| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS07865 | | signal peptide peptidase SppA | strong | 100 | 100 |
| o | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS12895 | | signal peptide peptidase SppA | sig. | 36 | 99 |
| o | Phocaeicola dorei CL03T12C01 | ABI39_RS07925 | | signal peptide peptidase SppA | insig. | 36 | 99 |
| o | Bacteroides thetaiotaomicron VPI-5482 | BT1879 | | protease IV (NCBI ptt file) | sig. | 35 | 99 |
| o | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_02220 | | signal peptide peptidase SppA | cofit | 35 | 99 |
| o | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS13925 | | signal peptide peptidase SppA | no data | 35 | 99 |
| o | Bacteroides ovatus ATCC 8483 | BACOVA_02940 | | signal peptide peptidase SppA, 67K type | strong | 33 | 99 |
| o | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS04415 | | signal peptide peptidase SppA | strong | 35 | 99 |
| o | Bacteroides stercoris CC31F | HMPREF1181_RS07630 | | signal peptide peptidase SppA | sig. | 34 | 99 |
| o | Cellulophaga baltica 18 | M666_RS07935 | | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS03985 | | signal peptide peptidase SppA | insig. | 40 | 78 |
| o | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2783 | | signal peptide peptidase SppA, 67K type | strong | 35 | 96 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS12520 | | signal peptide peptidase SppA | strong | 39 | 78 |
| o | Enterobacter asburiae PDN3 | EX28DRAFT_1767 | | signal peptide peptidase SppA, 67K type | cofit | 34 | 98 |
| o | Enterobacter sp. TBS_079 | MPMX20_01850 | | Protease 4 | strong | 34 | 98 |
| o | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS05290 | | signal peptide peptidase SppA | cofit | 33 | 99 |
| o | Escherichia coli BL21 | ECD_01735 | | protease IV (signal peptide peptidase) | insig. | 34 | 98 |
| o | Escherichia coli BW25113 | b1766 | sppA | protease IV (signal peptide peptidase) (NCBI) | sig. | 34 | 98 |
| o | Rhodanobacter denitrificans MT42 | LRK55_RS10795 | | signal peptide peptidase SppA | cofit | 40 | 79 |
| o | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS11090 | | signal peptide peptidase SppA | cofit | 40 | 79 |
| o | Klebsiella pneumoniae MKP103 | KDGMDA_19255 | | signal peptide peptidase SppA | insig. | 34 | 97 |
| o | Erwinia amylovora T8 | OLJFJH_13245 | | signal peptide peptidase SppA | insig. | 33 | 98 |
| o | Escherichia fergusonii Becca | EFB2_02228 | | Protease 4 | insig. | 34 | 98 |
| o | Escherichia coli ECOR27 | NOLOHH_17325 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECOR38 | HEPCGN_05185 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECRC62 | BNILDI_16110 | sppA | signal peptide peptidase SppA | cofit | 34 | 98 |
| o | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_01966 | | Protease 4 | insig. | 34 | 98 |
| o | Escherichia coli Nissle 1917 | ECOLIN_RS09855 | | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Shewanella amazonensis SB2B | Sama_1723 | | signal peptide peptidase SppA, 67K type (RefSeq) | sig. | 35 | 99 |
| o | Shewanella sp. ANA-3 | Shewana3_1964 | | signal peptide peptidase SppA, 67K type (RefSeq) | strong | 34 | 98 |
| o | Shewanella loihica PV-4 | Shew_1941 | | signal peptide peptidase SppA, 67K type (RefSeq) | sig. | 36 | 96 |
| o | Rhodanobacter sp. FW510-T8 | OKGIIK_12785 | sppA | signal peptide peptidase SppA | cofit | 39 | 83 |
| o | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3483 | | Signal peptide peptidase SppA (EC 3.4.21.-) | insig. | 33 | 98 |
| o | Escherichia coli ECRC100 | OKFHMN_26815 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECRC101 | MCAODC_18595 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECRC102 | NIAGMN_01250 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECRC98 | JDDGAC_01390 | sppA | signal peptide peptidase SppA | insig. | 34 | 98 |
| o | Escherichia coli ECRC99 | KEDOAH_01295 | sppA | signal peptide peptidase SppA | no data | 34 | 98 |
| o | Shewanella oneidensis MR-1 | SO2420 | sppA | signal peptide peptidase SppA, 67K type (NCBI ptt file) | strong | 34 | 96 |
| o | Klebsiella michiganensis M5al | BWI76_RS11585 | | signal peptide peptidase A | sig. | 34 | 90 |
| o | Rahnella sp. WP5 | EX31_RS06305 | | signal peptide peptidase SppA | insig. | 32 | 98 |
| o | Serratia liquefaciens MT49 | IAI46_14325 | | signal peptide peptidase SppA | insig. | 33 | 93 |
| o | Pectobacterium carotovorum WPP14 | HER17_RS11105 | | signal peptide peptidase SppA | insig. | 33 | 98 |
| o | Vibrio cholerae E7946 ATCC 55056 | CSW01_09950 | | signal peptide peptidase SppA | insig. | 35 | 96 |
| o | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.4759.1 | | protease IV | strong | 38 | 77 |
| o | Alteromonas macleodii MIT1002 | MIT1002_01840 | | Protease 4 | strong | 36 | 93 |
| o | Dickeya dadantii 3937 | DDA3937_RS10290 | | signal peptide peptidase SppA | cofit | 32 | 98 |
| o | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS02805 | | signal peptide peptidase SppA | cofit | 34 | 91 |
| o | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_22640 | sppA | signal peptide peptidase SppA | cofit | 34 | 91 |
| o | Erwinia tracheiphila SCR3 | LU632_RS12970 | sppA | signal peptide peptidase SppA | sig. | 34 | 91 |
| o | Pantoea sp. MT58 | IAI47_08970 | | signal peptide peptidase SppA | insig. | 34 | 91 |
| o | Dickeya dianthicola ME23 | DZA65_RS10775 | | signal peptide peptidase SppA | insig. | 32 | 98 |
| o | Dickeya dianthicola 67-19 | HGI48_RS10300 | | signal peptide peptidase SppA | insig. | 31 | 98 |
| o | Lysobacter sp. OAE881 | ABIE51_RS02175 | | signal peptide peptidase SppA | strong | 36 | 79 |
| o | Kangiella aquimarina DSM 16071 | B158DRAFT_1578 | | signal peptide peptidase SppA, 67K type | strong | 32 | 88 |
| | Mycobacterium tuberculosis H37Rv | Rv0724 | | Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) | insig. | 36 | 78 |
| o | Sphingomonas koreensis DSMZ 15582 | Ga0059261_1351 | | signal peptide peptidase SppA, 67K type | strong | 33 | 82 |
| o | Sphingobium sp. HT1-2 | GFF1301 | | Signal peptide peptidase SppA (protease 4) | cofit | 33 | 80 |
| o | Azospirillum sp. SherDot2 | MPMX19_00798 | | Protease 4 | insig. | 32 | 84 |
| o | Magnetospirillum magneticum AMB-1 | AMB_RS08065 | | serine protease | cofit | 32 | 83 |
| o | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS01460 | | signal peptide peptidase SppA | cofit | 32 | 89 |
| o | Fusobacterium nucleatum SB010 | HUW76_03895 | | signal peptide peptidase SppA | strong | 31 | 83 |
| o | Azospirillum brasilense Sp245 | AZOBR_RS10750 | | protease IV | insig. | 33 | 83 |
| o | Rhodospirillum rubrum S1H | Rru_A2621 | | Peptidase S49 (NCBI) | insig. | 30 | 92 |
| o | Caulobacter crescentus NA1000 | CCNA_00976 | | signal peptide peptidase A | strong | 29 | 87 |
| o | Caulobacter crescentus NA1000 Δfur | CCNA_00976 | | signal peptide peptidase A | cofit | 29 | 87 |
| | Fusobacterium nucleatum SB010 | HUW76_05945 | | signal peptide peptidase SppA | cofit | 28 | 73 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1703 | | signal peptide peptidase SppA, 36K type (RefSeq) | sig. | 35 | 42 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU3149 | sppA | signal peptide peptidase SppA, 36K type (TIGR) | cofit | 36 | 38 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1916 | sppA | signal peptide peptidase A. Serine peptidase. MEROPS family S49 | sig. | 37 | 31 |
| | Methanococcus maripaludis JJ | MMJJ_RS08835 | | signal peptide peptidase SppA | insig. | 35 | 34 |
| | Rhizobium sp. OAE497 | ABIE40_RS01840 | | signal peptide peptidase SppA | insig. | 34 | 33 |
| | Methanococcus maripaludis S2 | MMP_RS05530 | | signal peptide peptidase SppA | insig. | 34 | 34 |
| | Sinorhizobium meliloti 1021 | SMc01135 | | protease IV transmembrane protein | insig. | 33 | 35 |
| | Bosea sp. OAE506 | ABIE41_RS00300 | | signal peptide peptidase SppA | sig. | 33 | 36 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_3163 | | signal peptide peptidase SppA, 36K type (RefSeq) | insig. | 36 | 29 |
| | Pseudomonas segetis P6 | MPMX49_02074 | | hypothetical protein | strong | 33 | 33 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS13505 | | signal peptide peptidase SppA | sig. | 34 | 31 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_5946 | | Periplasmic serine proteases (ClpP class) | insig. | 30 | 41 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_15125 | | S49 family peptidase | insig. | 31 | 33 |
| | Pseudomonas putida KT2440 | PP_1908 | | putative Peptidase | insig. | 29 | 41 |
| | Rhodopseudomonas palustris CGA009 | TX73_000340 | | signal peptide peptidase SppA | insig. | 35 | 27 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_20135 | | peptidase S49 | strong | 31 | 37 |
| | Pseudomonas sp. RS175 | PFR28_03016 | | hypothetical protein | sig. | 31 | 37 |
| | Pseudomonas sp. DMC3 | GFF4763 | | hypothetical protein | insig. | 30 | 37 |
| | Acinetobacter baumannii LAC-4 | RR41_RS04580 | | signal peptide peptidase SppA | sig. | 33 | 27 |
| | Pseudomonas sp. BP01 | JOY50_RS16820 | | S49 family peptidase | insig. | 31 | 37 |
| | Agrobacterium fabrum C58 | Atu0637 | | proteinase sohB | sig. | 32 | 29 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_457 | | Periplasmic serine proteases (ClpP class) | insig. | 30 | 33 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_2099 | | Periplasmic serine proteases (ClpP class) | insig. | 30 | 33 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2075 | | Peptidase, U7 family | strong | 37 | 26 |
| | Pseudomonas sp. SVBP6 | COO64_RS05835 | | S49 family peptidase | insig. | 32 | 33 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1641 | | Peptidase S49, SppA | insig. | 32 | 32 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1641 | | Peptidase S49, SppA | insig. | 32 | 32 |
| | Sinorhizobium meliloti 1021 | SMc00857 | | protease | strong | 34 | 28 |
| | Rhizobium sp. OAE497 | ABIE40_RS05390 | | S49 family peptidase | insig. | 31 | 33 |
| | Dechlorosoma suillum PS | Dsui_2440 | | ClpP class periplasmic serine protease | strong | 29 | 35 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS12770 | | protease SohB | insig. | 32 | 37 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS12770 | | protease SohB | sig. | 32 | 37 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS10105 | | S49 family peptidase | insig. | 30 | 35 |