Conservation of cofitness between BT1861 and BT3718 in Bacteroides thetaiotaomicron VPI-5482

87 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Bacteroides thetaiotaomicron VPI-5482 1.0 BT1861 2-isopropylmalate synthase (EC 2.3.3.13) (from data) 1.0 BT3718 gamma-glutamyl phosphate reductase (NCBI ptt file) 0.96 2
Bacteroides ovatus ATCC 8483 0.99 BACOVA_04604 2-isopropylmalate synthase 0.90 BACOVA_03534 glutamate-5-semialdehyde dehydrogenase 0.96 5
Bacteroides stercoris CC31F 0.92 HMPREF1181_RS14150 2-isopropylmalate synthase 0.73 HMPREF1181_RS03320 glutamate-5-semialdehyde dehydrogenase 0.91 22
Phocaeicola vulgatus CL09T03C04 0.90 HMPREF1058_RS14545 2-isopropylmalate synthase 0.61 HMPREF1058_RS08645 glutamate-5-semialdehyde dehydrogenase 0.93 5
Phocaeicola dorei CL03T12C01 0.90 ABI39_RS10195 2-isopropylmalate synthase 0.62 ABI39_RS02875 glutamate-5-semialdehyde dehydrogenase 0.80 17
Parabacteroides merdae CL09T00C40 0.86 HMPREF1078_RS16665 2-isopropylmalate synthase 0.68 HMPREF1078_RS10655 glutamate-5-semialdehyde dehydrogenase 0.91 47
Vibrio cholerae E7946 ATCC 55056 0.48 CSW01_12595 2-isopropylmalate synthase 0.37 CSW01_11570 glutamate-5-semialdehyde dehydrogenase low > 62
Marinobacter adhaerens HP15 0.47 HP15_538 2-isopropylmalate synthase 0.33 HP15_601 gamma-glutamyl phosphate reductase — —
Pectobacterium carotovorum WPP14 0.47 HER17_RS03085 2-isopropylmalate synthase 0.35 HER17_RS04705 glutamate-5-semialdehyde dehydrogenase 0.97 26
Serratia liquefaciens MT49 0.47 IAI46_03355 2-isopropylmalate synthase 0.37 IAI46_04435 glutamate-5-semialdehyde dehydrogenase 0.63 37
Shewanella loihica PV-4 0.47 Shew_3472 2-isopropylmalate synthase (RefSeq) 0.35 Shew_2847 proA gamma-glutamyl phosphate reductase (RefSeq) 0.98 15
Alteromonas macleodii MIT1002 0.47 MIT1002_00949 2-isopropylmalate synthase 0.38 MIT1002_01885 Gamma-glutamyl phosphate reductase 0.98 13
Shewanella sp. ANA-3 0.47 Shewana3_3761 2-isopropylmalate synthase (RefSeq) 0.34 Shewana3_0955 proA gamma-glutamyl phosphate reductase (RefSeq) 0.95 14
Dickeya dadantii 3937 0.47 DDA3937_RS18115 2-isopropylmalate synthase 0.37 DDA3937_RS16530 glutamate-5-semialdehyde dehydrogenase low > 74
Dickeya dianthicola ME23 0.47 DZA65_RS19200 2-isopropylmalate synthase 0.36 DZA65_RS17690 glutamate-5-semialdehyde dehydrogenase low > 75
Dickeya dianthicola 67-19 0.47 HGI48_RS18055 2-isopropylmalate synthase 0.36 HGI48_RS16600 glutamate-5-semialdehyde dehydrogenase 0.81 34
Shewanella oneidensis MR-1 0.47 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) 0.34 SO1122 proA gamma-glutamyl phosphate reductase (NCBI ptt file) 0.98 8
Pseudomonas stutzeri RCH2 0.46 Psest_1056 2-isopropylmalate synthase, bacterial type 0.32 Psest_0508 gamma-glutamyl phosphate reductase low > 67
Shewanella amazonensis SB2B 0.46 Sama_0335 2-isopropylmalate synthase (RefSeq) 0.34 Sama_2515 proA gamma-glutamyl phosphate reductase (RefSeq) 0.93 22
Dechlorosoma suillum PS 0.46 Dsui_3519 2-isopropylmalate synthase, bacterial type 0.31 Dsui_1220 gamma-glutamyl phosphate reductase — —
Escherichia coli ECRC99 0.46 KEDOAH_17440 2-isopropylmalate synthase 0.37 KEDOAH_18485 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC101 0.46 MCAODC_01230 2-isopropylmalate synthase 0.37 MCAODC_00190 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.46 OHPLBJKB_03583 2-isopropylmalate synthase 0.37 OHPLBJKB_03397 Gamma-glutamyl phosphate reductase low > 73
Escherichia coli Nissle 1917 0.46 ECOLIN_RS00400 2-isopropylmalate synthase 0.37 ECOLIN_RS01830 glutamate-5-semialdehyde dehydrogenase low > 52
Escherichia coli ECOR38 0.46 HEPCGN_08695 2-isopropylmalate synthase 0.37 HEPCGN_07775 proA glutamate-5-semialdehyde dehydrogenase low > 85
Escherichia coli ECOR27 0.46 NOLOHH_03060 2-isopropylmalate synthase 0.37 NOLOHH_02045 proA glutamate-5-semialdehyde dehydrogenase low > 57
Escherichia coli ECRC98 0.46 JDDGAC_14310 2-isopropylmalate synthase 0.37 JDDGAC_13295 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC102 0.46 NIAGMN_08565 2-isopropylmalate synthase 0.37 NIAGMN_07530 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC101 0.46 OKFHMN_10715 2-isopropylmalate synthase 0.37 OKFHMN_09670 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli ECRC62 0.46 BNILDI_08550 2-isopropylmalate synthase 0.37 BNILDI_00240 proA glutamate-5-semialdehyde dehydrogenase — —
Escherichia fergusonii Becca 0.46 EFB2_03971 2-isopropylmalate synthase 0.36 EFB2_03777 Gamma-glutamyl phosphate reductase low > 86
Klebsiella michiganensis M5al 0.46 BWI76_RS04680 2-isopropylmalate synthase 0.38 BWI76_RS05835 gamma-glutamyl-phosphate reductase 0.84 41
Escherichia coli BL21 0.46 ECD_00076 2-isopropylmalate synthase 0.38 ECD_00240 gamma-glutamylphosphate reductase 0.62 26
Magnetospirillum magneticum AMB-1 0.46 AMB_RS17765 2-isopropylmalate synthase 0.34 AMB_RS20640 glutamate-5-semialdehyde dehydrogenase — —
Escherichia coli BW25113 0.46 b0074 leuA 2-isopropylmalate synthase (NCBI) 0.37 b0243 proA gamma-glutamyl phosphate reductase (NCBI) 0.94 16
Rahnella sp. WP5 0.45 EX31_RS03680 2-isopropylmalate synthase 0.37 EX31_RS20975 glutamate-5-semialdehyde dehydrogenase 0.95 22
Erwinia tracheiphila SCR3 0.45 LU632_RS02880 leuA 2-isopropylmalate synthase 0.36 LU632_RS01190 proA glutamate-5-semialdehyde dehydrogenase 0.67 36
Pantoea sp. MT58 0.45 IAI47_16000 2-isopropylmalate synthase 0.37 IAI47_15115 glutamate-5-semialdehyde dehydrogenase 0.92 35
Enterobacter asburiae PDN3 0.45 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) 0.38 EX28DRAFT_2650 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.69 38
Caulobacter crescentus NA1000 Δfur 0.45 CCNA_01610 2-isopropylmalate synthase 0.29 CCNA_03543 gamma-glutamyl phosphate reductase low > 67
Caulobacter crescentus NA1000 0.45 CCNA_01610 2-isopropylmalate synthase 0.29 CCNA_03543 gamma-glutamyl phosphate reductase 0.85 13
Phaeobacter inhibens DSM 17395 0.45 PGA1_c26470 2-isopropylmalate synthase LeuA 0.33 PGA1_c15520 gamma-glutamyl phosphate reductase ProA 0.85 25
Enterobacter sp. TBS_079 0.44 MPMX20_00769 2-isopropylmalate synthase 0.39 MPMX20_00928 Gamma-glutamyl phosphate reductase 0.89 29
Synechococcus elongatus PCC 7942 0.44 Synpcc7942_1410 leuA 2-isopropylmalate synthase 0.29 Synpcc7942_2265 proA glutamate-5-semialdehyde dehydrogenase — —
Desulfovibrio vulgaris Hildenborough JW710 0.44 DVU2981 leuA 2-isopropylmalate synthase (TIGR) 0.32 DVU1953 proA gamma-glutamyl phosphate reductase (TIGR) 0.84 28
Desulfovibrio vulgaris Miyazaki F 0.44 DvMF_1791 2-isopropylmalate synthase (RefSeq) 0.32 DvMF_0612 proA gamma-glutamyl phosphate reductase (RefSeq) 0.90 21
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS24195 2-isopropylmalate synthase 0.34 QEN71_RS26940 glutamate-5-semialdehyde dehydrogenase low > 153
Burkholderia phytofirmans PsJN 0.43 BPHYT_RS06570 2-isopropylmalate synthase 0.32 BPHYT_RS16770 gamma-glutamyl phosphate reductase — —
Variovorax sp. OAS795 0.43 ABID97_RS14910 2-isopropylmalate synthase 0.29 ABID97_RS04600 glutamate-5-semialdehyde dehydrogenase — —
Paraburkholderia graminis OAS925 0.43 ABIE53_001580 2-isopropylmalate synthase 0.32 ABIE53_003523 glutamate-5-semialdehyde dehydrogenase low > 113
Hydrogenophaga sp. GW460-11-11-14-LB1 0.43 GFF4281 2-isopropylmalate synthase (EC 2.3.3.13) 0.31 GFF2641 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 90
Variovorax sp. SCN45 0.43 GFF1165 2-isopropylmalate synthase (EC 2.3.3.13) 0.30 GFF6326 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.62 71
Bosea sp. OAE506 0.43 ABIE41_RS13000 2-isopropylmalate synthase 0.28 ABIE41_RS07580 glutamate-5-semialdehyde dehydrogenase — —
Paraburkholderia bryophila 376MFSha3.1 0.43 H281DRAFT_04556 2-isopropylmalate synthase 0.32 H281DRAFT_06324 glutamate-5-semialdehyde dehydrogenase low > 103
Acidovorax sp. GW101-3H11 0.43 Ac3H11_530 2-isopropylmalate synthase (EC 2.3.3.13) 0.31 Ac3H11_704 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 79
Dinoroseobacter shibae DFL-12 0.42 Dshi_0596 2-isopropylmalate synthase (RefSeq) 0.33 Dshi_1469 gamma-glutamyl phosphate reductase (RefSeq) — —
Dyella japonica UNC79MFTsu3.2 0.42 ABZR86_RS15970 2-isopropylmalate synthase 0.34 ABZR86_RS08680 glutamate-5-semialdehyde dehydrogenase low > 74
Rhodopseudomonas palustris CGA009 0.42 TX73_010545 2-isopropylmalate synthase 0.30 TX73_000855 glutamate-5-semialdehyde dehydrogenase — —
Rhodanobacter denitrificans MT42 0.42 LRK55_RS09985 2-isopropylmalate synthase 0.33 LRK55_RS02125 glutamate-5-semialdehyde dehydrogenase low > 63
Rhodanobacter denitrificans FW104-10B01 0.42 LRK54_RS10345 2-isopropylmalate synthase 0.33 LRK54_RS02370 glutamate-5-semialdehyde dehydrogenase 0.89 7
Cupriavidus basilensis FW507-4G11 0.41 RR42_RS05465 2-isopropylmalate synthase 0.30 RR42_RS17530 gamma-glutamyl phosphate reductase low > 128
Ralstonia solanacearum PSI07 0.41 RPSI07_RS14285 2-isopropylmalate synthase 0.31 RPSI07_RS11475 glutamate-5-semialdehyde dehydrogenase low > 81
Ralstonia solanacearum IBSBF1503 0.41 RALBFv3_RS03025 2-isopropylmalate synthase 0.31 RALBFv3_RS05825 glutamate-5-semialdehyde dehydrogenase low > 76
Ralstonia solanacearum GMI1000 0.41 RS_RS10395 2-isopropylmalate synthase 0.31 RS_RS13715 gamma-glutamyl-phosphate reductase — —
Ralstonia solanacearum UW163 0.41 UW163_RS10700 2-isopropylmalate synthase 0.31 UW163_RS07800 glutamate-5-semialdehyde dehydrogenase — —
Ralstonia sp. UNC404CL21Col 0.41 ABZR87_RS14930 2-isopropylmalate synthase 0.31 ABZR87_RS01395 glutamate-5-semialdehyde dehydrogenase low > 80
Lysobacter sp. OAE881 0.40 ABIE51_RS17570 2-isopropylmalate synthase 0.30 ABIE51_RS13365 glutamate-5-semialdehyde dehydrogenase 0.77 57
Xanthomonas campestris pv. campestris strain 8004 0.40 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) 0.31 Xcc-8004.2327.1 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 74
Rhodanobacter sp. FW510-T8 0.40 OKGIIK_13575 leuA 2-isopropylmalate synthase 0.30 OKGIIK_09415 proA glutamate-5-semialdehyde dehydrogenase low > 52
Sinorhizobium meliloti 1021 0.17 SMc02546 alpha-isopropylmalate/homocitrate synthase family transferase 0.32 SMc03777 gamma-glutamyl phosphate reductase low > 103
Rhizobium sp. OAE497 0.17 ABIE40_RS06220 citramalate synthase 0.35 ABIE40_RS18925 glutamate-5-semialdehyde dehydrogenase 0.68 13
Bifidobacterium breve UCC2003 0.13 BBR_RS11170 2-isopropylmalate synthase 0.39 BBR_RS14075 glutamate-5-semialdehyde dehydrogenase low > 34
Pseudomonas sp. S08-1 0.13 OH686_17570 2-isopropylmalate synthase 0.32 OH686_09340 Gamma-glutamyl phosphate reductase 0.63 33
Pseudomonas fluorescens FW300-N2C3 0.13 AO356_06550 2-isopropylmalate synthase 0.33 AO356_15290 gamma-glutamyl phosphate reductase low > 104
Pseudomonas fluorescens FW300-N2E2 0.13 Pf6N2E2_3170 2-isopropylmalate synthase (EC 2.3.3.13) 0.33 Pf6N2E2_4993 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 103
Pseudomonas sp. RS175 0.13 PFR28_00305 2-isopropylmalate synthase 0.33 PFR28_03872 Gamma-glutamyl phosphate reductase — —
Pseudomonas putida KT2440 0.12 PP_1025 2-isopropylmalate synthase 0.33 PP_4811 Gamma-glutamyl phosphate reductase low > 96
Pseudomonas fluorescens GW456-L13 0.12 PfGW456L13_4854 2-isopropylmalate synthase (EC 2.3.3.13) 0.33 PfGW456L13_1356 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 87
Pseudomonas fluorescens FW300-N1B4 0.12 Pf1N1B4_847 2-isopropylmalate synthase (EC 2.3.3.13) 0.33 Pf1N1B4_2688 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) low > 87
Pseudomonas simiae WCS417 0.12 PS417_23110 2-isopropylmalate synthase 0.32 PS417_24745 gamma-glutamyl phosphate reductase 0.62 44
Acinetobacter radioresistens SK82 0.12 MPMX26_03077 2-isopropylmalate synthase 0.35 MPMX26_00417 Gamma-glutamyl phosphate reductase — —
Pseudomonas fluorescens SBW25 0.12 PFLU_RS24765 2-isopropylmalate synthase 0.32 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase — —
Agrobacterium fabrum C58 0.12 Atu2264 2-isopropylmalate synthase 0.34 Atu2779 gamma-glutamyl phosphate reductase — —
Pseudomonas syringae pv. syringae B728a 0.12 Psyr_1257 2-isopropylmalate synthase 0.34 Psyr_4369 glutamate-5-semialdehyde dehydrogenase 0.86 18
Pseudomonas syringae pv. syringae B728a ΔmexB 0.12 Psyr_1257 2-isopropylmalate synthase 0.34 Psyr_4369 glutamate-5-semialdehyde dehydrogenase 0.95 4
Pseudomonas fluorescens SBW25-INTG 0.12 PFLU_RS24765 2-isopropylmalate synthase 0.32 PFLU_RS26675 glutamate-5-semialdehyde dehydrogenase — —
Castellaniella sp019104865 MT123 0.12 ABCV34_RS12420 2-isopropylmalate synthase 0.34 ABCV34_RS00845 glutamate-5-semialdehyde dehydrogenase — —
Sphingomonas koreensis DSMZ 15582 0.11 Ga0059261_4031 2-isopropylmalate synthase, yeast type 0.32 Ga0059261_2506 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.97 29

Not shown: 2 genomes with orthologs for BT1861 only; 13 genomes with orthologs for BT3718 only