COO64_RS05985 | htpX | protease HtpX | insig. | 32 | 78 |
| | Pectobacterium carotovorum WPP14 | HER17_RS11545 | | protease HtpX | insig. | 32 | 86 |
| | Dickeya dadantii 3937 | DDA3937_RS11460 | | protease HtpX | sig. | 31 | 86 |
| | Pseudomonas sp. BP01 | JOY50_RS16990 | htpX | protease HtpX | insig. | 31 | 78 |
| | Pantoea sp. MT58 | IAI47_08710 | | protease HtpX | strong | 31 | 86 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13516_RS08840 | htpX | protease HtpX | cofit | 31 | 86 |
| | Rahnella sp. WP5 | EX31_RS24885 | | protease HtpX | no data | 32 | 86 |
| | Pseudomonas segetis P6 | ACVTMO_RS11285 | htpX | protease HtpX | insig. | 32 | 84 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_2016 | | Zn-dependent protease with chaperone function | insig. | 36 | 64 |
| | Marinobacter adhaerens HP15 | HP15_2097 | | protease HtpX-like protein | sig. | 32 | 78 |
| | Pseudomonas putida KT2440 | PP_1871 | | Protease HtpX | strong | 30 | 78 |
| | Pseudomonas sp. S08-1 | OH686_22565 | | Protease HtpX | strong | 34 | 65 |
| | Lysobacter sp. OAE881 | ABIE51_RS13515 | | protease HtpX | insig. | 34 | 78 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS16415 | | heat shock protein HtpX | insig. | 34 | 79 |
| | Pseudomonas orientalis W4I3 | QF045_RS11280 | | protease HtpX | cofit | 35 | 64 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_01843 | | Protease HtpX | cofit | 34 | 64 |
| | Pseudomonas protegens RBAN4 | FABNJH_21935 | htpX | protease HtpX | insig. | 34 | 63 |
| | Pseudomonas sp. RS175 | PFR28_00983 | | Protease HtpX | strong | 34 | 64 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_3616 | | Heat shock protein, Metallo peptidase, MEROPS family M48B | sig. | 34 | 64 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3616 | | Heat shock protein, Metallo peptidase, MEROPS family M48B | sig. | 34 | 64 |
| | Pseudomonas sp. DMC3 | GFF4597 | | Protease HtpX | cofit | 34 | 64 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_03095 | | protease HtpX | strong | 34 | 64 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2447 | | Probable protease htpX homolog (EC 3.4.24.-) | strong | 31 | 78 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_19145 | | protease HtpX | strong | 31 | 78 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_2250 | | Probable protease htpX homolog (EC 3.4.24.-) | strong | 34 | 63 |
| | Pseudomonas simiae WCS417 | PS417_08555 | | protease HtpX | no data | 33 | 64 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_262 | | Probable protease htpX homolog (EC 3.4.24.-) | strong | 31 | 78 |
| | Variovorax sp. SCN45 | GFF4554 | | Protease HtpX | insig. | 33 | 82 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF526 | | Heat shock protease | cofit | 36 | 82 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS08505 | | protease HtpX | strong | 33 | 63 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS08505 | | protease HtpX | strong | 33 | 63 |
| | Variovorax sp. OAS795 | ABID97_RS06055 | | protease HtpX | strong | 33 | 82 |
| | Erwinia amylovora T8 | OLJFJH_13015 | | protease HtpX | sig. | 34 | 86 |
| | Shewanella amazonensis SB2B | Sama_1443 | | heat shock protein HtpX (RefSeq) | no data | 36 | 63 |
| | Shewanella sp. ANA-3 | Shewana3_2512 | | heat shock protein HtpX (RefSeq) | cofit | 36 | 62 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_00485 | | Zn-dependent protease | insig. | 36 | 70 |
| | Klebsiella pneumoniae MRSN742743 | KFA93_RS24540 | | zinc metalloprotease HtpX | insig. | 36 | 70 |
| | Shewanella oneidensis MR-1 | SO2728 | htpX | peptidase HtpX (NCBI ptt file) | strong | 35 | 63 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_05670 | | protease HtpX | cofit | 33 | 64 |
| | Shewanella loihica PV-4 | Shew_1723 | | heat shock protein HtpX (RefSeq) | strong | 34 | 63 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS02205 | | protease HtpX | no data | 31 | 83 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_22345 | htpX | protease HtpX | no data | 33 | 60 |
| | Erwinia tracheiphila SCR3 | LU632_RS13240 | htpX | protease HtpX | no data | 34 | 60 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_0847 | | Zn-dependent protease with chaperone function | insig. | 30 | 75 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS04525 | | M48 family metallopeptidase | insig. | 30 | 74 |
| | Marinobacter adhaerens HP15 | HP15_2354 | | peptidase M48, Ste24p | insig. | 28 | 74 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS05475 | | M48 family metallopeptidase | sig. | 30 | 73 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS05250 | | M48 family metallopeptidase | insig. | 30 | 72 |
| | Pseudomonas protegens RBAN4 | FABNJH_13080 | | Peptidase-M48 domain-containing protein | insig. | 27 | 65 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1790 | | Heat shock protein HtpX (EC 3.4.24.-) | insig. | 25 | 71 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS12410 | | M48 family metalloprotease | insig. | 26 | 51 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS18755 | | M48 family metallopeptidase | insig. | 25 | 50 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01288 | | peptidase, M48 family | insig. | 26 | 61 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF5732 | | macromolecule metabolism; macromolecule degradation; degradation of proteins, peptides, glycopeptides | cofit | 30 | 60 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT0149 | | peptidase (NCBI ptt file) | sig. | 27 | 60 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS01680 | | M48 family metallopeptidase | sig. | 23 | 61 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01090 | | hypothetical protein | insig. | 24 | 50 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS15385 | | M48 family metallopeptidase | insig. | 24 | 61 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS14775 | | peptidase M48 | cofit | 25 | 60 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1678 | | macromolecule metabolism; macromolecule degradation; degradation of proteins, peptides, glycopeptides | insig. | 27 | 74 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0332 | | Zn-dependent protease with chaperone function | insig. | 26 | 55 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS07000 | | M48 family metallopeptidase | strong | 24 | 75 |
| | Methylophilus sp. DMC18 | GFF1172 | | Protease HtpX | cofit | 26 | 64 |
| | Sphingobium sp. HT1-2 | GFF3449 | | hypothetical protein | cofit | 27 | 63 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13516_RS03905 | loiP | metalloprotease LoiP | cofit | 25 | 81 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06545 | | peptidase M48 Ste24p | insig. | 24 | 79 |
| | Acinetobacter radioresistens SK82 | MPMX26_01126 | | Beta-barrel assembly-enhancing protease | no data | 32 | 58 |
| | Shewanella oneidensis MR-1 | SO1137 | | conserved hypothetical protein (NCBI ptt file) | sig. | 27 | 62 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS14295 | | M48 family metallopeptidase | insig. | 25 | 60 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS24875 | | hypothetical protein | insig. | 21 | 83 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_12770 | | heat-shock protein HtpX | insig. | 38 | 22 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS12195 | | peptidase | insig. | 31 | 31 |
| | Alteromonas macleodii MIT1002 | MIT1002_00315 | | heat shock protein HtpX | insig. | 37 | 20 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS17815 | | M48 family metallopeptidase | sig. | 28 | 49 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_11220 | | Peptidase-M48 domain-containing protein | insig. | 28 | 49 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS40030 | | M48 family metallopeptidase | insig. | 28 | 49 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS26750 | | M48 family metallopeptidase | insig. | 27 | 58 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS04250 | | M48 family metallopeptidase | strong | 25 | 59 |
| | Dechlorosoma suillum PS | Dsui_3223 | | Zn-dependent protease with chaperone function | cofit | 23 | 65 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS09640 | | M48 family metallopeptidase | sig. | 25 | 59 |
| | Pseudomonas sp. S08-1 | OH686_14520 | | hypothetical protein | insig. | 28 | 54 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS10150 | | M48 family metallopeptidase | insig. | 23 | 87 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS14725 | | peptidase M48 | no data | 23 | 59 |
| | Variovorax sp. OAS795 | ABID97_RS08785 | | M48 family metallopeptidase | cofit | 27 | 60 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3666 | | Putative metalloprotease yggG (EC 3.4.24.-) | insig. | 26 | 61 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1729 | | putative Zn-dependent protease containing TPR repeats | insig. | 28 | 45 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13516_RS21575 | | M48 family metallopeptidase | insig. | 28 | 44 |
| | Paraburkholderia graminis OAS925 | ABIE53_003120 | | STE24 endopeptidase | sig. | 22 | 59 |
| | Pantoea sp. MT58 | IAI47_03675 | | M48 family metallopeptidase | insig. | 24 | 80 |
| | Pantoea sp. MT58 | IAI47_20955 | | M48 family metallopeptidase | insig. | 28 | 44 |