Conservation of cofitness between b0243 and b2020 in Escherichia coli BW25113

99 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b0243 proA gamma-glutamyl phosphate reductase (NCBI) 1.0 b2020 hisD histidinol dehydrogenase (NCBI) 0.94 7
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_03397 Gamma-glutamyl phosphate reductase 0.98 OHPLBJKB_01680 Histidinol dehydrogenase low > 73
Escherichia coli BL21 0.99 ECD_00240 gamma-glutamylphosphate reductase 0.99 ECD_01922 bifunctional histidinal dehydrogenase/ histidinol dehydrogenase low > 60
Escherichia coli ECOR27 0.99 NOLOHH_02045 proA glutamate-5-semialdehyde dehydrogenase 0.99 NOLOHH_15830 hisD Histidinol dehydrogenase low > 57
Escherichia coli ECOR38 0.99 HEPCGN_07775 proA glutamate-5-semialdehyde dehydrogenase 0.99 HEPCGN_03220 hisD Histidinol dehydrogenase low > 85
Escherichia coli ECRC62 0.99 BNILDI_00240 proA glutamate-5-semialdehyde dehydrogenase 0.99 BNILDI_14740 hisD Histidinol dehydrogenase — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS01830 glutamate-5-semialdehyde dehydrogenase 0.99 ECOLIN_RS11945 histidinol dehydrogenase — —
Escherichia coli ECRC101 0.99 MCAODC_00190 proA glutamate-5-semialdehyde dehydrogenase 0.98 MCAODC_20425 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC102 0.99 NIAGMN_07530 proA glutamate-5-semialdehyde dehydrogenase 0.98 NIAGMN_22460 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC99 0.99 KEDOAH_18485 proA glutamate-5-semialdehyde dehydrogenase 0.98 KEDOAH_03635 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC98 0.99 JDDGAC_13295 proA glutamate-5-semialdehyde dehydrogenase 0.98 JDDGAC_28625 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC101 0.99 OKFHMN_09670 proA glutamate-5-semialdehyde dehydrogenase 0.98 OKFHMN_24515 hisD Histidinol dehydrogenase — —
Escherichia fergusonii Becca 0.99 EFB2_03777 Gamma-glutamyl phosphate reductase 0.98 EFB2_01836 Histidinol dehydrogenase low > 86
Enterobacter asburiae PDN3 0.88 EX28DRAFT_2650 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.89 EX28DRAFT_0539 histidinol dehydrogenase 0.91 9
Enterobacter sp. TBS_079 0.88 MPMX20_00928 Gamma-glutamyl phosphate reductase 0.89 MPMX20_03002 Histidinol dehydrogenase 0.93 8
Klebsiella michiganensis M5al 0.86 BWI76_RS05835 gamma-glutamyl-phosphate reductase 0.88 BWI76_RS18925 histidinol dehydrogenase 0.83 20
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.86 GFF4115 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.93 GFF3912 Histidinol dehydrogenase (EC 1.1.1.23) low > 78
Dickeya dadantii 3937 0.79 DDA3937_RS16530 glutamate-5-semialdehyde dehydrogenase 0.80 DDA3937_RS09735 histidinol dehydrogenase 0.84 8
Dickeya dianthicola ME23 0.78 DZA65_RS17690 glutamate-5-semialdehyde dehydrogenase 0.79 DZA65_RS10055 histidinol dehydrogenase low > 75
Serratia liquefaciens MT49 0.77 IAI46_04435 glutamate-5-semialdehyde dehydrogenase 0.85 IAI46_08210 histidinol dehydrogenase low > 86
Pantoea sp. MT58 0.75 IAI47_15115 glutamate-5-semialdehyde dehydrogenase 0.82 IAI47_07090 histidinol dehydrogenase 0.92 16
Dickeya dianthicola 67-19 0.74 HGI48_RS16600 glutamate-5-semialdehyde dehydrogenase 0.79 HGI48_RS09745 histidinol dehydrogenase low > 71
Erwinia tracheiphila SCR3 0.74 LU632_RS01190 proA glutamate-5-semialdehyde dehydrogenase 0.81 LU632_RS08945 hisD histidinol dehydrogenase low > 74
Pectobacterium carotovorum WPP14 0.74 HER17_RS04705 glutamate-5-semialdehyde dehydrogenase 0.80 HER17_RS12230 histidinol dehydrogenase 0.97 4
Rahnella sp. WP5 0.73 EX31_RS20975 glutamate-5-semialdehyde dehydrogenase 0.79 EX31_RS11440 histidinol dehydrogenase 0.95 33
Vibrio cholerae E7946 ATCC 55056 0.58 CSW01_11570 glutamate-5-semialdehyde dehydrogenase 0.63 CSW01_05750 histidinol dehydrogenase low > 62
Shewanella loihica PV-4 0.57 Shew_2847 proA gamma-glutamyl phosphate reductase (RefSeq) 0.57 Shew_2198 histidinol dehydrogenase (RefSeq) 0.95 33
Shewanella sp. ANA-3 0.56 Shewana3_0955 proA gamma-glutamyl phosphate reductase (RefSeq) 0.56 Shewana3_1853 hisD histidinol dehydrogenase (RefSeq) 0.94 19
Shewanella oneidensis MR-1 0.56 SO1122 proA gamma-glutamyl phosphate reductase (NCBI ptt file) 0.57 SO2073 hisD histidinol dehydrogenase (NCBI ptt file) 0.98 9
Shewanella amazonensis SB2B 0.55 Sama_2515 proA gamma-glutamyl phosphate reductase (RefSeq) 0.59 Sama_1942 hisD histidinol dehydrogenase (RefSeq) 0.94 26
Bifidobacterium breve UCC2003 0.44 BBR_RS14075 glutamate-5-semialdehyde dehydrogenase 0.28 BBR_RS17055 histidinol dehydrogenase low > 34
Pseudomonas sp. S08-1 0.44 OH686_09340 Gamma-glutamyl phosphate reductase 0.34 OH686_08470 Histidinol dehydrogenase 0.84 1
Pseudomonas fluorescens SBW25-INTG 0.44 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase 0.33 PFLU_RS04470 histidinol dehydrogenase — —
Pseudomonas fluorescens SBW25 0.44 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase 0.33 PFLU_RS04470 histidinol dehydrogenase — —
Acinetobacter radioresistens SK82 0.44 MPMX26_00417 Gamma-glutamyl phosphate reductase 0.32 MPMX26_02587 Histidinol dehydrogenase 0.73 24
Pseudomonas simiae WCS417 0.44 PS417_24745 gamma-glutamyl phosphate reductase 0.33 PS417_04420 histidinol dehydrogenase 0.64 17
Pseudomonas syringae pv. syringae B728a 0.44 Psyr_4369 glutamate-5-semialdehyde dehydrogenase 0.33 Psyr_4133 histidinol dehydrogenase 0.82 20
Pseudomonas syringae pv. syringae B728a ΔmexB 0.44 Psyr_4369 glutamate-5-semialdehyde dehydrogenase 0.33 Psyr_4133 histidinol dehydrogenase 0.89 17
Marinobacter adhaerens HP15 0.43 HP15_601 gamma-glutamyl phosphate reductase 0.33 HP15_2428 histidinol dehydrogenase — —
Mycobacterium tuberculosis H37Rv 0.43 Rv2427c Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase) 0.27 Rv1599 Probable histidinol dehydrogenase HisD (HDH) — —
Pseudomonas stutzeri RCH2 0.43 Psest_0508 gamma-glutamyl phosphate reductase 0.34 Psest_3298 histidinol dehydrogenase 0.84 4
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS26940 glutamate-5-semialdehyde dehydrogenase 0.31 QEN71_RS27865 histidinol dehydrogenase low > 153
Herbaspirillum seropedicae SmR1 0.43 HSERO_RS02965 gamma-glutamyl phosphate reductase 0.33 HSERO_RS20345 histidinol dehydrogenase low > 78
Dechlorosoma suillum PS 0.42 Dsui_1220 gamma-glutamyl phosphate reductase 0.33 Dsui_1411 histidinol dehydrogenase — —
Pseudomonas fluorescens FW300-N2E2 0.42 Pf6N2E2_4993 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.33 Pf6N2E2_3252 Histidinol dehydrogenase (EC 1.1.1.23) low > 103
Pseudomonas sp. RS175 0.42 PFR28_03872 Gamma-glutamyl phosphate reductase 0.33 PFR28_00187 Histidinol dehydrogenase — —
Variovorax sp. SCN45 0.42 GFF6326 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.33 GFF5345 Histidinol dehydrogenase (EC 1.1.1.23) — —
Pseudomonas fluorescens GW456-L13 0.42 PfGW456L13_1356 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.33 PfGW456L13_5000 Histidinol dehydrogenase (EC 1.1.1.23) low > 87
Pseudomonas fluorescens FW300-N2C3 0.42 AO356_15290 gamma-glutamyl phosphate reductase 0.33 AO356_06965 histidinol dehydrogenase low > 104
Pseudomonas fluorescens FW300-N2E3 0.42 AO353_06495 gamma-glutamyl phosphate reductase 0.33 AO353_05110 histidinol dehydrogenase 0.63 38
Pseudomonas fluorescens FW300-N1B4 0.42 Pf1N1B4_2688 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.33 Pf1N1B4_1066 Histidinol dehydrogenase (EC 1.1.1.23) — —
Pontibacter actiniarum KMM 6156, DSM 19842 0.42 CA264_07720 gamma-glutamyl-phosphate reductase 0.45 CA264_05030 histidinol dehydrogenase low > 74
Bacteroides stercoris CC31F 0.42 HMPREF1181_RS03320 glutamate-5-semialdehyde dehydrogenase 0.50 HMPREF1181_RS04860 histidinol dehydrogenase 0.96 15
Castellaniella sp019104865 MT123 0.41 ABCV34_RS00845 glutamate-5-semialdehyde dehydrogenase 0.31 ABCV34_RS11230 histidinol dehydrogenase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF2641 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.31 GFF1314 Histidinol dehydrogenase (EC 1.1.1.23) — —
Ralstonia sp. UNC404CL21Col 0.41 ABZR87_RS01395 glutamate-5-semialdehyde dehydrogenase 0.32 ABZR87_RS02500 histidinol dehydrogenase — —
Kangiella aquimarina DSM 16071 0.41 B158DRAFT_1470 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.25 B158DRAFT_2293 histidinol dehydrogenase low > 40
Paraburkholderia bryophila 376MFSha3.1 0.41 H281DRAFT_06324 glutamate-5-semialdehyde dehydrogenase 0.31 H281DRAFT_05652 histidinol dehydrogenase — —
Burkholderia phytofirmans PsJN 0.41 BPHYT_RS16770 gamma-glutamyl phosphate reductase 0.31 BPHYT_RS17710 histidinol dehydrogenase — —
Pseudomonas putida KT2440 0.41 PP_4811 Gamma-glutamyl phosphate reductase 0.32 PP_0966 Histidinol dehydrogenase low > 96
Rhodanobacter denitrificans MT42 0.41 LRK55_RS02125 glutamate-5-semialdehyde dehydrogenase 0.53 LRK55_RS01385 histidinol dehydrogenase low > 63
Rhodanobacter denitrificans FW104-10B01 0.41 LRK54_RS02370 glutamate-5-semialdehyde dehydrogenase 0.53 LRK54_RS01605 histidinol dehydrogenase 0.77 27
Xanthomonas campestris pv. campestris strain 8004 0.41 Xcc-8004.2327.1 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.48 Xcc-8004.2948.1 Histidinol dehydrogenase (EC 1.1.1.23) 0.72 43
Variovorax sp. OAS795 0.40 ABID97_RS04600 glutamate-5-semialdehyde dehydrogenase 0.33 ABID97_RS23160 histidinol dehydrogenase — —
Acidovorax sp. GW101-3H11 0.40 Ac3H11_704 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.32 Ac3H11_4724 Histidinol dehydrogenase (EC 1.1.1.23) — —
Paraburkholderia graminis OAS925 0.40 ABIE53_003523 glutamate-5-semialdehyde dehydrogenase 0.31 ABIE53_003701 histidinol dehydrogenase — —
Ralstonia solanacearum IBSBF1503 0.40 RALBFv3_RS05825 glutamate-5-semialdehyde dehydrogenase 0.32 RALBFv3_RS06845 histidinol dehydrogenase — —
Alteromonas macleodii MIT1002 0.40 MIT1002_01885 Gamma-glutamyl phosphate reductase 0.54 MIT1002_02633 Histidinol dehydrogenase 0.97 28
Ralstonia solanacearum UW163 0.40 UW163_RS07800 glutamate-5-semialdehyde dehydrogenase 0.32 UW163_RS06770 histidinol dehydrogenase — —
Rhodospirillum rubrum S1H 0.40 Rru_A1238 Gamma-glutamyl phosphate reductase GPR (NCBI) 0.31 Rru_A2771 Histidinol dehydrogenase (NCBI) — —
Ralstonia solanacearum GMI1000 0.40 RS_RS13715 gamma-glutamyl-phosphate reductase 0.32 RS_RS14790 histidinol dehydrogenase — —
Ralstonia solanacearum PSI07 0.40 RPSI07_RS11475 glutamate-5-semialdehyde dehydrogenase 0.32 RPSI07_RS10390 histidinol dehydrogenase — —
Magnetospirillum magneticum AMB-1 0.40 AMB_RS20640 glutamate-5-semialdehyde dehydrogenase 0.34 AMB_RS16905 histidinol dehydrogenase — —
Lysobacter sp. OAE881 0.40 ABIE51_RS13365 glutamate-5-semialdehyde dehydrogenase 0.49 ABIE51_RS13325 histidinol dehydrogenase 0.90 33
Mucilaginibacter yixingensis YX-36 DSM 26809 0.39 ABZR88_RS22165 glutamate-5-semialdehyde dehydrogenase 0.44 ABZR88_RS06880 histidinol dehydrogenase — —
Pedobacter sp. GW460-11-11-14-LB5 0.39 CA265_RS20850 glutamate-5-semialdehyde dehydrogenase 0.44 CA265_RS03635 histidinol dehydrogenase 0.91 35
Sphingomonas koreensis DSMZ 15582 0.39 Ga0059261_2506 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.31 Ga0059261_1281 histidinol dehydrogenase 0.95 32
Azospirillum sp. SherDot2 0.39 MPMX19_01943 Gamma-glutamyl phosphate reductase 0.32 MPMX19_05543 Histidinol dehydrogenase — —
Desulfovibrio vulgaris Hildenborough JW710 0.39 DVU1953 proA gamma-glutamyl phosphate reductase (TIGR) 0.32 DVU0796 hisD histidinol dehydrogenase (TIGR) 0.80 29
Dyella japonica UNC79MFTsu3.2 0.39 ABZR86_RS08680 glutamate-5-semialdehyde dehydrogenase 0.53 ABZR86_RS06730 histidinol dehydrogenase 0.89 22
Bacteroides thetaiotaomicron VPI-5482 0.39 BT3718 gamma-glutamyl phosphate reductase (NCBI ptt file) 0.52 BT0201 histidinol dehydrogenase (NCBI ptt file) 0.94 13
Dinoroseobacter shibae DFL-12 0.39 Dshi_1469 gamma-glutamyl phosphate reductase (RefSeq) 0.34 Dshi_0979 Histidinol dehydrogenase (RefSeq) — —
Bacteroides ovatus ATCC 8483 0.38 BACOVA_03534 glutamate-5-semialdehyde dehydrogenase 0.53 BACOVA_01234 histidinol dehydrogenase 0.94 25
Desulfovibrio vulgaris Miyazaki F 0.38 DvMF_0612 proA gamma-glutamyl phosphate reductase (RefSeq) 0.30 DvMF_2814 hisD histidinol dehydrogenase (RefSeq) 0.94 13
Rhodanobacter sp. FW510-T8 0.37 OKGIIK_09415 proA glutamate-5-semialdehyde dehydrogenase 0.53 OKGIIK_04950 hisD histidinol dehydrogenase low > 52
Cupriavidus basilensis FW507-4G11 0.37 RR42_RS17530 gamma-glutamyl phosphate reductase 0.35 RR42_RS18915 histidinol dehydrogenase — —
Rhodopseudomonas palustris CGA009 0.37 TX73_000855 glutamate-5-semialdehyde dehydrogenase 0.32 TX73_023540 histidinol dehydrogenase — —
Sinorhizobium meliloti 1021 0.37 SMc03777 gamma-glutamyl phosphate reductase 0.35 SMc02307 histidinol dehydrogenase 0.85 56
Rhizobium sp. OAE497 0.36 ABIE40_RS18925 glutamate-5-semialdehyde dehydrogenase 0.34 ABIE40_RS02725 histidinol dehydrogenase 0.92 15
Phaeobacter inhibens DSM 17395 0.36 PGA1_c15520 gamma-glutamyl phosphate reductase ProA 0.33 PGA1_c31190 histidinol dehydrogenase HisD — —
Agrobacterium fabrum C58 0.36 Atu2779 gamma-glutamyl phosphate reductase 0.34 Atu0537 histidinol dehydrogenase — —
Caulobacter crescentus NA1000 Δfur 0.36 CCNA_03543 gamma-glutamyl phosphate reductase 0.27 CCNA_02431 histidinol dehydrogenase low > 67
Caulobacter crescentus NA1000 0.36 CCNA_03543 gamma-glutamyl phosphate reductase 0.27 CCNA_02431 histidinol dehydrogenase 0.92 11
Phocaeicola dorei CL03T12C01 0.35 ABI39_RS02875 glutamate-5-semialdehyde dehydrogenase 0.50 ABI39_RS11835 histidinol dehydrogenase 0.83 29
Parabacteroides merdae CL09T00C40 0.35 HMPREF1078_RS10655 glutamate-5-semialdehyde dehydrogenase 0.48 HMPREF1078_RS02450 histidinol dehydrogenase 0.97 14
Phocaeicola vulgatus CL09T03C04 0.35 HMPREF1058_RS08645 glutamate-5-semialdehyde dehydrogenase 0.51 HMPREF1058_RS15875 histidinol dehydrogenase 0.96 7
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_2265 proA glutamate-5-semialdehyde dehydrogenase 0.33 Synpcc7942_1519 hisD histidinol dehydrogenase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.34 A4249_RS16120 glutamate-5-semialdehyde dehydrogenase 0.38 A4249_RS10695 histidinol dehydrogenase 0.99 21
Bosea sp. OAE506 0.33 ABIE41_RS07580 glutamate-5-semialdehyde dehydrogenase 0.32 ABIE41_RS24015 histidinol dehydrogenase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.29 Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) (from data) 0.47 Echvi_2459 histidinol dehydrogenase 0.83 32

Not shown: 1 genomes with orthologs for b0243 only; 2 genomes with orthologs for b2020 only