Conservation of cofitness between Atu2747 and Atu2709 in Agrobacterium fabrum C58

99 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Agrobacterium fabrum C58 1.0 Atu2747 hypothetical protein 1.0 Atu2709 3-isopropylmalate dehydratase, large subunit 0.89 4
Sinorhizobium meliloti 1021 0.77 SMc02812 hypothetical protein 0.88 SMc03823 isopropylmalate isomerase large subunit 0.53 11
Rhizobium sp. OAE497 0.76 ABIE40_RS19180 YggS family pyridoxal phosphate-dependent enzyme 0.87 ABIE40_RS18380 3-isopropylmalate dehydratase large subunit
Azospirillum brasilense Sp245 0.62 AZOBR_RS01870 alanine racemase 0.73 AZOBR_RS03545 isopropylmalate isomerase
Magnetospirillum magneticum AMB-1 0.61 AMB_RS00120 YggS family pyridoxal phosphate-dependent enzyme 0.72 AMB_RS20560 3-isopropylmalate dehydratase large subunit
Azospirillum sp. SherDot2 0.60 MPMX19_00050 Pyridoxal phosphate homeostasis protein 0.74 MPMX19_01998 3-isopropylmalate dehydratase large subunit low > 112
Rhodopseudomonas palustris CGA009 0.59 TX73_001485 YggS family pyridoxal phosphate-dependent enzyme 0.76 TX73_001245 3-isopropylmalate dehydratase large subunit
Bosea sp. OAE506 0.58 ABIE41_RS04720 YggS family pyridoxal phosphate-dependent enzyme 0.79 ABIE41_RS11660 3-isopropylmalate dehydratase large subunit
Rhodospirillum rubrum S1H 0.57 Rru_A3634 Protein of unknown function UPF0001 (NCBI) 0.72 Rru_A1189 3-isopropylmalate dehydratase large subunit region (NCBI) low > 58
Dinoroseobacter shibae DFL-12 0.53 Dshi_0042 alanine racemase domain protein (RefSeq) 0.65 Dshi_0085 3-isopropylmalate dehydratase, large subunit (RefSeq) low > 64
Brevundimonas sp. GW460-12-10-14-LB2 0.53 A4249_RS13760 YggS family pyridoxal phosphate-dependent enzyme 0.49 A4249_RS10005 3-isopropylmalate dehydratase large subunit low > 48
Phaeobacter inhibens DSM 17395 0.53 PGA1_c33360 putative alanine racemase 0.69 PGA1_c29780 3-isopropylmalate dehydratase large subunit low > 62
Ralstonia solanacearum GMI1000 0.53 RS_RS20395 YggS family pyridoxal phosphate-dependent enzyme 0.66 RS_RS10000 3-isopropylmalate dehydratase large subunit low > 80
Caulobacter crescentus NA1000 Δfur 0.51 CCNA_03861 pyridoxal 5'-phosphate dependent enzyme class III 0.66 CCNA_00196 3-isopropylmalate dehydratase large subunit low > 67
Caulobacter crescentus NA1000 0.51 CCNA_03861 pyridoxal 5'-phosphate dependent enzyme class III 0.66 CCNA_00196 3-isopropylmalate dehydratase large subunit 0.59 41
Ralstonia solanacearum PSI07 0.51 RPSI07_RS02580 YggS family pyridoxal phosphate-dependent enzyme 0.67 RPSI07_RS14695 3-isopropylmalate dehydratase large subunit low > 81
Ralstonia solanacearum IBSBF1503 0.51 RALBFv3_RS20285 YggS family pyridoxal phosphate-dependent enzyme 0.67 RALBFv3_RS02620 3-isopropylmalate dehydratase large subunit low > 76
Ralstonia solanacearum UW163 0.51 UW163_RS18890 YggS family pyridoxal phosphate-dependent enzyme 0.67 UW163_RS11105 3-isopropylmalate dehydratase large subunit
Sphingomonas koreensis DSMZ 15582 0.49 Ga0059261_2216 pyridoxal phosphate enzyme, YggS family 0.63 Ga0059261_4223 3-isopropylmalate dehydratase, large subunit low > 68
Dickeya dianthicola ME23 0.40 DZA65_RS03335 YggS family pyridoxal phosphate-dependent enzyme 0.63 DZA65_RS19210 3-isopropylmalate dehydratase large subunit low > 75
Shewanella loihica PV-4 0.37 Shew_1137 alanine racemase domain-containing protein (RefSeq) 0.63 Shew_3470 isopropylmalate isomerase large subunit (RefSeq) low > 60
Herbaspirillum seropedicae SmR1 0.35 HSERO_RS18995 hypothetical protein 0.66 HSERO_RS16515 isopropylmalate isomerase 0.31 46
Paraburkholderia sabiae LMG 24235 0.35 QEN71_RS26595 YggS family pyridoxal phosphate-dependent enzyme 0.66 QEN71_RS17605 3-isopropylmalate dehydratase large subunit low > 153
Paraburkholderia graminis OAS925 0.34 ABIE53_000841 pyridoxal phosphate enzyme (YggS family) 0.65 ABIE53_004801 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit low > 113
Burkholderia phytofirmans PsJN 0.34 BPHYT_RS03495 hypothetical protein 0.66 BPHYT_RS33915 isopropylmalate isomerase 0.68 21
Shewanella sp. ANA-3 0.34 Shewana3_1194 hypothetical protein (RefSeq) 0.63 Shewana3_3759 isopropylmalate isomerase large subunit (RefSeq) low > 73
Paraburkholderia bryophila 376MFSha3.1 0.34 H281DRAFT_04680 hypothetical protein 0.66 H281DRAFT_06075 3-isopropylmalate dehydratase, large subunit low > 103
Vibrio cholerae E7946 ATCC 55056 0.34 CSW01_02455 YggS family pyridoxal phosphate enzyme 0.60 CSW01_12605 3-isopropylmalate dehydratase large subunit low > 62
Ralstonia sp. UNC404CL21Col 0.33 ABZR87_RS01225 YggS family pyridoxal phosphate-dependent enzyme 0.68 ABZR87_RS14540 3-isopropylmalate dehydratase large subunit low > 80
Dickeya dadantii 3937 0.33 DDA3937_RS17300 YggS family pyridoxal phosphate-dependent enzyme 0.64 DDA3937_RS18125 3-isopropylmalate dehydratase large subunit 0.69 2
Alteromonas macleodii MIT1002 0.33 MIT1002_03061 pyridoxal phosphate enzyme, YggS family 0.61 MIT1002_00947 3-isopropylmalate dehydratase large subunit low > 70
Castellaniella sp019104865 MT123 0.33 ABCV34_RS02955 YggS family pyridoxal phosphate-dependent enzyme 0.67 ABCV34_RS04290 3-isopropylmalate dehydratase large subunit low > 48
Shewanella amazonensis SB2B 0.33 Sama_2477 hypothetical protein (RefSeq) 0.61 Sama_0337 isopropylmalate isomerase large subunit (RefSeq) low > 62
Enterobacter asburiae PDN3 0.32 EX28DRAFT_2989 pyridoxal phosphate enzyme, YggS family 0.64 EX28DRAFT_3668 3-isopropylmalate dehydratase, large subunit 0.56 76
Variovorax sp. OAS795 0.32 ABID97_RS00250 YggS family pyridoxal phosphate-dependent enzyme 0.65 ABID97_RS08465 3-isopropylmalate dehydratase large subunit
Shewanella oneidensis MR-1 0.32 SO3352 conserved hypothetical protein TIGR00044 (NCBI ptt file) 0.63 SO4234 leuC 3-isopropylmalate dehydratase, large subunit (NCBI ptt file) low > 76
Hydrogenophaga sp. GW460-11-11-14-LB1 0.32 GFF2722 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.65 GFF3363 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 90
Rhodanobacter denitrificans FW104-10B01 0.32 LRK54_RS02905 YggS family pyridoxal phosphate-dependent enzyme 0.56 LRK54_RS07375 3-isopropylmalate dehydratase large subunit low > 59
Rhodanobacter denitrificans MT42 0.32 LRK55_RS02655 YggS family pyridoxal phosphate-dependent enzyme 0.56 LRK55_RS07105 3-isopropylmalate dehydratase large subunit low > 63
Kangiella aquimarina DSM 16071 0.32 B158DRAFT_0196 pyridoxal phosphate enzyme, YggS family 0.65 B158DRAFT_1319 3-isopropylmalate dehydratase, large subunit low > 40
Pseudomonas syringae pv. syringae B728a ΔmexB 0.31 Psyr_0477 Protein of unknown function UPF0001 0.63 Psyr_1983 3-isopropylmalate dehydratase, large subunit 0.49 60
Pseudomonas fluorescens FW300-N2E3 0.31 AO353_10505 hypothetical protein 0.64 AO353_20620 isopropylmalate isomerase low > 101
Pseudomonas syringae pv. syringae B728a 0.31 Psyr_0477 Protein of unknown function UPF0001 0.63 Psyr_1983 3-isopropylmalate dehydratase, large subunit 0.44 43
Klebsiella michiganensis M5al 0.31 BWI76_RS24100 YggS family pyridoxal phosphate enzyme 0.64 BWI76_RS04670 3-isopropylmalate dehydratase large subunit low > 92
Lysobacter sp. OAE881 0.31 ABIE51_RS16060 YggS family pyridoxal phosphate-dependent enzyme 0.52 ABIE51_RS17575 3-isopropylmalate dehydratase large subunit low > 62
Variovorax sp. SCN45 0.31 GFF3744 Pyridoxal phosphate-containing protein YggS 0.66 GFF3890 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
Dickeya dianthicola 67-19 0.31 HGI48_RS17345 YggS family pyridoxal phosphate-dependent enzyme 0.63 HGI48_RS18065 3-isopropylmalate dehydratase large subunit low > 71
Pseudomonas sp. S08-1 0.30 OH686_10975 Pyridoxal phosphate-containing protein YggS 0.64 OH686_04480 3-isopropylmalate dehydratase large subunit low > 80
Pectobacterium carotovorum WPP14 0.30 HER17_RS03810 YggS family pyridoxal phosphate-dependent enzyme 0.63 HER17_RS03075 3-isopropylmalate dehydratase large subunit 0.67 47
Enterobacter sp. TBS_079 0.30 MPMX20_03809 Pyridoxal phosphate homeostasis protein 0.64 MPMX20_00767 3-isopropylmalate dehydratase large subunit 1 low > 85
Escherichia fergusonii Becca 0.30 EFB2_00951 Pyridoxal phosphate homeostasis protein 0.64 EFB2_03973 3-isopropylmalate dehydratase large subunit low > 86
Escherichia coli BL21 0.30 ECD_02781 UPF0001 family protein, PLP-binding 0.64 ECD_00074 3-isopropylmalate dehydratase large subunit low > 60
Escherichia coli ECOR38 0.30 HEPCGN_18560 yggS pyridoxal phosphate homeostasis protein 0.64 HEPCGN_08705 leuC1 3-isopropylmalate dehydratase large subunit 1 low > 85
Escherichia coli HS(pFamp)R (ATCC 700891) 0.30 OHPLBJKB_00765 Pyridoxal phosphate homeostasis protein 0.64 OHPLBJKB_03585 3-isopropylmalate dehydratase large subunit low > 73
Desulfovibrio vulgaris Hildenborough JW710 0.30 DVU0051 conserved hypothetical protein TIGR00044 (TIGR) 0.23 DVU2982 leuC 3-isopropylmalate dehydratase / (R)-citramalate isomerase, large subunit LeuC (EC 4.2.1.33; EC 4.2.1.35) (from data) low > 55
Escherichia coli ECRC98 0.30 JDDGAC_22885 yggS pyridoxal phosphate homeostasis protein 0.64 JDDGAC_14320 leuC1 3-isopropylmalate dehydratase large subunit 1
Escherichia coli ECRC101 0.30 OKFHMN_19255 yggS pyridoxal phosphate homeostasis protein 0.64 OKFHMN_10725 leuC1 3-isopropylmalate dehydratase large subunit 1
Escherichia coli ECOR27 0.30 NOLOHH_11125 yggS pyridoxal phosphate homeostasis protein 0.64 NOLOHH_03070 leuC1 3-isopropylmalate dehydratase large subunit 1 low > 57
Escherichia coli Nissle 1917 0.30 ECOLIN_RS16415 pyridoxal phosphate homeostasis protein 0.64 ECOLIN_RS00390 3-isopropylmalate dehydratase large subunit low > 52
Escherichia coli BW25113 0.30 b2951 yggS predicted enzyme (NCBI) 0.64 b0072 leuC isopropylmalate isomerase large subunit (NCBI) low > 76
Escherichia coli ECRC102 0.30 NIAGMN_17020 yggS pyridoxal phosphate homeostasis protein 0.64 NIAGMN_08575 leuC1 3-isopropylmalate dehydratase large subunit 1
Escherichia coli ECRC101 0.30 MCAODC_09775 yggS pyridoxal phosphate homeostasis protein 0.64 MCAODC_01240 leuC1 3-isopropylmalate dehydratase large subunit 1
Escherichia coli ECRC62 0.30 BNILDI_09705 yggS pyridoxal phosphate homeostasis protein 0.64 BNILDI_08540 leuC1 3-isopropylmalate dehydratase large subunit 1
Escherichia coli ECRC99 0.30 KEDOAH_08885 yggS pyridoxal phosphate homeostasis protein 0.64 KEDOAH_17430 leuC1 3-isopropylmalate dehydratase large subunit 1
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.30 GFF3054 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.64 GFF166 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 78
Dechlorosoma suillum PS 0.30 Dsui_0603 pyridoxal phosphate enzyme, YggS family 0.62 Dsui_3201 3-isopropylmalate dehydratase, large subunit
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS09305 YggS family pyridoxal phosphate-dependent enzyme 0.51 ABZR86_RS15960 3-isopropylmalate dehydratase large subunit
Rhodanobacter sp. FW510-T8 0.29 OKGIIK_09885 Pyridoxal phosphate homeostasis protein 0.50 OKGIIK_13585 leuC 3-isopropylmalate dehydratase large subunit low > 52
Pseudomonas stutzeri RCH2 0.29 Psest_0284 pyridoxal phosphate enzyme, YggS family 0.63 Psest_2591 3-isopropylmalate dehydratase, large subunit 0.54 7
Acidovorax sp. GW101-3H11 0.29 Ac3H11_4474 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.64 Ac3H11_1525 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 79
Rahnella sp. WP5 0.29 EX31_RS02685 YggS family pyridoxal phosphate-dependent enzyme 0.63 EX31_RS03690 3-isopropylmalate dehydratase large subunit low > 89
Pseudomonas fluorescens FW300-N2C3 0.29 AO356_13425 hypothetical protein 0.64 AO356_21400 isopropylmalate isomerase 0.22 94
Pantoea sp. MT58 0.29 IAI47_03595 YggS family pyridoxal phosphate-dependent enzyme 0.64 IAI47_16010 3-isopropylmalate dehydratase large subunit 0.64 14
Pseudomonas putida KT2440 0.28 PP_5094 putative enzyme with PLP binding domain 0.64 PP_1985 3-isopropylmalate dehydratase large subunit low > 96
Pseudomonas simiae WCS417 0.28 PS417_26725 hypothetical protein 0.63 PS417_18600 isopropylmalate isomerase 0.36 10
Cupriavidus basilensis FW507-4G11 0.28 RR42_RS17355 hypothetical protein 0.67 RR42_RS14400 isopropylmalate isomerase low > 128
Erwinia tracheiphila SCR3 0.28 LU632_RS05460 YggS family pyridoxal phosphate-dependent enzyme 0.60 LU632_RS02870 leuC 3-isopropylmalate dehydratase large subunit low > 74
Pseudomonas fluorescens GW456-L13 0.27 PfGW456L13_1011 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.64 PfGW456L13_3948 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) 0.37 14
Pseudomonas fluorescens SBW25-INTG 0.27 PFLU_RS28370 YggS family pyridoxal phosphate-dependent enzyme 0.64 PFLU_RS20580 3-isopropylmalate dehydratase large subunit low > 109
Acinetobacter radioresistens SK82 0.27 MPMX26_02404 Pyridoxal phosphate homeostasis protein 0.64 MPMX26_00345 3-isopropylmalate dehydratase large subunit low > 36
Pseudomonas fluorescens SBW25 0.27 PFLU_RS28370 YggS family pyridoxal phosphate-dependent enzyme 0.64 PFLU_RS20580 3-isopropylmalate dehydratase large subunit low > 109
Pseudomonas fluorescens FW300-N2E2 0.27 Pf6N2E2_4601 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.64 Pf6N2E2_63 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) 0.26 48
Desulfovibrio vulgaris Miyazaki F 0.27 DvMF_2208 alanine racemase domain protein (RefSeq) 0.22 DvMF_1792 3-isopropylmalate dehydratase large subunit (RefSeq) low > 51
Marinobacter adhaerens HP15 0.26 HP15_288 alanine racemase domain protein 0.65 HP15_1834 protein containing 3-isopropylmalate dehydratase, large subunit region domain low > 73
Pseudomonas sp. RS175 0.26 PFR28_04242 Pyridoxal phosphate homeostasis protein 0.65 PFR28_02824 3-isopropylmalate dehydratase large subunit low > 88
Synechococcus elongatus PCC 7942 0.26 Synpcc7942_2060 ylmE hypothetical protein 0.49 Synpcc7942_1898 leuC isopropylmalate isomerase large subunit
Parabacteroides merdae CL09T00C40 0.25 HMPREF1078_RS15965 YggS family pyridoxal phosphate-dependent enzyme 0.51 HMPREF1078_RS16660 3-isopropylmalate dehydratase large subunit low > 61
Mucilaginibacter yixingensis YX-36 DSM 26809 0.25 ABZR88_RS11740 YggS family pyridoxal phosphate-dependent enzyme 0.53 ABZR88_RS11595 3-isopropylmalate dehydratase large subunit
Serratia liquefaciens MT49 0.25 IAI46_21410 YggS family pyridoxal phosphate-dependent enzyme 0.62 IAI46_03345 3-isopropylmalate dehydratase large subunit low > 86
Bacteroides thetaiotaomicron VPI-5482 0.25 BT1332 conserved hypothetical protein (NCBI ptt file) 0.50 BT1860 3-isopropylmalate dehydratase large subunit (NCBI ptt file) 0.25 45
Xanthomonas campestris pv. campestris strain 8004 0.25 Xcc-8004.1711.1 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC 0.64 Xcc-8004.1049.1 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 74
Echinicola vietnamensis KMM 6221, DSM 17526 0.24 Echvi_2233 pyridoxal phosphate enzyme, YggS family 0.53 Echvi_2059 3-isopropylmalate dehydratase, large subunit low > 79
Bacteroides ovatus ATCC 8483 0.24 BACOVA_00593 pyridoxal phosphate enzyme, YggS family 0.51 BACOVA_04603 3-isopropylmalate dehydratase, large subunit low > 94
Bacteroides stercoris CC31F 0.23 HMPREF1181_RS10865 YggS family pyridoxal phosphate-dependent enzyme 0.52 HMPREF1181_RS14145 3-isopropylmalate dehydratase large subunit low > 56
Pedobacter sp. GW460-11-11-14-LB5 0.23 CA265_RS06285 YggS family pyridoxal phosphate enzyme 0.53 CA265_RS15830 3-isopropylmalate dehydratase large subunit low > 88
Pontibacter actiniarum KMM 6156, DSM 19842 0.23 CA264_06410 YggS family pyridoxal phosphate enzyme 0.53 CA264_09435 3-isopropylmalate dehydratase large subunit low > 74
Mycobacterium tuberculosis H37Rv 0.21 Rv2148c Conserved protein 0.59 Rv2988c Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI)
Bifidobacterium breve UCC2003 0.21 BBR_RS11570 YggS family pyridoxal phosphate-dependent enzyme 0.55 BBR_RS19630 3-isopropylmalate dehydratase large subunit low > 34
Phocaeicola vulgatus CL09T03C04 0.21 HMPREF1058_RS06240 YggS family pyridoxal phosphate-dependent enzyme 0.50 HMPREF1058_RS14550 3-isopropylmalate dehydratase large subunit low > 67
Phocaeicola dorei CL03T12C01 0.21 ABI39_RS20000 YggS family pyridoxal phosphate-dependent enzyme 0.50 ABI39_RS10200 3-isopropylmalate dehydratase large subunit low > 72

Not shown: 1 genomes with orthologs for Atu2747 only; 3 genomes with orthologs for Atu2709 only