Conservation of cofitness between b2499 and b4245 in Escherichia coli BW25113

93 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2499 purM phosphoribosylaminoimidazole synthetase (NCBI) 1.0 b4245 pyrB aspartate carbamoyltransferase catalytic subunit (NCBI) 0.86 12
Escherichia coli Nissle 1917 1.00 ECOLIN_RS14190 phosphoribosylformylglycinamidine cyclo-ligase 1.00 ECOLIN_RS24625 aspartate carbamoyltransferase low > 52
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_01227 Phosphoribosylformylglycinamidine cyclo-ligase 1.00 OHPLBJKB_03789 Aspartate carbamoyltransferase catalytic subunit 0.45 8
Escherichia coli BL21 1.00 ECD_02391 phosphoribosylaminoimidazole synthetase 1.00 ECD_04113 aspartate carbamoyltransferase, catalytic subunit 0.75 10
Escherichia coli ECOR27 0.99 NOLOHH_13460 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 NOLOHH_04125 pyrB aspartate carbamoyltransferase low > 57
Escherichia coli ECOR38 0.99 HEPCGN_20975 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 HEPCGN_10060 pyrB aspartate carbamoyltransferase low > 85
Escherichia coli ECRC62 0.99 BNILDI_12270 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 BNILDI_07385 pyrB aspartate carbamoyltransferase — —
Escherichia fergusonii Becca 0.99 EFB2_01399 Phosphoribosylformylglycinamidine cyclo-ligase 1.00 EFB2_04288 Aspartate carbamoyltransferase catalytic subunit low > 86
Escherichia coli ECRC101 0.99 MCAODC_12340 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 MCAODC_02370 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC102 0.99 NIAGMN_19580 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 NIAGMN_09715 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC99 0.99 KEDOAH_06410 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 KEDOAH_16290 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC101 0.99 OKFHMN_21810 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 OKFHMN_11865 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC98 0.99 JDDGAC_25755 purM Phosphoribosylformylglycinamidine cyclo-ligase 1.00 JDDGAC_15505 pyrB aspartate carbamoyltransferase — —
Enterobacter asburiae PDN3 0.94 EX28DRAFT_0168 phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.93 EX28DRAFT_3446 aspartate carbamoyltransferase (EC 2.1.3.2) — —
Enterobacter sp. TBS_079 0.94 MPMX20_03354 Phosphoribosylformylglycinamidine cyclo-ligase 0.92 MPMX20_00544 Aspartate carbamoyltransferase catalytic subunit 0.85 33
Klebsiella michiganensis M5al 0.93 BWI76_RS20965 phosphoribosylformylglycinamidine cyclo-ligase 0.94 BWI76_RS02995 aspartate carbamoyltransferase 0.57 81
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.93 GFF2169 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.96 GFF930 Aspartate carbamoyltransferase (EC 2.1.3.2) low > 78
Rahnella sp. WP5 0.90 EX31_RS22695 phosphoribosylformylglycinamidine cyclo-ligase 0.88 EX31_RS12785 aspartate carbamoyltransferase 0.88 52
Pantoea sp. MT58 0.89 IAI47_05180 phosphoribosylformylglycinamidine cyclo-ligase 0.87 IAI47_16860 aspartate carbamoyltransferase 0.98 6
Pectobacterium carotovorum WPP14 0.88 HER17_RS15465 phosphoribosylformylglycinamidine cyclo-ligase 0.87 HER17_RS19510 aspartate carbamoyltransferase 0.94 15
Serratia liquefaciens MT49 0.88 IAI46_18885 phosphoribosylformylglycinamidine cyclo-ligase 0.90 IAI46_02275 aspartate carbamoyltransferase 0.44 79
Erwinia tracheiphila SCR3 0.87 LU632_RS08275 purM phosphoribosylformylglycinamidine cyclo-ligase 0.86 LU632_RS20950 pyrB aspartate carbamoyltransferase 0.95 5
Dickeya dadantii 3937 0.87 DDA3937_RS06025 phosphoribosylformylglycinamidine cyclo-ligase 0.86 DDA3937_RS01925 aspartate carbamoyltransferase 0.87 10
Dickeya dianthicola ME23 0.86 DZA65_RS06420 phosphoribosylformylglycinamidine cyclo-ligase 0.87 DZA65_RS01970 aspartate carbamoyltransferase 0.60 65
Dickeya dianthicola 67-19 0.86 HGI48_RS06070 phosphoribosylformylglycinamidine cyclo-ligase 0.86 HGI48_RS01900 aspartate carbamoyltransferase 0.82 8
Shewanella amazonensis SB2B 0.77 Sama_2097 phosphoribosylaminoimidazole synthetase (RefSeq) 0.34 Sama_0840 aspartate carbamoyltransferase (RefSeq) low > 62
Vibrio cholerae E7946 ATCC 55056 0.77 CSW01_11350 phosphoribosylformylglycinamidine cyclo-ligase 0.74 CSW01_12725 aspartate carbamoyltransferase 0.61 18
Shewanella sp. ANA-3 0.76 Shewana3_2545 phosphoribosylaminoimidazole synthetase (RefSeq) 0.35 Shewana3_3070 aspartate carbamoyltransferase (RefSeq) 0.87 34
Shewanella oneidensis MR-1 0.75 SO2760 purM phosphoribosylformylglycinamidine cyclo-ligase (NCBI ptt file) 0.35 SO1301 pyrB aspartate carbamoyltransferase (NCBI ptt file) 0.84 43
Shewanella loihica PV-4 0.75 Shew_1513 phosphoribosylaminoimidazole synthetase (RefSeq) 0.34 Shew_1013 aspartate carbamoyltransferase (RefSeq) — —
Alteromonas macleodii MIT1002 0.73 MIT1002_02219 Phosphoribosylformylglycinamidine cyclo-ligase 0.34 MIT1002_00423 Aspartate carbamoyltransferase catalytic chain 0.85 56
Kangiella aquimarina DSM 16071 0.70 B158DRAFT_2385 phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.33 B158DRAFT_0021 aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas stutzeri RCH2 0.70 Psest_1474 phosphoribosylaminoimidazole synthetase 0.23 Psest_0291 aspartate carbamoyltransferase — —
Pseudomonas putida KT2440 0.69 PP_1665 Phosphoribosylformylglycinamidine cyclo-ligase 0.23 PP_4998 Aspartate carbamoyltransferase — —
Pseudomonas fluorescens SBW25 0.69 PFLU_RS22065 phosphoribosylformylglycinamidine cyclo-ligase 0.23 PFLU_RS28345 aspartate carbamoyltransferase — —
Pseudomonas fluorescens SBW25-INTG 0.69 PFLU_RS22065 phosphoribosylformylglycinamidine cyclo-ligase 0.23 PFLU_RS28345 aspartate carbamoyltransferase — —
Pseudomonas fluorescens FW300-N2C3 0.69 AO356_19090 phosphoribosylaminoimidazole synthetase 0.23 AO356_13450 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas syringae pv. syringae B728a 0.69 Psyr_3689 phosphoribosylformylglycinamidine cyclo-ligase 0.22 Psyr_0482 aspartate carbamoyltransferase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.69 Psyr_3689 phosphoribosylformylglycinamidine cyclo-ligase 0.22 Psyr_0482 aspartate carbamoyltransferase — —
Pseudomonas sp. S08-1 0.69 OH686_18995 Phosphoribosylformylglycinamidine cyclo-ligase 0.23 OH686_10940 aspartate carbamoyltransferase — —
Pseudomonas fluorescens FW300-N2E2 0.69 Pf6N2E2_5729 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.23 Pf6N2E2_4606 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas simiae WCS417 0.69 PS417_20120 phosphoribosylaminoimidazole synthetase 0.23 PS417_26700 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas fluorescens FW300-N1B4 0.68 Pf1N1B4_3698 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.23 Pf1N1B4_2347 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas sp. RS175 0.68 PFR28_03217 Phosphoribosylformylglycinamidine cyclo-ligase 0.23 PFR28_04237 Aspartate carbamoyltransferase — —
Pseudomonas fluorescens FW300-N2E3 0.68 AO353_02680 phosphoribosylaminoimidazole synthetase 0.23 AO353_08135 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas fluorescens GW456-L13 0.68 PfGW456L13_4252 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.23 PfGW456L13_1016 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Marinobacter adhaerens HP15 0.67 HP15_1299 phosphoribosylaminoimidazole synthetase 0.23 HP15_3507 aspartate carbamoyltransferase — —
Acinetobacter radioresistens SK82 0.67 MPMX26_02206 Phosphoribosylformylglycinamidine cyclo-ligase 0.23 MPMX26_01099 Aspartate carbamoyltransferase low > 36
Dechlorosoma suillum PS 0.62 Dsui_1519 phosphoribosylaminoimidazole synthetase 0.21 Dsui_0596 aspartate carbamoyltransferase — —
Cupriavidus basilensis FW507-4G11 0.59 RR42_RS17220 phosphoribosylaminoimidazole synthetase 0.22 RR42_RS15860 aspartate carbamoyltransferase catalytic subunit — —
Herbaspirillum seropedicae SmR1 0.56 HSERO_RS03165 phosphoribosylaminoimidazole synthetase 0.21 HSERO_RS02330 aspartate carbamoyltransferase — —
Rhodanobacter denitrificans FW104-10B01 0.56 LRK54_RS12945 phosphoribosylformylglycinamidine cyclo-ligase 0.23 LRK54_RS04220 aspartate carbamoyltransferase catalytic subunit — —
Rhodospirillum rubrum S1H 0.56 Rru_A2167 Phosphoribosylformylglycinamidine cyclo-ligase (NCBI) 0.21 Rru_A3190 Aspartate carbamoyltransferase (NCBI) low > 58
Rhodanobacter denitrificans MT42 0.56 LRK55_RS12645 phosphoribosylformylglycinamidine cyclo-ligase 0.23 LRK55_RS03990 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum PSI07 0.55 RPSI07_RS12020 phosphoribosylformylglycinamidine cyclo-ligase 0.22 RPSI07_RS20635 aspartate carbamoyltransferase catalytic subunit — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.55 GFF3433 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.21 GFF651 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Acidovorax sp. GW101-3H11 0.55 Ac3H11_1318 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.21 Ac3H11_3978 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Ralstonia solanacearum IBSBF1503 0.55 RALBFv3_RS05280 phosphoribosylformylglycinamidine cyclo-ligase 0.22 RALBFv3_RS12625 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia sp. UNC404CL21Col 0.55 ABZR87_RS00915 phosphoribosylformylglycinamidine cyclo-ligase 0.22 ABZR87_RS08625 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum UW163 0.55 UW163_RS08345 phosphoribosylformylglycinamidine cyclo-ligase 0.22 UW163_RS00940 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum GMI1000 0.54 RS_RS13145 phosphoribosylformylglycinamidine cyclo-ligase 0.22 RS_RS03410 aspartate carbamoyltransferase — —
Azospirillum brasilense Sp245 0.54 AZOBR_RS16290 phosphoribosylaminoimidazole synthetase 0.23 AZOBR_RS20575 aspartate carbamoyltransferase 0.49 61
Xanthomonas campestris pv. campestris strain 8004 0.54 Xcc-8004.1676.1 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) 0.22 Xcc-8004.1722.1 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Lysobacter sp. OAE881 0.54 ABIE51_RS15890 phosphoribosylformylglycinamidine cyclo-ligase 0.22 ABIE51_RS16015 aspartate carbamoyltransferase catalytic subunit low > 62
Agrobacterium fabrum C58 0.53 Atu1141 Phosphoribosylglycinamide synthetase 0.21 Atu1308 aspartate carbamoyl transferase catalytic subunit 0.91 16
Azospirillum sp. SherDot2 0.53 MPMX19_01304 Phosphoribosylformylglycinamidine cyclo-ligase 0.22 MPMX19_01054 Aspartate carbamoyltransferase 0.82 31
Synechococcus elongatus PCC 7942 0.53 Synpcc7942_0851 purM phosphoribosylaminoimidazole synthetase 0.21 Synpcc7942_0670 pyrB aspartate carbamoyltransferase catalytic subunit — —
Dyella japonica UNC79MFTsu3.2 0.53 ABZR86_RS19865 phosphoribosylformylglycinamidine cyclo-ligase 0.22 ABZR86_RS10390 aspartate carbamoyltransferase catalytic subunit — —
Rhizobium sp. OAE497 0.52 ABIE40_RS06560 phosphoribosylformylglycinamidine cyclo-ligase 0.21 ABIE40_RS07385 aspartate carbamoyltransferase catalytic subunit — —
Phaeobacter inhibens DSM 17395 0.52 PGA1_c13260 phosphoribosylformylglycinamidine cyclo-ligase PurM 0.22 PGA1_c03060 aspartate carbamoyltransferase PyrB 0.85 17
Rhodanobacter sp. FW510-T8 0.52 OKGIIK_02315 purM phosphoribosylformylglycinamidine cyclo-ligase 0.22 OKGIIK_11095 pyrB aspartate carbamoyltransferase catalytic subunit — —
Magnetospirillum magneticum AMB-1 0.52 AMB_RS14330 phosphoribosylformylglycinamidine cyclo-ligase 0.23 AMB_RS18300 aspartate carbamoyltransferase — —
Sinorhizobium meliloti 1021 0.51 SMc00615 phosphoribosylaminoimidazole synthetase 0.23 SMc01360 aspartate carbamoyltransferase catalytic subunit 0.84 65
Caulobacter crescentus NA1000 Δfur 0.50 CCNA_01775 phosphoribosylformylglycinamidine cyclo-ligase 0.20 CCNA_02525 aspartate carbamoyltransferase low > 67
Caulobacter crescentus NA1000 0.50 CCNA_01775 phosphoribosylformylglycinamidine cyclo-ligase 0.20 CCNA_02525 aspartate carbamoyltransferase 0.90 4
Desulfovibrio vulgaris Miyazaki F 0.49 DvMF_0202 phosphoribosylaminoimidazole synthetase (RefSeq) 0.17 DvMF_1425 pyrB aspartate carbamoyltransferase catalytic subunit (RefSeq) — —
Dinoroseobacter shibae DFL-12 0.49 Dshi_1889 phosphoribosylformylglycinamidine cyclo-ligase (RefSeq) 0.22 Dshi_3091 aspartate carbamoyltransferase (RefSeq) 0.83 13
Desulfovibrio vulgaris Hildenborough JW710 0.48 DVU1406 purM phosphoribosylformylglycinamidine cyclo-ligase (TIGR) 0.19 DVU2901 pyrB aspartate carbamoyltransferase (TIGR) — —
Bosea sp. OAE506 0.48 ABIE41_RS17040 phosphoribosylformylglycinamidine cyclo-ligase 0.20 ABIE41_RS17230 aspartate carbamoyltransferase catalytic subunit low > 77
Bifidobacterium breve UCC2003 0.47 BBR_RS13375 phosphoribosylformylglycinamidine cyclo-ligase 0.41 BBR_RS15425 aspartate carbamoyltransferase low > 34
Rhodopseudomonas palustris CGA009 0.47 TX73_015785 phosphoribosylformylglycinamidine cyclo-ligase 0.19 TX73_016120 aspartate carbamoyltransferase catalytic subunit — —
Fusobacterium nucleatum SB010 0.47 HUW76_05175 phosphoribosylformylglycinamidine cyclo-ligase 0.23 HUW76_08765 aspartate carbamoyltransferase catalytic subunit low > 35
Mycobacterium tuberculosis H37Rv 0.40 Rv0809 Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.21 Rv1380 Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase) — —
Methanococcus maripaludis S2 0.29 MMP_RS06450 phosphoribosylformylglycinamidine cyclo-ligase 0.44 MMP_RS08545 aspartate carbamoyltransferase — —
Methanococcus maripaludis JJ 0.29 MMJJ_RS07900 phosphoribosylformylglycinamidine cyclo-ligase 0.44 MMJJ_RS05825 aspartate carbamoyltransferase — —
Bacteroides stercoris CC31F 0.10 HMPREF1181_RS06340 phosphoribosylformylglycinamidine cyclo-ligase 0.48 HMPREF1181_RS14990 aspartate carbamoyltransferase 0.91 4
Parabacteroides merdae CL09T00C40 0.10 HMPREF1078_RS13965 AIR synthase-related protein 0.51 HMPREF1078_RS01350 aspartate carbamoyltransferase — —
Phocaeicola dorei CL03T12C01 0.10 ABI39_RS00475 phosphoribosylformylglycinamidine cyclo-ligase 0.48 ABI39_RS17400 aspartate carbamoyltransferase — —
Bacteroides thetaiotaomicron VPI-5482 0.10 BT4211 putative phosphoribosylformylglycinamidine cyclo-ligase (NCBI ptt file) 0.49 BT0742 aspartate carbamoyltransferase catalytic chain (NCBI ptt file) — —
Phocaeicola vulgatus CL09T03C04 0.10 HMPREF1058_RS08025 phosphoribosylformylglycinamidine cyclo-ligase 0.48 HMPREF1058_RS03820 aspartate carbamoyltransferase — —
Bacteroides ovatus ATCC 8483 0.10 BACOVA_05058 hypothetical protein 0.49 BACOVA_02450 aspartate carbamoyltransferase — —
Pedobacter sp. GW460-11-11-14-LB5 0.09 CA265_RS05175 phosphoribosylformylglycinamidine cyclo-ligase 0.24 CA265_RS14660 aspartate carbamoyltransferase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.08 Echvi_0734 Phosphoribosylaminoimidazole (AIR) synthetase 0.23 Echvi_4661 aspartate carbamoyltransferase — —
Pontibacter actiniarum KMM 6156, DSM 19842 0.08 CA264_17695 phosphoribosylformylglycinamidine cyclo-ligase 0.22 CA264_20465 aspartate carbamoyltransferase low > 74

Not shown: 9 genomes with orthologs for b2499 only; 1 genomes with orthologs for b4245 only