Conservation of cofitness between b0386 and b0243 in Escherichia coli BW25113

100 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b0386 proC pyrroline-5-carboxylate reductase (NCBI) 1.0 b0243 proA gamma-glutamyl phosphate reductase (NCBI) 0.90 1
Escherichia coli Nissle 1917 1.00 ECOLIN_RS02345 pyrroline-5-carboxylate reductase 0.99 ECOLIN_RS01830 glutamate-5-semialdehyde dehydrogenase low > 52
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03288 Pyrroline-5-carboxylate reductase 0.99 OHPLBJKB_03397 Gamma-glutamyl phosphate reductase low > 73
Escherichia coli BL21 1.00 ECD_00333 pyrroline-5-carboxylate reductase, NAD(P)-binding 0.99 ECD_00240 gamma-glutamylphosphate reductase low > 60
Escherichia coli ECOR38 1.00 HEPCGN_07250 proC pyrroline-5-carboxylate reductase 0.99 HEPCGN_07775 proA glutamate-5-semialdehyde dehydrogenase low > 85
Escherichia coli ECOR27 1.00 NOLOHH_01535 proC pyrroline-5-carboxylate reductase 0.99 NOLOHH_02045 proA glutamate-5-semialdehyde dehydrogenase low > 57
Escherichia coli ECRC62 1.00 BNILDI_22950 proC pyrroline-5-carboxylate reductase 0.99 BNILDI_00240 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC101 1.00 MCAODC_27835 proC pyrroline-5-carboxylate reductase 0.99 MCAODC_00190 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC98 1.00 JDDGAC_12265 proC pyrroline-5-carboxylate reductase 0.99 JDDGAC_13295 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC101 1.00 OKFHMN_08610 proC pyrroline-5-carboxylate reductase 0.99 OKFHMN_09670 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC99 1.00 KEDOAH_19355 proC pyrroline-5-carboxylate reductase 0.99 KEDOAH_18485 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC102 1.00 NIAGMN_06665 proC pyrroline-5-carboxylate reductase 0.99 NIAGMN_07530 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia fergusonii Becca 0.99 EFB2_03670 Pyrroline-5-carboxylate reductase 0.99 EFB2_03777 Gamma-glutamyl phosphate reductase 0.56 80
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF4283 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.86 GFF4115 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS06170 pyrroline-5-carboxylate reductase 0.86 BWI76_RS05835 gamma-glutamyl-phosphate reductase — —
Enterobacter sp. TBS_079 0.93 MPMX20_00976 Pyrroline-5-carboxylate reductase 0.88 MPMX20_00928 Gamma-glutamyl phosphate reductase 0.94 1
Enterobacter asburiae PDN3 0.93 EX28DRAFT_2585 pyrroline-5-carboxylate reductase 0.88 EX28DRAFT_2650 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.80 2
Erwinia tracheiphila SCR3 0.71 LU632_RS18995 proC pyrroline-5-carboxylate reductase 0.74 LU632_RS01190 proA glutamate-5-semialdehyde dehydrogenase 0.67 11
Pantoea sp. MT58 0.64 IAI47_14945 pyrroline-5-carboxylate reductase 0.75 IAI47_15115 glutamate-5-semialdehyde dehydrogenase 0.89 2
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_2058 proC pyrroline-5-carboxylate reductase 0.35 Synpcc7942_2265 proA glutamate-5-semialdehyde dehydrogenase — —
Lysobacter sp. OAE881 0.30 ABIE51_RS16065 pyrroline-5-carboxylate reductase 0.40 ABIE51_RS13365 glutamate-5-semialdehyde dehydrogenase 0.81 57
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS10425 pyrroline-5-carboxylate reductase 0.39 ABZR86_RS08680 glutamate-5-semialdehyde dehydrogenase 0.90 21
Shewanella loihica PV-4 0.29 Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.57 Shew_2847 proA gamma-glutamyl phosphate reductase (RefSeq) 0.95 9
Marinobacter adhaerens HP15 0.29 HP15_287 pyrroline-5-carboxylate reductase 0.43 HP15_601 gamma-glutamyl phosphate reductase — —
Shewanella amazonensis SB2B 0.29 Sama_2478 pyrroline-5-carboxylate reductase (RefSeq) 0.55 Sama_2515 proA gamma-glutamyl phosphate reductase (RefSeq) 0.98 1
Pseudomonas sp. S08-1 0.28 OH686_10980 pyrroline-5-carboxylate reductase 0.44 OH686_09340 Gamma-glutamyl phosphate reductase 0.69 16
Alteromonas macleodii MIT1002 0.28 MIT1002_03062 Pyrroline-5-carboxylate reductase 0.40 MIT1002_01885 Gamma-glutamyl phosphate reductase 0.97 15
Kangiella aquimarina DSM 16071 0.28 B158DRAFT_0197 pyrroline-5-carboxylate reductase 0.41 B158DRAFT_1470 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) low > 40
Pectobacterium carotovorum WPP14 0.28 HER17_RS03805 pyrroline-5-carboxylate reductase 0.74 HER17_RS04705 glutamate-5-semialdehyde dehydrogenase — —
Dechlorosoma suillum PS 0.28 Dsui_0602 pyrroline-5-carboxylate reductase 0.42 Dsui_1220 gamma-glutamyl phosphate reductase — —
Pseudomonas stutzeri RCH2 0.28 Psest_0283 pyrroline-5-carboxylate reductase 0.43 Psest_0508 gamma-glutamyl phosphate reductase — —
Shewanella oneidensis MR-1 0.28 SO3354 proC pyrroline-5-carboxylate reductase (NCBI ptt file) 0.56 SO1122 proA gamma-glutamyl phosphate reductase (NCBI ptt file) 0.99 1
Dickeya dadantii 3937 0.28 DDA3937_RS17305 pyrroline-5-carboxylate reductase 0.79 DDA3937_RS16530 glutamate-5-semialdehyde dehydrogenase 0.90 1
Rhodanobacter denitrificans MT42 0.27 LRK55_RS04030 pyrroline-5-carboxylate reductase 0.41 LRK55_RS02125 glutamate-5-semialdehyde dehydrogenase — —
Acidovorax sp. GW101-3H11 0.27 Ac3H11_788 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.40 Ac3H11_704 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) — —
Rhodanobacter denitrificans FW104-10B01 0.27 LRK54_RS04260 pyrroline-5-carboxylate reductase 0.41 LRK54_RS02370 glutamate-5-semialdehyde dehydrogenase 0.85 3
Rhodanobacter sp. FW510-T8 0.27 OKGIIK_11135 proC pyrroline-5-carboxylate reductase 0.37 OKGIIK_09415 proA glutamate-5-semialdehyde dehydrogenase low > 52
Shewanella sp. ANA-3 0.27 Shewana3_1193 pyrroline-5-carboxylate reductase (RefSeq) 0.56 Shewana3_0955 proA gamma-glutamyl phosphate reductase (RefSeq) 0.97 1
Paraburkholderia graminis OAS925 0.27 ABIE53_000840 pyrroline-5-carboxylate reductase 0.40 ABIE53_003523 glutamate-5-semialdehyde dehydrogenase low > 113
Vibrio cholerae E7946 ATCC 55056 0.27 CSW01_02450 pyrroline-5-carboxylate reductase 0.58 CSW01_11570 glutamate-5-semialdehyde dehydrogenase low > 62
Pseudomonas putida KT2440 0.27 PP_5095 pyrroline-5-carboxylate reductase 0.41 PP_4811 Gamma-glutamyl phosphate reductase low > 96
Burkholderia phytofirmans PsJN 0.27 BPHYT_RS03490 pyrroline-5-carboxylate reductase 0.41 BPHYT_RS16770 gamma-glutamyl phosphate reductase — —
Paraburkholderia bryophila 376MFSha3.1 0.27 H281DRAFT_04679 pyrroline-5-carboxylate reductase 0.41 H281DRAFT_06324 glutamate-5-semialdehyde dehydrogenase 0.42 59
Pseudomonas simiae WCS417 0.27 PS417_26730 pyrroline-5-carboxylate reductase 0.44 PS417_24745 gamma-glutamyl phosphate reductase 0.76 1
Serratia liquefaciens MT49 0.26 IAI46_21415 pyrroline-5-carboxylate reductase 0.77 IAI46_04435 glutamate-5-semialdehyde dehydrogenase 0.70 17
Dickeya dianthicola 67-19 0.26 HGI48_RS17350 pyrroline-5-carboxylate reductase 0.74 HGI48_RS16600 glutamate-5-semialdehyde dehydrogenase — —
Pseudomonas fluorescens SBW25-INTG 0.26 PFLU_RS28375 pyrroline-5-carboxylate reductase 0.44 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase — —
Dickeya dianthicola ME23 0.26 DZA65_RS18440 pyrroline-5-carboxylate reductase 0.78 DZA65_RS17690 glutamate-5-semialdehyde dehydrogenase — —
Ralstonia sp. UNC404CL21Col 0.26 ABZR87_RS01230 pyrroline-5-carboxylate reductase 0.41 ABZR87_RS01395 glutamate-5-semialdehyde dehydrogenase — —
Ralstonia solanacearum PSI07 0.26 RPSI07_RS11720 pyrroline-5-carboxylate reductase 0.40 RPSI07_RS11475 glutamate-5-semialdehyde dehydrogenase 0.54 77
Pseudomonas fluorescens SBW25 0.26 PFLU_RS28375 pyrroline-5-carboxylate reductase 0.44 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase — —
Desulfovibrio vulgaris Hildenborough JW710 0.26 DVU2332 proC pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.39 DVU1953 proA gamma-glutamyl phosphate reductase (TIGR) 0.90 2
Cupriavidus basilensis FW507-4G11 0.26 RR42_RS17360 pyrroline-5-carboxylate reductase 0.37 RR42_RS17530 gamma-glutamyl phosphate reductase — —
Ralstonia solanacearum UW163 0.26 UW163_RS08045 pyrroline-5-carboxylate reductase 0.40 UW163_RS07800 glutamate-5-semialdehyde dehydrogenase — —
Ralstonia solanacearum IBSBF1503 0.26 RALBFv3_RS05580 pyrroline-5-carboxylate reductase 0.40 RALBFv3_RS05825 glutamate-5-semialdehyde dehydrogenase low > 76
Variovorax sp. SCN45 0.26 GFF5553 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.42 GFF6326 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) — —
Rahnella sp. WP5 0.26 EX31_RS02690 pyrroline-5-carboxylate reductase 0.73 EX31_RS20975 glutamate-5-semialdehyde dehydrogenase 0.97 11
Pseudomonas sp. RS175 0.26 PFR28_04243 Pyrroline-5-carboxylate reductase 0.42 PFR28_03872 Gamma-glutamyl phosphate reductase — —
Pseudomonas fluorescens FW300-N2E3 0.26 AO353_08165 pyrroline-5-carboxylate reductase 0.42 AO353_06495 gamma-glutamyl phosphate reductase 0.77 2
Paraburkholderia sabiae LMG 24235 0.26 QEN71_RS26600 pyrroline-5-carboxylate reductase 0.43 QEN71_RS26940 glutamate-5-semialdehyde dehydrogenase low > 153
Hydrogenophaga sp. GW460-11-11-14-LB1 0.25 GFF2806 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.41 GFF2641 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.83 2
Herbaspirillum seropedicae SmR1 0.25 HSERO_RS18990 pyrroline-5-carboxylate reductase 0.43 HSERO_RS02965 gamma-glutamyl phosphate reductase low > 78
Ralstonia solanacearum GMI1000 0.25 RS_RS13440 pyrroline-5-carboxylate reductase 0.40 RS_RS13715 gamma-glutamyl-phosphate reductase — —
Bifidobacterium breve UCC2003 0.25 BBR_RS14625 pyrroline-5-carboxylate reductase 0.44 BBR_RS14075 glutamate-5-semialdehyde dehydrogenase low > 34
Pseudomonas syringae pv. syringae B728a ΔmexB 0.25 Psyr_0476 pyrroline-5-carboxylate reductase 0.44 Psyr_4369 glutamate-5-semialdehyde dehydrogenase 0.85 7
Pseudomonas fluorescens FW300-N1B4 0.25 Pf1N1B4_2341 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.42 Pf1N1B4_2688 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) — —
Desulfovibrio vulgaris Miyazaki F 0.25 DvMF_3161 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.38 DvMF_0612 proA gamma-glutamyl phosphate reductase (RefSeq) 0.96 2
Pseudomonas syringae pv. syringae B728a 0.25 Psyr_0476 pyrroline-5-carboxylate reductase 0.44 Psyr_4369 glutamate-5-semialdehyde dehydrogenase — —
Pseudomonas fluorescens GW456-L13 0.25 PfGW456L13_1010 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.42 PfGW456L13_1356 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 87
Phocaeicola vulgatus CL09T03C04 0.25 HMPREF1058_RS08830 pyrroline-5-carboxylate reductase 0.35 HMPREF1058_RS08645 glutamate-5-semialdehyde dehydrogenase 0.96 1
Phocaeicola dorei CL03T12C01 0.25 ABI39_RS02960 pyrroline-5-carboxylate reductase 0.35 ABI39_RS02875 glutamate-5-semialdehyde dehydrogenase 0.86 7
Xanthomonas campestris pv. campestris strain 8004 0.24 Xcc-8004.1710.1 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.41 Xcc-8004.2327.1 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.59 23
Agrobacterium fabrum C58 0.24 Atu2209 pyrroline-5-carboxylate reductase 0.36 Atu2779 gamma-glutamyl phosphate reductase — —
Pseudomonas fluorescens FW300-N2E2 0.24 Pf6N2E2_4600 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.42 Pf6N2E2_4993 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) — —
Variovorax sp. OAS795 0.24 ABID97_RS01555 pyrroline-5-carboxylate reductase 0.40 ABID97_RS04600 glutamate-5-semialdehyde dehydrogenase — —
Phaeobacter inhibens DSM 17395 0.24 PGA1_c24700 pyrroline-5-carboxylate reductase ProC 0.36 PGA1_c15520 gamma-glutamyl phosphate reductase ProA 0.96 1
Pseudomonas fluorescens FW300-N2C3 0.24 AO356_13420 pyrroline-5-carboxylate reductase 0.42 AO356_15290 gamma-glutamyl phosphate reductase — —
Rhizobium sp. OAE497 0.23 ABIE40_RS13005 pyrroline-5-carboxylate reductase 0.36 ABIE40_RS18925 glutamate-5-semialdehyde dehydrogenase 0.77 4
Castellaniella sp019104865 MT123 0.23 ABCV34_RS03610 pyrroline-5-carboxylate reductase 0.41 ABCV34_RS00845 glutamate-5-semialdehyde dehydrogenase — —
Sinorhizobium meliloti 1021 0.23 SMc02677 pyrroline-5-carboxylate reductase 0.37 SMc03777 gamma-glutamyl phosphate reductase 0.69 5
Dinoroseobacter shibae DFL-12 0.23 Dshi_2645 pyrroline-5-carboxylate reductase (RefSeq) 0.39 Dshi_1469 gamma-glutamyl phosphate reductase (RefSeq) — —
Bacteroides thetaiotaomicron VPI-5482 0.23 BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.39 BT3718 gamma-glutamyl phosphate reductase (NCBI ptt file) 0.95 1
Azospirillum sp. SherDot2 0.22 MPMX19_01399 Pyrroline-5-carboxylate reductase 0.39 MPMX19_01943 Gamma-glutamyl phosphate reductase — —
Bacteroides stercoris CC31F 0.22 HMPREF1181_RS03440 pyrroline-5-carboxylate reductase 0.42 HMPREF1181_RS03320 glutamate-5-semialdehyde dehydrogenase 0.95 17
Rhodopseudomonas palustris CGA009 0.22 TX73_022630 pyrroline-5-carboxylate reductase 0.37 TX73_000855 glutamate-5-semialdehyde dehydrogenase — —
Mycobacterium tuberculosis H37Rv 0.22 Rv0500 Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase) 0.43 Rv2427c Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase) — —
Magnetospirillum magneticum AMB-1 0.22 AMB_RS02820 pyrroline-5-carboxylate reductase 0.40 AMB_RS20640 glutamate-5-semialdehyde dehydrogenase — —
Azospirillum brasilense Sp245 0.22 AZOBR_RS06245 pyrroline-5-carboxylate reductase 0.39 AZOBR_RS04075 gamma-glutamyl phosphate reductase — —
Bacteroides ovatus ATCC 8483 0.22 BACOVA_03587 pyrroline-5-carboxylate reductase 0.38 BACOVA_03534 glutamate-5-semialdehyde dehydrogenase 0.91 5
Rhodospirillum rubrum S1H 0.21 Rru_A3281 Delta 1-pyrroline-5-carboxylate reductase (NCBI) 0.40 Rru_A1238 Gamma-glutamyl phosphate reductase GPR (NCBI) — —
Acinetobacter radioresistens SK82 0.21 MPMX26_00572 Pyrroline-5-carboxylate reductase 0.44 MPMX26_00417 Gamma-glutamyl phosphate reductase 0.99 1
Pontibacter actiniarum KMM 6156, DSM 19842 0.21 CA264_07730 pyrroline-5-carboxylate reductase 0.42 CA264_07720 gamma-glutamyl-phosphate reductase 0.74 2
Echinicola vietnamensis KMM 6221, DSM 17526 0.20 Echvi_2479 pyrroline-5-carboxylate reductase 0.29 Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) (from data) 0.79 10
Caulobacter crescentus NA1000 0.20 CCNA_00528 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.36 CCNA_03543 gamma-glutamyl phosphate reductase 0.98 2
Caulobacter crescentus NA1000 Δfur 0.20 CCNA_00528 pyrroline-5-carboxylate reductase 0.36 CCNA_03543 gamma-glutamyl phosphate reductase low > 67
Mucilaginibacter yixingensis YX-36 DSM 26809 0.19 ABZR88_RS09865 pyrroline-5-carboxylate reductase 0.39 ABZR88_RS22165 glutamate-5-semialdehyde dehydrogenase 0.92 4
Parabacteroides merdae CL09T00C40 0.18 HMPREF1078_RS10620 pyrroline-5-carboxylate reductase 0.35 HMPREF1078_RS10655 glutamate-5-semialdehyde dehydrogenase 0.98 4
Pedobacter sp. GW460-11-11-14-LB5 0.18 CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.39 CA265_RS20850 glutamate-5-semialdehyde dehydrogenase 0.96 3
Sphingomonas koreensis DSMZ 15582 0.17 Ga0059261_3321 pyrroline-5-carboxylate reductase 0.39 Ga0059261_2506 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) low > 68
Bosea sp. OAE506 0.17 ABIE41_RS11365 pyrroline-5-carboxylate reductase 0.33 ABIE41_RS07580 glutamate-5-semialdehyde dehydrogenase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.14 A4249_RS09840 pyrroline-5-carboxylate reductase dimerization domain-containing protein 0.34 A4249_RS16120 glutamate-5-semialdehyde dehydrogenase 0.97 35

Not shown: 0 genomes with orthologs for b0386 only; 0 genomes with orthologs for b0243 only