| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Shewanella oneidensis MR-1 | SO2540 | | response regulator (NCBI ptt file) | sig. | 100 | 100 |
| o | Alteromonas macleodii MIT1002 | MIT1002_03634 | | Transcriptional regulatory protein YycF | sig. | 46 | 95 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS15245 | | response regulator | insig. | 39 | 66 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04086 | | response regulator receiver domain protein | insig. | 36 | 66 |
| | Methanococcus maripaludis S2 | MMP_RS06720 | | response regulator transcription factor | strong | 37 | 61 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1058 | | two-component system sensor histidine kinase (NCBI ptt file) | strong | 35 | 66 |
| | Methanococcus maripaludis JJ | MMJJ_RS07635 | | response regulator transcription factor | strong | 36 | 61 |
| | Dinoroseobacter shibae DFL-12 | Dshi_1538 | | two component transcriptional regulator, winged helix family (RefSeq) | no data | 34 | 62 |
| | Azospirillum sp. SherDot2 | MPMX19_03749 | | KDP operon transcriptional regulatory protein KdpE | insig. | 43 | 58 |
| | Pseudomonas stutzeri RCH2 | Psest_1185 | | heavy metal response regulator | insig. | 36 | 60 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS15030 | | response regulator transcription factor | insig. | 38 | 62 |
| | Azospirillum sp. SherDot2 | MPMX19_01858 | | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP | insig. | 41 | 60 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14200 | | chemotaxis protein CheY | strong | 39 | 62 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS08110 | | response regulator | cofit | 39 | 62 |
| | Lysobacter sp. OAE881 | ABIE51_RS14390 | | response regulator | insig. | 39 | 60 |
| | Azospirillum sp. SherDot2 | MPMX19_04555 | | Sensor histidine kinase RcsC | insig. | 39 | 58 |
| | Rhodospirillum rubrum S1H | Rru_A0603 | | Two component Transcriptional regulator, Winged helix family (NCBI) | cofit | 38 | 61 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03562 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 38 | 62 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS06810 | | response regulator | insig. | 32 | 61 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS20605 | | response regulator | insig. | 32 | 61 |
| | Acinetobacter radioresistens SK82 | MPMX26_02509 | | Sensor histidine kinase RcsC | cofit | 28 | 86 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS17305 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 33 | 67 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03885 | | response regulator transcription factor | strong | 39 | 60 |
| | Pseudomonas stutzeri RCH2 | Psest_1894 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | no data | 36 | 61 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11370 | | response regulator transcription factor | no data | 34 | 64 |
| | Marinobacter adhaerens HP15 | HP15_3518 | | CheA signal transduction histidine kinase | cofit | 30 | 59 |
| | Rhodopseudomonas palustris CGA009 | TX73_024820 | | phosphate regulon transcriptional regulator PhoB | insig. | 38 | 60 |
| | Mycobacterium tuberculosis H37Rv | Rv0981 | | Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) | insig. | 38 | 60 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1453 | rpaB | two component transcriptional regulator, winged helix family | no data | 35 | 61 |
| | Paraburkholderia graminis OAS925 | ABIE53_005703 | | two-component system copper resistance phosphate regulon response regulator CusR | sig. | 38 | 60 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 38 | 64 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 38 | 64 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS06935 | | phosphate regulon transcriptional regulatory protein PhoB | insig. | 36 | 61 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03646 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 33 | 74 |
| | Azospirillum brasilense Sp245 | AZOBR_RS23980 | | Fis family transcriptional regulator | insig. | 41 | 60 |
| | Sphingobium sp. HT1-2 | GFF2987 | | DNA-binding response regulator KdpE | cofit | 36 | 61 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU0258 | | sensory box histidine kinase/response regulator (TIGR) | strong | 36 | 58 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_0095 | rpaA | two component transcriptional regulator, winged helix family | strong | 35 | 61 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_03275 | | hybrid sensor histidine kinase/response regulator | insig. | 36 | 58 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03320 | | EAL domain-containing protein | insig. | 32 | 60 |
| | Xanthobacter sp. DMC5 | GFF2342 | | Phosphate regulon transcriptional regulatory protein PhoB | no data | 36 | 60 |
| | Acinetobacter baumannii LAC-4 | RR41_RS03425 | | hybrid sensor histidine kinase/response regulator | insig. | 31 | 62 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15805 | | two component system response regulator RpaA | strong | 37 | 60 |
| | Sinorhizobium meliloti 1021 | SMc02140 | | phosphate regulon transcriptional regulatory protein | strong | 35 | 60 |
| | Pseudomonas sp. RS175 | PFR28_04227 | | Sensor histidine kinase RcsC | insig. | 34 | 58 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c15730 | | phosphate regulon transcriptional regulatory protein PhoB | strong | 32 | 64 |
| | Pseudomonas sp. S08-1 | OH686_01885 | | DNA-binding response regulator KdpE | insig. | 36 | 62 |
| | Shewanella oneidensis MR-1 | SO1228 | torR | torcad operon transcriptional regulatory protein TorR (NCBI ptt file) | insig. | 35 | 60 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_0187 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 34 | 60 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_2309 | | Response regulator containing a CheY-like receiver domain and a GGDEF domain | insig. | 34 | 60 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT0732 | | two-component system response regulator (NCBI ptt file) | no data | 34 | 61 |
| | Pseudomonas sp. DMC3 | GFF4642 | | Transcriptional regulatory protein KdpE | cofit | 38 | 60 |
| | Pseudomonas orientalis W4I3 | QF045_RS24850 | | response regulator transcription factor | cofit | 38 | 64 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1993 | | two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq) | sig. | 37 | 56 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_2416 | srrA | two component transcriptional regulator, winged helix family | sig. | 37 | 61 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS05130 | | response regulator | insig. | 33 | 54 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_4617 | | Signal transduction histidine kinase CheA (EC 2.7.3.-) | strong | 33 | 58 |
| | Alteromonas macleodii MIT1002 | MIT1002_01320 | | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP | cofit | 39 | 58 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS24320 | | response regulator transcription factor | cofit | 38 | 64 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS24320 | | response regulator transcription factor | strong | 38 | 64 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_04690 | | Transcriptional regulatory protein OmpR | cofit | 38 | 64 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2490 | | sensor histidine kinase | insig. | 37 | 60 |
| | Pseudomonas sp. SVBP6 | COO64_RS09705 | | response regulator | insig. | 36 | 60 |
| | Marinobacter adhaerens HP15 | HP15_2961 | | two component transcriptional regulator, winged helix family | insig. | 35 | 66 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS20630 | | transcriptional regulator | sig. | 35 | 60 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS10705 | | response regulator | insig. | 33 | 74 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS04815 | | response regulator transcription factor | insig. | 32 | 63 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS02130 | | hybrid sensor histidine kinase/response regulator | strong | 31 | 58 |
| | Azospirillum sp. SherDot2 | MPMX19_03714 | | Sensor histidine kinase RcsC | insig. | 38 | 55 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS15265 | | EAL domain-containing response regulator | insig. | 38 | 60 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS15265 | | EAL domain-containing response regulator | insig. | 38 | 60 |
| | Methylophilus sp. DMC18 | GFF2713 | | Transcriptional regulatory protein OmpR | no data | 35 | 61 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_13500 | | histidine kinase | sig. | 33 | 58 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1461 | | two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq) | no data | 45 | 53 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_181 | | Two-component response regulator | insig. | 35 | 58 |
| | Bosea sp. OAE506 | ABIE41_RS10985 | | response regulator | insig. | 35 | 55 |
| | Dickeya dadantii 3937 | DDA3937_RS07165 | | response regulator transcription factor | insig. | 34 | 73 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS12050 | | response regulator | insig. | 36 | 61 |
| | Pseudomonas segetis P6 | ACVTMO_RS14065 | | response regulator | strong | 33 | 61 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS03105 | | response regulator transcription factor | strong | 33 | 63 |
| | Xanthobacter sp. DMC5 | GFF1990 | | Sensor histidine kinase RcsC | insig. | 32 | 60 |
| | Shewanella amazonensis SB2B | Sama_1718 | | response regulator receiver protein (RefSeq) | strong | 39 | 59 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16445 | | chemotaxis protein CheY | no data | 36 | 62 |
| | Variovorax sp. SCN45 | GFF408 | | Two-component system response regulator OmpR | insig. | 35 | 60 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_0855 | pixG | response regulator receiver domain protein (CheY-like) | insig. | 34 | 60 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS11775 | | response regulator | sig. | 33 | 54 |
| | Rhizobium sp. OAE497 | ABIE40_RS02310 | | phosphate regulon transcriptional regulator PhoB | insig. | 33 | 60 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF3270 | | Two-component response regulator | insig. | 33 | 73 |
| | Variovorax sp. OAS795 | ABID97_RS23505 | | response regulator transcription factor | insig. | 32 | 67 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02740 | | response regulator receiver domain protein | strong | 30 | 62 |
| | Pseudomonas segetis P6 | ACVTMO_RS03120 | | Hpt domain-containing protein | cofit | 29 | 66 |
| | Rhizobium sp. OAE497 | ABIE40_RS02870 | | chemotaxis response regulator CheY1 | no data | 36 | 62 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_03410 | | chemotaxis protein CheY | strong | 38 | 61 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_03092 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 37 | 60 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_03295 | | transcriptional regulator | insig. | 37 | 60 |
| | Pseudomonas stutzeri RCH2 | Psest_3845 | | phosphate regulon transcriptional regulatory protein PhoB | sig. | 36 | 63 |
| | Shewanella sp. ANA-3 | Shewana3_1051 | | DNA-binding transcriptional regulator TorR (RefSeq) | insig. | 35 | 60 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04977 | | response regulator receiver domain protein | cofit | 35 | 72 |
| | Variovorax sp. SCN45 | GFF2488 | | Two-component transcriptional response regulator, LuxR family | insig. | 34 | 60 |
| | Agrobacterium fabrum C58 | Atu1297 | | two component response regulator | insig. | 33 | 60 |