| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Pseudomonas putida KT2440 | 1.0 | PP_4724 | | Carbamoyl-phosphate synthase small chain | 1.0 | PP_0966 | | Histidinol dehydrogenase | 0.53 | 17 |
| Pseudomonas fluorescens FW300-N2E3 | 0.94 | AO353_05635 | | carbamoyl phosphate synthase small subunit | 0.92 | AO353_05110 | | histidinol dehydrogenase | — | — |
| Pseudomonas simiae WCS417 | 0.93 | PS417_24045 | | carbamoyl phosphate synthase small subunit | 0.91 | PS417_04420 | | histidinol dehydrogenase | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.93 | Pf1N1B4_1173 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.92 | Pf1N1B4_1066 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.92 | Pf6N2E2_3365 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.90 | Pf6N2E2_3252 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.92 | AO356_07485 | | carbamoyl phosphate synthase small subunit | 0.90 | AO356_06965 | | histidinol dehydrogenase | — | — |
| Pseudomonas sp. RS175 | 0.92 | PFR28_00076 | | Carbamoyl-phosphate synthase small chain | 0.90 | PFR28_00187 | | Histidinol dehydrogenase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.92 | PfGW456L13_5100 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.91 | PfGW456L13_5000 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.92 | PFLU_RS25885 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.92 | PFLU_RS04470 | | histidinol dehydrogenase | — | — |
| Pseudomonas fluorescens SBW25 | 0.92 | PFLU_RS25885 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.92 | PFLU_RS04470 | | histidinol dehydrogenase | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.91 | Psyr_4192 | | carbamoyl-phosphate synthase small subunit | 0.89 | Psyr_4133 | | histidinol dehydrogenase | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.91 | Psyr_4192 | | carbamoyl-phosphate synthase small subunit | 0.89 | Psyr_4133 | | histidinol dehydrogenase | — | — |
| Pseudomonas sp. S08-1 | 0.88 | OH686_17075 | | Carbamoyl-phosphate synthase small chain | 0.85 | OH686_08470 | | Histidinol dehydrogenase | — | — |
| Pseudomonas stutzeri RCH2 | 0.87 | Psest_0967 | | carbamoyl-phosphate synthase, small subunit | 0.85 | Psest_3298 | | histidinol dehydrogenase | — | — |
| Vibrio cholerae E7946 ATCC 55056 | 0.75 | CSW01_12105 | | carbamoyl-phosphate synthase small subunit | 0.34 | CSW01_05750 | | histidinol dehydrogenase | low | > 62 |
| Marinobacter adhaerens HP15 | 0.75 | HP15_3078 | | carbamoyl-phosphate synthase small chain | 0.70 | HP15_2428 | | histidinol dehydrogenase | 0.42 | 8 |
| Shewanella amazonensis SB2B | 0.74 | Sama_2504 | | carbamoyl phosphate synthase small subunit (RefSeq) | 0.33 | Sama_1942 | hisD | histidinol dehydrogenase (RefSeq) | 0.74 | 52 |
| Rahnella sp. WP5 | 0.72 | EX31_RS03835 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | EX31_RS11440 | | histidinol dehydrogenase | 0.95 | 27 |
| Shewanella oneidensis MR-1 | 0.72 | SO1141 | carA | carbamoyl-phosphate synthase, small subunit (NCBI ptt file) | 0.32 | SO2073 | hisD | histidinol dehydrogenase (NCBI ptt file) | 0.90 | 23 |
| Pectobacterium carotovorum WPP14 | 0.72 | HER17_RS02895 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | HER17_RS12230 | | histidinol dehydrogenase | 0.96 | 11 |
| Klebsiella michiganensis M5al | 0.72 | BWI76_RS04465 | | carbamoyl-phosphate synthase small subunit | 0.31 | BWI76_RS18925 | | histidinol dehydrogenase | 0.49 | 64 |
| Enterobacter asburiae PDN3 | 0.72 | EX28DRAFT_3637 | | carbamoyl-phosphate synthase, small subunit | 0.31 | EX28DRAFT_0539 | | histidinol dehydrogenase | — | — |
| Kangiella aquimarina DSM 16071 | 0.71 | B158DRAFT_0615 | | carbamoyl-phosphate synthase, small subunit | 0.28 | B158DRAFT_2293 | | histidinol dehydrogenase | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.71 | GFF214 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.32 | GFF3912 | | Histidinol dehydrogenase (EC 1.1.1.23) | low | > 78 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.71 | OHPLBJKB_03625 | | Carbamoyl-phosphate synthase small chain | 0.32 | OHPLBJKB_01680 | | Histidinol dehydrogenase | low | > 73 |
| Escherichia coli BL21 | 0.71 | ECD_00036 | | carbamoyl phosphate synthetase small subunit, glutamine amidotransferase | 0.32 | ECD_01922 | | bifunctional histidinal dehydrogenase/ histidinol dehydrogenase | low | > 60 |
| Escherichia coli BW25113 | 0.71 | b0032 | carA | carbamoyl-phosphate synthase small subunit (NCBI) | 0.32 | b2020 | hisD | histidinol dehydrogenase (NCBI) | 0.85 | 34 |
| Escherichia coli Nissle 1917 | 0.71 | ECOLIN_RS00175 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | ECOLIN_RS11945 | | histidinol dehydrogenase | — | — |
| Escherichia fergusonii Becca | 0.71 | EFB2_04013 | | Carbamoyl-phosphate synthase small chain | 0.32 | EFB2_01836 | | Histidinol dehydrogenase | low | > 86 |
| Enterobacter sp. TBS_079 | 0.71 | MPMX20_00739 | | Carbamoyl-phosphate synthase small chain | 0.31 | MPMX20_03002 | | Histidinol dehydrogenase | 0.84 | 40 |
| Dickeya dianthicola ME23 | 0.71 | DZA65_RS19385 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | DZA65_RS10055 | | histidinol dehydrogenase | low | > 75 |
| Escherichia coli ECRC98 | 0.71 | JDDGAC_14540 | carA | carbamoyl phosphate synthase small subunit | 0.32 | JDDGAC_28625 | hisD | Histidinol dehydrogenase | — | — |
| Dickeya dadantii 3937 | 0.71 | DDA3937_RS18310 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.33 | DDA3937_RS09735 | | histidinol dehydrogenase | 0.84 | 18 |
| Escherichia coli ECRC62 | 0.71 | BNILDI_08325 | carA | carbamoyl phosphate synthase small subunit | 0.31 | BNILDI_14740 | hisD | Histidinol dehydrogenase | — | — |
| Alteromonas macleodii MIT1002 | 0.71 | MIT1002_01466 | | Carbamoyl-phosphate synthase small chain | 0.32 | MIT1002_02633 | | Histidinol dehydrogenase | 0.98 | 18 |
| Escherichia coli ECOR27 | 0.71 | NOLOHH_03275 | carA | carbamoyl phosphate synthase small subunit | 0.32 | NOLOHH_15830 | hisD | Histidinol dehydrogenase | low | > 57 |
| Escherichia coli ECRC102 | 0.71 | NIAGMN_08795 | carA | carbamoyl phosphate synthase small subunit | 0.32 | NIAGMN_22460 | hisD | Histidinol dehydrogenase | — | — |
| Escherichia coli ECRC99 | 0.71 | KEDOAH_17210 | carA | carbamoyl phosphate synthase small subunit | 0.32 | KEDOAH_03635 | hisD | Histidinol dehydrogenase | — | — |
| Escherichia coli ECRC101 | 0.71 | OKFHMN_10945 | carA | carbamoyl phosphate synthase small subunit | 0.32 | OKFHMN_24515 | hisD | Histidinol dehydrogenase | — | — |
| Escherichia coli ECRC101 | 0.71 | MCAODC_01460 | carA | carbamoyl phosphate synthase small subunit | 0.32 | MCAODC_20425 | hisD | Histidinol dehydrogenase | — | — |
| Dickeya dianthicola 67-19 | 0.71 | HGI48_RS18245 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | HGI48_RS09745 | | histidinol dehydrogenase | low | > 71 |
| Shewanella loihica PV-4 | 0.71 | Shew_2839 | | carbamoyl phosphate synthase small subunit (RefSeq) | 0.33 | Shew_2198 | | histidinol dehydrogenase (RefSeq) | 0.83 | 60 |
| Escherichia coli ECOR38 | 0.71 | HEPCGN_08930 | carA | carbamoyl phosphate synthase small subunit | 0.32 | HEPCGN_03220 | hisD | Histidinol dehydrogenase | low | > 85 |
| Lysobacter sp. OAE881 | 0.70 | ABIE51_RS11625 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | ABIE51_RS13325 | | histidinol dehydrogenase | 0.55 | 30 |
| Shewanella sp. ANA-3 | 0.70 | Shewana3_0967 | | carbamoyl phosphate synthase small subunit (RefSeq) | 0.33 | Shewana3_1853 | hisD | histidinol dehydrogenase (RefSeq) | 0.92 | 30 |
| Serratia liquefaciens MT49 | 0.70 | IAI46_03190 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.30 | IAI46_08210 | | histidinol dehydrogenase | low | > 86 |
| Acinetobacter radioresistens SK82 | 0.70 | MPMX26_00767 | | Carbamoyl-phosphate synthase small chain | 0.57 | MPMX26_02587 | | Histidinol dehydrogenase | low | > 36 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.70 | Xcc-8004.2914.1 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.35 | Xcc-8004.2948.1 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Dechlorosoma suillum PS | 0.69 | Dsui_3065 | | carbamoyl-phosphate synthase, small subunit | 0.63 | Dsui_1411 | | histidinol dehydrogenase | — | — |
| Pantoea sp. MT58 | 0.69 | IAI47_16120 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.30 | IAI47_07090 | | histidinol dehydrogenase | 0.89 | 15 |
| Cupriavidus basilensis FW507-4G11 | 0.69 | RR42_RS13520 | | carbamoyl phosphate synthase small subunit | 0.66 | RR42_RS18915 | | histidinol dehydrogenase | — | — |
| Ralstonia solanacearum PSI07 | 0.69 | RPSI07_RS15245 | | carbamoyl-phosphate synthase small subunit | 0.63 | RPSI07_RS10390 | | histidinol dehydrogenase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.68 | RALBFv3_RS02200 | | carbamoyl-phosphate synthase small subunit | 0.62 | RALBFv3_RS06845 | | histidinol dehydrogenase | — | — |
| Ralstonia solanacearum UW163 | 0.68 | UW163_RS15510 | | carbamoyl-phosphate synthase small subunit | 0.62 | UW163_RS06770 | | histidinol dehydrogenase | — | — |
| Ralstonia sp. UNC404CL21Col | 0.68 | ABZR87_RS14150 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.62 | ABZR87_RS02500 | | histidinol dehydrogenase | — | — |
| Erwinia tracheiphila SCR3 | 0.68 | LU632_RS02755 | carA | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | LU632_RS08945 | hisD | histidinol dehydrogenase | 0.60 | 57 |
| Paraburkholderia sabiae LMG 24235 | 0.68 | QEN71_RS04775 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.62 | QEN71_RS27865 | | histidinol dehydrogenase | — | — |
| Ralstonia solanacearum GMI1000 | 0.68 | RS_RS07620 | | carbamoyl-phosphate synthase small subunit | 0.62 | RS_RS14790 | | histidinol dehydrogenase | — | — |
| Herbaspirillum seropedicae SmR1 | 0.68 | HSERO_RS06920 | | carbamoyl phosphate synthase small subunit | 0.63 | HSERO_RS20345 | | histidinol dehydrogenase | — | — |
| Rhodanobacter denitrificans FW104-10B01 | 0.67 | LRK54_RS17995 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | LRK54_RS01605 | | histidinol dehydrogenase | — | — |
| Burkholderia phytofirmans PsJN | 0.66 | BPHYT_RS14195 | | carbamoyl phosphate synthase small subunit | 0.63 | BPHYT_RS17710 | | histidinol dehydrogenase | — | — |
| Rhodanobacter denitrificans MT42 | 0.66 | LRK55_RS17850 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | LRK55_RS01385 | | histidinol dehydrogenase | — | — |
| Dyella japonica UNC79MFTsu3.2 | 0.66 | ABZR86_RS05605 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | ABZR86_RS06730 | | histidinol dehydrogenase | — | — |
| Variovorax sp. OAS795 | 0.66 | ABID97_RS17090 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.64 | ABID97_RS23160 | | histidinol dehydrogenase | — | — |
| Acidovorax sp. GW101-3H11 | 0.66 | Ac3H11_435 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.63 | Ac3H11_4724 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Rhodanobacter sp. FW510-T8 | 0.66 | OKGIIK_07300 | | carbamoyl phosphate synthase small subunit | 0.32 | OKGIIK_04950 | hisD | histidinol dehydrogenase | low | > 52 |
| Paraburkholderia graminis OAS925 | 0.66 | ABIE53_003005 | | carbamoyl-phosphate synthase small subunit | 0.62 | ABIE53_003701 | | histidinol dehydrogenase | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.66 | H281DRAFT_04402 | | carbamoyl-phosphate synthase small subunit | 0.62 | H281DRAFT_05652 | | histidinol dehydrogenase | — | — |
| Variovorax sp. SCN45 | 0.66 | GFF377 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.64 | GFF5345 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.64 | GFF4899 | | Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) | 0.62 | GFF1314 | | Histidinol dehydrogenase (EC 1.1.1.23) | — | — |
| Castellaniella sp019104865 MT123 | 0.62 | ABCV34_RS15505 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.56 | ABCV34_RS11230 | | histidinol dehydrogenase | — | — |
| Phaeobacter inhibens DSM 17395 | 0.52 | PGA1_c06670 | | carbamoyl-phosphate synthase small chain | 0.46 | PGA1_c31190 | | histidinol dehydrogenase HisD | — | — |
| Azospirillum sp. SherDot2 | 0.52 | MPMX19_00757 | | Carbamoyl-phosphate synthase small chain | 0.44 | MPMX19_05543 | | Histidinol dehydrogenase | — | — |
| Rhodospirillum rubrum S1H | 0.50 | Rru_A2885 | | Carbamoyl-phosphate synthase, small subunit (NCBI) | 0.47 | Rru_A2771 | | Histidinol dehydrogenase (NCBI) | 0.59 | 51 |
| Magnetospirillum magneticum AMB-1 | 0.50 | AMB_RS03600 | | carbamoyl-phosphate synthase small subunit | 0.46 | AMB_RS16905 | | histidinol dehydrogenase | — | — |
| Rhodopseudomonas palustris CGA009 | 0.50 | TX73_006555 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.43 | TX73_023540 | | histidinol dehydrogenase | — | — |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.50 | A4249_RS16140 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.28 | A4249_RS10695 | | histidinol dehydrogenase | — | — |
| Dinoroseobacter shibae DFL-12 | 0.49 | Dshi_2387 | | carbamoyl-phosphate synthase, small subunit (RefSeq) | 0.45 | Dshi_0979 | | Histidinol dehydrogenase (RefSeq) | — | — |
| Sinorhizobium meliloti 1021 | 0.48 | SMc01569 | | carbamoyl phosphate synthase small subunit | 0.47 | SMc02307 | | histidinol dehydrogenase | 0.63 | 51 |
| Bosea sp. OAE506 | 0.47 | ABIE41_RS11975 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.45 | ABIE41_RS24015 | | histidinol dehydrogenase | — | — |
| Sphingomonas koreensis DSMZ 15582 | 0.47 | Ga0059261_4243 | | carbamoyl-phosphate synthase, small subunit | 0.44 | Ga0059261_1281 | | histidinol dehydrogenase | — | — |
| Rhizobium sp. OAE497 | 0.47 | ABIE40_RS12765 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.45 | ABIE40_RS02725 | | histidinol dehydrogenase | — | — |
| Agrobacterium fabrum C58 | 0.47 | Atu2170 | | carbamoylphosphate synthase small chain | 0.44 | Atu0537 | | histidinol dehydrogenase | — | — |
| Caulobacter crescentus NA1000 | 0.47 | CCNA_02925 | | carbamoyl-phosphate synthase small chain | 0.38 | CCNA_02431 | | histidinol dehydrogenase | — | — |
| Caulobacter crescentus NA1000 Δfur | 0.47 | CCNA_02925 | | carbamoyl-phosphate synthase small chain | 0.38 | CCNA_02431 | | histidinol dehydrogenase | low | > 67 |
| Synechococcus elongatus PCC 7942 | 0.45 | Synpcc7942_2122 | carA | carbamoyl phosphate synthase small subunit | 0.42 | Synpcc7942_1519 | hisD | histidinol dehydrogenase | — | — |
| Bifidobacterium breve UCC2003 | 0.39 | BBR_RS13630 | | carbamoyl-phosphate synthase small subunit | 0.31 | BBR_RS17055 | | histidinol dehydrogenase | low | > 34 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.39 | CA265_RS15240 | | carbamoyl phosphate synthase small subunit | 0.33 | CA265_RS03635 | | histidinol dehydrogenase | — | — |
| Desulfovibrio vulgaris Miyazaki F | 0.39 | DvMF_2370 | | carbamoyl phosphate synthase small subunit (RefSeq) | 0.39 | DvMF_2814 | hisD | histidinol dehydrogenase (RefSeq) | 0.64 | 48 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.39 | Echvi_0226 | | carbamoyl-phosphate synthase, small subunit | 0.30 | Echvi_2459 | | histidinol dehydrogenase | — | — |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.38 | CA264_19490 | | carbamoyl phosphate synthase small subunit | 0.29 | CA264_05030 | | histidinol dehydrogenase | low | > 74 |
| Desulfovibrio vulgaris Hildenborough JW710 | 0.38 | DVU3113 | carA | carbamoyl-phosphate synthase, small subunit (TIGR) | 0.41 | DVU0796 | hisD | histidinol dehydrogenase (TIGR) | — | — |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.38 | ABZR88_RS17830 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.32 | ABZR88_RS06880 | | histidinol dehydrogenase | — | — |
| Mycobacterium tuberculosis H37Rv | 0.38 | Rv1383 | | Probable carbamoyl-phosphate synthase small chain CarA (carbamoyl-phosphate synthetase glutamine chain) | 0.28 | Rv1599 | | Probable histidinol dehydrogenase HisD (HDH) | — | — |
| Methanococcus maripaludis JJ | 0.37 | MMJJ_RS06195 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.35 | MMJJ_RS00120 | | histidinol dehydrogenase | — | — |
| Methanococcus maripaludis S2 | 0.36 | MMP_RS08170 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.35 | MMP_RS05015 | | histidinol dehydrogenase | — | — |
| Bacteroides thetaiotaomicron VPI-5482 | 0.33 | BT0556 | | carbamoyl phosphate synthetase III (glutamine-hydrolyzing) (NCBI ptt file) | 0.28 | BT0201 | | histidinol dehydrogenase (NCBI ptt file) | low | > 81 |
| Bacteroides ovatus ATCC 8483 | 0.33 | BACOVA_03753 | | carbamoyl-phosphate synthase, small subunit | 0.28 | BACOVA_01234 | | histidinol dehydrogenase | low | > 94 |
| Phocaeicola vulgatus CL09T03C04 | 0.33 | HMPREF1058_RS06875 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.29 | HMPREF1058_RS15875 | | histidinol dehydrogenase | low | > 67 |
| Parabacteroides merdae CL09T00C40 | 0.33 | HMPREF1078_RS01295 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.31 | HMPREF1078_RS02450 | | histidinol dehydrogenase | low | > 61 |
| Phocaeicola dorei CL03T12C01 | 0.33 | ABI39_RS20670 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.29 | ABI39_RS11835 | | histidinol dehydrogenase | low | > 72 |
| Bacteroides stercoris CC31F | 0.32 | HMPREF1181_RS16070 | | glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | 0.29 | HMPREF1181_RS04860 | | histidinol dehydrogenase | low | > 56 |
Not shown: 2 genomes with orthologs for PP_4724 only; 0 genomes with orthologs for PP_0966 only