Conservation of cofitness between BWI76_RS00805 and BWI76_RS04665 in Klebsiella michiganensis M5al

96 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS00805 5,10-methylenetetrahydrofolate reductase 1.0 BWI76_RS04665 3-isopropylmalate dehydratase small subunit 0.92 1
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF2329 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.93 GFF167 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 78
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4413 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.92 EX28DRAFT_3667 3-isopropylmalate dehydratase, small subunit 0.54 57
Enterobacter sp. TBS_079 0.95 MPMX20_04529 5,10-methylenetetrahydrofolate reductase 0.93 MPMX20_00766 3-isopropylmalate dehydratase small subunit 1 0.73 22
Escherichia coli ECOR27 0.95 NOLOHH_05810 metF methylenetetrahydrofolate reductase 0.88 NOLOHH_03075 leuD 3-isopropylmalate dehydratase small subunit 0.89 54
Escherichia coli BL21 0.95 ECD_03827 5,10-methylenetetrahydrofolate reductase 0.88 ECD_00073 3-isopropylmalate dehydratase small subunit 0.92 17
Escherichia coli BW25113 0.95 b3941 metF 5,10-methylenetetrahydrofolate reductase (NCBI) 0.88 b0071 leuD isopropylmalate isomerase small subunit (NCBI) 0.95 12
Escherichia coli ECRC62 0.95 BNILDI_05725 metF methylenetetrahydrofolate reductase 0.88 BNILDI_08535 leuD 3-isopropylmalate dehydratase small subunit 0.96 40
Escherichia coli HS(pFamp)R (ATCC 700891) 0.95 OHPLBJKB_04109 5,10-methylenetetrahydrofolate reductase 0.88 OHPLBJKB_03586 3-isopropylmalate dehydratase small subunit 0.41 42
Escherichia coli ECOR38 0.95 HEPCGN_12310 metF methylenetetrahydrofolate reductase 0.88 HEPCGN_08710 leuD 3-isopropylmalate dehydratase small subunit 0.89 56
Escherichia coli ECRC100 0.95 OKFHMN_13665 metF methylenetetrahydrofolate reductase 0.87 OKFHMN_10730 leuD 3-isopropylmalate dehydratase small subunit 0.95 49
Escherichia coli ECRC102 0.95 NIAGMN_11420 metF methylenetetrahydrofolate reductase 0.87 NIAGMN_08580 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC99 0.95 KEDOAH_14495 metF methylenetetrahydrofolate reductase 0.87 KEDOAH_17425 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC101 0.95 MCAODC_04165 metF methylenetetrahydrofolate reductase 0.87 MCAODC_01245 leuD 3-isopropylmalate dehydratase small subunit 0.97 11
Escherichia coli ECRC98 0.95 JDDGAC_17290 metF methylenetetrahydrofolate reductase 0.87 JDDGAC_14325 leuD 3-isopropylmalate dehydratase small subunit 0.96 12
Escherichia fergusonii Becca 0.94 EFB2_04672 5,10-methylenetetrahydrofolate reductase 0.88 EFB2_03974 3-isopropylmalate dehydratase small subunit low > 86
Escherichia coli Nissle 1917 0.94 ECOLIN_RS22760 methylenetetrahydrofolate reductase 0.88 ECOLIN_RS00385 3-isopropylmalate dehydratase small subunit 0.89 24
Pantoea sp. MT58 0.92 IAI47_00890 methylenetetrahydrofolate reductase 0.83 IAI47_16015 3-isopropylmalate dehydratase small subunit low > 76
Serratia liquefaciens MT49 0.92 IAI46_24530 methylenetetrahydrofolate reductase 0.84 IAI46_03340 3-isopropylmalate dehydratase small subunit low > 86
Dickeya dadantii 3937 0.91 DDA3937_RS00960 methylenetetrahydrofolate reductase 0.84 DDA3937_RS18130 3-isopropylmalate dehydratase small subunit low > 74
Rahnella sp. WP5 0.91 EX31_RS14205 methylenetetrahydrofolate reductase 0.84 EX31_RS03695 3-isopropylmalate dehydratase small subunit 0.91 24
Pectobacterium carotovorum WPP14 0.90 HER17_RS00950 methylenetetrahydrofolate reductase 0.84 HER17_RS03070 3-isopropylmalate dehydratase small subunit low > 75
Dickeya dianthicola 67-19 0.90 HGI48_RS20415 methylenetetrahydrofolate reductase 0.83 HGI48_RS18070 3-isopropylmalate dehydratase small subunit low > 71
Dickeya dianthicola ME23 0.90 DZA65_RS21460 methylenetetrahydrofolate reductase 0.84 DZA65_RS19215 3-isopropylmalate dehydratase small subunit 0.70 28
Erwinia tracheiphila SCR3 0.87 LU632_RS19630 metF methylenetetrahydrofolate reductase 0.74 LU632_RS02865 leuD 3-isopropylmalate dehydratase small subunit low > 74
Vibrio cholerae E7946 ATCC 55056 0.78 CSW01_13560 methylenetetrahydrofolate reductase 0.73 CSW01_12610 3-isopropylmalate dehydratase small subunit low > 62
Shewanella oneidensis MR-1 0.76 SO4054 metF 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.60 SO4233 leuD 3-isopropylmalate dehydratase, small subunit (NCBI ptt file) 0.96 17
Shewanella amazonensis SB2B 0.76 Sama_3169 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.60 Sama_0338 leuD isopropylmalate isomerase small subunit (RefSeq) 0.97 10
Shewanella sp. ANA-3 0.76 Shewana3_3612 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.59 Shewana3_3758 leuD isopropylmalate isomerase small subunit (RefSeq) 0.97 6
Shewanella loihica PV-4 0.75 Shew_0522 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.63 Shew_3469 isopropylmalate isomerase small subunit (RefSeq) 0.98 22
Alteromonas macleodii MIT1002 0.70 MIT1002_03670 5,10-methylenetetrahydrofolate reductase 0.62 MIT1002_00946 3-isopropylmalate dehydratase small subunit 1 low > 70
Kangiella aquimarina DSM 16071 0.61 B158DRAFT_2461 5,10-methylenetetrahydrofolate reductase (NAD(P)) (EC 1.5.1.20) 0.59 B158DRAFT_1320 3-isopropylmalate dehydratase, small subunit low > 40
Azospirillum brasilense Sp245 0.55 AZOBR_RS09540 5 10-methylenetetrahydrofolate reductase 0.50 AZOBR_RS14135 isopropylmalate isomerase 0.74 13
Magnetospirillum magneticum AMB-1 0.55 AMB_RS02230 methylenetetrahydrofolate reductase 0.51 AMB_RS20565 3-isopropylmalate dehydratase small subunit
Azospirillum sp. SherDot2 0.55 MPMX19_00635 5,10-methylenetetrahydrofolate reductase 0.51 MPMX19_00606 3-isopropylmalate dehydratase small subunit 1 0.94 5
Sphingomonas koreensis DSMZ 15582 0.54 Ga0059261_0992 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.37 Ga0059261_4225 3-isopropylmalate dehydratase, small subunit low > 68
Bosea sp. OAE506 0.52 ABIE41_RS12475 methylenetetrahydrofolate reductase [NAD(P)H] 0.47 ABIE41_RS11640 3-isopropylmalate dehydratase small subunit
Rhodospirillum rubrum S1H 0.52 Rru_A1530 5,10-methylenetetrahydrofolate reductase (NCBI) 0.50 Rru_A1190 3-isopropylmalate dehydratase small subunit region (NCBI) 0.69 41
Caulobacter crescentus NA1000 0.48 CCNA_02224 methylenetetrahydrofolate reductase 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.96 11
Caulobacter crescentus NA1000 Δfur 0.48 CCNA_02224 methylenetetrahydrofolate reductase 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit low > 67
Rhodopseudomonas palustris CGA009 0.46 TX73_019175 methylenetetrahydrofolate reductase [NAD(P)H] 0.51 TX73_001215 3-isopropylmalate dehydratase small subunit
Brevundimonas sp. GW460-12-10-14-LB2 0.46 A4249_RS07925 methylenetetrahydrofolate reductase [NAD(P)H] 0.40 A4249_RS10000 3-isopropylmalate dehydratase small subunit 0.98 43
Rhizobium sp. OAE497 0.41 ABIE40_RS11950 methylenetetrahydrofolate reductase [NAD(P)H] 0.48 ABIE40_RS19040 3-isopropylmalate dehydratase small subunit 0.98 6
Paraburkholderia sabiae LMG 24235 0.41 QEN71_RS28715 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 QEN71_RS17615 3-isopropylmalate dehydratase small subunit 0.85 33
Paraburkholderia bryophila 376MFSha3.1 0.40 H281DRAFT_05801 5,10-methylenetetrahydrofolate reductase (NAD(P)) 0.59 H281DRAFT_06073 3-isopropylmalate dehydratase, small subunit 0.63 14
Paraburkholderia graminis OAS925 0.40 ABIE53_000061 methylenetetrahydrofolate reductase (NADPH) 0.57 ABIE53_004803 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit 0.92 3
Phaeobacter inhibens DSM 17395 0.40 PGA1_c11700 5,10-methylenetetrahydrofolate reductase MetF 0.49 PGA1_c29790 3-isopropylmalate dehydratase small subunit 0.89 17
Cupriavidus basilensis FW507-4G11 0.39 RR42_RS01385 5,10-methylenetetrahydrofolate reductase 0.59 RR42_RS14390 3-isopropylmalate dehydratase 0.76 21
Burkholderia phytofirmans PsJN 0.39 BPHYT_RS18705 5,10-methylenetetrahydrofolate reductase 0.58 BPHYT_RS33905 3-isopropylmalate dehydratase small subunit 0.45 51
Agrobacterium fabrum C58 0.39 Atu2123 methylenetetrahydrofolate reductase 0.49 Atu2790 3-isopropylmalate dehydratase, small subunit 0.60 12
Dechlorosoma suillum PS 0.39 Dsui_0640 5,10-methylenetetrahydrofolate reductase 0.56 Dsui_3199 3-isopropylmalate dehydratase, small subunit
Ralstonia sp. UNC404CL21Col 0.38 ABZR87_RS04865 methylenetetrahydrofolate reductase [NAD(P)H] 0.60 ABZR87_RS14535 3-isopropylmalate dehydratase small subunit 0.77 8
Ralstonia solanacearum GMI1000 0.38 RS_RS00460 methylenetetrahydrofolate reductase [NAD(P)H] 0.59 RS_RS09995 3-isopropylmalate dehydratase small subunit
Ralstonia solanacearum PSI07 0.38 RPSI07_RS23495 methylenetetrahydrofolate reductase [NAD(P)H] 0.59 RPSI07_RS14700 3-isopropylmalate dehydratase small subunit
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS09875 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 RALBFv3_RS02615 3-isopropylmalate dehydratase small subunit 0.53 59
Ralstonia solanacearum UW163 0.38 UW163_RS03705 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 UW163_RS11110 3-isopropylmalate dehydratase small subunit
Pseudomonas sp. RS175 0.38 PFR28_04202 5,10-methylenetetrahydrofolate reductase 0.62 PFR28_02823 3-isopropylmalate dehydratase small subunit 1 0.63 16
Xanthomonas campestris pv. campestris strain 8004 0.37 Xcc-8004.4336.1 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.61 Xcc-8004.1050.1 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 74
Dinoroseobacter shibae DFL-12 0.37 Dshi_2080 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.51 Dshi_0083 3-isopropylmalate dehydratase, small subunit (RefSeq)
Pseudomonas simiae WCS417 0.37 PS417_26510 5,10-methylenetetrahydrofolate reductase 0.61 PS417_18595 3-isopropylmalate dehydratase 0.45 13
Pseudomonas sp. S08-1 0.37 OH686_10820 methylenetetrahydrofolate reductase [NAD(P)H] 0.62 OH686_04475 3-isopropylmalate dehydratase small subunit 0.69 33
Sinorhizobium meliloti 1021 0.37 SMc01843 5,10-methylenetetrahydrofolate reductase 0.49 SMc03795 isopropylmalate isomerase small subunit 0.95 24
Marinobacter adhaerens HP15 0.37 HP15_2917 5,10-methylenetetrahydrofolate reductase-like protein 0.55 HP15_1833 isopropylmalate isomerase small subunit 0.92 11
Pseudomonas fluorescens SBW25 0.37 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.61 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.51 89
Pseudomonas fluorescens SBW25-INTG 0.37 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.61 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.74 17
Pseudomonas fluorescens FW300-N1B4 0.37 Pf1N1B4_2384 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.62 Pf1N1B4_14 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
Pseudomonas fluorescens FW300-N2E2 0.37 Pf6N2E2_4638 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.62 Pf6N2E2_64 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.72 13
Rhodanobacter denitrificans FW104-10B01 0.37 LRK54_RS12030 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 LRK54_RS07370 3-isopropylmalate dehydratase small subunit low > 59
Rhodanobacter denitrificans MT42 0.37 LRK55_RS11765 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 LRK55_RS07100 3-isopropylmalate dehydratase small subunit low > 63
Pseudomonas fluorescens FW300-N2E3 0.36 AO353_08015 5,10-methylenetetrahydrofolate reductase 0.62 AO353_20625 3-isopropylmalate dehydratase 0.85 11
Pseudomonas fluorescens FW300-N2C3 0.36 AO356_13605 5,10-methylenetetrahydrofolate reductase 0.61 AO356_21405 3-isopropylmalate dehydratase 0.94 15
Rhodanobacter sp. FW510-T8 0.36 OKGIIK_11830 metF methylenetetrahydrofolate reductase [NAD(P)H] 0.40 OKGIIK_13590 leuD 3-isopropylmalate dehydratase small subunit low > 52
Herbaspirillum seropedicae SmR1 0.36 HSERO_RS21425 5,10-methylenetetrahydrofolate reductase 0.57 HSERO_RS16505 3-isopropylmalate dehydratase small subunit low > 78
Pseudomonas fluorescens GW456-L13 0.36 PfGW456L13_1050 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.62 PfGW456L13_3947 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.93 11
Pseudomonas putida KT2440 0.36 PP_4977 5,10-methylenetetrahydrofolate reductase 0.62 PP_1986 3-isopropylmalate dehydratase small subunit 0.44 52
Dyella japonica UNC79MFTsu3.2 0.36 ABZR86_RS11570 methylenetetrahydrofolate reductase [NAD(P)H] 0.40 ABZR86_RS15955 3-isopropylmalate dehydratase small subunit 0.92 52
Pseudomonas stutzeri RCH2 0.36 Psest_0313 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.63 Psest_2590 3-isopropylmalate dehydratase, small subunit 0.85 18
Pseudomonas syringae pv. syringae B728a ΔmexB 0.36 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.61 Psyr_1984 3-isopropylmalate dehydratase, small subunit low > 86
Pseudomonas syringae pv. syringae B728a 0.36 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.61 Psyr_1984 3-isopropylmalate dehydratase, small subunit 0.67 8
Lysobacter sp. OAE881 0.35 ABIE51_RS16490 methylenetetrahydrofolate reductase [NAD(P)H] 0.42 ABIE51_RS17580 3-isopropylmalate dehydratase small subunit 0.91 50
Castellaniella sp019104865 MT123 0.35 ABCV34_RS13550 methylenetetrahydrofolate reductase [NAD(P)H] 0.55 ABCV34_RS04285 3-isopropylmalate dehydratase small subunit low > 48
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF1692 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.58 GFF3361 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
Acidovorax sp. GW101-3H11 0.34 Ac3H11_3045 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.57 Ac3H11_1527 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.88 16
Variovorax sp. OAS795 0.33 ABID97_RS25015 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 ABID97_RS08460 3-isopropylmalate dehydratase small subunit
Variovorax sp. SCN45 0.32 GFF2055 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.60 GFF3889 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 127
Acinetobacter radioresistens SK82 0.32 MPMX26_01002 5,10-methylenetetrahydrofolate reductase 0.55 MPMX26_00346 3-isopropylmalate dehydratase small subunit 1 low > 36
Bifidobacterium breve UCC2003 0.23 BBR_RS15410 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 BBR_RS19625 3-isopropylmalate dehydratase small subunit 0.32 1
Mucilaginibacter yixingensis YX-36 DSM 26809 0.22 ABZR88_RS20935 methylenetetrahydrofolate reductase [NAD(P)H] 0.45 ABZR88_RS11600 3-isopropylmalate dehydratase small subunit
Echinicola vietnamensis KMM 6221, DSM 17526 0.21 Echvi_3637 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.38 Echvi_2060 3-isopropylmalate dehydratase, small subunit
Parabacteroides merdae CL09T00C40 0.21 HMPREF1078_RS07860 methylenetetrahydrofolate reductase [NAD(P)H] 0.42 HMPREF1078_RS16655 3-isopropylmalate dehydratase small subunit low > 61
Pedobacter sp. GW460-11-11-14-LB5 0.21 CA265_RS23445 methylenetetrahydrofolate reductase [NAD(P)H] 0.44 CA265_RS15840 3-isopropylmalate dehydratase small subunit 0.93 34
Bacteroides thetaiotaomicron VPI-5482 0.20 BT3821 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.39 BT1859 3-isopropylmalate dehydratase small subunit (NCBI ptt file) low > 81
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_16780 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 CA264_09440 3-isopropylmalate dehydratase small subunit low > 74
Phocaeicola dorei CL03T12C01 0.19 ABI39_RS15570 methylenetetrahydrofolate reductase [NAD(P)H] 0.42 ABI39_RS10205 3-isopropylmalate dehydratase small subunit low > 72
Phocaeicola vulgatus CL09T03C04 0.19 HMPREF1058_RS01490 methylenetetrahydrofolate reductase [NAD(P)H] 0.42 HMPREF1058_RS14555 3-isopropylmalate dehydratase small subunit low > 67
Bacteroides stercoris CC31F 0.18 HMPREF1181_RS00120 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 HMPREF1181_RS14140 3-isopropylmalate dehydratase small subunit low > 56
Bacteroides ovatus ATCC 8483 0.16 BACOVA_03666 methylenetetrahydrofolate reductase (NAD(P)H) 0.39 BACOVA_04602 3-isopropylmalate dehydratase, small subunit low > 94

Not shown: 3 genomes with orthologs for BWI76_RS00805 only; 2 genomes with orthologs for BWI76_RS04665 only