| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Dinoroseobacter shibae DFL-12 | Dshi_0449 | | two component transcriptional regulator, winged helix family (RefSeq) | insig. | 100 | 100 |
| o | Xanthobacter sp. DMC5 | GFF3712 | | Response regulator MprA | strong | 46 | 96 |
| o | Sphingobium sp. HT1-2 | GFF5337 | | two-component system, response regulator | cofit | 41 | 93 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS09450 | | response regulator transcription factor | insig. | 35 | 94 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS16110 | | two-component system response regulator RppA | insig. | 38 | 93 |
| | Rhodospirillum rubrum S1H | Rru_A2913 | | Two component Transcriptional regulator, Winged helix family (NCBI) | insig. | 38 | 94 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01550 | | two-component system response regulator RppA | no data | 38 | 93 |
| | Mycobacterium tuberculosis H37Rv | Rv0981 | | Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) | insig. | 36 | 94 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4209 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 33 | 93 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_14215 | | DNA-binding response regulator | insig. | 36 | 96 |
| | Variovorax sp. SCN45 | GFF11 | | Two-component transcriptional response regulator, OmpR family | insig. | 35 | 93 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1873 | | two component transcriptional regulator, winged helix family | insig. | 33 | 96 |
| | Caulobacter crescentus NA1000 | CCNA_01351 | | two-component response regulator protein | cofit | 38 | 93 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_01351 | | two-component response regulator protein | cofit | 38 | 93 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS03005 | | heavy metal response regulator transcription factor | sig. | 36 | 96 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS32585 | | heavy metal response regulator transcription factor | sig. | 36 | 96 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS15000 | | response regulator transcription factor | strong | 32 | 95 |
| | Mycobacterium tuberculosis H37Rv | Rv0602c | | Two component DNA binding transcriptional regulatory protein TcrA | insig. | 36 | 93 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_02615 | | DNA-binding response regulator | sig. | 33 | 95 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT0990 | | two-component system response regulator (NCBI ptt file) | sig. | 32 | 95 |
| | Pseudomonas sp. SVBP6 | COO64_RS09510 | | heavy metal response regulator transcription factor | insig. | 36 | 96 |
| | Bosea sp. OAE506 | ABIE41_RS01150 | | response regulator transcription factor | insig. | 39 | 93 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS10810 | | response regulator transcription factor | insig. | 37 | 93 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS14385 | | response regulator transcription factor | strong | 33 | 96 |
| | Pseudomonas orientalis W4I3 | QF045_RS10330 | | heavy metal response regulator transcription factor | insig. | 35 | 96 |
| | Shewanella loihica PV-4 | Shew_0097 | | two component transcriptional regulator (RefSeq) | strong | 35 | 93 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_00355 | | transcriptional regulator | insig. | 37 | 96 |
| | Pseudomonas simiae WCS417 | PS417_07685 | | transcriptional regulator | insig. | 35 | 96 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | sig. | 34 | 95 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | insig. | 34 | 95 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS15305 | | heavy metal response regulator transcription factor | insig. | 38 | 94 |
| | Mycobacterium tuberculosis H37Rv | Rv0903c | | Two component response transcriptional regulatory protein PrrA | no data | 38 | 89 |
| | Pseudomonas sp. RS175 | PFR28_03244 | | Transcriptional regulatory protein PhoP | strong | 37 | 96 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS07760 | | heavy metal response regulator transcription factor | insig. | 36 | 96 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS07760 | | heavy metal response regulator transcription factor | insig. | 36 | 96 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_11860 | | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_00180 | | response regulator receiver domain protein | sig. | 32 | 95 |
| | Azospirillum sp. SherDot2 | MPMX19_00794 | | Transcriptional activator protein CopR | sig. | 36 | 96 |
| | Pseudomonas sp. DMC3 | GFF1296 | | Transcriptional activator protein CopR | insig. | 38 | 96 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4017 | | Copper-sensing two-component system response regulator CusR | insig. | 35 | 96 |
| | Shewanella loihica PV-4 | Shew_0583 | | two component transcriptional regulator (RefSeq) | insig. | 33 | 96 |
| | Azospirillum brasilense Sp245 | AZOBR_RS10800 | | XRE family transcriptional regulator | sig. | 36 | 97 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_01669 | | Transcriptional activator protein CopR | cofit | 35 | 96 |
| | Rhodopseudomonas palustris CGA009 | TX73_009945 | | response regulator transcription factor | insig. | 35 | 94 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS04655 | | DNA-binding response regulator | strong | 33 | 93 |
| | Escherichia fergusonii Becca | EFB2_03523 | | Transcriptional regulatory protein CusR | insig. | 35 | 94 |
| | Escherichia coli ECOR38 | HEPCGN_00585 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Escherichia coli ECRC100 | OKFHMN_07705 | cusR | copper response regulator transcription factor CusR | cofit | 35 | 94 |
| | Escherichia coli ECRC101 | MCAODC_26920 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Escherichia coli ECRC102 | NIAGMN_05760 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Escherichia coli ECRC62 | BNILDI_22095 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Escherichia coli ECRC98 | JDDGAC_11350 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Escherichia coli ECRC99 | KEDOAH_20265 | cusR | copper response regulator transcription factor CusR | no data | 35 | 94 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_03138 | | Transcriptional regulatory protein CusR | insig. | 35 | 94 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS03125 | | copper response regulator transcription factor CusR | no data | 35 | 94 |
| | Escherichia coli BW25113 | b0571 | cusR | DNA-binding response regulator in two-component regulatory system with CusS (NCBI) | insig. | 35 | 94 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS17605 | | response regulator transcription factor | sig. | 34 | 93 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS06525 | phoP;inference=COORDINATES | two-component system response regulator PhoP | sig. | 36 | 96 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_05465 | | two-component system response regulator PhoP | sig. | 36 | 96 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS46275 | phoP;inference=COORDINATES | two-component system response regulator PhoP | insig. | 36 | 96 |
| | Pseudomonas sp. SVBP6 | COO64_RS09985 | | response regulator transcription factor | insig. | 35 | 95 |
| | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS20860 | | DNA-binding response regulator | insig. | 38 | 94 |
| | Ralstonia solanacearum UW163 | UW163_RS21995 | | DNA-binding response regulator | insig. | 38 | 94 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_67 | | Copper-sensing two-component system response regulator CusR | no data | 37 | 96 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_18965 | | transcriptional regulator | strong | 36 | 96 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_00710 | | copper/silver response regulator transcription factor SilR | insig. | 33 | 94 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_00640 | | copper response regulator transcription factor PcoR | insig. | 35 | 96 |
| | Xanthobacter sp. DMC5 | GFF2342 | | Phosphate regulon transcriptional regulatory protein PhoB | no data | 37 | 96 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1120 | | DNA-binding heavy metal response regulator | insig. | 36 | 98 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_2011 | | Transcriptional regulatory protein PhoP | strong | 35 | 96 |
| | Pseudomonas sp. S08-1 | OH686_22680 | | Copper-sensing two-component system response regulator CusR | strong | 35 | 96 |
| | Escherichia coli BL21 | ECD_00532 | | response regulator in two-component regulatory system with CusS | insig. | 35 | 94 |
| | Escherichia coli ECOR27 | NOLOHH_24085 | cusR | copper response regulator transcription factor CusR | insig. | 35 | 94 |
| | Pseudomonas sp. DMC3 | GFF3411 | | Transcriptional activator protein CopR | cofit | 34 | 94 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_02648 | | Transcriptional regulatory protein CusR | insig. | 34 | 95 |
| | Caulobacter crescentus NA1000 | CCNA_02845 | | two-component response regulator | strong | 34 | 93 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02845 | | two-component response regulator | cofit | 34 | 93 |
| | Alteromonas macleodii MIT1002 | MIT1002_03097 | | Transcriptional activator protein CopR | insig. | 33 | 95 |
| | Sphingobium sp. HT1-2 | GFF5177 | | Two-component transcriptional response regulator, OmpR family | cofit | 38 | 94 |
| | Pseudomonas sp. SVBP6 | COO64_RS07420 | | response regulator | insig. | 36 | 96 |
| | Variovorax sp. SCN45 | GFF4042 | | Copper-sensing two-component system response regulator CusR | insig. | 35 | 96 |
| | Shewanella sp. ANA-3 | Shewana3_0615 | | two component transcriptional regulator (RefSeq) | sig. | 33 | 95 |
| | Shewanella oneidensis MR-1 | SO0622 | | DNA-binding response regulator (NCBI ptt file) | insig. | 33 | 95 |
| | Rhodopseudomonas palustris CGA009 | TX73_024820 | | phosphate regulon transcriptional regulator PhoB | insig. | 36 | 97 |
| | Shewanella oneidensis MR-1 | SO4428 | | DNA-binding response regulator (NCBI ptt file) | strong | 33 | 96 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_5704 | | Transcriptional regulatory protein PhoP | strong | 36 | 96 |
| | Pseudomonas sp. DMC3 | GFF4840 | | Virulence transcriptional regulatory protein PhoP | cofit | 35 | 96 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS12570 | | response regulator transcription factor | insig. | 33 | 95 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS12570 | | response regulator transcription factor | insig. | 33 | 95 |
| | Pseudomonas orientalis W4I3 | QF045_RS14560 | | response regulator transcription factor | cofit | 33 | 95 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_15165 | | DNA-binding response regulator | insig. | 33 | 94 |
| | Pseudomonas simiae WCS417 | PS417_11825 | | transcriptional regulator | sig. | 33 | 95 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2622 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 30 | 95 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS01665 | | response regulator transcription factor | insig. | 35 | 94 |
| | Pseudomonas putida KT2440 | PP_5383 | | transcriptional activator protein | insig. | 34 | 97 |
| | Shewanella sp. ANA-3 | Shewana3_0282 | | two component transcriptional regulator (RefSeq) | insig. | 33 | 96 |
| | Mycobacterium tuberculosis H37Rv | Rv1033c | | Two component transcriptional regulator TrcR | insig. | 33 | 97 |
| | Pseudomonas sp. BP01 | JOY50_RS08590 | | heavy metal response regulator transcription factor | insig. | 35 | 97 |
| | Xanthobacter sp. DMC5 | GFF3127 | | Transcriptional regulatory protein CusR | no data | 35 | 94 |
| | Dickeya dianthicola 67-19 | HGI48_RS03485 | | heavy metal response regulator transcription factor | insig. | 33 | 94 |