Conservation of cofitness between BWI76_RS02510 and BWI76_RS09910 in Klebsiella michiganensis M5al

88 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS02510 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 1.0 BWI76_RS09910 dihydroorotate dehydrogenase (quinone) 0.24 20
Enterobacter asburiae PDN3 0.80 EX28DRAFT_3364 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.92 EX28DRAFT_1998 dihydroorotate oxidase A (EC 1.3.3.1)
Escherichia coli Nissle 1917 0.79 ECOLIN_RS24205 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 ECOLIN_RS04965 quinone-dependent dihydroorotate dehydrogenase
Enterobacter sp. TBS_079 0.79 MPMX20_00448 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.92 MPMX20_01596 Dihydroorotate dehydrogenase (quinone) low > 85
Escherichia coli BW25113 0.79 b4167 yjeF predicted carbohydrate kinase (NCBI) 0.93 b0945 pyrD dihydroorotate dehydrogenase (NCBI) low > 76
Escherichia coli BL21 0.79 ECD_04034 bifunctional NAD(P)H-hydrate repair enzyme; C-terminal domain ADP-dependent (S)-NAD(P)H-hydrate dehydratase and N-terminal domain NAD(P)H-hydrate epimerase 0.93 ECD_00949 dihydro-orotate oxidase, FMN-linked low > 61
Escherichia coli ECRC102 0.78 NIAGMN_10130 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 NIAGMN_03015 pyrD quinone-dependent dihydroorotate dehydrogenase
Escherichia coli ECRC99 0.78 KEDOAH_15875 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 KEDOAH_22440 pyrD quinone-dependent dihydroorotate dehydrogenase
Escherichia coli ECRC100 0.78 OKFHMN_12280 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 OKFHMN_05295 pyrD quinone-dependent dihydroorotate dehydrogenase low > 80
Escherichia coli ECRC98 0.78 JDDGAC_15920 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 JDDGAC_08905 pyrD quinone-dependent dihydroorotate dehydrogenase low > 86
Escherichia coli ECRC101 0.78 MCAODC_02795 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 MCAODC_24685 pyrD quinone-dependent dihydroorotate dehydrogenase low > 87
Escherichia fergusonii Becca 0.78 EFB2_04368 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.93 EFB2_03126 Dihydroorotate dehydrogenase (quinone) low > 86
Escherichia coli ECRC62 0.78 BNILDI_06945 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 BNILDI_20015 pyrD quinone-dependent dihydroorotate dehydrogenase low > 75
Escherichia coli ECOR27 0.78 NOLOHH_04545 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 NOLOHH_21850 pyrD quinone-dependent dihydroorotate dehydrogenase low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.78 OHPLBJKB_03875 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.93 OHPLBJKB_02721 Dihydroorotate dehydrogenase (quinone) low > 73
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.78 GFF820 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.93 GFF3236 Dihydroorotate dehydrogenase (EC 1.3.3.1) low > 78
Escherichia coli ECOR38 0.78 HEPCGN_10510 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.93 HEPCGN_23225 pyrD quinone-dependent dihydroorotate dehydrogenase low > 87
Erwinia tracheiphila SCR3 0.67 LU632_RS02030 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.83 LU632_RS09955 pyrD quinone-dependent dihydroorotate dehydrogenase low > 74
Rahnella sp. WP5 0.65 EX31_RS08845 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.87 EX31_RS18095 quinone-dependent dihydroorotate dehydrogenase low > 89
Pantoea sp. MT58 0.64 IAI47_02565 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.82 IAI47_12705 quinone-dependent dihydroorotate dehydrogenase low > 76
Dickeya dianthicola 67-19 0.64 HGI48_RS18570 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.85 HGI48_RS12925 quinone-dependent dihydroorotate dehydrogenase low > 71
Dickeya dianthicola ME23 0.63 DZA65_RS19705 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.85 DZA65_RS13390 quinone-dependent dihydroorotate dehydrogenase low > 75
Serratia liquefaciens MT49 0.63 IAI46_01600 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.86 IAI46_08805 quinone-dependent dihydroorotate dehydrogenase low > 86
Pectobacterium carotovorum WPP14 0.62 HER17_RS02560 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.86 HER17_RS12005 quinone-dependent dihydroorotate dehydrogenase low > 75
Dickeya dadantii 3937 0.60 DDA3937_RS18635 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.85 DDA3937_RS12855 quinone-dependent dihydroorotate dehydrogenase low > 74
Vibrio cholerae E7946 ATCC 55056 0.39 CSW01_14940 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.71 CSW01_07490 dihydroorotate dehydrogenase (quinone) low > 62
Alteromonas macleodii MIT1002 0.38 MIT1002_03793 Nicotinamide nucleotide repair protein 0.58 MIT1002_02035 Dihydroorotate dehydrogenase (quinone) low > 70
Shewanella amazonensis SB2B 0.36 Sama_3030 YjeF protein (RefSeq) 0.63 Sama_1593 dihydroorotate dehydrogenase 2 (RefSeq) low > 62
Shewanella sp. ANA-3 0.36 Shewana3_0592 carbohydrate kinase, YjeF related protein (RefSeq) 0.65 Shewana3_1786 dihydroorotate dehydrogenase 2 (RefSeq) low > 73
Shewanella oneidensis MR-1 0.36 SO0598 yjeF yjeF protein (NCBI ptt file) 0.64 SO2592 pyrD dihydroorotate dehydrogenase (NCBI ptt file) low > 76
Rhodanobacter denitrificans FW104-10B01 0.34 LRK54_RS15135 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.49 LRK54_RS15985 quinone-dependent dihydroorotate dehydrogenase
Shewanella loihica PV-4 0.34 Shew_0561 carbohydrate kinase, YjeF-related protein (RefSeq) 0.63 Shew_1810 dihydroorotate dehydrogenase 2 (RefSeq) low > 60
Rhodanobacter denitrificans MT42 0.34 LRK55_RS14850 NAD(P)H-hydrate dehydratase 0.49 LRK55_RS15740 quinone-dependent dihydroorotate dehydrogenase
Lysobacter sp. OAE881 0.34 ABIE51_RS08050 NAD(P)H-hydrate dehydratase 0.45 ABIE51_RS13725 quinone-dependent dihydroorotate dehydrogenase
Dyella japonica UNC79MFTsu3.2 0.33 ABZR86_RS00840 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.49 ABZR86_RS07450 quinone-dependent dihydroorotate dehydrogenase
Xanthomonas campestris pv. campestris strain 8004 0.31 Xcc-8004.2253.1 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.46 Xcc-8004.3032.1 Dihydroorotate dehydrogenase (EC 1.3.3.1)
Marinobacter adhaerens HP15 0.31 HP15_2504 carbohydrate kinase, YjeF related protein 0.48 HP15_1377 dihydroorotate dehydrogenase low > 73
Pseudomonas stutzeri RCH2 0.31 Psest_0678 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.55 Psest_1947 dihydroorotate dehydrogenase, subfamily 2 low > 67
Pseudomonas fluorescens FW300-N1B4 0.31 Pf1N1B4_1417 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.58 Pf1N1B4_3842 Dihydroorotate dehydrogenase (EC 1.3.3.1)
Rhodanobacter sp. FW510-T8 0.31 OKGIIK_03905 Bifunctional NAD(P)H-hydrate repair enzyme 0.47 OKGIIK_09010 pyrD quinone-dependent dihydroorotate dehydrogenase
Pseudomonas sp. RS175 0.30 PFR28_05116 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.57 PFR28_01054 Dihydroorotate dehydrogenase (quinone)
Pseudomonas fluorescens FW300-N2E2 0.30 Pf6N2E2_3619 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.57 Pf6N2E2_2347 Dihydroorotate dehydrogenase (EC 1.3.3.1)
Pseudomonas fluorescens GW456-L13 0.30 PfGW456L13_159 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.56 PfGW456L13_4095 Dihydroorotate dehydrogenase (EC 1.3.3.1)
Pseudomonas fluorescens FW300-N2C3 0.30 AO356_08680 carbohydrate kinase 0.57 AO356_02610 dihydroorotate dehydrogenase (quinone)
Pseudomonas fluorescens FW300-N2E3 0.30 AO353_13120 carbohydrate kinase 0.57 AO353_00780 dihydroorotate dehydrogenase (quinone)
Pseudomonas syringae pv. syringae B728a ΔmexB 0.28 Psyr_0567 Protein of unknown function UPF0031:YjeF-related protein, N-terminal 0.57 Psyr_2106 dihydroorotate oxidase A
Pseudomonas sp. S08-1 0.28 OH686_09495 NAD(P)H-hydrate epimerase / ADP-dependent (S)-NAD(P)H-hydrate dehydratase 0.56 OH686_03120 dihydroorotate dehydrogenase (fumarate)
Pseudomonas syringae pv. syringae B728a 0.28 Psyr_0567 Protein of unknown function UPF0031:YjeF-related protein, N-terminal 0.57 Psyr_2106 dihydroorotate oxidase A
Kangiella aquimarina DSM 16071 0.27 B158DRAFT_1947 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.56 B158DRAFT_2228 dihydroorotate oxidase A (EC 1.3.3.1)
Burkholderia phytofirmans PsJN 0.26 BPHYT_RS09505 carbohydrate kinase 0.57 BPHYT_RS08565 dihydroorotate dehydrogenase low > 109
Ralstonia sp. UNC404CL21Col 0.24 ABZR87_RS12740 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.55 ABZR87_RS13360 quinone-dependent dihydroorotate dehydrogenase
Ralstonia solanacearum UW163 0.24 UW163_RS14605 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.55 UW163_RS14880 quinone-dependent dihydroorotate dehydrogenase
Ralstonia solanacearum IBSBF1503 0.24 RALBFv3_RS01295 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.55 RALBFv3_RS01570 quinone-dependent dihydroorotate dehydrogenase
Paraburkholderia graminis OAS925 0.24 ABIE53_002139 hydroxyethylthiazole kinase-like uncharacterized protein yjeF 0.57 ABIE53_001954 dihydroorotate dehydrogenase
Herbaspirillum seropedicae SmR1 0.23 HSERO_RS11180 sugar kinase 0.54 HSERO_RS16155 dihydroorotate dehydrogenase
Paraburkholderia bryophila 376MFSha3.1 0.23 H281DRAFT_00907 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.55 H281DRAFT_00743 dihydroorotate oxidase A
Ralstonia solanacearum GMI1000 0.23 RS_RS08700 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.54 RS_RS08160 dihydroorotate dehydrogenase (quinone)
Ralstonia solanacearum PSI07 0.23 RPSI07_RS16180 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.54 RPSI07_RS15920 quinone-dependent dihydroorotate dehydrogenase
Paraburkholderia sabiae LMG 24235 0.22 QEN71_RS21930 NAD(P)H-hydrate dehydratase 0.57 QEN71_RS22765 quinone-dependent dihydroorotate dehydrogenase
Acinetobacter radioresistens SK82 0.21 MPMX26_01782 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.54 MPMX26_01120 Dihydroorotate dehydrogenase (quinone)
Cupriavidus basilensis FW507-4G11 0.21 RR42_RS09070 carbohydrate kinase 0.53 RR42_RS07465 dihydroorotate dehydrogenase
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_16280 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.40 CA264_00865 dihydroorotate dehydrogenase (quinone) low > 74
Castellaniella sp019104865 MT123 0.20 ABCV34_RS02980 NAD(P)H-hydrate dehydratase 0.52 ABCV34_RS07790 quinone-dependent dihydroorotate dehydrogenase
Bacteroides thetaiotaomicron VPI-5482 0.20 BT4383 putative sugar kinase (NCBI ptt file) 0.26 BT1009 dihydroorotate dehydrogenase (NCBI ptt file) low > 81
Dechlorosoma suillum PS 0.20 Dsui_2898 yjeF-like protein, hydroxyethylthiazole kinase-related protein 0.57 Dsui_2978 dihydroorotate dehydrogenase, subfamily 2
Rhizobium sp. OAE497 0.20 ABIE40_RS09345 NAD(P)H-hydrate dehydratase 0.39 ABIE40_RS02420 quinone-dependent dihydroorotate dehydrogenase
Bosea sp. OAE506 0.19 ABIE41_RS16885 NAD(P)H-hydrate dehydratase 0.33 ABIE41_RS24065 quinone-dependent dihydroorotate dehydrogenase low > 77
Pedobacter sp. GW460-11-11-14-LB5 0.18 CA265_RS24885 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.42 CA265_RS14005 dihydroorotate dehydrogenase (quinone)
Acidovorax sp. GW101-3H11 0.18 Ac3H11_415 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.52 Ac3H11_4100 Dihydroorotate dehydrogenase (EC 1.3.3.1)
Echinicola vietnamensis KMM 6221, DSM 17526 0.18 Echvi_0073 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.41 Echvi_1806 dihydroorotate dehydrogenase, subfamily 2
Azospirillum sp. SherDot2 0.18 MPMX19_01552 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.38 MPMX19_02083 Dihydroorotate dehydrogenase (quinone)
Azospirillum brasilense Sp245 0.18 AZOBR_RS07115 hypothetical protein 0.38 AZOBR_RS13520 dihydroorotate dehydrogenase low > 97
Variovorax sp. SCN45 0.17 GFF397 NAD(P)H-hydrate epimerase (EC 5.1.99.6) / ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) 0.50 GFF960 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2)
Variovorax sp. OAS795 0.17 ABID97_RS17190 NAD(P)H-hydrate dehydratase 0.50 ABID97_RS14065 quinone-dependent dihydroorotate dehydrogenase
Mucilaginibacter yixingensis YX-36 DSM 26809 0.17 ABZR88_RS18865 NAD(P)H-hydrate dehydratase 0.40 ABZR88_RS12040 quinone-dependent dihydroorotate dehydrogenase
Hydrogenophaga sp. GW460-11-11-14-LB1 0.16 GFF4918 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.49 GFF4211 Dihydroorotate dehydrogenase (EC 1.3.3.1) low > 90
Rhodopseudomonas palustris CGA009 0.15 TX73_015380 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.38 TX73_004110 quinone-dependent dihydroorotate dehydrogenase
Sinorhizobium meliloti 1021 0.15 SMc00946 hypothetical protein 0.40 SMc02245 dihydroorotate dehydrogenase 2 low > 103
Agrobacterium fabrum C58 0.15 Atu1768 hypothetical protein 0.41 Atu0486 dihydroorotate dehydrogenase low > 89
Dinoroseobacter shibae DFL-12 0.14 Dshi_1837 carbohydrate kinase, YjeF related protein (RefSeq) 0.32 Dshi_0847 Dihydroorotate oxidase (RefSeq) low > 64
Caulobacter crescentus NA1000 0.14 CCNA_02043 sugar kinase 0.31 CCNA_00562 dihydroorotate dehydrogenase low > 66
Caulobacter crescentus NA1000 Δfur 0.14 CCNA_02043 sugar kinase 0.31 CCNA_00562 dihydroorotate dehydrogenase low > 67
Sphingomonas koreensis DSMZ 15582 0.14 Ga0059261_0649 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.39 Ga0059261_1468 dihydroorotate oxidase A (EC 1.3.3.1)
Phaeobacter inhibens DSM 17395 0.13 PGA1_c18700 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.34 PGA1_c12150 dihydroorotate dehydrogenase PyrD low > 62
Magnetospirillum magneticum AMB-1 0.13 AMB_RS14075 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.35 AMB_RS19685 quinone-dependent dihydroorotate dehydrogenase
Methanococcus maripaludis S2 0.12 MMP_RS01375 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.11 MMP_RS02330 dihydroorotate dehydrogenase
Mycobacterium tuberculosis H37Rv 0.12 Rv3433c Conserved protein 0.36 Rv2139 Probable dihydroorotate dehydrogenase PyrD
Methanococcus maripaludis JJ 0.12 MMJJ_RS04000 NAD(P)H-hydrate dehydratase 0.11 MMJJ_RS02945 dihydroorotate dehydrogenase
Rhodospirillum rubrum S1H 0.11 Rru_A1547 hypothetical protein (NCBI) 0.37 Rru_A0514 Dihydroorotate dehydrogenase 2 (NCBI) low > 58

Not shown: 6 genomes with orthologs for BWI76_RS02510 only; 6 genomes with orthologs for BWI76_RS09910 only