Conservation of cofitness between b3941 and b3770 in Escherichia coli BW25113

98 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3941 metF 5,10-methylenetetrahydrofolate reductase (NCBI) 1.0 b3770 ilvE branched-chain amino acid aminotransferase (NCBI) 0.97 3
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04109 5,10-methylenetetrahydrofolate reductase 1.00 OHPLBJKB_04283 Branched-chain-amino-acid aminotransferase low > 73
Escherichia coli BL21 1.00 ECD_03827 5,10-methylenetetrahydrofolate reductase 1.00 ECD_03648 branched-chain amino acid aminotransferase 0.71 20
Escherichia coli ECOR27 1.00 NOLOHH_05810 metF methylenetetrahydrofolate reductase 1.00 NOLOHH_06780 ilvE branched-chain-amino-acid transaminase low > 57
Escherichia coli ECRC62 1.00 BNILDI_05725 metF methylenetetrahydrofolate reductase 1.00 BNILDI_04745 ilvE branched-chain-amino-acid transaminase
Escherichia coli ECRC99 1.00 KEDOAH_14495 metF methylenetetrahydrofolate reductase 1.00 KEDOAH_13505 ilvE branched-chain-amino-acid transaminase
Escherichia coli ECRC102 1.00 NIAGMN_11420 metF methylenetetrahydrofolate reductase 1.00 NIAGMN_12400 ilvE branched-chain-amino-acid transaminase
Escherichia coli ECOR38 1.00 HEPCGN_12310 metF methylenetetrahydrofolate reductase 1.00 HEPCGN_13355 ilvE branched-chain-amino-acid transaminase low > 85
Escherichia coli ECRC98 1.00 JDDGAC_17290 metF methylenetetrahydrofolate reductase 1.00 JDDGAC_18265 ilvE branched-chain-amino-acid transaminase
Escherichia coli ECRC101 1.00 MCAODC_04165 metF methylenetetrahydrofolate reductase 1.00 MCAODC_05150 ilvE branched-chain-amino-acid transaminase
Escherichia coli ECRC101 1.00 OKFHMN_13665 metF methylenetetrahydrofolate reductase 1.00 OKFHMN_14645 ilvE branched-chain-amino-acid transaminase
Escherichia fergusonii Becca 0.99 EFB2_04672 5,10-methylenetetrahydrofolate reductase 1.00 EFB2_04866 Branched-chain-amino-acid aminotransferase low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS22760 methylenetetrahydrofolate reductase 1.00 ECOLIN_RS21660 branched-chain-amino-acid transaminase low > 52
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF2329 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.98 GFF2902 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 78
Enterobacter sp. TBS_079 0.95 MPMX20_04529 5,10-methylenetetrahydrofolate reductase 0.99 MPMX20_04500 Branched-chain-amino-acid aminotransferase low > 85
Klebsiella michiganensis M5al 0.95 BWI76_RS00805 5,10-methylenetetrahydrofolate reductase 0.97 BWI76_RS00970 branched chain amino acid aminotransferase 0.50 91
Enterobacter asburiae PDN3 0.94 EX28DRAFT_4413 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.98 EX28DRAFT_4442 branched-chain amino acid aminotransferase, group I 0.53 66
Pantoea sp. MT58 0.92 IAI47_00890 methylenetetrahydrofolate reductase 0.91 IAI47_01030 branched-chain amino acid transaminase 0.48 44
Serratia liquefaciens MT49 0.91 IAI46_24530 methylenetetrahydrofolate reductase 0.92 IAI46_24350 branched-chain-amino-acid transaminase low > 86
Dickeya dadantii 3937 0.90 DDA3937_RS00960 methylenetetrahydrofolate reductase 0.91 DDA3937_RS20160 branched-chain-amino-acid transaminase low > 74
Rahnella sp. WP5 0.89 EX31_RS14205 methylenetetrahydrofolate reductase 0.90 EX31_RS15000 branched-chain amino acid transaminase low > 89
Pectobacterium carotovorum WPP14 0.88 HER17_RS00950 methylenetetrahydrofolate reductase 0.90 HER17_RS01070 branched-chain amino acid transaminase low > 75
Dickeya dianthicola 67-19 0.88 HGI48_RS20415 methylenetetrahydrofolate reductase 0.90 HGI48_RS20300 branched-chain-amino-acid transaminase low > 71
Dickeya dianthicola ME23 0.88 DZA65_RS21460 methylenetetrahydrofolate reductase 0.91 DZA65_RS21340 branched-chain amino acid transaminase 0.65 45
Erwinia tracheiphila SCR3 0.86 LU632_RS19630 metF methylenetetrahydrofolate reductase 0.90 LU632_RS24405 branched-chain amino acid transaminase low > 74
Vibrio cholerae E7946 ATCC 55056 0.79 CSW01_13560 methylenetetrahydrofolate reductase 0.75 CSW01_00145 branched-chain-amino-acid transaminase low > 62
Shewanella loihica PV-4 0.76 Shew_0522 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.68 Shew_0291 branched-chain amino acid aminotransferase (RefSeq) 0.93 34
Shewanella amazonensis SB2B 0.75 Sama_3169 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.19 Sama_3299 branched-chain amino acid aminotransferase (RefSeq) low > 62
Shewanella sp. ANA-3 0.75 Shewana3_3612 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.19 Shewana3_3830 branched-chain amino acid aminotransferase (RefSeq) low > 73
Shewanella oneidensis MR-1 0.75 SO4054 metF 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.19 SO0340 ilvE branched-chain amino acid aminotransferase (NCBI ptt file) 0.88 57
Alteromonas macleodii MIT1002 0.70 MIT1002_03670 5,10-methylenetetrahydrofolate reductase 0.17 MIT1002_00377 Branched-chain-amino-acid aminotransferase 2 low > 70
Kangiella aquimarina DSM 16071 0.59 B158DRAFT_2461 5,10-methylenetetrahydrofolate reductase (NAD(P)) (EC 1.5.1.20) 0.20 B158DRAFT_0078 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase low > 40
Magnetospirillum magneticum AMB-1 0.55 AMB_RS02230 methylenetetrahydrofolate reductase 0.31 AMB_RS02850 branched-chain amino acid aminotransferase
Azospirillum brasilense Sp245 0.54 AZOBR_RS24245 5 10-methylenetetrahydrofolate reductase 0.31 AZOBR_RS16425 branched-chain amino acid aminotransferase low > 97
Azospirillum sp. SherDot2 0.54 MPMX19_00635 5,10-methylenetetrahydrofolate reductase 0.18 MPMX19_02406 Branched-chain-amino-acid aminotransferase low > 112
Sphingomonas koreensis DSMZ 15582 0.54 Ga0059261_0992 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.23 Ga0059261_3811 branched-chain amino acid aminotransferase, group II 0.63 57
Rhodospirillum rubrum S1H 0.51 Rru_A1530 5,10-methylenetetrahydrofolate reductase (NCBI) 0.32 Rru_A2223 Branched-chain amino acid aminotransferase I (NCBI) low > 58
Bosea sp. OAE506 0.50 ABIE41_RS12475 methylenetetrahydrofolate reductase [NAD(P)H] 0.28 ABIE41_RS11405 branched-chain amino acid aminotransferase low > 77
Caulobacter crescentus NA1000 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.31 CCNA_03024 branched-chain amino acid aminotransferase low > 66
Caulobacter crescentus NA1000 Δfur 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.31 CCNA_03024 branched-chain amino acid aminotransferase low > 67
Rhodopseudomonas palustris CGA009 0.46 TX73_019175 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 TX73_022650 branched-chain amino acid aminotransferase
Brevundimonas sp. GW460-12-10-14-LB2 0.45 A4249_RS07925 methylenetetrahydrofolate reductase [NAD(P)H] 0.27 A4249_RS09820 branched-chain amino acid aminotransferase
Rhizobium sp. OAE497 0.41 ABIE40_RS11950 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 ABIE40_RS22240 branched-chain amino acid aminotransferase low > 107
Paraburkholderia sabiae LMG 24235 0.41 QEN71_RS28715 methylenetetrahydrofolate reductase [NAD(P)H] 0.44 QEN71_RS02410 branched-chain amino acid transaminase low > 153
Paraburkholderia bryophila 376MFSha3.1 0.40 H281DRAFT_05801 5,10-methylenetetrahydrofolate reductase (NAD(P)) 0.43 H281DRAFT_04193 branched chain amino acid aminotransferase apoenzyme low > 103
Phaeobacter inhibens DSM 17395 0.40 PGA1_c11700 5,10-methylenetetrahydrofolate reductase MetF 0.29 PGA1_c34110 branched-chain-amino-acid aminotransferase IlvE 0.86 22
Paraburkholderia graminis OAS925 0.39 ABIE53_000061 methylenetetrahydrofolate reductase (NADPH) 0.43 ABIE53_003432 branched-chain amino acid aminotransferase low > 113
Burkholderia phytofirmans PsJN 0.38 BPHYT_RS18705 5,10-methylenetetrahydrofolate reductase 0.43 BPHYT_RS16285 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) low > 109
Cupriavidus basilensis FW507-4G11 0.38 RR42_RS01385 5,10-methylenetetrahydrofolate reductase 0.20 RR42_RS25890 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) low > 128
Agrobacterium fabrum C58 0.38 Atu2123 methylenetetrahydrofolate reductase 0.18 Atu0871 branched-chain-amino-acid aminotransferase low > 89
Ralstonia solanacearum PSI07 0.38 RPSI07_RS23495 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 RPSI07_RS21175 branched-chain amino acid transaminase low > 81
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS09875 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 RALBFv3_RS12155 branched-chain amino acid transaminase low > 76
Ralstonia solanacearum UW163 0.38 UW163_RS03705 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 UW163_RS01455 branched-chain amino acid transaminase
Dechlorosoma suillum PS 0.38 Dsui_0640 5,10-methylenetetrahydrofolate reductase 0.47 Dsui_2030 branched-chain amino acid aminotransferase, group I
Ralstonia solanacearum GMI1000 0.38 RS_RS00460 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 RS_RS02840 branched-chain amino acid transaminase low > 80
Ralstonia sp. UNC404CL21Col 0.37 ABZR87_RS04865 methylenetetrahydrofolate reductase [NAD(P)H] 0.25 ABZR87_RS18540 branched-chain amino acid aminotransferase low > 80
Marinobacter adhaerens HP15 0.37 HP15_2917 5,10-methylenetetrahydrofolate reductase-like protein 0.43 HP15_436 branched-chain-amino-acid aminotransferase
Dinoroseobacter shibae DFL-12 0.36 Dshi_2080 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.26 Dshi_3301 branched-chain amino acid aminotransferase (RefSeq)
Pseudomonas sp. S08-1 0.36 OH686_10820 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 OH686_09695 branched-chain amino acid aminotransferase low > 80
Sinorhizobium meliloti 1021 0.36 SMc01843 5,10-methylenetetrahydrofolate reductase 0.21 SMc02896 branched-chain amino acid aminotransferase low > 103
Pseudomonas sp. RS175 0.36 PFR28_04202 5,10-methylenetetrahydrofolate reductase 0.21 PFR28_02449 putative branched-chain-amino-acid aminotransferase low > 88
Xanthomonas campestris pv. campestris strain 8004 0.36 Xcc-8004.4336.1 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.19 Xcc-8004.4199.1 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 74
Pseudomonas putida KT2440 0.36 PP_4977 5,10-methylenetetrahydrofolate reductase 0.19 PP_3511 Branched-chain-amino-acid aminotransferase 0.46 45
Pseudomonas simiae WCS417 0.36 PS417_26510 5,10-methylenetetrahydrofolate reductase 0.21 PS417_17565 branched-chain amino acid aminotransferase low > 88
Pseudomonas fluorescens FW300-N2E2 0.36 Pf6N2E2_4638 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.21 Pf6N2E2_477 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 103
Pseudomonas fluorescens SBW25 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.21 PFLU_RS19375 branched-chain amino acid aminotransferase 0.48 109
Pseudomonas fluorescens SBW25-INTG 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.21 PFLU_RS19375 branched-chain amino acid aminotransferase low > 109
Pseudomonas fluorescens FW300-N2C3 0.35 AO356_13605 5,10-methylenetetrahydrofolate reductase 0.21 AO356_22970 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) low > 104
Herbaspirillum seropedicae SmR1 0.35 HSERO_RS21425 5,10-methylenetetrahydrofolate reductase 0.44 HSERO_RS03330 branched-chain amino acid aminotransferase low > 78
Pseudomonas fluorescens FW300-N1B4 0.35 Pf1N1B4_2384 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.22 Pf1N1B4_4476 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 87
Rhodanobacter sp. FW510-T8 0.35 OKGIIK_11830 metF methylenetetrahydrofolate reductase [NAD(P)H] 0.56 OKGIIK_11840 ilvE branched-chain amino acid transaminase low > 52
Rhodanobacter denitrificans FW104-10B01 0.35 LRK54_RS12030 methylenetetrahydrofolate reductase [NAD(P)H] 0.56 LRK54_RS12020 branched-chain amino acid transaminase low > 59
Rhodanobacter denitrificans MT42 0.35 LRK55_RS11765 methylenetetrahydrofolate reductase [NAD(P)H] 0.56 LRK55_RS11755 branched-chain amino acid transaminase low > 63
Dyella japonica UNC79MFTsu3.2 0.35 ABZR86_RS11570 methylenetetrahydrofolate reductase [NAD(P)H] 0.56 ABZR86_RS15965 branched-chain amino acid transaminase 0.95 19
Pseudomonas fluorescens FW300-N2E3 0.35 AO353_08015 5,10-methylenetetrahydrofolate reductase 0.20 AO353_26655 branched-chain amino acid aminotransferase low > 101
Pseudomonas stutzeri RCH2 0.35 Psest_0313 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.46 Psest_0450 Branched-chain amino acid aminotransferase (EC 2.6.1.42) (from data) low > 67
Pseudomonas fluorescens GW456-L13 0.35 PfGW456L13_1050 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.27 PfGW456L13_4923 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 87
Pseudomonas syringae pv. syringae B728a 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.22 Psyr_1148 branched chain amino acid aminotransferase apoenzyme 0.66 13
Pseudomonas syringae pv. syringae B728a ΔmexB 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.22 Psyr_1148 branched chain amino acid aminotransferase apoenzyme low > 86
Castellaniella sp019104865 MT123 0.34 ABCV34_RS13550 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 ABCV34_RS07930 branched-chain amino acid transaminase low > 48
Lysobacter sp. OAE881 0.34 ABIE51_RS16490 methylenetetrahydrofolate reductase [NAD(P)H] 0.55 ABIE51_RS16505 branched-chain amino acid transaminase low > 62
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF1692 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.46 GFF1835 Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Acidovorax sp. GW101-3H11 0.34 Ac3H11_3045 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.46 Ac3H11_3369 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 79
Variovorax sp. OAS795 0.33 ABID97_RS25015 methylenetetrahydrofolate reductase [NAD(P)H] 0.44 ABID97_RS03790 branched-chain amino acid transaminase low > 91
Variovorax sp. SCN45 0.32 GFF2055 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.44 GFF5079 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 127
Acinetobacter radioresistens SK82 0.31 MPMX26_01002 5,10-methylenetetrahydrofolate reductase 0.40 MPMX26_00445 Branched-chain-amino-acid aminotransferase low > 36
Desulfovibrio vulgaris Hildenborough JW710 0.28 DVU0997 metF 5,10-methylenetetrahydrofolate reductase (TIGR) 0.46 DVU3197 ilvE branched-chain amino acid aminotransferase (TIGR) 0.86 10
Desulfovibrio vulgaris Miyazaki F 0.27 DvMF_3034 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.46 DvMF_2268 branched-chain amino acid aminotransferase (RefSeq)
Bifidobacterium breve UCC2003 0.24 BBR_RS15410 methylenetetrahydrofolate reductase [NAD(P)H] 0.17 BBR_RS15210 branched-chain amino acid aminotransferase low > 34
Mucilaginibacter yixingensis YX-36 DSM 26809 0.22 ABZR88_RS20935 methylenetetrahydrofolate reductase [NAD(P)H] 0.16 ABZR88_RS22095 branched-chain amino acid aminotransferase
Parabacteroides merdae CL09T00C40 0.21 HMPREF1078_RS07860 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 HMPREF1078_RS07855 branched-chain amino acid aminotransferase low > 61
Echinicola vietnamensis KMM 6221, DSM 17526 0.21 Echvi_3637 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.18 Echvi_2202 branched-chain amino acid aminotransferase, group II low > 79
Pedobacter sp. GW460-11-11-14-LB5 0.21 CA265_RS23445 methylenetetrahydrofolate reductase [NAD(P)H] 0.29 CA265_RS15785 branched-chain-amino-acid transaminase low > 88
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_16780 methylenetetrahydrofolate reductase [NAD(P)H] 0.32 CA264_06940 branched-chain amino acid aminotransferase low > 74
Phocaeicola dorei CL03T12C01 0.19 ABI39_RS15570 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 ABI39_RS01415 branched-chain amino acid aminotransferase low > 72
Bacteroides thetaiotaomicron VPI-5482 0.18 BT3821 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.19 BT3892 branched-chain amino acid aminotransferase (NCBI ptt file)
Phocaeicola vulgatus CL09T03C04 0.18 HMPREF1058_RS01490 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 HMPREF1058_RS02220 branched-chain amino acid aminotransferase low > 67
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS00120 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 HMPREF1181_RS06865 branched-chain amino acid aminotransferase low > 56
Bacteroides ovatus ATCC 8483 0.15 BACOVA_03666 methylenetetrahydrofolate reductase (NAD(P)H) 0.30 BACOVA_03679 branched-chain-amino-acid transaminase low > 94

Not shown: 1 genomes with orthologs for b3941 only; 4 genomes with orthologs for b3770 only