Conservation of cofitness between NOLOHH_13075 and NOLOHH_23190 in Escherichia coli ECOR27

90 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECOR27 1.0 NOLOHH_13075 lepA translation elongation factor 4 1.0 NOLOHH_23190 nadA quinolinate synthase NadA 0.68 13
Escherichia coli ECRC101 1.00 MCAODC_11930 lepA translation elongation factor 4 0.99 MCAODC_25980 nadA quinolinate synthase NadA low > 87
Escherichia coli ECRC99 1.00 KEDOAH_06820 lepA translation elongation factor 4 0.99 KEDOAH_21205 nadA quinolinate synthase NadA — —
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_01138 Elongation factor 4 0.99 OHPLBJKB_02963 Quinolinate synthase A low > 73
Escherichia coli ECRC102 1.00 NIAGMN_19170 lepA translation elongation factor 4 0.99 NIAGMN_04810 nadA quinolinate synthase NadA — —
Escherichia coli BL21 1.00 ECD_02463 back-translocating elongation factor EF4, GTPase 1.00 ECD_00703 quinolinate synthase, subunit A low > 61
Escherichia coli ECRC98 1.00 JDDGAC_25065 lepA translation elongation factor 4 0.99 JDDGAC_10415 nadA quinolinate synthase NadA low > 86
Escherichia coli ECRC100 1.00 OKFHMN_21400 lepA translation elongation factor 4 0.99 OKFHMN_06760 nadA quinolinate synthase NadA low > 80
Escherichia coli Nissle 1917 1.00 ECOLIN_RS14540 translation elongation factor 4 0.98 ECOLIN_RS03990 quinolinate synthase NadA low > 55
Escherichia coli ECRC62 1.00 BNILDI_11875 lepA translation elongation factor 4 1.00 BNILDI_21185 nadA quinolinate synthase NadA low > 75
Escherichia coli BW25113 1.00 b2569 lepA GTP-binding protein LepA (NCBI) 1.00 b0750 nadA quinolinate synthetase (NCBI) low > 76
Escherichia coli ECOR38 1.00 HEPCGN_20545 lepA translation elongation factor 4 0.99 HEPCGN_01515 nadA quinolinate synthase NadA low > 87
Escherichia fergusonii Becca 1.00 EFB2_01327 Elongation factor 4 0.98 EFB2_03356 Quinolinate synthase A low > 86
Klebsiella michiganensis M5al 0.94 BWI76_RS21335 elongation factor 4 0.90 BWI76_RS08580 quinolinate synthetase — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF2477 Translation elongation factor LepA 0.90 GFF4 Quinolinate synthetase (EC 2.5.1.72) — —
Enterobacter asburiae PDN3 0.94 EX28DRAFT_0076 elongation factor 4 0.89 EX28DRAFT_2245 quinolinate synthetase (EC 2.5.1.72) low > 76
Enterobacter sp. TBS_079 0.93 MPMX20_03440 Elongation factor 4 0.89 MPMX20_01377 Quinolinate synthase A low > 85
Dickeya dadantii 3937 0.92 DDA3937_RS15745 elongation factor 4 0.80 DDA3937_RS06545 quinolinate synthase NadA low > 74
Dickeya dianthicola ME23 0.92 DZA65_RS16910 elongation factor 4 0.81 DZA65_RS06945 quinolinate synthase NadA low > 75
Dickeya dianthicola 67-19 0.92 HGI48_RS15830 elongation factor 4 0.81 HGI48_RS06595 quinolinate synthase NadA low > 71
Pectobacterium carotovorum WPP14 0.92 HER17_RS05805 translation elongation factor 4 0.85 HER17_RS14820 quinolinate synthase NadA low > 75
Serratia liquefaciens MT49 0.91 IAI46_19560 elongation factor 4 0.86 IAI46_06380 quinolinate synthase NadA low > 86
Rahnella sp. WP5 0.91 EX31_RS21825 elongation factor 4 0.83 EX31_RS23525 quinolinate synthase NadA low > 89
Pantoea sp. MT58 0.89 IAI47_04870 elongation factor 4 0.87 IAI47_13635 quinolinate synthase NadA low > 76
Vibrio cholerae E7946 ATCC 55056 0.85 CSW01_12465 elongation factor 4 0.74 CSW01_09180 quinolinate synthase low > 62
Shewanella sp. ANA-3 0.83 Shewana3_3028 GTP-binding protein LepA (RefSeq) 0.74 Shewana3_2128 quinolinate synthetase (RefSeq) — —
Shewanella oneidensis MR-1 0.83 SO1346 lepA GTP-binding protein LepA (NCBI ptt file) 0.74 SO2342 nadA quinolinate synthetase complex, subunit A (NCBI ptt file) low > 76
Shewanella loihica PV-4 0.82 Shew_1052 GTP-binding protein LepA (RefSeq) 0.75 Shew_1928 quinolinate synthetase (RefSeq) — —
Alteromonas macleodii MIT1002 0.81 MIT1002_02715 Elongation factor 4 0.71 MIT1002_01344 Quinolinate synthase A — —
Kangiella aquimarina DSM 16071 0.81 B158DRAFT_2184 GTP-binding protein LepA 0.69 B158DRAFT_2453 quinolinate synthetase (EC 2.5.1.72) — —
Shewanella amazonensis SB2B 0.80 Sama_0878 GTP-binding protein LepA (RefSeq) 0.74 Sama_1712 quinolinate synthetase (RefSeq) — —
Pseudomonas sp. S08-1 0.76 OH686_20065 elongation factor 4 0.66 OH686_19190 quinolinate synthetase complex, A subunit low > 80
Pseudomonas sp. RS175 0.76 PFR28_03525 Elongation factor 4 0.66 PFR28_03388 Quinolinate synthase A — —
Pseudomonas putida KT2440 0.76 PP_1431 Elongation factor 4 0.67 PP_1231 quinolinate synthase [4Fe-4S] cluster subunit — —
Pseudomonas fluorescens SBW25-INTG 0.75 PFLU_RS05250 elongation factor 4 0.65 PFLU_RS24025 quinolinate synthase NadA low > 109
Pseudomonas fluorescens GW456-L13 0.75 PfGW456L13_4842 Translation elongation factor LepA 0.66 PfGW456L13_1863 Quinolinate synthetase (EC 2.5.1.72) low > 87
Pseudomonas fluorescens FW300-N2E2 0.75 Pf6N2E2_5423 Translation elongation factor LepA 0.66 Pf6N2E2_5553 Quinolinate synthetase (EC 2.5.1.72) — —
Pseudomonas fluorescens SBW25 0.75 PFLU_RS05250 elongation factor 4 0.65 PFLU_RS24025 quinolinate synthase NadA 0.68 16
Pseudomonas fluorescens FW300-N2C3 0.75 AO356_17485 elongation factor 4 0.66 AO356_18145 quinolinate synthase A low > 104
Pseudomonas stutzeri RCH2 0.75 Psest_3095 GTP-binding protein LepA 0.67 Psest_1509 quinolinate synthetase complex, A subunit — —
Pseudomonas simiae WCS417 0.75 PS417_05180 elongation factor 4 0.65 PS417_22385 quinolinate synthase A — —
Pseudomonas fluorescens FW300-N2E3 0.75 AO353_04520 elongation factor 4 0.65 AO353_03525 quinolinate synthase A low > 101
Pseudomonas fluorescens FW300-N1B4 0.75 Pf1N1B4_895 Translation elongation factor LepA 0.66 Pf1N1B4_626 Quinolinate synthetase (EC 2.5.1.72) — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.74 Psyr_3954 GTP-binding protein LepA 0.64 Psyr_1542 quinolinate synthetase low > 86
Pseudomonas syringae pv. syringae B728a 0.74 Psyr_3954 GTP-binding protein LepA 0.64 Psyr_1542 quinolinate synthetase low > 86
Marinobacter adhaerens HP15 0.74 HP15_781 GTP-binding protein LepA 0.68 HP15_2032 quinolinate synthetase complex, A subunit — —
Acinetobacter radioresistens SK82 0.73 MPMX26_02159 Elongation factor 4 0.68 MPMX26_02602 Quinolinate synthase A low > 36
Herbaspirillum seropedicae SmR1 0.73 HSERO_RS09650 elongation factor 4 0.62 HSERO_RS11065 quinolinate synthetase low > 78
Burkholderia phytofirmans PsJN 0.73 BPHYT_RS14380 elongation factor 4 0.61 BPHYT_RS15650 quinolinate synthetase low > 109
Paraburkholderia bryophila 376MFSha3.1 0.72 H281DRAFT_04360 GTP-binding protein LepA 0.61 H281DRAFT_04071 quinolinate synthetase low > 103
Paraburkholderia graminis OAS925 0.72 ABIE53_003038 GTP-binding protein LepA 0.62 ABIE53_003294 quinolinate synthase low > 113
Cupriavidus basilensis FW507-4G11 0.71 RR42_RS14055 elongation factor 4 0.64 RR42_RS17020 quinolinate synthetase low > 128
Rhodanobacter sp. FW510-T8 0.71 OKGIIK_07885 Elongation factor 4 0.21 OKGIIK_00930 nadA quinolinate synthase NadA low > 52
Rhodanobacter denitrificans FW104-10B01 0.70 LRK54_RS16955 translation elongation factor 4 0.23 LRK54_RS13900 quinolinate synthase NadA low > 59
Rhodanobacter denitrificans MT42 0.70 LRK55_RS16670 translation elongation factor 4 0.23 LRK55_RS13615 quinolinate synthase NadA low > 63
Paraburkholderia sabiae LMG 24235 0.70 QEN71_RS04600 translation elongation factor 4 0.62 QEN71_RS03060 quinolinate synthase NadA low > 153
Ralstonia solanacearum PSI07 0.70 RPSI07_RS18990 elongation factor 4 0.63 RPSI07_RS12650 quinolinate synthase NadA low > 81
Castellaniella sp019104865 MT123 0.70 ABCV34_RS08335 translation elongation factor 4 0.58 ABCV34_RS03700 quinolinate synthase NadA — —
Ralstonia sp. UNC404CL21Col 0.69 ABZR87_RS10190 translation elongation factor 4 0.64 ABZR87_RS00355 quinolinate synthase NadA low > 80
Variovorax sp. SCN45 0.68 GFF3867 Translation elongation factor LepA 0.59 GFF2575 Quinolinate synthetase (EC 2.5.1.72) low > 127
Variovorax sp. OAS795 0.68 ABID97_RS08350 translation elongation factor 4 0.60 ABID97_RS07415 quinolinate synthase NadA low > 91
Acidovorax sp. GW101-3H11 0.68 Ac3H11_1569 Translation elongation factor LepA 0.60 Ac3H11_3837 Quinolinate synthetase (EC 2.5.1.72) low > 79
Hydrogenophaga sp. GW460-11-11-14-LB1 0.68 GFF3343 Translation elongation factor LepA 0.59 GFF1216 Quinolinate synthetase (EC 2.5.1.72) low > 90
Ralstonia solanacearum IBSBF1503 0.68 RALBFv3_RS14470 elongation factor 4 0.63 RALBFv3_RS04735 quinolinate synthase NadA low > 76
Ralstonia solanacearum UW163 0.68 UW163_RS11935 elongation factor 4 0.63 UW163_RS08935 quinolinate synthase NadA — —
Ralstonia solanacearum GMI1000 0.68 RS_RS05250 elongation factor 4 0.63 RS_RS12295 quinolinate synthase — —
Magnetospirillum magneticum AMB-1 0.63 AMB_RS19545 elongation factor 4 0.35 AMB_RS19660 quinolinate synthase NadA — —
Azospirillum sp. SherDot2 0.62 MPMX19_00092 Elongation factor 4 0.24 MPMX19_05670 Quinolinate synthase A — —
Desulfovibrio vulgaris Miyazaki F 0.61 DvMF_2717 GTP-binding protein LepA (RefSeq) 0.13 DvMF_0525 quinolinate synthetase (RefSeq) — —
Azospirillum brasilense Sp245 0.61 AZOBR_RS00860 elongation factor 4 0.22 AZOBR_RS18690 quinolinate synthetase low > 97
Agrobacterium fabrum C58 0.61 Atu0241 GTP-binding protein LepA 0.23 Atu4098 quinolinate synthetase — —
Caulobacter crescentus NA1000 Δfur 0.60 CCNA_01086 GTP-binding protein lepA 0.24 CCNA_03006 quinolinate synthetase A — —
Caulobacter crescentus NA1000 0.60 CCNA_01086 GTP-binding protein lepA 0.24 CCNA_03006 quinolinate synthetase A — —
Sinorhizobium meliloti 1021 0.60 SMc00349 GTP-binding protein LepA 0.23 SMc02601 quinolinate synthetase low > 103
Rhizobium sp. OAE497 0.60 ABIE40_RS01055 translation elongation factor 4 0.24 ABIE40_RS23255 quinolinate synthase NadA low > 107
Sphingomonas koreensis DSMZ 15582 0.59 Ga0059261_3979 elongation factor 4 0.36 Ga0059261_0051 quinolinate synthetase (EC 2.5.1.72) — —
Brevundimonas sp. GW460-12-10-14-LB2 0.59 A4249_RS10390 translation elongation factor 4 0.24 A4249_RS00620 quinolinate synthase NadA low > 48
Rhodopseudomonas palustris CGA009 0.59 TX73_001825 translation elongation factor 4 0.23 TX73_005425 quinolinate synthase NadA — —
Rhodospirillum rubrum S1H 0.58 Rru_A3365 Small GTP-binding protein domain (NCBI) 0.23 Rru_A1434 Quinolinate synthetase A (NCBI) — —
Phaeobacter inhibens DSM 17395 0.58 PGA1_c24090 GTP-binding protein LepA 0.22 PGA1_c27790 quinolinate synthetase A — —
Synechococcus elongatus PCC 7942 0.58 Synpcc7942_0479 lepA GTP-binding protein LepA 0.33 Synpcc7942_1448 nadA quinolinate synthetase low > 38
Fusobacterium nucleatum SB010 0.57 HUW76_04720 elongation factor 4 0.27 HUW76_10740 quinolinate synthase NadA low > 35
Pedobacter sp. GW460-11-11-14-LB5 0.56 CA265_RS08955 elongation factor 4 0.34 CA265_RS21180 quinolinate synthase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.56 ABZR88_RS09405 translation elongation factor 4 0.36 ABZR88_RS20650 quinolinate synthase NadA — —
Parabacteroides merdae CL09T00C40 0.56 HMPREF1078_RS09970 translation elongation factor 4 0.34 HMPREF1078_RS06555 quinolinate synthase NadA — —
Phocaeicola dorei CL03T12C01 0.56 ABI39_RS20175 translation elongation factor 4 0.36 ABI39_RS05755 quinolinate synthase NadA — —
Phocaeicola vulgatus CL09T03C04 0.56 HMPREF1058_RS06410 elongation factor 4 0.36 HMPREF1058_RS11230 quinolinate synthase NadA — —
Bacteroides stercoris CC31F 0.55 HMPREF1181_RS16590 elongation factor 4 0.35 HMPREF1181_RS01920 quinolinate synthase NadA — —
Bacteroides ovatus ATCC 8483 0.54 BACOVA_02258 GTP-binding protein LepA 0.34 BACOVA_02839 quinolinate synthetase complex, A subunit low > 94
Bacteroides thetaiotaomicron VPI-5482 0.53 BT0632 GTP-binding protein, membrane GTPase lepA (NCBI ptt file) 0.35 BT3164 quinolinate synthetase A (NCBI ptt file) — —
Mycobacterium tuberculosis H37Rv 0.53 Rv2404c Probable GTP-binding protein LepA (GTP-binding elongation factor) 0.23 Rv1594 Probable quinolinate synthetase NadA — —

Not shown: 11 genomes with orthologs for NOLOHH_13075 only; 2 genomes with orthologs for NOLOHH_23190 only