Conservation of cofitness between b3941 and b2021 in Escherichia coli BW25113

97 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3941 metF 5,10-methylenetetrahydrofolate reductase (NCBI) 1.0 b2021 hisC histidinol-phosphate aminotransferase (NCBI) 0.95 13
Escherichia coli ECRC62 1.00 BNILDI_05725 metF methylenetetrahydrofolate reductase 0.99 BNILDI_14735 hisC histidinol-phosphate transaminase
Escherichia coli ECOR27 1.00 NOLOHH_05810 metF methylenetetrahydrofolate reductase 1.00 NOLOHH_15825 hisC histidinol-phosphate transaminase low > 57
Escherichia coli BL21 1.00 ECD_03827 5,10-methylenetetrahydrofolate reductase 0.99 ECD_01923 histidinol-phosphate aminotransferase low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04109 5,10-methylenetetrahydrofolate reductase 0.99 OHPLBJKB_01679 Histidinol-phosphate aminotransferase low > 73
Escherichia coli ECOR38 1.00 HEPCGN_12310 metF methylenetetrahydrofolate reductase 0.99 HEPCGN_03215 hisC histidinol-phosphate transaminase low > 85
Escherichia coli ECRC99 1.00 KEDOAH_14495 metF methylenetetrahydrofolate reductase 1.00 KEDOAH_03640 hisC histidinol-phosphate transaminase
Escherichia coli ECRC102 1.00 NIAGMN_11420 metF methylenetetrahydrofolate reductase 1.00 NIAGMN_22455 hisC histidinol-phosphate transaminase
Escherichia coli ECRC98 1.00 JDDGAC_17290 metF methylenetetrahydrofolate reductase 1.00 JDDGAC_28620 hisC histidinol-phosphate transaminase
Escherichia coli ECRC101 1.00 OKFHMN_13665 metF methylenetetrahydrofolate reductase 1.00 OKFHMN_24510 hisC histidinol-phosphate transaminase
Escherichia coli ECRC101 1.00 MCAODC_04165 metF methylenetetrahydrofolate reductase 1.00 MCAODC_20430 hisC histidinol-phosphate transaminase
Escherichia fergusonii Becca 0.99 EFB2_04672 5,10-methylenetetrahydrofolate reductase 1.00 EFB2_01835 Histidinol-phosphate aminotransferase low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS22760 methylenetetrahydrofolate reductase 0.99 ECOLIN_RS11950 histidinol-phosphate transaminase
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF2329 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.91 GFF3911 Histidinol-phosphate aminotransferase (EC 2.6.1.9) low > 78
Enterobacter sp. TBS_079 0.95 MPMX20_04529 5,10-methylenetetrahydrofolate reductase 0.89 MPMX20_03003 Histidinol-phosphate aminotransferase 0.74 15
Klebsiella michiganensis M5al 0.95 BWI76_RS00805 5,10-methylenetetrahydrofolate reductase 0.87 BWI76_RS18930 histidinol-phosphate transaminase 0.86 33
Enterobacter asburiae PDN3 0.94 EX28DRAFT_4413 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.89 EX28DRAFT_0538 histidinol-phosphate aminotransferase low > 76
Pantoea sp. MT58 0.92 IAI47_00890 methylenetetrahydrofolate reductase 0.76 IAI47_07085 histidinol-phosphate transaminase 0.47 48
Serratia liquefaciens MT49 0.91 IAI46_24530 methylenetetrahydrofolate reductase 0.78 IAI46_08205 histidinol-phosphate transaminase low > 86
Dickeya dadantii 3937 0.90 DDA3937_RS00960 methylenetetrahydrofolate reductase 0.73 DDA3937_RS09730 histidinol-phosphate transaminase 0.39 48
Rahnella sp. WP5 0.89 EX31_RS14205 methylenetetrahydrofolate reductase 0.76 EX31_RS11445 histidinol-phosphate transaminase 0.90 37
Pectobacterium carotovorum WPP14 0.88 HER17_RS00950 methylenetetrahydrofolate reductase 0.74 HER17_RS12235 histidinol-phosphate transaminase low > 75
Dickeya dianthicola 67-19 0.88 HGI48_RS20415 methylenetetrahydrofolate reductase 0.73 HGI48_RS09740 histidinol-phosphate transaminase 0.48 37
Dickeya dianthicola ME23 0.88 DZA65_RS21460 methylenetetrahydrofolate reductase 0.73 DZA65_RS10050 histidinol-phosphate transaminase 0.67 36
Erwinia tracheiphila SCR3 0.86 LU632_RS19630 metF methylenetetrahydrofolate reductase 0.76 LU632_RS08940 hisC histidinol-phosphate transaminase low > 74
Vibrio cholerae E7946 ATCC 55056 0.79 CSW01_13560 methylenetetrahydrofolate reductase 0.58 CSW01_05755 histidinol-phosphate transaminase low > 62
Shewanella loihica PV-4 0.76 Shew_0522 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.40 Shew_2199 histidinol-phosphate aminotransferase (RefSeq) 0.95 31
Shewanella amazonensis SB2B 0.75 Sama_3169 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.33 Sama_1943 histidinol-phosphate aminotransferase (RefSeq) 0.97 13
Shewanella sp. ANA-3 0.75 Shewana3_3612 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.42 Shewana3_1852 histidinol phosphate aminotransferase (RefSeq) 0.97 9
Shewanella oneidensis MR-1 0.75 SO4054 metF 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.42 SO2072 hisC histidinol-phosphate aminotransferase (NCBI ptt file) 0.97 13
Alteromonas macleodii MIT1002 0.70 MIT1002_03670 5,10-methylenetetrahydrofolate reductase 0.49 MIT1002_02634 Histidinol-phosphate aminotransferase low > 70
Kangiella aquimarina DSM 16071 0.59 B158DRAFT_2461 5,10-methylenetetrahydrofolate reductase (NAD(P)) (EC 1.5.1.20) 0.20 B158DRAFT_2325 histidinol-phosphate aminotransferase low > 40
Magnetospirillum magneticum AMB-1 0.55 AMB_RS02230 methylenetetrahydrofolate reductase 0.19 AMB_RS00655 histidinol-phosphate aminotransferase family protein
Azospirillum brasilense Sp245 0.54 AZOBR_RS24245 5 10-methylenetetrahydrofolate reductase 0.16 AZOBR_RS20485 histidinol-phosphate aminotransferase [EC:2.6.1.9] (from data) low > 97
Azospirillum sp. SherDot2 0.54 MPMX19_00635 5,10-methylenetetrahydrofolate reductase 0.16 MPMX19_04389 Histidinol-phosphate aminotransferase
Sphingomonas koreensis DSMZ 15582 0.54 Ga0059261_0992 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.14 Ga0059261_2299 histidinol-phosphate aminotransferase 0.64 44
Rhodospirillum rubrum S1H 0.51 Rru_A1530 5,10-methylenetetrahydrofolate reductase (NCBI) 0.16 Rru_A3264 Histidinol-phosphate aminotransferase (NCBI) 0.84 26
Caulobacter crescentus NA1000 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.16 CCNA_02617 histidinol-phosphate aminotransferase low > 66
Caulobacter crescentus NA1000 Δfur 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.16 CCNA_02617 histidinol-phosphate aminotransferase low > 67
Rhodopseudomonas palustris CGA009 0.46 TX73_019175 methylenetetrahydrofolate reductase [NAD(P)H] 0.12 TX73_023035 histidinol-phosphate transaminase
Brevundimonas sp. GW460-12-10-14-LB2 0.45 A4249_RS07925 methylenetetrahydrofolate reductase [NAD(P)H] 0.15 A4249_RS11450 histidinol-phosphate transaminase low > 48
Rhizobium sp. OAE497 0.41 ABIE40_RS11950 methylenetetrahydrofolate reductase [NAD(P)H] 0.12 ABIE40_RS17595 histidinol-phosphate transaminase 0.94 23
Paraburkholderia sabiae LMG 24235 0.41 QEN71_RS28715 methylenetetrahydrofolate reductase [NAD(P)H] 0.20 QEN71_RS27860 histidinol-phosphate transaminase 0.59 106
Phaeobacter inhibens DSM 17395 0.40 PGA1_c11700 5,10-methylenetetrahydrofolate reductase MetF 0.15 PGA1_c25240 histidinol-phosphate aminotransferase [EC:2.6.1.9] (from data)
Paraburkholderia bryophila 376MFSha3.1 0.40 H281DRAFT_05801 5,10-methylenetetrahydrofolate reductase (NAD(P)) 0.19 H281DRAFT_05654 histidinol phosphate aminotransferase apoenzyme low > 103
Paraburkholderia graminis OAS925 0.39 ABIE53_000061 methylenetetrahydrofolate reductase (NADPH) 0.19 ABIE53_003700 histidinol-phosphate aminotransferase low > 113
Burkholderia phytofirmans PsJN 0.38 BPHYT_RS18705 5,10-methylenetetrahydrofolate reductase 0.18 BPHYT_RS02830 aspartate aminotransferase low > 109
Cupriavidus basilensis FW507-4G11 0.38 RR42_RS01385 5,10-methylenetetrahydrofolate reductase 0.18 RR42_RS18910 histidinol-phosphate aminotransferase
Ralstonia solanacearum PSI07 0.38 RPSI07_RS23495 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 RPSI07_RS10395 histidinol-phosphate transaminase
Agrobacterium fabrum C58 0.38 Atu2123 methylenetetrahydrofolate reductase 0.11 Atu2810 cobalamin biosynthetic protein low > 89
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS09875 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 RALBFv3_RS06840 histidinol-phosphate transaminase
Ralstonia solanacearum UW163 0.38 UW163_RS03705 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 UW163_RS06775 histidinol-phosphate transaminase
Dechlorosoma suillum PS 0.38 Dsui_0640 5,10-methylenetetrahydrofolate reductase 0.15 Dsui_1414 histidinol-phosphate aminotransferase
Ralstonia solanacearum GMI1000 0.38 RS_RS00460 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 RS_RS14785 histidinol-phosphate aminotransferase 1
Ralstonia sp. UNC404CL21Col 0.37 ABZR87_RS04865 methylenetetrahydrofolate reductase [NAD(P)H] 0.19 ABZR87_RS02495 histidinol-phosphate transaminase low > 80
Marinobacter adhaerens HP15 0.37 HP15_2917 5,10-methylenetetrahydrofolate reductase-like protein 0.18 HP15_2427 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) 0.92 13
Dinoroseobacter shibae DFL-12 0.36 Dshi_2080 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.14 Dshi_2946 histidinol-phosphate aminotransferase (RefSeq)
Pseudomonas sp. S08-1 0.36 OH686_10820 methylenetetrahydrofolate reductase [NAD(P)H] 0.17 OH686_20875 histidinol-phosphate transaminase low > 80
Sinorhizobium meliloti 1021 0.36 SMc01843 5,10-methylenetetrahydrofolate reductase 0.13 SMc00710 histidinol-phosphate aminotransferase low > 103
Pseudomonas sp. RS175 0.36 PFR28_04202 5,10-methylenetetrahydrofolate reductase 0.17 PFR28_00908 Histidinol-phosphate aminotransferase low > 88
Xanthomonas campestris pv. campestris strain 8004 0.36 Xcc-8004.4336.1 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.38 Xcc-8004.2947.1 Histidinol-phosphate aminotransferase (EC 2.6.1.9) low > 74
Pseudomonas simiae WCS417 0.36 PS417_26510 5,10-methylenetetrahydrofolate reductase 0.17 PS417_08130 aspartate aminotransferase low > 88
Pseudomonas fluorescens FW300-N2E2 0.36 Pf6N2E2_4638 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.18 Pf6N2E2_2519 Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57) low > 103
Pseudomonas putida KT2440 0.36 PP_4977 5,10-methylenetetrahydrofolate reductase 0.17 PP_0967 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) 0.50 29
Pseudomonas fluorescens SBW25-INTG 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.17 PFLU_RS08100 histidinol-phosphate transaminase low > 109
Pseudomonas fluorescens SBW25 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.17 PFLU_RS08100 histidinol-phosphate transaminase low > 109
Pseudomonas fluorescens FW300-N1B4 0.35 Pf1N1B4_2384 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.18 Pf1N1B4_349 Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57) 0.57 66
Rhodanobacter sp. FW510-T8 0.35 OKGIIK_11830 metF methylenetetrahydrofolate reductase [NAD(P)H] 0.38 OKGIIK_04955 hisC histidinol-phosphate transaminase low > 52
Rhodanobacter denitrificans FW104-10B01 0.35 LRK54_RS12030 methylenetetrahydrofolate reductase [NAD(P)H] 0.38 LRK54_RS01600 histidinol-phosphate transaminase 0.53 53
Herbaspirillum seropedicae SmR1 0.35 HSERO_RS21425 5,10-methylenetetrahydrofolate reductase 0.16 HSERO_RS23520 histidinol-phosphate aminotransferase low > 78
Pseudomonas fluorescens FW300-N2C3 0.35 AO356_13605 5,10-methylenetetrahydrofolate reductase 0.18 AO356_03460 aspartate aminotransferase low > 104
Rhodanobacter denitrificans MT42 0.35 LRK55_RS11765 methylenetetrahydrofolate reductase [NAD(P)H] 0.37 LRK55_RS01380 histidinol-phosphate transaminase low > 63
Dyella japonica UNC79MFTsu3.2 0.35 ABZR86_RS11570 methylenetetrahydrofolate reductase [NAD(P)H] 0.35 ABZR86_RS06725 histidinol-phosphate transaminase 0.95 18
Pseudomonas fluorescens FW300-N2E3 0.35 AO353_08015 5,10-methylenetetrahydrofolate reductase 0.18 AO353_02065 aspartate aminotransferase 0.44 91
Pseudomonas stutzeri RCH2 0.35 Psest_0313 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.18 Psest_1985 histidinol-phosphate aminotransferase low > 67
Pseudomonas fluorescens GW456-L13 0.35 PfGW456L13_1050 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.17 PfGW456L13_2177 Biosynthetic Aromatic amino acid aminotransferase beta (EC 2.6.1.57) low > 87
Pseudomonas syringae pv. syringae B728a 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.15 Psyr_4132 histidinol phosphate aminotransferase apoenzyme 0.67 9
Pseudomonas syringae pv. syringae B728a ΔmexB 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.15 Psyr_4132 histidinol phosphate aminotransferase apoenzyme low > 86
Castellaniella sp019104865 MT123 0.34 ABCV34_RS13550 methylenetetrahydrofolate reductase [NAD(P)H] 0.18 ABCV34_RS02645 histidinol-phosphate transaminase low > 48
Lysobacter sp. OAE881 0.34 ABIE51_RS16490 methylenetetrahydrofolate reductase [NAD(P)H] 0.34 ABIE51_RS13320 histidinol-phosphate transaminase 0.96 35
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF1692 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.19 GFF1493 Histidinol-phosphate aminotransferase (EC 2.6.1.9)
Acidovorax sp. GW101-3H11 0.34 Ac3H11_3045 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.18 Ac3H11_4729 histidinol-phosphate transaminase (EC 2.6.1.9) (from data)
Variovorax sp. OAS795 0.33 ABID97_RS25015 methylenetetrahydrofolate reductase [NAD(P)H] 0.17 ABID97_RS23145 histidinol-phosphate transaminase low > 91
Variovorax sp. SCN45 0.32 GFF2055 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.18 GFF5348 Histidinol-phosphate aminotransferase (EC 2.6.1.9) low > 127
Acinetobacter radioresistens SK82 0.31 MPMX26_01002 5,10-methylenetetrahydrofolate reductase 0.17 MPMX26_02586 Histidinol-phosphate aminotransferase low > 36
Desulfovibrio vulgaris Hildenborough JW710 0.28 DVU0997 metF 5,10-methylenetetrahydrofolate reductase (TIGR) 0.19 DVU1029 hisC histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) 0.75 41
Desulfovibrio vulgaris Miyazaki F 0.27 DvMF_3034 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.18 DvMF_0908 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data)
Bifidobacterium breve UCC2003 0.24 BBR_RS15410 methylenetetrahydrofolate reductase [NAD(P)H] 0.14 BBR_RS17050 histidinol-phosphate transaminase low > 34
Mucilaginibacter yixingensis YX-36 DSM 26809 0.22 ABZR88_RS20935 methylenetetrahydrofolate reductase [NAD(P)H] 0.34 ABZR88_RS06875 histidinol-phosphate transaminase low > 71
Parabacteroides merdae CL09T00C40 0.21 HMPREF1078_RS07860 methylenetetrahydrofolate reductase [NAD(P)H] 0.32 HMPREF1078_RS02445 histidinol-phosphate transaminase low > 61
Echinicola vietnamensis KMM 6221, DSM 17526 0.21 Echvi_3637 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.32 Echvi_2458 histidinol-phosphate aminotransferase 0.87 31
Pedobacter sp. GW460-11-11-14-LB5 0.21 CA265_RS23445 methylenetetrahydrofolate reductase [NAD(P)H] 0.36 CA265_RS03630 histidinol-phosphate transaminase 0.95 16
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_16780 methylenetetrahydrofolate reductase [NAD(P)H] 0.35 CA264_05035 histidinol-phosphate transaminase low > 74
Phocaeicola dorei CL03T12C01 0.19 ABI39_RS15570 methylenetetrahydrofolate reductase [NAD(P)H] 0.28 ABI39_RS11840 histidinol-phosphate transaminase low > 72
Bacteroides thetaiotaomicron VPI-5482 0.18 BT3821 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.27 BT0202 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) low > 81
Phocaeicola vulgatus CL09T03C04 0.18 HMPREF1058_RS01490 methylenetetrahydrofolate reductase [NAD(P)H] 0.28 HMPREF1058_RS15880 histidinol-phosphate transaminase low > 67
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS00120 methylenetetrahydrofolate reductase [NAD(P)H] 0.29 HMPREF1181_RS04855 histidinol-phosphate transaminase low > 56
Bacteroides ovatus ATCC 8483 0.15 BACOVA_03666 methylenetetrahydrofolate reductase (NAD(P)H) 0.29 BACOVA_01233 histidinol-phosphate transaminase low > 94

Not shown: 2 genomes with orthologs for b3941 only; 4 genomes with orthologs for b2021 only