Conservation of cofitness between ECD_04103 and ECD_00629 in Escherichia coli BL21

86 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_04103 putative antibiotic peptide MccB17 maturation peptidase 1.0 ECD_00629 tRNA-i(6)A37 methylthiotransferase 0.71 4
Escherichia coli ECOR27 1.00 NOLOHH_04185 pmbA metalloprotease PmbA 1.00 NOLOHH_23605 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 75
Escherichia coli BW25113 1.00 b4235 pmbA predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17 (NCBI) 1.00 b0661 miaB isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) 0.25 38
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03800 Metalloprotease PmbA 1.00 OHPLBJKB_03051 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 73
Escherichia coli ECOR38 1.00 HEPCGN_10125 pmbA metalloprotease PmbA 1.00 HEPCGN_01005 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 87
Escherichia coli ECRC100 1.00 OKFHMN_11925 pmbA metalloprotease PmbA 1.00 OKFHMN_07225 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB 0.85 24
Escherichia coli ECRC101 1.00 MCAODC_02430 pmbA metalloprotease PmbA 1.00 MCAODC_26440 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 87
Escherichia coli ECRC102 1.00 NIAGMN_09775 pmbA metalloprotease PmbA 1.00 NIAGMN_05280 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB
Escherichia coli ECRC62 1.00 BNILDI_07325 pmbA metalloprotease PmbA 1.00 BNILDI_21610 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 75
Escherichia coli ECRC99 1.00 KEDOAH_16230 pmbA metalloprotease PmbA 1.00 KEDOAH_20745 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB
Escherichia coli ECRC98 1.00 JDDGAC_15565 pmbA metalloprotease PmbA 1.00 JDDGAC_10870 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 86
Escherichia fergusonii Becca 0.99 EFB2_04298 Metalloprotease PmbA 1.00 EFB2_03438 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 0.31 38
Escherichia coli Nissle 1917 0.99 ECOLIN_RS24570 metalloprotease PmbA 1.00 ECOLIN_RS03555 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB
Enterobacter sp. TBS_079 0.96 MPMX20_00517 Metalloprotease PmbA 0.91 MPMX20_01311 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF904 TldE protein, part of TldE/TldD proteolytic complex 0.99 GFF4579 tRNA-i(6)A37 methylthiotransferase low > 78
Enterobacter asburiae PDN3 0.96 EX28DRAFT_3422 Predicted Zn-dependent proteases and their inactivated homologs 0.91 EX28DRAFT_2310 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB low > 76
Klebsiella michiganensis M5al 0.94 BWI76_RS02850 metalloprotease PmbA 0.97 BWI76_RS08135 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB
Serratia liquefaciens MT49 0.86 IAI46_22575 metalloprotease PmbA 0.86 IAI46_06025 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 86
Rahnella sp. WP5 0.85 EX31_RS12320 metalloprotease PmbA 0.84 EX31_RS23205 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 89
Pectobacterium carotovorum WPP14 0.84 HER17_RS20090 metalloprotease PmbA 0.89 HER17_RS15165 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 75
Pantoea sp. MT58 0.84 IAI47_02765 metalloprotease PmbA 0.87 IAI47_13945 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 76
Dickeya dadantii 3937 0.81 DDA3937_RS01500 metalloprotease PmbA 0.88 DDA3937_RS06250 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 74
Erwinia tracheiphila SCR3 0.81 LU632_RS02145 pmbA metalloprotease PmbA 0.88 LU632_RS16305 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 74
Dickeya dianthicola ME23 0.81 DZA65_RS01480 metalloprotease PmbA 0.88 DZA65_RS06640 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 75
Dickeya dianthicola 67-19 0.81 HGI48_RS01415 metalloprotease PmbA 0.88 HGI48_RS06295 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 71
Vibrio cholerae E7946 ATCC 55056 0.64 CSW01_12845 metalloprotease PmbA 0.77 CSW01_04915 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 62
Shewanella sp. ANA-3 0.59 Shewana3_3631 microcin-processing peptidase 1 (RefSeq) 0.77 Shewana3_1008 tRNA-i(6)A37 thiotransferase enzyme MiaB (RefSeq) low > 73
Shewanella amazonensis SB2B 0.59 Sama_0482 PmbA protein (RefSeq) 0.77 Sama_2575 tRNA-i(6)A37 modification enzyme MiaB (RefSeq) low > 62
Shewanella oneidensis MR-1 0.59 SO4078 pmbA pmba protein (NCBI ptt file) 0.77 SO1181 miaB tRNA-i(6)A37 modification enzyme MiaB (NCBI ptt file) low > 76
Shewanella loihica PV-4 0.57 Shew_0416 peptidase U62, modulator of DNA gyrase (RefSeq) 0.75 Shew_2923 tRNA-i(6)A37 thiotransferase enzyme MiaB (RefSeq) low > 60
Alteromonas macleodii MIT1002 0.54 MIT1002_00230 peptidase PmbA 0.78 MIT1002_01480 (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB low > 70
Pseudomonas sp. RS175 0.48 PFR28_00163 Metalloprotease PmbA 0.62 PFR28_03848 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 88
Pseudomonas fluorescens SBW25 0.48 PFLU_RS04350 metalloprotease PmbA 0.62 PFLU_RS26555 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 109
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS04350 metalloprotease PmbA 0.62 PFLU_RS26555 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 109
Pseudomonas fluorescens FW300-N2E2 0.48 Pf6N2E2_3278 TldE protein, part of TldE/TldD proteolytic complex 0.63 Pf6N2E2_5018 tRNA-i(6)A37 methylthiotransferase low > 103
Pseudomonas fluorescens FW300-N2C3 0.48 AO356_07085 peptidase PmbA 0.63 AO356_15410 (dimethylallyl)adenosine tRNA methylthiotransferase low > 104
Pseudomonas simiae WCS417 0.47 PS417_04295 peptidase PmbA 0.62 PS417_24625 (dimethylallyl)adenosine tRNA methylthiotransferase low > 88
Pseudomonas fluorescens FW300-N1B4 0.47 Pf1N1B4_1090 TldE protein, part of TldE/TldD proteolytic complex 0.63 Pf1N1B4_2712 tRNA-i(6)A37 methylthiotransferase low > 87
Pseudomonas fluorescens GW456-L13 0.47 PfGW456L13_5024 TldE protein, part of TldE/TldD proteolytic complex 0.63 PfGW456L13_1380 tRNA-i(6)A37 methylthiotransferase low > 87
Pseudomonas fluorescens FW300-N2E3 0.47 AO353_05205 peptidase PmbA 0.63 AO353_06375 (dimethylallyl)adenosine tRNA methylthiotransferase 0.33 40
Pseudomonas syringae pv. syringae B728a ΔmexB 0.46 Psyr_4154 microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 0.62 Psyr_4345 tRNA-i(6)A37 thiotransferase enzyme MiaB low > 86
Pseudomonas syringae pv. syringae B728a 0.46 Psyr_4154 microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 0.62 Psyr_4345 tRNA-i(6)A37 thiotransferase enzyme MiaB low > 86
Pseudomonas stutzeri RCH2 0.45 Psest_3318 Predicted Zn-dependent proteases and their inactivated homologs 0.64 Psest_0532 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB low > 67
Herbaspirillum seropedicae SmR1 0.45 HSERO_RS09265 peptidase C69 0.58 HSERO_RS03615 (dimethylallyl)adenosine tRNA methylthiotransferase low > 78
Xanthomonas campestris pv. campestris strain 8004 0.45 Xcc-8004.1885.1 TldE protein, part of TldE/TldD proteolytic complex 0.63 Xcc-8004.2224.1 tRNA-i(6)A37 methylthiotransferase low > 74
Variovorax sp. OAS795 0.45 ABID97_RS20695 metalloprotease PmbA 0.57 ABID97_RS06475 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 91
Dyella japonica UNC79MFTsu3.2 0.45 ABZR86_RS21700 metalloprotease PmbA 0.64 ABZR86_RS09895 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 74
Rhodanobacter sp. FW510-T8 0.45 OKGIIK_10260 pmbA metalloprotease PmbA 0.63 OKGIIK_02990 miaB tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 52
Pseudomonas sp. S08-1 0.45 OH686_08570 TldE protein, part of TldE/TldD proteolytic complex 0.64 OH686_09215 tRNA-i(6)A37 thiotransferase enzyme MiaB low > 80
Variovorax sp. SCN45 0.45 GFF4697 TldE protein, part of TldE/TldD proteolytic complex 0.57 GFF7320 tRNA-i(6)A37 methylthiotransferase (EC 2.8.4.3) low > 127
Rhodanobacter denitrificans FW104-10B01 0.44 LRK54_RS03375 metalloprotease PmbA 0.62 LRK54_RS13750 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 59
Rhodanobacter denitrificans MT42 0.44 LRK55_RS03125 metalloprotease PmbA 0.63 LRK55_RS13465 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 63
Dechlorosoma suillum PS 0.44 Dsui_1234 putative Zn-dependent protease-like protein 0.61 Dsui_1194 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB low > 51
Acidovorax sp. GW101-3H11 0.44 Ac3H11_3262 TldE protein, part of TldE/TldD proteolytic complex 0.56 Ac3H11_4008 tRNA-i(6)A37 methylthiotransferase low > 79
Ralstonia solanacearum UW163 0.43 UW163_RS15845 metalloprotease PmbA 0.57 UW163_RS01760 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB
Ralstonia solanacearum IBSBF1503 0.43 RALBFv3_RS13965 metalloprotease PmbA 0.57 RALBFv3_RS11825 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 76
Ralstonia sp. UNC404CL21Col 0.43 ABZR87_RS09660 metalloprotease PmbA 0.56 ABZR87_RS07780 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 80
Ralstonia solanacearum PSI07 0.43 RPSI07_RS19505 metalloprotease PmbA 0.57 RPSI07_RS21380 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 81
Paraburkholderia bryophila 376MFSha3.1 0.43 H281DRAFT_04304 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 0.57 H281DRAFT_04239 tRNA-i(6)A37 thiotransferase enzyme MiaB low > 103
Kangiella aquimarina DSM 16071 0.43 B158DRAFT_2075 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 0.69 B158DRAFT_0099 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB low > 40
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS04270 metalloprotease PmbA 0.58 QEN71_RS02195 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 153
Burkholderia phytofirmans PsJN 0.43 BPHYT_RS14705 peptidase C69 0.57 BPHYT_RS16535 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 109
Castellaniella sp019104865 MT123 0.42 ABCV34_RS10610 metalloprotease PmbA 0.58 ABCV34_RS15345 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 48
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF3655 TldE protein, part of TldE/TldD proteolytic complex 0.57 GFF613 tRNA-i(6)A37 methylthiotransferase low > 90
Lysobacter sp. OAE881 0.41 ABIE51_RS06805 metalloprotease PmbA 0.63 ABIE51_RS15455 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 62
Ralstonia solanacearum GMI1000 0.41 RS_RS04700 metalloprotease PmbA 0.57 RS_RS02645 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 80
Cupriavidus basilensis FW507-4G11 0.41 RR42_RS14750 peptidase PMbA 0.58 RR42_RS02855 dimethylallyladenosine tRNA methylthiotransferase low > 128
Azospirillum brasilense Sp245 0.34 AZOBR_RS11930 modulator protein 0.43 AZOBR_RS01475 (dimethylallyl)adenosine tRNA methylthiotransferase low > 97
Azospirillum sp. SherDot2 0.34 MPMX19_01886 Metalloprotease PmbA 0.44 MPMX19_02511 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 112
Sphingomonas koreensis DSMZ 15582 0.30 Ga0059261_0810 Predicted Zn-dependent proteases and their inactivated homologs 0.37 Ga0059261_1604 tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB low > 68
Magnetospirillum magneticum AMB-1 0.29 AMB_RS22120 TldD/PmbA family protein 0.43 AMB_RS22585 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase low > 64
Rhodopseudomonas palustris CGA009 0.29 TX73_005930 TldD/PmbA family protein 0.38 TX73_002325 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 86
Rhodospirillum rubrum S1H 0.29 Rru_A0575 Peptidase U62, modulator of DNA gyrase (NCBI) 0.42 Rru_A3770 tRNA-i(6)A37 modification enzyme MiaB (NCBI) low > 58
Caulobacter crescentus NA1000 Δfur 0.28 CCNA_00311 Zn-dependent protease family protein 0.41 CCNA_00054 tRNA 2-methylthioadenosine synthase low > 67
Caulobacter crescentus NA1000 0.28 CCNA_00311 Zn-dependent protease family protein 0.41 CCNA_00054 tRNA 2-methylthioadenosine synthase low > 66
Sinorhizobium meliloti 1021 0.28 SMc00897 PMBA protein 0.43 SMc01115 (dimethylallyl)adenosine tRNA methylthiotransferase low > 103
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS09195 TldD/PmbA family protein 0.40 A4249_RS14720 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 48
Agrobacterium fabrum C58 0.27 Atu0693 PmbA/TldD related protein 0.42 Atu0356 miaB protein low > 89
Phaeobacter inhibens DSM 17395 0.27 PGA1_c33480 protein PmbA 0.40 PGA1_c04710 (dimethylallyl)adenosine tRNA methylthiotransferase MiaB
Rhizobium sp. OAE497 0.27 ABIE40_RS03780 TldD/PmbA family protein 0.41 ABIE40_RS01705 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 107
Dinoroseobacter shibae DFL-12 0.26 Dshi_0064 peptidase U62 modulator of DNA gyrase (RefSeq) 0.42 Dshi_1019 RNA modification enzyme, MiaB family (RefSeq) low > 64
Bacteroides thetaiotaomicron VPI-5482 0.20 BT3649 putative modulator of DNA gyrase (NCBI ptt file) 0.34 BT3195 conserved hypothetical protein (NCBI ptt file) low > 81
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS03170 TldD/PmbA family protein 0.34 HMPREF1181_RS01770 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 56
Parabacteroides merdae CL09T00C40 0.16 HMPREF1078_RS03625 TldD/PmbA family protein 0.32 HMPREF1078_RS17135 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 61
Synechococcus elongatus PCC 7942 0.09 Synpcc7942_1289 pmbA putative modulator of DNA gyrase 0.35 Synpcc7942_2374 tRNA-i(6)A37 thiotransferase enzyme MiaB low > 38
Pedobacter sp. GW460-11-11-14-LB5 0.06 CA265_RS02445 peptidase C69 0.29 CA265_RS21675 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 88
Pontibacter actiniarum KMM 6156, DSM 19842 0.06 CA264_16645 peptidase C69 0.32 CA264_05315 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB low > 74

Not shown: 2 genomes with orthologs for ECD_04103 only; 15 genomes with orthologs for ECD_00629 only