Conservation of cofitness between b3941 and b0071 in Escherichia coli BW25113

95 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3941 metF 5,10-methylenetetrahydrofolate reductase (NCBI) 1.0 b0071 leuD isopropylmalate isomerase small subunit (NCBI) 0.95 12
Escherichia coli BL21 1.00 ECD_03827 5,10-methylenetetrahydrofolate reductase 1.00 ECD_00073 3-isopropylmalate dehydratase small subunit low > 60
Escherichia coli ECOR27 1.00 NOLOHH_05810 metF methylenetetrahydrofolate reductase 1.00 NOLOHH_03075 leuD 3-isopropylmalate dehydratase small subunit low > 57
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04109 5,10-methylenetetrahydrofolate reductase 1.00 OHPLBJKB_03586 3-isopropylmalate dehydratase small subunit 0.41 42
Escherichia coli ECRC62 1.00 BNILDI_05725 metF methylenetetrahydrofolate reductase 1.00 BNILDI_08535 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC98 1.00 JDDGAC_17290 metF methylenetetrahydrofolate reductase 0.99 JDDGAC_14325 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECOR38 1.00 HEPCGN_12310 metF methylenetetrahydrofolate reductase 0.99 HEPCGN_08710 leuD 3-isopropylmalate dehydratase small subunit low > 85
Escherichia coli ECRC101 1.00 MCAODC_04165 metF methylenetetrahydrofolate reductase 0.99 MCAODC_01245 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC101 1.00 OKFHMN_13665 metF methylenetetrahydrofolate reductase 0.99 OKFHMN_10730 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC102 1.00 NIAGMN_11420 metF methylenetetrahydrofolate reductase 0.99 NIAGMN_08580 leuD 3-isopropylmalate dehydratase small subunit
Escherichia coli ECRC99 1.00 KEDOAH_14495 metF methylenetetrahydrofolate reductase 0.99 KEDOAH_17425 leuD 3-isopropylmalate dehydratase small subunit
Escherichia fergusonii Becca 0.99 EFB2_04672 5,10-methylenetetrahydrofolate reductase 0.99 EFB2_03974 3-isopropylmalate dehydratase small subunit low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS22760 methylenetetrahydrofolate reductase 0.99 ECOLIN_RS00385 3-isopropylmalate dehydratase small subunit low > 52
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF2329 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.92 GFF167 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 78
Enterobacter sp. TBS_079 0.95 MPMX20_04529 5,10-methylenetetrahydrofolate reductase 0.90 MPMX20_00766 3-isopropylmalate dehydratase small subunit 1 0.73 22
Klebsiella michiganensis M5al 0.95 BWI76_RS00805 5,10-methylenetetrahydrofolate reductase 0.89 BWI76_RS04665 3-isopropylmalate dehydratase small subunit 0.92 1
Enterobacter asburiae PDN3 0.94 EX28DRAFT_4413 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.89 EX28DRAFT_3667 3-isopropylmalate dehydratase, small subunit 0.54 57
Pantoea sp. MT58 0.92 IAI47_00890 methylenetetrahydrofolate reductase 0.79 IAI47_16015 3-isopropylmalate dehydratase small subunit low > 76
Serratia liquefaciens MT49 0.91 IAI46_24530 methylenetetrahydrofolate reductase 0.81 IAI46_03340 3-isopropylmalate dehydratase small subunit low > 86
Dickeya dadantii 3937 0.90 DDA3937_RS00960 methylenetetrahydrofolate reductase 0.83 DDA3937_RS18130 3-isopropylmalate dehydratase small subunit low > 74
Rahnella sp. WP5 0.89 EX31_RS14205 methylenetetrahydrofolate reductase 0.84 EX31_RS03695 3-isopropylmalate dehydratase small subunit 0.91 24
Dickeya dianthicola 67-19 0.88 HGI48_RS20415 methylenetetrahydrofolate reductase 0.82 HGI48_RS18070 3-isopropylmalate dehydratase small subunit low > 71
Pectobacterium carotovorum WPP14 0.88 HER17_RS00950 methylenetetrahydrofolate reductase 0.82 HER17_RS03070 3-isopropylmalate dehydratase small subunit low > 75
Dickeya dianthicola ME23 0.88 DZA65_RS21460 methylenetetrahydrofolate reductase 0.83 DZA65_RS19215 3-isopropylmalate dehydratase small subunit 0.70 28
Erwinia tracheiphila SCR3 0.86 LU632_RS19630 metF methylenetetrahydrofolate reductase 0.72 LU632_RS02865 leuD 3-isopropylmalate dehydratase small subunit low > 74
Vibrio cholerae E7946 ATCC 55056 0.79 CSW01_13560 methylenetetrahydrofolate reductase 0.72 CSW01_12610 3-isopropylmalate dehydratase small subunit low > 62
Shewanella loihica PV-4 0.76 Shew_0522 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.62 Shew_3469 isopropylmalate isomerase small subunit (RefSeq) 0.98 22
Shewanella amazonensis SB2B 0.75 Sama_3169 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.58 Sama_0338 leuD isopropylmalate isomerase small subunit (RefSeq) 0.97 10
Shewanella sp. ANA-3 0.75 Shewana3_3612 metF 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.59 Shewana3_3758 leuD isopropylmalate isomerase small subunit (RefSeq) 0.97 6
Shewanella oneidensis MR-1 0.75 SO4054 metF 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.58 SO4233 leuD 3-isopropylmalate dehydratase, small subunit (NCBI ptt file) 0.96 17
Alteromonas macleodii MIT1002 0.70 MIT1002_03670 5,10-methylenetetrahydrofolate reductase 0.60 MIT1002_00946 3-isopropylmalate dehydratase small subunit 1 low > 70
Kangiella aquimarina DSM 16071 0.59 B158DRAFT_2461 5,10-methylenetetrahydrofolate reductase (NAD(P)) (EC 1.5.1.20) 0.57 B158DRAFT_1320 3-isopropylmalate dehydratase, small subunit low > 40
Magnetospirillum magneticum AMB-1 0.55 AMB_RS02230 methylenetetrahydrofolate reductase 0.48 AMB_RS20565 3-isopropylmalate dehydratase small subunit
Azospirillum brasilense Sp245 0.54 AZOBR_RS24245 5 10-methylenetetrahydrofolate reductase 0.47 AZOBR_RS14135 isopropylmalate isomerase low > 97
Azospirillum sp. SherDot2 0.54 MPMX19_00635 5,10-methylenetetrahydrofolate reductase 0.50 MPMX19_00606 3-isopropylmalate dehydratase small subunit 1 0.94 5
Sphingomonas koreensis DSMZ 15582 0.54 Ga0059261_0992 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.38 Ga0059261_4225 3-isopropylmalate dehydratase, small subunit low > 68
Rhodospirillum rubrum S1H 0.51 Rru_A1530 5,10-methylenetetrahydrofolate reductase (NCBI) 0.48 Rru_A1190 3-isopropylmalate dehydratase small subunit region (NCBI) 0.69 41
Bosea sp. OAE506 0.50 ABIE41_RS12475 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 ABIE41_RS11640 3-isopropylmalate dehydratase small subunit
Caulobacter crescentus NA1000 Δfur 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit low > 67
Caulobacter crescentus NA1000 0.47 CCNA_02224 methylenetetrahydrofolate reductase 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.96 11
Rhodopseudomonas palustris CGA009 0.46 TX73_019175 methylenetetrahydrofolate reductase [NAD(P)H] 0.50 TX73_001215 3-isopropylmalate dehydratase small subunit
Brevundimonas sp. GW460-12-10-14-LB2 0.45 A4249_RS07925 methylenetetrahydrofolate reductase [NAD(P)H] 0.37 A4249_RS10000 3-isopropylmalate dehydratase small subunit 0.98 43
Rhizobium sp. OAE497 0.41 ABIE40_RS11950 methylenetetrahydrofolate reductase [NAD(P)H] 0.48 ABIE40_RS19040 3-isopropylmalate dehydratase small subunit 0.98 6
Paraburkholderia sabiae LMG 24235 0.41 QEN71_RS28715 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 QEN71_RS17615 3-isopropylmalate dehydratase small subunit 0.85 33
Phaeobacter inhibens DSM 17395 0.40 PGA1_c11700 5,10-methylenetetrahydrofolate reductase MetF 0.48 PGA1_c29790 3-isopropylmalate dehydratase small subunit 0.89 17
Paraburkholderia bryophila 376MFSha3.1 0.40 H281DRAFT_05801 5,10-methylenetetrahydrofolate reductase (NAD(P)) 0.58 H281DRAFT_06073 3-isopropylmalate dehydratase, small subunit 0.63 14
Paraburkholderia graminis OAS925 0.39 ABIE53_000061 methylenetetrahydrofolate reductase (NADPH) 0.57 ABIE53_004803 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit 0.92 3
Burkholderia phytofirmans PsJN 0.38 BPHYT_RS18705 5,10-methylenetetrahydrofolate reductase 0.58 BPHYT_RS33905 3-isopropylmalate dehydratase small subunit 0.45 51
Cupriavidus basilensis FW507-4G11 0.38 RR42_RS01385 5,10-methylenetetrahydrofolate reductase 0.57 RR42_RS14390 3-isopropylmalate dehydratase 0.76 21
Ralstonia solanacearum PSI07 0.38 RPSI07_RS23495 methylenetetrahydrofolate reductase [NAD(P)H] 0.59 RPSI07_RS14700 3-isopropylmalate dehydratase small subunit
Agrobacterium fabrum C58 0.38 Atu2123 methylenetetrahydrofolate reductase 0.49 Atu2790 3-isopropylmalate dehydratase, small subunit 0.60 12
Ralstonia solanacearum UW163 0.38 UW163_RS03705 methylenetetrahydrofolate reductase [NAD(P)H] 0.57 UW163_RS11110 3-isopropylmalate dehydratase small subunit
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS09875 methylenetetrahydrofolate reductase [NAD(P)H] 0.57 RALBFv3_RS02615 3-isopropylmalate dehydratase small subunit 0.53 59
Dechlorosoma suillum PS 0.38 Dsui_0640 5,10-methylenetetrahydrofolate reductase 0.55 Dsui_3199 3-isopropylmalate dehydratase, small subunit
Ralstonia solanacearum GMI1000 0.38 RS_RS00460 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 RS_RS09995 3-isopropylmalate dehydratase small subunit
Ralstonia sp. UNC404CL21Col 0.37 ABZR87_RS04865 methylenetetrahydrofolate reductase [NAD(P)H] 0.58 ABZR87_RS14535 3-isopropylmalate dehydratase small subunit 0.77 8
Marinobacter adhaerens HP15 0.37 HP15_2917 5,10-methylenetetrahydrofolate reductase-like protein 0.54 HP15_1833 isopropylmalate isomerase small subunit 0.92 11
Sinorhizobium meliloti 1021 0.36 SMc01843 5,10-methylenetetrahydrofolate reductase 0.49 SMc03795 isopropylmalate isomerase small subunit 0.95 24
Dinoroseobacter shibae DFL-12 0.36 Dshi_2080 5,10-methylenetetrahydrofolate reductase (RefSeq) 0.50 Dshi_0083 3-isopropylmalate dehydratase, small subunit (RefSeq)
Pseudomonas sp. S08-1 0.36 OH686_10820 methylenetetrahydrofolate reductase [NAD(P)H] 0.63 OH686_04475 3-isopropylmalate dehydratase small subunit 0.69 33
Pseudomonas sp. RS175 0.36 PFR28_04202 5,10-methylenetetrahydrofolate reductase 0.64 PFR28_02823 3-isopropylmalate dehydratase small subunit 1 0.63 16
Xanthomonas campestris pv. campestris strain 8004 0.36 Xcc-8004.4336.1 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.61 Xcc-8004.1050.1 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 74
Pseudomonas putida KT2440 0.36 PP_4977 5,10-methylenetetrahydrofolate reductase 0.63 PP_1986 3-isopropylmalate dehydratase small subunit 0.44 52
Pseudomonas simiae WCS417 0.36 PS417_26510 5,10-methylenetetrahydrofolate reductase 0.62 PS417_18595 3-isopropylmalate dehydratase 0.45 13
Pseudomonas fluorescens FW300-N2E2 0.36 Pf6N2E2_4638 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.63 Pf6N2E2_64 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.72 13
Pseudomonas fluorescens SBW25-INTG 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.74 17
Pseudomonas fluorescens SBW25 0.36 PFLU_RS28165 methylenetetrahydrofolate reductase [NAD(P)H] 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.51 89
Pseudomonas fluorescens FW300-N1B4 0.35 Pf1N1B4_2384 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.63 Pf1N1B4_14 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
Pseudomonas fluorescens FW300-N2C3 0.35 AO356_13605 5,10-methylenetetrahydrofolate reductase 0.62 AO356_21405 3-isopropylmalate dehydratase 0.94 15
Rhodanobacter denitrificans FW104-10B01 0.35 LRK54_RS12030 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 LRK54_RS07370 3-isopropylmalate dehydratase small subunit low > 59
Rhodanobacter denitrificans MT42 0.35 LRK55_RS11765 methylenetetrahydrofolate reductase [NAD(P)H] 0.46 LRK55_RS07100 3-isopropylmalate dehydratase small subunit low > 63
Herbaspirillum seropedicae SmR1 0.35 HSERO_RS21425 5,10-methylenetetrahydrofolate reductase 0.58 HSERO_RS16505 3-isopropylmalate dehydratase small subunit low > 78
Dyella japonica UNC79MFTsu3.2 0.35 ABZR86_RS11570 methylenetetrahydrofolate reductase [NAD(P)H] 0.40 ABZR86_RS15955 3-isopropylmalate dehydratase small subunit 0.92 52
Pseudomonas stutzeri RCH2 0.35 Psest_0313 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.62 Psest_2590 3-isopropylmalate dehydratase, small subunit 0.85 18
Pseudomonas fluorescens FW300-N2E3 0.35 AO353_08015 5,10-methylenetetrahydrofolate reductase 0.64 AO353_20625 3-isopropylmalate dehydratase 0.85 11
Pseudomonas fluorescens GW456-L13 0.35 PfGW456L13_1050 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.64 PfGW456L13_3947 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.93 11
Pseudomonas syringae pv. syringae B728a ΔmexB 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.60 Psyr_1984 3-isopropylmalate dehydratase, small subunit low > 86
Pseudomonas syringae pv. syringae B728a 0.35 Psyr_0459 5,10-methylenetetrahydrofolate reductase 0.60 Psyr_1984 3-isopropylmalate dehydratase, small subunit 0.67 8
Castellaniella sp019104865 MT123 0.34 ABCV34_RS13550 methylenetetrahydrofolate reductase [NAD(P)H] 0.54 ABCV34_RS04285 3-isopropylmalate dehydratase small subunit low > 48
Lysobacter sp. OAE881 0.34 ABIE51_RS16490 methylenetetrahydrofolate reductase [NAD(P)H] 0.39 ABIE51_RS17580 3-isopropylmalate dehydratase small subunit 0.91 50
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF1692 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.58 GFF3361 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
Acidovorax sp. GW101-3H11 0.34 Ac3H11_3045 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.56 Ac3H11_1527 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.88 16
Variovorax sp. OAS795 0.33 ABID97_RS25015 methylenetetrahydrofolate reductase [NAD(P)H] 0.57 ABID97_RS08460 3-isopropylmalate dehydratase small subunit
Variovorax sp. SCN45 0.32 GFF2055 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) 0.59 GFF3889 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 127
Acinetobacter radioresistens SK82 0.31 MPMX26_01002 5,10-methylenetetrahydrofolate reductase 0.55 MPMX26_00346 3-isopropylmalate dehydratase small subunit 1 low > 36
Bifidobacterium breve UCC2003 0.24 BBR_RS15410 methylenetetrahydrofolate reductase [NAD(P)H] 0.42 BBR_RS19625 3-isopropylmalate dehydratase small subunit 0.32 1
Mucilaginibacter yixingensis YX-36 DSM 26809 0.22 ABZR88_RS20935 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 ABZR88_RS11600 3-isopropylmalate dehydratase small subunit
Parabacteroides merdae CL09T00C40 0.21 HMPREF1078_RS07860 methylenetetrahydrofolate reductase [NAD(P)H] 0.40 HMPREF1078_RS16655 3-isopropylmalate dehydratase small subunit low > 61
Echinicola vietnamensis KMM 6221, DSM 17526 0.21 Echvi_3637 5,10-methylenetetrahydrofolate reductase, prokaryotic form 0.38 Echvi_2060 3-isopropylmalate dehydratase, small subunit
Pedobacter sp. GW460-11-11-14-LB5 0.21 CA265_RS23445 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 CA265_RS15840 3-isopropylmalate dehydratase small subunit 0.93 34
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_16780 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 CA264_09440 3-isopropylmalate dehydratase small subunit low > 74
Phocaeicola dorei CL03T12C01 0.19 ABI39_RS15570 methylenetetrahydrofolate reductase [NAD(P)H] 0.41 ABI39_RS10205 3-isopropylmalate dehydratase small subunit low > 72
Bacteroides thetaiotaomicron VPI-5482 0.18 BT3821 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) 0.38 BT1859 3-isopropylmalate dehydratase small subunit (NCBI ptt file) low > 81
Phocaeicola vulgatus CL09T03C04 0.18 HMPREF1058_RS01490 methylenetetrahydrofolate reductase [NAD(P)H] 0.40 HMPREF1058_RS14555 3-isopropylmalate dehydratase small subunit low > 67
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS00120 methylenetetrahydrofolate reductase [NAD(P)H] 0.43 HMPREF1181_RS14140 3-isopropylmalate dehydratase small subunit low > 56
Bacteroides ovatus ATCC 8483 0.15 BACOVA_03666 methylenetetrahydrofolate reductase (NAD(P)H) 0.39 BACOVA_04602 3-isopropylmalate dehydratase, small subunit low > 94

Not shown: 4 genomes with orthologs for b3941 only; 2 genomes with orthologs for b0071 only