Conservation of cofitness between b0074 and b3771 in Escherichia coli BW25113

88 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b0074 leuA 2-isopropylmalate synthase (NCBI) 1.0 b3771 ilvD dihydroxy-acid dehydratase (NCBI) 0.98 4
Escherichia coli BL21 1.00 ECD_00076 2-isopropylmalate synthase 1.00 ECD_03649 dihydroxyacid dehydratase 0.73 8
Escherichia coli ECOR27 1.00 NOLOHH_03060 2-isopropylmalate synthase 1.00 NOLOHH_06775 ilvD dihydroxy-acid dehydratase low > 57
Escherichia coli ECRC62 1.00 BNILDI_08550 2-isopropylmalate synthase 1.00 BNILDI_04750 ilvD dihydroxy-acid dehydratase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03583 2-isopropylmalate synthase 1.00 OHPLBJKB_04282 Dihydroxy-acid dehydratase low > 73
Escherichia fergusonii Becca 1.00 EFB2_03971 2-isopropylmalate synthase 0.99 EFB2_04865 Dihydroxy-acid dehydratase low > 86
Escherichia coli Nissle 1917 1.00 ECOLIN_RS00400 2-isopropylmalate synthase 0.99 ECOLIN_RS21665 dihydroxy-acid dehydratase low > 52
Escherichia coli ECOR38 1.00 HEPCGN_08695 2-isopropylmalate synthase 1.00 HEPCGN_13350 ilvD dihydroxy-acid dehydratase low > 85
Escherichia coli ECRC102 1.00 NIAGMN_08565 2-isopropylmalate synthase 1.00 NIAGMN_12395 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC98 1.00 JDDGAC_14310 2-isopropylmalate synthase 1.00 JDDGAC_18260 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC101 1.00 MCAODC_01230 2-isopropylmalate synthase 1.00 MCAODC_05145 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC101 1.00 OKFHMN_10715 2-isopropylmalate synthase 1.00 OKFHMN_14640 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC99 1.00 KEDOAH_17440 2-isopropylmalate synthase 1.00 KEDOAH_13510 ilvD dihydroxy-acid dehydratase — —
Klebsiella michiganensis M5al 0.95 BWI76_RS04680 2-isopropylmalate synthase 0.96 BWI76_RS00975 dihydroxy-acid dehydratase 0.93 11
Enterobacter asburiae PDN3 0.94 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) 0.96 EX28DRAFT_4443 dihydroxy-acid dehydratase 0.96 4
Enterobacter sp. TBS_079 0.94 MPMX20_00769 2-isopropylmalate synthase 0.97 MPMX20_04499 Dihydroxy-acid dehydratase 0.93 12
Pectobacterium carotovorum WPP14 0.87 HER17_RS03085 2-isopropylmalate synthase 0.91 HER17_RS01075 dihydroxy-acid dehydratase 0.99 7
Erwinia tracheiphila SCR3 0.86 LU632_RS02880 leuA 2-isopropylmalate synthase 0.86 LU632_RS24400 ilvD dihydroxy-acid dehydratase 0.93 4
Dickeya dianthicola 67-19 0.86 HGI48_RS18055 2-isopropylmalate synthase 0.91 HGI48_RS20295 dihydroxy-acid dehydratase 0.88 8
Dickeya dadantii 3937 0.86 DDA3937_RS18115 2-isopropylmalate synthase 0.92 DDA3937_RS20155 dihydroxy-acid dehydratase 0.72 50
Dickeya dianthicola ME23 0.86 DZA65_RS19200 2-isopropylmalate synthase 0.91 DZA65_RS21335 dihydroxy-acid dehydratase 0.91 9
Serratia liquefaciens MT49 0.85 IAI46_03355 2-isopropylmalate synthase 0.90 IAI46_24345 dihydroxy-acid dehydratase 0.58 62
Pantoea sp. MT58 0.84 IAI47_16000 2-isopropylmalate synthase 0.89 IAI47_01035 dihydroxy-acid dehydratase 0.98 4
Rahnella sp. WP5 0.82 EX31_RS03680 2-isopropylmalate synthase 0.87 EX31_RS15005 dihydroxy-acid dehydratase 0.96 7
Vibrio cholerae E7946 ATCC 55056 0.69 CSW01_12595 2-isopropylmalate synthase 0.85 CSW01_00140 dihydroxy-acid dehydratase low > 62
Shewanella amazonensis SB2B 0.67 Sama_0335 2-isopropylmalate synthase (RefSeq) 0.79 Sama_3279 dihydroxy-acid dehydratase (RefSeq) 0.95 11
Shewanella sp. ANA-3 0.66 Shewana3_3761 2-isopropylmalate synthase (RefSeq) 0.80 Shewana3_0358 dihydroxy-acid dehydratase (RefSeq) 0.96 7
Shewanella oneidensis MR-1 0.66 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) 0.80 SO4345 ilvD dihydroxy-acid dehydratase (NCBI ptt file) 0.99 5
Shewanella loihica PV-4 0.66 Shew_3472 2-isopropylmalate synthase (RefSeq) 0.78 Shew_0292 dihydroxy-acid dehydratase (RefSeq) 0.98 24
Alteromonas macleodii MIT1002 0.62 MIT1002_00949 2-isopropylmalate synthase 0.79 MIT1002_04041 Dihydroxy-acid dehydratase 0.97 19
Pseudomonas stutzeri RCH2 0.47 Psest_1056 2-isopropylmalate synthase, bacterial type 0.75 Psest_0234 dihydroxy-acid dehydratase — —
Dechlorosoma suillum PS 0.46 Dsui_3519 2-isopropylmalate synthase, bacterial type 0.74 Dsui_1122 dihydroxy-acid dehydratase — —
Marinobacter adhaerens HP15 0.45 HP15_538 2-isopropylmalate synthase 0.70 HP15_595 dihydroxy-acid dehydratase low > 73
Desulfovibrio vulgaris Miyazaki F 0.44 DvMF_1791 2-isopropylmalate synthase (RefSeq) 0.39 DvMF_2034 dihydroxy-acid dehydratase (RefSeq) 0.89 24
Phocaeicola vulgatus CL09T03C04 0.44 HMPREF1058_RS14545 2-isopropylmalate synthase 0.64 HMPREF1058_RS16815 dihydroxy-acid dehydratase 0.94 2
Phocaeicola dorei CL03T12C01 0.44 ABI39_RS10195 2-isopropylmalate synthase 0.64 ABI39_RS12715 dihydroxy-acid dehydratase 0.88 3
Desulfovibrio vulgaris Hildenborough JW710 0.43 DVU2981 leuA 2-isopropylmalate synthase (TIGR) 0.39 DVU3373 ilvD dihydroxy-acid dehydratase (TIGR) 0.92 5
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS16665 2-isopropylmalate synthase 0.65 HMPREF1078_RS16695 dihydroxy-acid dehydratase 0.94 23
Paraburkholderia bryophila 376MFSha3.1 0.42 H281DRAFT_04556 2-isopropylmalate synthase 0.74 H281DRAFT_05312 dihydroxyacid dehydratase low > 103
Bacteroides stercoris CC31F 0.42 HMPREF1181_RS14150 2-isopropylmalate synthase 0.64 HMPREF1181_RS08335 dihydroxy-acid dehydratase 0.93 8
Magnetospirillum magneticum AMB-1 0.42 AMB_RS17765 2-isopropylmalate synthase 0.73 AMB_RS12770 dihydroxy-acid dehydratase — —
Ralstonia solanacearum PSI07 0.42 RPSI07_RS14285 2-isopropylmalate synthase 0.29 RPSI07_RS12840 dihydroxy-acid dehydratase — —
Ralstonia solanacearum UW163 0.42 UW163_RS10700 2-isopropylmalate synthase 0.29 UW163_RS09135 dihydroxy-acid dehydratase — —
Ralstonia solanacearum IBSBF1503 0.42 RALBFv3_RS03025 2-isopropylmalate synthase 0.29 RALBFv3_RS04535 dihydroxy-acid dehydratase — —
Paraburkholderia graminis OAS925 0.42 ABIE53_001580 2-isopropylmalate synthase 0.74 ABIE53_006513 dihydroxy-acid dehydratase low > 113
Ralstonia solanacearum GMI1000 0.42 RS_RS10395 2-isopropylmalate synthase 0.28 RS_RS12105 dihydroxy-acid dehydratase — —
Burkholderia phytofirmans PsJN 0.42 BPHYT_RS06570 2-isopropylmalate synthase 0.74 BPHYT_RS10100 dihydroxy-acid dehydratase low > 109
Ralstonia sp. UNC404CL21Col 0.42 ABZR87_RS14930 2-isopropylmalate synthase 0.75 ABZR87_RS00240 dihydroxy-acid dehydratase low > 80
Bacteroides ovatus ATCC 8483 0.42 BACOVA_04604 2-isopropylmalate synthase 0.62 BACOVA_03302 dihydroxy-acid dehydratase 0.95 9
Bacteroides thetaiotaomicron VPI-5482 0.42 BT1861 2-isopropylmalate synthase (EC 2.3.3.13) (from data) 0.63 BT2078 dihydroxy-acid dehydratase (NCBI ptt file) 0.96 3
Paraburkholderia sabiae LMG 24235 0.42 QEN71_RS24195 2-isopropylmalate synthase 0.74 QEN71_RS21095 dihydroxy-acid dehydratase low > 153
Rhodopseudomonas palustris CGA009 0.42 TX73_010545 2-isopropylmalate synthase 0.74 TX73_007515 dihydroxy-acid dehydratase — —
Cupriavidus basilensis FW507-4G11 0.42 RR42_RS05465 2-isopropylmalate synthase 0.29 RR42_RS16210 dihydroxy-acid dehydratase — —
Bosea sp. OAE506 0.41 ABIE41_RS13000 2-isopropylmalate synthase 0.29 ABIE41_RS15690 dihydroxy-acid dehydratase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF4281 2-isopropylmalate synthase (EC 2.3.3.13) 0.64 GFF2073 Dihydroxy-acid dehydratase (EC 4.2.1.9) low > 90
Synechococcus elongatus PCC 7942 0.41 Synpcc7942_1410 leuA 2-isopropylmalate synthase 0.75 Synpcc7942_0626 ilvD dihydroxy-acid dehydratase — —
Dyella japonica UNC79MFTsu3.2 0.41 ABZR86_RS15970 2-isopropylmalate synthase 0.28 ABZR86_RS15945 dihydroxy-acid dehydratase 0.97 14
Variovorax sp. OAS795 0.41 ABID97_RS14910 2-isopropylmalate synthase 0.31 ABID97_RS17500 dihydroxy-acid dehydratase — —
Acidovorax sp. GW101-3H11 0.41 Ac3H11_530 2-isopropylmalate synthase (EC 2.3.3.13) 0.74 Ac3H11_955 Dihydroxy-acid dehydratase (EC 4.2.1.9) low > 79
Variovorax sp. SCN45 0.41 GFF1165 2-isopropylmalate synthase (EC 2.3.3.13) 0.31 GFF471 Dihydroxy-acid dehydratase (EC 4.2.1.9) — —
Caulobacter crescentus NA1000 0.40 CCNA_01610 2-isopropylmalate synthase 0.72 CCNA_03139 dihydroxy-acid dehydratase 0.83 21
Caulobacter crescentus NA1000 Δfur 0.40 CCNA_01610 2-isopropylmalate synthase 0.72 CCNA_03139 dihydroxy-acid dehydratase low > 67
Lysobacter sp. OAE881 0.40 ABIE51_RS17570 2-isopropylmalate synthase 0.27 ABIE51_RS17540 dihydroxy-acid dehydratase 0.86 15
Phaeobacter inhibens DSM 17395 0.40 PGA1_c26470 2-isopropylmalate synthase LeuA 0.70 PGA1_c29490 dihydroxy-acid dehydratase LivD 0.91 8
Rhodanobacter denitrificans FW104-10B01 0.39 LRK54_RS10345 2-isopropylmalate synthase 0.26 LRK54_RS10320 dihydroxy-acid dehydratase 0.89 8
Rhodanobacter denitrificans MT42 0.39 LRK55_RS09985 2-isopropylmalate synthase 0.26 LRK55_RS09960 dihydroxy-acid dehydratase low > 63
Xanthomonas campestris pv. campestris strain 8004 0.39 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) 0.72 Xcc-8004.451.1 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.76 24
Rhodanobacter sp. FW510-T8 0.38 OKGIIK_13575 leuA 2-isopropylmalate synthase 0.27 OKGIIK_13600 ilvD dihydroxy-acid dehydratase low > 52
Dinoroseobacter shibae DFL-12 0.38 Dshi_0596 2-isopropylmalate synthase (RefSeq) 0.31 Dshi_0129 dihydroxy-acid dehydratase (RefSeq) — —
Methanococcus maripaludis JJ 0.29 MMJJ_RS08870 2-isopropylmalate synthase 0.35 MMJJ_RS03675 dihydroxy-acid dehydratase — —
Methanococcus maripaludis S2 0.28 MMP_RS05500 2-isopropylmalate synthase 0.35 MMP_RS01700 dihydroxy-acid dehydratase low > 25
Sinorhizobium meliloti 1021 0.15 SMc02546 alpha-isopropylmalate/homocitrate synthase family transferase 0.75 SMc04045 dihydroxy-acid dehydratase low > 103
Rhizobium sp. OAE497 0.15 ABIE40_RS06220 citramalate synthase 0.75 ABIE40_RS08005 dihydroxy-acid dehydratase 0.58 100
Pseudomonas sp. S08-1 0.12 OH686_17570 2-isopropylmalate synthase 0.75 OH686_14100 dihydroxy-acid dehydratase 0.74 14
Sphingomonas koreensis DSMZ 15582 0.12 Ga0059261_4031 2-isopropylmalate synthase, yeast type 0.28 Ga0059261_4216 Dihydroxyacid dehydratase/phosphogluconate dehydratase 0.99 4
Pseudomonas fluorescens FW300-N2C3 0.11 AO356_06550 2-isopropylmalate synthase 0.75 AO356_13250 dihydroxy-acid dehydratase 0.95 9
Pseudomonas fluorescens FW300-N2E2 0.11 Pf6N2E2_3170 2-isopropylmalate synthase (EC 2.3.3.13) 0.75 Pf6N2E2_4564 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.94 4
Acinetobacter radioresistens SK82 0.10 MPMX26_00404 2-isopropylmalate synthase 0.29 MPMX26_03019 Dihydroxy-acid dehydratase 0.82 27
Pseudomonas sp. RS175 0.10 PFR28_00305 2-isopropylmalate synthase 0.75 PFR28_04278 Dihydroxy-acid dehydratase 0.77 4
Pseudomonas fluorescens GW456-L13 0.10 PfGW456L13_4854 2-isopropylmalate synthase (EC 2.3.3.13) 0.75 PfGW456L13_973 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.88 25
Castellaniella sp019104865 MT123 0.10 ABCV34_RS12420 2-isopropylmalate synthase 0.72 ABCV34_RS14810 dihydroxy-acid dehydratase low > 48
Pseudomonas fluorescens FW300-N1B4 0.10 Pf1N1B4_847 2-isopropylmalate synthase (EC 2.3.3.13) 0.75 Pf1N1B4_2303 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.92 5
Agrobacterium fabrum C58 0.10 Atu2264 2-isopropylmalate synthase 0.73 Atu1918 dihydroxy-acid dehydratase — —
Pseudomonas putida KT2440 0.10 PP_1025 2-isopropylmalate synthase 0.74 PP_5128 Dihydroxy-acid dehydratase 0.86 5
Pseudomonas syringae pv. syringae B728a 0.10 Psyr_1257 2-isopropylmalate synthase 0.74 Psyr_0469 dihydroxyacid dehydratase 0.92 7
Pseudomonas syringae pv. syringae B728a ΔmexB 0.10 Psyr_1257 2-isopropylmalate synthase 0.74 Psyr_0469 dihydroxyacid dehydratase 0.92 13
Pseudomonas fluorescens SBW25-INTG 0.10 PFLU_RS24765 2-isopropylmalate synthase 0.75 PFLU_RS28535 dihydroxy-acid dehydratase 0.90 4
Pseudomonas fluorescens SBW25 0.10 PFLU_RS24765 2-isopropylmalate synthase 0.75 PFLU_RS28535 dihydroxy-acid dehydratase 0.82 9
Pseudomonas simiae WCS417 0.10 PS417_23110 2-isopropylmalate synthase 0.75 PS417_26890 dihydroxy-acid dehydratase 0.90 7

Not shown: 0 genomes with orthologs for b0074 only; 13 genomes with orthologs for b3771 only