Conservation of cofitness between ECD_04103 and ECD_03104 in Escherichia coli BL21

86 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_04103 putative antibiotic peptide MccB17 maturation peptidase 1.0 ECD_03104 putative peptidase 0.74 3
Escherichia coli ECOR38 1.00 HEPCGN_10125 pmbA metalloprotease PmbA 1.00 HEPCGN_16620 tldD metalloprotease TldD low > 87
Escherichia coli ECRC101 1.00 MCAODC_02430 pmbA metalloprotease PmbA 0.99 MCAODC_08275 tldD metalloprotease TldD low > 87
Escherichia coli ECRC100 1.00 OKFHMN_11925 pmbA metalloprotease PmbA 0.99 OKFHMN_17755 tldD metalloprotease TldD 0.96 2
Escherichia coli ECRC102 1.00 NIAGMN_09775 pmbA metalloprotease PmbA 0.99 NIAGMN_15515 tldD metalloprotease TldD — —
Escherichia coli BW25113 1.00 b4235 pmbA predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17 (NCBI) 1.00 b3244 tldD predicted peptidase (NCBI) 0.75 1
Escherichia coli ECRC98 1.00 JDDGAC_15565 pmbA metalloprotease PmbA 0.99 JDDGAC_21380 tldD metalloprotease TldD low > 86
Escherichia coli ECRC62 1.00 BNILDI_07325 pmbA metalloprotease PmbA 1.00 BNILDI_01980 tldD metalloprotease TldD low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03800 Metalloprotease PmbA 1.00 OHPLBJKB_00460 Metalloprotease TldD low > 73
Escherichia coli ECRC99 1.00 KEDOAH_16230 pmbA metalloprotease PmbA 0.99 KEDOAH_10395 tldD metalloprotease TldD — —
Escherichia coli ECOR27 1.00 NOLOHH_04185 pmbA metalloprotease PmbA 1.00 NOLOHH_09555 tldD metalloprotease TldD low > 75
Escherichia fergusonii Becca 0.99 EFB2_04298 Metalloprotease PmbA 1.00 EFB2_00586 Metalloprotease TldD low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS24570 metalloprotease PmbA 1.00 ECOLIN_RS18595 metalloprotease TldD 0.47 11
Enterobacter sp. TBS_079 0.96 MPMX20_00517 Metalloprotease PmbA 0.90 MPMX20_04151 Metalloprotease TldD 0.31 10
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF904 TldE protein, part of TldE/TldD proteolytic complex 0.92 GFF2140 TldD protein, part of TldE/TldD proteolytic complex 0.53 1
Enterobacter asburiae PDN3 0.96 EX28DRAFT_3422 Predicted Zn-dependent proteases and their inactivated homologs 0.91 EX28DRAFT_3295 Predicted Zn-dependent proteases and their inactivated homologs low > 76
Klebsiella michiganensis M5al 0.94 BWI76_RS02850 metalloprotease PmbA 0.89 BWI76_RS25470 metalloprotease TldD low > 92
Serratia liquefaciens MT49 0.86 IAI46_22575 metalloprotease PmbA 0.84 IAI46_22685 metalloprotease TldD 0.55 28
Rahnella sp. WP5 0.85 EX31_RS12320 metalloprotease PmbA 0.81 EX31_RS12265 metalloprotease TldD 0.30 75
Pectobacterium carotovorum WPP14 0.84 HER17_RS20090 metalloprotease PmbA 0.82 HER17_RS20140 metalloprotease TldD low > 75
Pantoea sp. MT58 0.84 IAI47_02765 metalloprotease PmbA 0.85 IAI47_02465 metalloprotease TldD 0.93 1
Dickeya dadantii 3937 0.81 DDA3937_RS01500 metalloprotease PmbA 0.84 DDA3937_RS01460 metalloprotease TldD 0.91 1
Erwinia tracheiphila SCR3 0.81 LU632_RS02145 pmbA metalloprotease PmbA 0.82 LU632_RS21420 tldD metalloprotease TldD 0.75 14
Dickeya dianthicola ME23 0.81 DZA65_RS01480 metalloprotease PmbA 0.82 DZA65_RS01440 metalloprotease TldD low > 75
Dickeya dianthicola 67-19 0.81 HGI48_RS01415 metalloprotease PmbA 0.83 HGI48_RS01380 metalloprotease TldD low > 71
Vibrio cholerae E7946 ATCC 55056 0.64 CSW01_12845 metalloprotease PmbA 0.67 CSW01_02220 metalloprotease TldD 0.89 2
Shewanella sp. ANA-3 0.59 Shewana3_3631 microcin-processing peptidase 1 (RefSeq) 0.63 Shewana3_3641 microcin-processing peptidase 2 (RefSeq) 0.56 1
Shewanella amazonensis SB2B 0.59 Sama_0482 PmbA protein (RefSeq) 0.60 Sama_0474 TldD protein (RefSeq) 0.89 1
Shewanella oneidensis MR-1 0.59 SO4078 pmbA pmba protein (NCBI ptt file) 0.60 SO4091 tldD tldD protein (NCBI ptt file) 0.65 1
Shewanella loihica PV-4 0.57 Shew_0416 peptidase U62, modulator of DNA gyrase (RefSeq) 0.63 Shew_0410 peptidase U62, modulator of DNA gyrase (RefSeq) 0.65 4
Alteromonas macleodii MIT1002 0.54 MIT1002_00230 peptidase PmbA 0.65 MIT1002_00227 protease TldD 0.80 1
Pseudomonas sp. RS175 0.48 PFR28_00163 Metalloprotease PmbA 0.61 PFR28_00161 Metalloprotease TldD 0.68 1
Pseudomonas fluorescens FW300-N2C3 0.48 AO356_07085 peptidase PmbA 0.61 AO356_07095 protease TldD 0.75 1
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS04350 metalloprotease PmbA 0.62 PFLU_RS04340 metalloprotease TldD 0.69 1
Pseudomonas fluorescens SBW25 0.48 PFLU_RS04350 metalloprotease PmbA 0.62 PFLU_RS04340 metalloprotease TldD low > 109
Pseudomonas fluorescens FW300-N2E2 0.48 Pf6N2E2_3278 TldE protein, part of TldE/TldD proteolytic complex 0.61 Pf6N2E2_3280 TldD protein, part of TldE/TldD proteolytic complex 0.71 1
Pseudomonas simiae WCS417 0.47 PS417_04295 peptidase PmbA 0.61 PS417_04285 protease TldD 0.64 1
Pseudomonas putida KT2440 0.47 PP_0942 regulatory protease 0.64 PP_0940 putative protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD 0.57 1
Pseudomonas fluorescens FW300-N1B4 0.47 Pf1N1B4_1090 TldE protein, part of TldE/TldD proteolytic complex 0.61 Pf1N1B4_1092 TldD protein, part of TldE/TldD proteolytic complex 0.39 6
Pseudomonas fluorescens FW300-N2E3 0.47 AO353_05205 peptidase PmbA 0.62 AO353_05215 protease TldD 0.83 1
Pseudomonas fluorescens GW456-L13 0.47 PfGW456L13_5024 TldE protein, part of TldE/TldD proteolytic complex 0.62 PfGW456L13_5026 TldD protein, part of TldE/TldD proteolytic complex low > 87
Pseudomonas syringae pv. syringae B728a 0.46 Psyr_4154 microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 0.63 Psyr_4156 microcin-processing peptidase 2, Unknown type peptidase, MEROPS family U62 0.38 12
Pseudomonas syringae pv. syringae B728a ΔmexB 0.46 Psyr_4154 microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 0.63 Psyr_4156 microcin-processing peptidase 2, Unknown type peptidase, MEROPS family U62 0.36 15
Herbaspirillum seropedicae SmR1 0.45 HSERO_RS09265 peptidase C69 0.56 HSERO_RS07155 peptidase C69 0.46 2
Pseudomonas stutzeri RCH2 0.45 Psest_3318 Predicted Zn-dependent proteases and their inactivated homologs 0.61 Psest_3320 Predicted Zn-dependent proteases and their inactivated homologs 0.46 15
Xanthomonas campestris pv. campestris strain 8004 0.45 Xcc-8004.1885.1 TldE protein, part of TldE/TldD proteolytic complex 0.59 Xcc-8004.1883.1 TldD protein, part of TldE/TldD proteolytic complex 0.76 1
Variovorax sp. OAS795 0.45 ABID97_RS20695 metalloprotease PmbA 0.55 ABID97_RS06335 metalloprotease TldD 0.93 1
Dyella japonica UNC79MFTsu3.2 0.45 ABZR86_RS21700 metalloprotease PmbA 0.60 ABZR86_RS21715 metalloprotease TldD 0.53 27
Pseudomonas sp. S08-1 0.45 OH686_08570 TldE protein, part of TldE/TldD proteolytic complex 0.61 OH686_08580 TldD protein, part of TldE/TldD proteolytic complex 0.63 71
Rhodanobacter sp. FW510-T8 0.45 OKGIIK_10260 pmbA metalloprotease PmbA 0.59 OKGIIK_10280 tldD metalloprotease TldD 0.68 51
Variovorax sp. SCN45 0.45 GFF4697 TldE protein, part of TldE/TldD proteolytic complex 0.55 GFF4449 TldD protein, part of TldE/TldD proteolytic complex 0.83 34
Rhodanobacter denitrificans FW104-10B01 0.44 LRK54_RS03375 metalloprotease PmbA 0.57 LRK54_RS03395 metalloprotease TldD 0.96 1
Rhodanobacter denitrificans MT42 0.44 LRK55_RS03125 metalloprotease PmbA 0.57 LRK55_RS03145 metalloprotease TldD 0.69 62
Dechlorosoma suillum PS 0.44 Dsui_1234 putative Zn-dependent protease-like protein 0.56 Dsui_3401 putative Zn-dependent protease-like protein 0.84 6
Acidovorax sp. GW101-3H11 0.44 Ac3H11_3262 TldE protein, part of TldE/TldD proteolytic complex 0.56 Ac3H11_4036 TldD protein, part of TldE/TldD proteolytic complex 0.36 4
Ralstonia solanacearum UW163 0.43 UW163_RS15845 metalloprotease PmbA 0.58 UW163_RS08170 metalloprotease TldD — —
Ralstonia solanacearum IBSBF1503 0.43 RALBFv3_RS13965 metalloprotease PmbA 0.58 RALBFv3_RS05455 metalloprotease TldD 0.80 1
Ralstonia sp. UNC404CL21Col 0.43 ABZR87_RS09660 metalloprotease PmbA 0.58 ABZR87_RS01105 metalloprotease TldD 0.78 1
Paraburkholderia graminis OAS925 0.43 ABIE53_003116 PmbA protein 0.56 ABIE53_000851 TldD protein 0.68 1
Ralstonia solanacearum PSI07 0.43 RPSI07_RS19505 metalloprotease PmbA 0.58 RPSI07_RS11850 metalloprotease TldD low > 81
Paraburkholderia bryophila 376MFSha3.1 0.43 H281DRAFT_04304 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 0.56 H281DRAFT_04688 microcin-processing peptidase 2. Unknown type peptidase. MEROPS family U62 0.51 1
Kangiella aquimarina DSM 16071 0.43 B158DRAFT_2075 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 0.59 B158DRAFT_2072 microcin-processing peptidase 2. Unknown type peptidase. MEROPS family U62 0.48 15
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS04270 metalloprotease PmbA 0.55 QEN71_RS26555 metalloprotease TldD 0.87 1
Burkholderia phytofirmans PsJN 0.43 BPHYT_RS14705 peptidase C69 0.56 BPHYT_RS03540 peptidase C69 0.27 4
Castellaniella sp019104865 MT123 0.42 ABCV34_RS10610 metalloprotease PmbA 0.57 ABCV34_RS02590 metalloprotease TldD low > 48
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF3655 TldE protein, part of TldE/TldD proteolytic complex 0.56 GFF580 TldD protein, part of TldE/TldD proteolytic complex 0.93 1
Lysobacter sp. OAE881 0.41 ABIE51_RS06805 metalloprotease PmbA 0.59 ABIE51_RS06795 metalloprotease TldD 0.62 1
Ralstonia solanacearum GMI1000 0.41 RS_RS04700 metalloprotease PmbA 0.58 RS_RS13315 metalloprotease TldD 0.58 30
Cupriavidus basilensis FW507-4G11 0.41 RR42_RS14750 peptidase PMbA 0.57 RR42_RS05875 protease TldD 0.67 1
Azospirillum brasilense Sp245 0.34 AZOBR_RS11930 modulator protein 0.48 AZOBR_RS10600 peptidase C69 0.79 1
Azospirillum sp. SherDot2 0.34 MPMX19_01886 Metalloprotease PmbA 0.48 MPMX19_00882 Metalloprotease TldD 0.54 18
Sphingomonas koreensis DSMZ 15582 0.30 Ga0059261_0810 Predicted Zn-dependent proteases and their inactivated homologs 0.49 Ga0059261_2252 Predicted Zn-dependent proteases and their inactivated homologs low > 68
Magnetospirillum magneticum AMB-1 0.29 AMB_RS22120 TldD/PmbA family protein 0.49 AMB_RS21030 metalloprotease TldD low > 64
Rhodopseudomonas palustris CGA009 0.29 TX73_005930 TldD/PmbA family protein 0.46 TX73_004255 metalloprotease TldD 0.71 1
Rhodospirillum rubrum S1H 0.29 Rru_A0575 Peptidase U62, modulator of DNA gyrase (NCBI) 0.50 Rru_A0567 Peptidase U62, modulator of DNA gyrase (NCBI) 0.64 10
Caulobacter crescentus NA1000 Δfur 0.28 CCNA_00311 Zn-dependent protease family protein 0.47 CCNA_03522 Zn-dependent protease TldD low > 67
Caulobacter crescentus NA1000 0.28 CCNA_00311 Zn-dependent protease family protein 0.47 CCNA_03522 Zn-dependent protease TldD 0.92 1
Sinorhizobium meliloti 1021 0.28 SMc00897 PMBA protein 0.48 SMc00960 hypothetical protein 0.49 1
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS09195 TldD/PmbA family protein 0.47 A4249_RS10860 metalloprotease TldD low > 48
Agrobacterium fabrum C58 0.27 Atu0693 PmbA/TldD related protein 0.49 Atu0765 TldD 0.28 7
Phaeobacter inhibens DSM 17395 0.27 PGA1_c33480 protein PmbA 0.46 PGA1_c06240 protein TldD — —
Rhizobium sp. OAE497 0.27 ABIE40_RS03780 TldD/PmbA family protein 0.50 ABIE40_RS04050 metalloprotease TldD 0.95 4
Dinoroseobacter shibae DFL-12 0.26 Dshi_0064 peptidase U62 modulator of DNA gyrase (RefSeq) 0.45 Dshi_1139 peptidase U62 modulator of DNA gyrase (RefSeq) low > 64
Bacteroides thetaiotaomicron VPI-5482 0.20 BT3649 putative modulator of DNA gyrase (NCBI ptt file) 0.36 BT3648 putative modulator of DNA gyrase (NCBI ptt file) low > 81
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS03170 TldD/PmbA family protein 0.34 HMPREF1181_RS03165 TldD/PmbA family protein low > 56
Parabacteroides merdae CL09T00C40 0.16 HMPREF1078_RS03625 TldD/PmbA family protein 0.37 HMPREF1078_RS03620 TldD/PmbA family protein 0.84 1
Synechococcus elongatus PCC 7942 0.09 Synpcc7942_1289 pmbA putative modulator of DNA gyrase 0.24 Synpcc7942_1127 tldD microcin-processing peptidase 2. Unknown type peptidase. MEROPS family U62 0.97 1

Not shown: 2 genomes with orthologs for ECD_04103 only; 3 genomes with orthologs for ECD_03104 only