| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Escherichia coli BW25113 | 1.0 | b3941 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI) | 1.0 | b0074 | leuA | 2-isopropylmalate synthase (NCBI) | 0.96 | 8 |
| Escherichia coli ECRC62 | 1.00 | BNILDI_05725 | metF | methylenetetrahydrofolate reductase | 1.00 | BNILDI_08550 | | 2-isopropylmalate synthase | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 1.00 | OHPLBJKB_04109 | | 5,10-methylenetetrahydrofolate reductase | 1.00 | OHPLBJKB_03583 | | 2-isopropylmalate synthase | low | > 73 |
| Escherichia coli ECOR27 | 1.00 | NOLOHH_05810 | metF | methylenetetrahydrofolate reductase | 1.00 | NOLOHH_03060 | | 2-isopropylmalate synthase | low | > 57 |
| Escherichia coli BL21 | 1.00 | ECD_03827 | | 5,10-methylenetetrahydrofolate reductase | 1.00 | ECD_00076 | | 2-isopropylmalate synthase | 0.63 | 27 |
| Escherichia coli ECRC99 | 1.00 | KEDOAH_14495 | metF | methylenetetrahydrofolate reductase | 1.00 | KEDOAH_17440 | | 2-isopropylmalate synthase | — | — |
| Escherichia coli ECOR38 | 1.00 | HEPCGN_12310 | metF | methylenetetrahydrofolate reductase | 1.00 | HEPCGN_08695 | | 2-isopropylmalate synthase | low | > 85 |
| Escherichia coli ECRC102 | 1.00 | NIAGMN_11420 | metF | methylenetetrahydrofolate reductase | 1.00 | NIAGMN_08565 | | 2-isopropylmalate synthase | — | — |
| Escherichia coli ECRC98 | 1.00 | JDDGAC_17290 | metF | methylenetetrahydrofolate reductase | 1.00 | JDDGAC_14310 | | 2-isopropylmalate synthase | — | — |
| Escherichia coli ECRC101 | 1.00 | MCAODC_04165 | metF | methylenetetrahydrofolate reductase | 1.00 | MCAODC_01230 | | 2-isopropylmalate synthase | — | — |
| Escherichia coli ECRC101 | 1.00 | OKFHMN_13665 | metF | methylenetetrahydrofolate reductase | 1.00 | OKFHMN_10715 | | 2-isopropylmalate synthase | — | — |
| Escherichia fergusonii Becca | 0.99 | EFB2_04672 | | 5,10-methylenetetrahydrofolate reductase | 1.00 | EFB2_03971 | | 2-isopropylmalate synthase | low | > 86 |
| Escherichia coli Nissle 1917 | 0.99 | ECOLIN_RS22760 | | methylenetetrahydrofolate reductase | 1.00 | ECOLIN_RS00400 | | 2-isopropylmalate synthase | low | > 52 |
| Enterobacter sp. TBS_079 | 0.95 | MPMX20_04529 | | 5,10-methylenetetrahydrofolate reductase | 0.94 | MPMX20_00769 | | 2-isopropylmalate synthase | 0.75 | 9 |
| Klebsiella michiganensis M5al | 0.95 | BWI76_RS00805 | | 5,10-methylenetetrahydrofolate reductase | 0.95 | BWI76_RS04680 | | 2-isopropylmalate synthase | 0.91 | 10 |
| Enterobacter asburiae PDN3 | 0.94 | EX28DRAFT_4413 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.94 | EX28DRAFT_3670 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.56 | 43 |
| Pantoea sp. MT58 | 0.92 | IAI47_00890 | | methylenetetrahydrofolate reductase | 0.84 | IAI47_16000 | | 2-isopropylmalate synthase | low | > 76 |
| Serratia liquefaciens MT49 | 0.91 | IAI46_24530 | | methylenetetrahydrofolate reductase | 0.85 | IAI46_03355 | | 2-isopropylmalate synthase | 0.57 | 64 |
| Dickeya dadantii 3937 | 0.90 | DDA3937_RS00960 | | methylenetetrahydrofolate reductase | 0.86 | DDA3937_RS18115 | | 2-isopropylmalate synthase | low | > 74 |
| Rahnella sp. WP5 | 0.89 | EX31_RS14205 | | methylenetetrahydrofolate reductase | 0.82 | EX31_RS03680 | | 2-isopropylmalate synthase | 0.89 | 45 |
| Pectobacterium carotovorum WPP14 | 0.88 | HER17_RS00950 | | methylenetetrahydrofolate reductase | 0.87 | HER17_RS03085 | | 2-isopropylmalate synthase | low | > 75 |
| Dickeya dianthicola 67-19 | 0.88 | HGI48_RS20415 | | methylenetetrahydrofolate reductase | 0.86 | HGI48_RS18055 | | 2-isopropylmalate synthase | 0.46 | 53 |
| Dickeya dianthicola ME23 | 0.88 | DZA65_RS21460 | | methylenetetrahydrofolate reductase | 0.86 | DZA65_RS19200 | | 2-isopropylmalate synthase | 0.81 | 2 |
| Erwinia tracheiphila SCR3 | 0.86 | LU632_RS19630 | metF | methylenetetrahydrofolate reductase | 0.86 | LU632_RS02880 | leuA | 2-isopropylmalate synthase | low | > 74 |
| Vibrio cholerae E7946 ATCC 55056 | 0.79 | CSW01_13560 | | methylenetetrahydrofolate reductase | 0.69 | CSW01_12595 | | 2-isopropylmalate synthase | low | > 62 |
| Shewanella loihica PV-4 | 0.76 | Shew_0522 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.66 | Shew_3472 | | 2-isopropylmalate synthase (RefSeq) | 0.99 | 2 |
| Shewanella amazonensis SB2B | 0.75 | Sama_3169 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.67 | Sama_0335 | | 2-isopropylmalate synthase (RefSeq) | 0.96 | 21 |
| Shewanella sp. ANA-3 | 0.75 | Shewana3_3612 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.66 | Shewana3_3761 | | 2-isopropylmalate synthase (RefSeq) | 0.97 | 7 |
| Shewanella oneidensis MR-1 | 0.75 | SO4054 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) | 0.66 | SO4236 | leuA | 2-isopropylmalate synthase (NCBI ptt file) | 0.97 | 8 |
| Alteromonas macleodii MIT1002 | 0.70 | MIT1002_03670 | | 5,10-methylenetetrahydrofolate reductase | 0.62 | MIT1002_00949 | | 2-isopropylmalate synthase | low | > 70 |
| Magnetospirillum magneticum AMB-1 | 0.55 | AMB_RS02230 | | methylenetetrahydrofolate reductase | 0.42 | AMB_RS17765 | | 2-isopropylmalate synthase | — | — |
| Sphingomonas koreensis DSMZ 15582 | 0.54 | Ga0059261_0992 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.12 | Ga0059261_4031 | | 2-isopropylmalate synthase, yeast type | 0.63 | 53 |
| Bosea sp. OAE506 | 0.50 | ABIE41_RS12475 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.41 | ABIE41_RS13000 | | 2-isopropylmalate synthase | low | > 77 |
| Caulobacter crescentus NA1000 Δfur | 0.47 | CCNA_02224 | | methylenetetrahydrofolate reductase | 0.40 | CCNA_01610 | | 2-isopropylmalate synthase | low | > 67 |
| Caulobacter crescentus NA1000 | 0.47 | CCNA_02224 | | methylenetetrahydrofolate reductase | 0.40 | CCNA_01610 | | 2-isopropylmalate synthase | low | > 66 |
| Rhodopseudomonas palustris CGA009 | 0.46 | TX73_019175 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | TX73_010545 | | 2-isopropylmalate synthase | low | > 86 |
| Rhizobium sp. OAE497 | 0.41 | ABIE40_RS11950 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.15 | ABIE40_RS06220 | | citramalate synthase | low | > 107 |
| Paraburkholderia sabiae LMG 24235 | 0.41 | QEN71_RS28715 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | QEN71_RS24195 | | 2-isopropylmalate synthase | low | > 153 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.40 | H281DRAFT_05801 | | 5,10-methylenetetrahydrofolate reductase (NAD(P)) | 0.42 | H281DRAFT_04556 | | 2-isopropylmalate synthase | low | > 103 |
| Phaeobacter inhibens DSM 17395 | 0.40 | PGA1_c11700 | | 5,10-methylenetetrahydrofolate reductase MetF | 0.40 | PGA1_c26470 | | 2-isopropylmalate synthase LeuA | 0.92 | 3 |
| Paraburkholderia graminis OAS925 | 0.39 | ABIE53_000061 | | methylenetetrahydrofolate reductase (NADPH) | 0.42 | ABIE53_001580 | | 2-isopropylmalate synthase | low | > 113 |
| Burkholderia phytofirmans PsJN | 0.38 | BPHYT_RS18705 | | 5,10-methylenetetrahydrofolate reductase | 0.42 | BPHYT_RS06570 | | 2-isopropylmalate synthase | low | > 109 |
| Cupriavidus basilensis FW507-4G11 | 0.38 | RR42_RS01385 | | 5,10-methylenetetrahydrofolate reductase | 0.42 | RR42_RS05465 | | 2-isopropylmalate synthase | 0.36 | 89 |
| Ralstonia solanacearum PSI07 | 0.38 | RPSI07_RS23495 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | RPSI07_RS14285 | | 2-isopropylmalate synthase | low | > 81 |
| Agrobacterium fabrum C58 | 0.38 | Atu2123 | | methylenetetrahydrofolate reductase | 0.10 | Atu2264 | | 2-isopropylmalate synthase | 0.60 | 10 |
| Ralstonia solanacearum UW163 | 0.38 | UW163_RS03705 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | UW163_RS10700 | | 2-isopropylmalate synthase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.38 | RALBFv3_RS09875 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | RALBFv3_RS03025 | | 2-isopropylmalate synthase | low | > 76 |
| Dechlorosoma suillum PS | 0.38 | Dsui_0640 | | 5,10-methylenetetrahydrofolate reductase | 0.46 | Dsui_3519 | | 2-isopropylmalate synthase, bacterial type | — | — |
| Ralstonia solanacearum GMI1000 | 0.38 | RS_RS00460 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | RS_RS10395 | | 2-isopropylmalate synthase | low | > 80 |
| Ralstonia sp. UNC404CL21Col | 0.37 | ABZR87_RS04865 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | ABZR87_RS14930 | | 2-isopropylmalate synthase | low | > 80 |
| Marinobacter adhaerens HP15 | 0.37 | HP15_2917 | | 5,10-methylenetetrahydrofolate reductase-like protein | 0.45 | HP15_538 | | 2-isopropylmalate synthase | low | > 73 |
| Sinorhizobium meliloti 1021 | 0.36 | SMc01843 | | 5,10-methylenetetrahydrofolate reductase | 0.15 | SMc02546 | | alpha-isopropylmalate/homocitrate synthase family transferase | low | > 103 |
| Pseudomonas sp. S08-1 | 0.36 | OH686_10820 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.12 | OH686_17570 | | 2-isopropylmalate synthase | 0.69 | 34 |
| Dinoroseobacter shibae DFL-12 | 0.36 | Dshi_2080 | | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.38 | Dshi_0596 | | 2-isopropylmalate synthase (RefSeq) | — | — |
| Pseudomonas sp. RS175 | 0.36 | PFR28_04202 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | PFR28_00305 | | 2-isopropylmalate synthase | 0.63 | 17 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.36 | Xcc-8004.4336.1 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.39 | Xcc-8004.1056.1 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 74 |
| Pseudomonas fluorescens FW300-N2E2 | 0.36 | Pf6N2E2_4638 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.11 | Pf6N2E2_3170 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.68 | 21 |
| Pseudomonas simiae WCS417 | 0.36 | PS417_26510 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | PS417_23110 | | 2-isopropylmalate synthase | 0.44 | 21 |
| Pseudomonas putida KT2440 | 0.36 | PP_4977 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | PP_1025 | | 2-isopropylmalate synthase | 0.53 | 18 |
| Pseudomonas fluorescens SBW25 | 0.36 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.10 | PFLU_RS24765 | | 2-isopropylmalate synthase | 0.76 | 6 |
| Pseudomonas fluorescens SBW25-INTG | 0.36 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.10 | PFLU_RS24765 | | 2-isopropylmalate synthase | 0.78 | 5 |
| Pseudomonas fluorescens FW300-N1B4 | 0.35 | Pf1N1B4_2384 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.10 | Pf1N1B4_847 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.84 | 25 |
| Rhodanobacter denitrificans FW104-10B01 | 0.35 | LRK54_RS12030 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.39 | LRK54_RS10345 | | 2-isopropylmalate synthase | 0.72 | 13 |
| Rhodanobacter sp. FW510-T8 | 0.35 | OKGIIK_11830 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | OKGIIK_13575 | leuA | 2-isopropylmalate synthase | low | > 52 |
| Rhodanobacter denitrificans MT42 | 0.35 | LRK55_RS11765 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.39 | LRK55_RS09985 | | 2-isopropylmalate synthase | low | > 63 |
| Pseudomonas fluorescens FW300-N2C3 | 0.35 | AO356_13605 | | 5,10-methylenetetrahydrofolate reductase | 0.11 | AO356_06550 | | 2-isopropylmalate synthase | 0.94 | 14 |
| Dyella japonica UNC79MFTsu3.2 | 0.35 | ABZR86_RS11570 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.41 | ABZR86_RS15970 | | 2-isopropylmalate synthase | 0.98 | 1 |
| Pseudomonas stutzeri RCH2 | 0.35 | Psest_0313 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.47 | Psest_1056 | | 2-isopropylmalate synthase, bacterial type | low | > 67 |
| Pseudomonas fluorescens GW456-L13 | 0.35 | PfGW456L13_1050 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.10 | PfGW456L13_4854 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.92 | 12 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.35 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | Psyr_1257 | | 2-isopropylmalate synthase | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.35 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | Psyr_1257 | | 2-isopropylmalate synthase | 0.75 | 1 |
| Castellaniella sp019104865 MT123 | 0.34 | ABCV34_RS13550 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.10 | ABCV34_RS12420 | | 2-isopropylmalate synthase | 0.85 | 30 |
| Lysobacter sp. OAE881 | 0.34 | ABIE51_RS16490 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.40 | ABIE51_RS17570 | | 2-isopropylmalate synthase | 0.87 | 57 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.34 | GFF1692 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.41 | GFF4281 | | 2-isopropylmalate synthase (EC 2.3.3.13) | — | — |
| Acidovorax sp. GW101-3H11 | 0.34 | Ac3H11_3045 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.41 | Ac3H11_530 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 79 |
| Variovorax sp. OAS795 | 0.33 | ABID97_RS25015 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.41 | ABID97_RS14910 | | 2-isopropylmalate synthase | low | > 91 |
| Variovorax sp. SCN45 | 0.32 | GFF2055 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.41 | GFF1165 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 127 |
| Acinetobacter radioresistens SK82 | 0.31 | MPMX26_01002 | | 5,10-methylenetetrahydrofolate reductase | 0.10 | MPMX26_00404 | | 2-isopropylmalate synthase | low | > 36 |
| Desulfovibrio vulgaris Hildenborough JW710 | 0.28 | DVU0997 | metF | 5,10-methylenetetrahydrofolate reductase (TIGR) | 0.43 | DVU2981 | leuA | 2-isopropylmalate synthase (TIGR) | 0.88 | 8 |
| Desulfovibrio vulgaris Miyazaki F | 0.27 | DvMF_3034 | | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.44 | DvMF_1791 | | 2-isopropylmalate synthase (RefSeq) | — | — |
| Parabacteroides merdae CL09T00C40 | 0.21 | HMPREF1078_RS07860 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.43 | HMPREF1078_RS16665 | | 2-isopropylmalate synthase | low | > 61 |
| Phocaeicola dorei CL03T12C01 | 0.19 | ABI39_RS15570 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.44 | ABI39_RS10195 | | 2-isopropylmalate synthase | low | > 72 |
| Bacteroides thetaiotaomicron VPI-5482 | 0.18 | BT3821 | | 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) | 0.42 | BT1861 | | 2-isopropylmalate synthase (EC 2.3.3.13) (from data) | low | > 81 |
| Phocaeicola vulgatus CL09T03C04 | 0.18 | HMPREF1058_RS01490 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.44 | HMPREF1058_RS14545 | | 2-isopropylmalate synthase | low | > 67 |
| Bacteroides stercoris CC31F | 0.17 | HMPREF1181_RS00120 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.42 | HMPREF1181_RS14150 | | 2-isopropylmalate synthase | low | > 56 |
| Bacteroides ovatus ATCC 8483 | 0.15 | BACOVA_03666 | | methylenetetrahydrofolate reductase (NAD(P)H) | 0.42 | BACOVA_04604 | | 2-isopropylmalate synthase | low | > 94 |
Not shown: 14 genomes with orthologs for b3941 only; 3 genomes with orthologs for b0074 only