Conservation of cofitness between b4006 and b4245 in Escherichia coli BW25113

90 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b4006 purH bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) 1.0 b4245 pyrB aspartate carbamoyltransferase catalytic subunit (NCBI) 0.88 12
Escherichia coli BL21 1.00 ECD_03883 IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase 1.00 ECD_04113 aspartate carbamoyltransferase, catalytic subunit 0.84 5
Escherichia coli ECRC101 1.00 OKFHMN_13310 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 OKFHMN_11865 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC102 1.00 NIAGMN_11060 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 NIAGMN_09715 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC99 1.00 KEDOAH_14850 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 KEDOAH_16290 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC101 1.00 MCAODC_03810 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 MCAODC_02370 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECRC98 1.00 JDDGAC_16935 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 JDDGAC_15505 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECOR27 1.00 NOLOHH_05455 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 NOLOHH_04125 pyrB aspartate carbamoyltransferase low > 57
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_04043 Bifunctional purine biosynthesis protein PurH 1.00 OHPLBJKB_03789 Aspartate carbamoyltransferase catalytic subunit 0.63 5
Escherichia coli ECRC62 0.99 BNILDI_06065 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 BNILDI_07385 pyrB aspartate carbamoyltransferase — —
Escherichia coli ECOR38 0.99 HEPCGN_11950 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 HEPCGN_10060 pyrB aspartate carbamoyltransferase low > 85
Escherichia fergusonii Becca 0.99 EFB2_04604 Bifunctional purine biosynthesis protein PurH 1.00 EFB2_04288 Aspartate carbamoyltransferase catalytic subunit low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS23100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.00 ECOLIN_RS24625 aspartate carbamoyltransferase low > 52
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF4186 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.96 GFF930 Aspartate carbamoyltransferase (EC 2.1.3.2) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS01615 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase 0.94 BWI76_RS02995 aspartate carbamoyltransferase 0.62 78
Enterobacter sp. TBS_079 0.94 MPMX20_00226 Bifunctional purine biosynthesis protein PurH 0.92 MPMX20_00544 Aspartate carbamoyltransferase catalytic subunit 0.87 13
Enterobacter asburiae PDN3 0.94 EX28DRAFT_4545 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 0.93 EX28DRAFT_3446 aspartate carbamoyltransferase (EC 2.1.3.2) — —
Dickeya dadantii 3937 0.91 DDA3937_RS01220 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.86 DDA3937_RS01925 aspartate carbamoyltransferase 0.79 21
Pectobacterium carotovorum WPP14 0.90 HER17_RS20335 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.87 HER17_RS19510 aspartate carbamoyltransferase 0.96 17
Dickeya dianthicola ME23 0.90 DZA65_RS01260 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.87 DZA65_RS01970 aspartate carbamoyltransferase 0.63 54
Dickeya dianthicola 67-19 0.90 HGI48_RS01215 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.86 HGI48_RS01900 aspartate carbamoyltransferase 0.86 3
Pantoea sp. MT58 0.90 IAI47_18040 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.87 IAI47_16860 aspartate carbamoyltransferase 0.97 7
Serratia liquefaciens MT49 0.89 IAI46_01365 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.90 IAI46_02275 aspartate carbamoyltransferase 0.74 3
Rahnella sp. WP5 0.88 EX31_RS16860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.88 EX31_RS12785 aspartate carbamoyltransferase 0.89 61
Erwinia tracheiphila SCR3 0.88 LU632_RS01020 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.86 LU632_RS20950 pyrB aspartate carbamoyltransferase 0.71 12
Vibrio cholerae E7946 ATCC 55056 0.81 CSW01_01420 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase 0.74 CSW01_12725 aspartate carbamoyltransferase low > 62
Shewanella loihica PV-4 0.77 Shew_3412 purH bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (RefSeq) 0.34 Shew_1013 aspartate carbamoyltransferase (RefSeq) 0.85 14
Alteromonas macleodii MIT1002 0.76 MIT1002_03959 Bifunctional purine biosynthesis protein PurH 0.34 MIT1002_00423 Aspartate carbamoyltransferase catalytic chain — —
Shewanella amazonensis SB2B 0.76 Sama_0395 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (RefSeq) 0.34 Sama_0840 aspartate carbamoyltransferase (RefSeq) low > 62
Shewanella sp. ANA-3 0.74 Shewana3_0441 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (RefSeq) 0.35 Shewana3_3070 aspartate carbamoyltransferase (RefSeq) 0.89 43
Shewanella oneidensis MR-1 0.73 SO0442 purH phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI ptt file) 0.35 SO1301 pyrB aspartate carbamoyltransferase (NCBI ptt file) 0.89 57
Marinobacter adhaerens HP15 0.72 HP15_3227 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 HP15_3507 aspartate carbamoyltransferase — —
Kangiella aquimarina DSM 16071 0.71 B158DRAFT_0166 IMP cyclohydrolase (EC 3.5.4.10)/phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.33 B158DRAFT_0021 aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas fluorescens FW300-N1B4 0.70 Pf1N1B4_1315 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.23 Pf1N1B4_2347 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas sp. S08-1 0.69 OH686_07620 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 OH686_10940 aspartate carbamoyltransferase — —
Pseudomonas fluorescens FW300-N2C3 0.69 AO356_08225 phosphoribosylaminoimidazolecarboxamide formyltransferase 0.23 AO356_13450 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas sp. RS175 0.69 PFR28_05214 Bifunctional purine biosynthesis protein PurH 0.23 PFR28_04237 Aspartate carbamoyltransferase — —
Pseudomonas fluorescens FW300-N2E2 0.69 Pf6N2E2_3519 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.23 Pf6N2E2_4606 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas fluorescens GW456-L13 0.69 PfGW456L13_57 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.23 PfGW456L13_1016 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Pseudomonas fluorescens SBW25-INTG 0.69 PFLU_RS03015 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.23 PFLU_RS28345 aspartate carbamoyltransferase — —
Pseudomonas fluorescens SBW25 0.69 PFLU_RS03015 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.23 PFLU_RS28345 aspartate carbamoyltransferase — —
Acinetobacter radioresistens SK82 0.69 MPMX26_01141 Bifunctional purine biosynthesis protein PurH 0.23 MPMX26_01099 Aspartate carbamoyltransferase 0.80 23
Pseudomonas fluorescens FW300-N2E3 0.69 AO353_13650 phosphoribosylaminoimidazolecarboxamide formyltransferase 0.23 AO353_08135 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas simiae WCS417 0.69 PS417_02940 phosphoribosylaminoimidazolecarboxamide formyltransferase 0.23 PS417_26700 aspartate carbamoyltransferase catalytic subunit — —
Pseudomonas putida KT2440 0.68 PP_4822 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 PP_4998 Aspartate carbamoyltransferase — —
Pseudomonas stutzeri RCH2 0.68 Psest_1014 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 Psest_0291 aspartate carbamoyltransferase — —
Pseudomonas syringae pv. syringae B728a 0.68 Psyr_4406 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase 0.22 Psyr_0482 aspartate carbamoyltransferase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.68 Psyr_4406 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase 0.22 Psyr_0482 aspartate carbamoyltransferase — —
Dyella japonica UNC79MFTsu3.2 0.61 ABZR86_RS17045 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.22 ABZR86_RS10390 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia sp. UNC404CL21Col 0.59 ABZR87_RS07640 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.22 ABZR87_RS08625 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum PSI07 0.59 RPSI07_RS21530 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.22 RPSI07_RS20635 aspartate carbamoyltransferase catalytic subunit — —
Cupriavidus basilensis FW507-4G11 0.59 RR42_RS02720 phosphoribosylaminoimidazolecarboxamide formyltransferase 0.22 RR42_RS15860 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum IBSBF1503 0.59 RALBFv3_RS11685 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.22 RALBFv3_RS12625 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum UW163 0.59 UW163_RS01900 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.22 UW163_RS00940 aspartate carbamoyltransferase catalytic subunit — —
Rhodanobacter denitrificans MT42 0.59 LRK55_RS06570 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 LRK55_RS03990 aspartate carbamoyltransferase catalytic subunit — —
Ralstonia solanacearum GMI1000 0.59 RS_RS02505 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase 0.22 RS_RS03410 aspartate carbamoyltransferase — —
Rhodanobacter denitrificans FW104-10B01 0.58 LRK54_RS06825 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 LRK54_RS04220 aspartate carbamoyltransferase catalytic subunit — —
Herbaspirillum seropedicae SmR1 0.58 HSERO_RS02060 purine biosynthesis protein purH 0.21 HSERO_RS02330 aspartate carbamoyltransferase — —
Rhodanobacter sp. FW510-T8 0.58 OKGIIK_16805 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.22 OKGIIK_11095 pyrB aspartate carbamoyltransferase catalytic subunit — —
Lysobacter sp. OAE881 0.57 ABIE51_RS17760 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.22 ABIE51_RS16015 aspartate carbamoyltransferase catalytic subunit 0.79 9
Xanthomonas campestris pv. campestris strain 8004 0.56 Xcc-8004.659.1 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.22 Xcc-8004.1722.1 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.56 GFF636 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.21 GFF651 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Acidovorax sp. GW101-3H11 0.54 Ac3H11_3994 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 0.21 Ac3H11_3978 Aspartate carbamoyltransferase (EC 2.1.3.2) — —
Dechlorosoma suillum PS 0.54 Dsui_1595 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.21 Dsui_0596 aspartate carbamoyltransferase — —
Azospirillum sp. SherDot2 0.54 MPMX19_02325 Bifunctional purine biosynthesis protein PurH 0.22 MPMX19_01054 Aspartate carbamoyltransferase — —
Phaeobacter inhibens DSM 17395 0.52 PGA1_c32860 bifunctional purine biosynthesis protein PurH 0.22 PGA1_c03060 aspartate carbamoyltransferase PyrB — —
Rhodopseudomonas palustris CGA009 0.52 TX73_000145 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.19 TX73_016120 aspartate carbamoyltransferase catalytic subunit — —
Azospirillum brasilense Sp245 0.51 AZOBR_RS00225 purine biosynthesis protein purH 0.23 AZOBR_RS20575 aspartate carbamoyltransferase — —
Bosea sp. OAE506 0.51 ABIE41_RS05095 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.20 ABIE41_RS17230 aspartate carbamoyltransferase catalytic subunit 0.37 55
Dinoroseobacter shibae DFL-12 0.50 Dshi_0358 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (RefSeq) 0.22 Dshi_3091 aspartate carbamoyltransferase (RefSeq) — —
Magnetospirillum magneticum AMB-1 0.49 AMB_RS00505 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.23 AMB_RS18300 aspartate carbamoyltransferase — —
Rhodospirillum rubrum S1H 0.49 Rru_A3655 Phosphoribosylaminoimidazolecarboxamideformyltransferase (NCBI) 0.21 Rru_A3190 Aspartate carbamoyltransferase (NCBI) — —
Sinorhizobium meliloti 1021 0.47 SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 SMc01360 aspartate carbamoyltransferase catalytic subunit 0.84 65
Rhizobium sp. OAE497 0.47 ABIE40_RS19130 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.21 ABIE40_RS07385 aspartate carbamoyltransferase catalytic subunit — —
Caulobacter crescentus NA1000 Δfur 0.47 CCNA_00084 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.20 CCNA_02525 aspartate carbamoyltransferase low > 67
Caulobacter crescentus NA1000 0.47 CCNA_00084 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.20 CCNA_02525 aspartate carbamoyltransferase 0.93 11
Agrobacterium fabrum C58 0.46 Atu2823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.21 Atu1308 aspartate carbamoyl transferase catalytic subunit — —
Fusobacterium nucleatum SB010 0.44 HUW76_05195 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 HUW76_08765 aspartate carbamoyltransferase catalytic subunit low > 35
Synechococcus elongatus PCC 7942 0.42 Synpcc7942_0396 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.21 Synpcc7942_0670 pyrB aspartate carbamoyltransferase catalytic subunit — —
Mycobacterium tuberculosis H37Rv 0.40 Rv0957 Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC) 0.21 Rv1380 Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase) — —
Pedobacter sp. GW460-11-11-14-LB5 0.37 CA265_RS02705 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.24 CA265_RS14660 aspartate carbamoyltransferase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.35 ABZR88_RS16970 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.23 ABZR88_RS03460 aspartate carbamoyltransferase catalytic subunit — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_03657 putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.49 BACOVA_02450 aspartate carbamoyltransferase — —
Bacteroides stercoris CC31F 0.35 HMPREF1181_RS00165 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.48 HMPREF1181_RS14990 aspartate carbamoyltransferase 0.97 2
Bifidobacterium breve UCC2003 0.35 BBR_RS15690 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH 0.41 BBR_RS15425 aspartate carbamoyltransferase — —
Bacteroides thetaiotaomicron VPI-5482 0.35 BT3812 phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase; bifunctional purine biosynthesis protein purH (NCBI ptt file) 0.49 BT0742 aspartate carbamoyltransferase catalytic chain (NCBI ptt file) — —
Parabacteroides merdae CL09T00C40 0.35 HMPREF1078_RS16130 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.51 HMPREF1078_RS01350 aspartate carbamoyltransferase — —
Pontibacter actiniarum KMM 6156, DSM 19842 0.34 CA264_18630 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase 0.22 CA264_20465 aspartate carbamoyltransferase low > 74
Phocaeicola vulgatus CL09T03C04 0.34 HMPREF1058_RS13605 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.48 HMPREF1058_RS03820 aspartate carbamoyltransferase — —
Phocaeicola dorei CL03T12C01 0.34 ABI39_RS09195 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.48 ABI39_RS17400 aspartate carbamoyltransferase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.33 Echvi_1469 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 0.23 Echvi_4661 aspartate carbamoyltransferase — —

Not shown: 9 genomes with orthologs for b4006 only; 4 genomes with orthologs for b4245 only