| Organism |  Ratio1 |  Gene1 |  Name1 |  Description1 |  Ratio2 |  Gene2 |  Name2 |  Description2 |  Cofit |  Rank | 
 | Azospirillum sp. SherDot2 |  1.0 |  MPMX19_02207 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  1.0 |  MPMX19_01998 |   |  3-isopropylmalate dehydratase large subunit |  0.72 |  8 | 
 | Azospirillum brasilense Sp245 |  0.77 |  AZOBR_RS03140 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.93 |  AZOBR_RS03545 |   |  isopropylmalate isomerase |  — |  — | 
 | Magnetospirillum magneticum AMB-1 |  0.54 |  AMB_RS20250 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.80 |  AMB_RS20560 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Phaeobacter inhibens DSM 17395 |  0.50 |  PGA1_c04860 |   |  N-(5'-phosphoribosyl)anthranilate isomerase TrpF |  0.72 |  PGA1_c29780 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Dinoroseobacter shibae DFL-12 |  0.45 |  Dshi_1029 |   |  Phosphoribosylanthranilate isomerase (RefSeq) |  0.71 |  Dshi_0085 |   |  3-isopropylmalate dehydratase, large subunit (RefSeq) |  — |  — | 
 | Caulobacter crescentus NA1000 |  0.44 |  CCNA_03659 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.69 |  CCNA_00196 |   |  3-isopropylmalate dehydratase large subunit |  0.94 |  9 | 
 | Caulobacter crescentus NA1000 Δfur |  0.44 |  CCNA_03659 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.69 |  CCNA_00196 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 67 | 
 | Rhodospirillum rubrum S1H |  0.44 |  Rru_A3425 |   |  Phosphoribosylanthranilate isomerase (NCBI) |  0.81 |  Rru_A1189 |   |  3-isopropylmalate dehydratase large subunit region (NCBI) |  0.85 |  6 | 
 | Agrobacterium fabrum C58 |  0.43 |  Atu0017 |   |  N-(5-phosphoribosyl) anthranilate isomerase |  0.74 |  Atu2709 |   |  3-isopropylmalate dehydratase, large subunit |  0.85 |  6 | 
 | Rhodopseudomonas palustris CGA009 |  0.43 |  TX73_000355 |   |  phosphoribosylanthranilate isomerase |  0.73 |  TX73_001245 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Rhizobium sp. OAE497 |  0.43 |  ABIE40_RS19330 |   |  phosphoribosylanthranilate isomerase |  0.73 |  ABIE40_RS18380 |   |  3-isopropylmalate dehydratase large subunit |  0.76 |  39 | 
 | Sphingobium sp. HT1-2 |  0.43 |  GFF1625 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.67 |  GFF2630 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.90 |  8 | 
 | Sphingomonas koreensis DSMZ 15582 |  0.42 |  Ga0059261_0237 |   |  phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.67 |  Ga0059261_4223 |   |  3-isopropylmalate dehydratase, large subunit |  0.94 |  21 | 
 | Brevundimonas sp. GW460-12-10-14-LB2 |  0.42 |  A4249_RS11335 |   |  phosphoribosylanthranilate isomerase |  0.54 |  A4249_RS10005 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Sinorhizobium meliloti 1021 |  0.42 |  SMc02767 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.75 |  SMc03823 |   |  isopropylmalate isomerase large subunit |  0.69 |  59 | 
 | Xanthobacter sp. DMC5 |  0.40 |  GFF3881 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.67 |  GFF1852 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Pseudomonas sp. RS175 |  0.35 |  PFR28_02816 |   |  'N-(5'-phosphoribosyl)anthranilate isomerase' transl_table=11 |  0.68 |  PFR28_02824 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Pseudomonas segetis P6 |  0.35 |  MPMX49_03066 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.66 |  MPMX49_03074 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Acinetobacter baumannii LAC-4 |  0.35 |  RR41_RS03110 |   |  phosphoribosylanthranilate isomerase |  0.68 |  RR41_RS16900 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 55 | 
 | Herbaspirillum seropedicae SmR1 |  0.34 |  HSERO_RS16480 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.69 |  HSERO_RS16515 |   |  isopropylmalate isomerase |  0.84 |  9 | 
 | Bosea sp. OAE506 |  0.34 |  ABIE41_RS04265 |   |  phosphoribosylanthranilate isomerase |  0.73 |  ABIE41_RS11660 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Pseudomonas fluorescens FW300-N2E3 |  0.32 |  AO353_20665 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.67 |  AO353_20620 |   |  isopropylmalate isomerase |  0.93 |  11 | 
 | Pseudomonas fluorescens FW300-N2E2 |  0.32 |  Pf6N2E2_71 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.67 |  Pf6N2E2_63 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.86 |  21 | 
 | Marinobacter adhaerens HP15 |  0.32 |  HP15_1828 |   |  phosphoribosylanthranilate isomerase |  0.66 |  HP15_1834 |   |  protein containing 3-isopropylmalate dehydratase, large subunit region domain |  0.83 |  7 | 
 | Pseudomonas fluorescens FW300-N2C3 |  0.32 |  AO356_21440 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.67 |  AO356_21400 |   |  isopropylmalate isomerase |  0.93 |  19 | 
 | Dechlorosoma suillum PS |  0.31 |  Dsui_3193 |   |  phosphoribosylanthranilate isomerase |  0.65 |  Dsui_3201 |   |  3-isopropylmalate dehydratase, large subunit |  — |  — | 
 | Pseudomonas sp. DMC3 |  0.31 |  GFF793 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.67 |  GFF785 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 89 | 
 | Pseudomonas fluorescens GW456-L13 |  0.31 |  PfGW456L13_3940 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.67 |  PfGW456L13_3948 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.87 |  15 | 
 | Acinetobacter radioresistens SK82 |  0.31 |  MPMX26_02618 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.68 |  MPMX26_00345 |   |  3-isopropylmalate dehydratase large subunit |  0.95 |  21 | 
 | Pseudomonas simiae WCS417 |  0.30 |  PS417_18560 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.66 |  PS417_18600 |   |  isopropylmalate isomerase |  0.88 |  20 | 
 | Ralstonia solanacearum GMI1000 |  0.30 |  RS_RS09970 |   |  phosphoribosylanthranilate isomerase |  0.67 |  RS_RS10000 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Pseudomonas fluorescens SBW25 |  0.30 |  PFLU_RS20540 |   |  phosphoribosylanthranilate isomerase |  0.66 |  PFLU_RS20580 |   |  3-isopropylmalate dehydratase large subunit |  0.86 |  2 | 
 | Pseudomonas fluorescens SBW25-INTG |  0.30 |  PFLU_RS20540 |   |  phosphoribosylanthranilate isomerase |  0.66 |  PFLU_RS20580 |   |  3-isopropylmalate dehydratase large subunit |  0.87 |  7 | 
 | Ralstonia solanacearum IBSBF1503 |  0.29 |  RALBFv3_RS02590 |   |  phosphoribosylanthranilate isomerase |  0.67 |  RALBFv3_RS02620 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Ralstonia solanacearum UW163 |  0.29 |  UW163_RS11135 |   |  phosphoribosylanthranilate isomerase |  0.67 |  UW163_RS11105 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Ralstonia solanacearum PSI07 |  0.29 |  RPSI07_RS14725 |   |  phosphoribosylanthranilate isomerase |  0.67 |  RPSI07_RS14695 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Pontibacter actiniarum KMM 6156, DSM 19842 |  0.29 |  CA264_05075 |   |  hypothetical protein |  0.53 |  CA264_09435 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 74 | 
 | Pseudomonas lactucae CFBP13502 |  0.29 |  GEMAOFIL_03940 |   |  'N-(5'-phosphoribosyl)anthranilate isomerase' transl_table=11 |  0.67 |  GEMAOFIL_03948 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 93 | 
 | Paraburkholderia sabiae LMG 24235 |  0.29 |  QEN71_RS17640 |   |  phosphoribosylanthranilate isomerase |  0.69 |  QEN71_RS17605 |   |  3-isopropylmalate dehydratase large subunit |  0.75 |  61 | 
 | Pseudomonas putida KT2440 |  0.28 |  PP_1995 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.67 |  PP_1985 |   |  3-isopropylmalate dehydratase large subunit |  0.89 |  16 | 
 | Ralstonia sp. UNC404CL21Col |  0.28 |  ABZR87_RS14505 |   |  phosphoribosylanthranilate isomerase |  0.68 |  ABZR87_RS14540 |   |  3-isopropylmalate dehydratase large subunit |  0.90 |  3 | 
 | Bacteroides ovatus ATCC 8483 |  0.28 |  BACOVA_03784 |   |  N-(5'phosphoribosyl)anthranilate isomerase |  0.56 |  BACOVA_04603 |   |  3-isopropylmalate dehydratase, large subunit |  low |  > 96 | 
 | Pseudomonas sp. BP01 |  0.28 |  JOY50_RS16590 |   |  phosphoribosylanthranilate isomerase |  0.68 |  JOY50_RS16630 |  leuC |  3-isopropylmalate dehydratase large subunit |  0.71 |  15 | 
 | Pseudomonas sp. SVBP6 |  0.28 |  COO64_RS05625 |   |  phosphoribosylanthranilate isomerase |  0.68 |  COO64_RS05665 |  leuC |  3-isopropylmalate dehydratase large subunit |  0.98 |  27 | 
 | Burkholderia phytofirmans PsJN |  0.28 |  BPHYT_RS33880 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.68 |  BPHYT_RS33915 |   |  isopropylmalate isomerase |  0.92 |  15 | 
 | Pseudomonas sp. S08-1 |  0.28 |  OH686_04445 |   |  Phosphoribosylanthranilate isomerase  |  0.67 |  OH686_04480 |   |  3-isopropylmalate dehydratase large subunit  |  0.74 |  26 | 
 | Pedobacter sp. GW460-11-11-14-LB5 |  0.28 |  CA265_RS05015 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.54 |  CA265_RS15830 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Bacteroides thetaiotaomicron VPI-5482 |  0.28 |  BT0528 |   |  phosphoribosylanthranilate isomerase (EC 5.3.1.24) (from data) |  0.56 |  BT1860 |   |  3-isopropylmalate dehydratase large subunit (NCBI ptt file) |  0.82 |  36 | 
 | Pseudomonas stutzeri RCH2 |  0.28 |  Psest_2584 |   |  Phosphoribosylanthranilate isomerase |  0.68 |  Psest_2591 |   |  3-isopropylmalate dehydratase, large subunit |  0.76 |  20 | 
 | Synechococcus elongatus PCC 7942 |  0.28 |  Synpcc7942_0408 |  trpF |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.53 |  Synpcc7942_1898 |  leuC |  isopropylmalate isomerase large subunit |  — |  — | 
 | Bacteroides stercoris CC31F |  0.27 |  HMPREF1181_RS15345 |   |  phosphoribosylanthranilate isomerase |  0.56 |  HMPREF1181_RS14145 |   |  3-isopropylmalate dehydratase large subunit |  0.85 |  28 | 
 | Cupriavidus basilensis FW507-4G11 |  0.27 |  RR42_RS14365 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.70 |  RR42_RS14400 |   |  isopropylmalate isomerase |  0.70 |  21 | 
 | Paraburkholderia bryophila 376MFSha3.1 |  0.27 |  H281DRAFT_06068 |   |  phosphoribosylanthranilate isomerase |  0.69 |  H281DRAFT_06075 |   |  3-isopropylmalate dehydratase, large subunit |  0.54 |  19 | 
 | Paraburkholderia graminis OAS925 |  0.27 |  ABIE53_004808 |   |  phosphoribosylanthranilate isomerase |  0.69 |  ABIE53_004801 |   |  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit |  — |  — | 
 | Pseudomonas aeruginosa PA14 |  0.27 |  IKLFDK_15840 |   |  phosphoribosylanthranilate isomerase |  0.68 |  IKLFDK_15880 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 100 | 
 | Pseudomonas syringae pv. syringae B728a ΔmexB |  0.26 |  Psyr_1663 |   |  phosphoribosylanthranilate isomerase |  0.67 |  Psyr_1983 |   |  3-isopropylmalate dehydratase, large subunit |  0.70 |  6 | 
 | Pseudomonas syringae pv. syringae B728a |  0.26 |  Psyr_1663 |   |  phosphoribosylanthranilate isomerase |  0.67 |  Psyr_1983 |   |  3-isopropylmalate dehydratase, large subunit |  0.65 |  17 | 
 | Phocaeicola vulgatus CL09T03C04 |  0.26 |  HMPREF1058_RS07195 |   |  phosphoribosylanthranilate isomerase |  0.56 |  HMPREF1058_RS14550 |   |  3-isopropylmalate dehydratase large subunit |  0.83 |  21 | 
 | Castellaniella sp019104865 MT123 |  0.26 |  ABCV34_RS04250 |   |  phosphoribosylanthranilate isomerase |  0.68 |  ABCV34_RS04290 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Phocaeicola dorei CL03T12C01 |  0.26 |  ABI39_RS21070 |   |  phosphoribosylanthranilate isomerase |  0.56 |  ABI39_RS10200 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Parabacteroides merdae CL09T00C40 |  0.25 |  HMPREF1078_RS00125 |   |  phosphoribosylanthranilate isomerase |  0.55 |  HMPREF1078_RS16660 |   |  3-isopropylmalate dehydratase large subunit |  0.89 |  22 | 
 | Dyella japonica UNC79MFTsu3.2 |  0.25 |  ABZR86_RS08010 |   |  phosphoribosylanthranilate isomerase |  0.51 |  ABZR86_RS15960 |   |  3-isopropylmalate dehydratase large subunit |  0.88 |  52 | 
 | Methylophilus sp. DMC18 |  0.24 |  GFF655 |   |  N-(5'-phosphoribosyl)anthranilate isomerase |  0.70 |  GFF646 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Hydrogenophaga sp. GW460-11-11-14-LB1 |  0.24 |  GFF3356 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.68 |  GFF3363 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.82 |  20 | 
 | Rhodanobacter sp000427505 FW510-R12 |  0.24 |  LRK53_RS08340 |   |  phosphoribosylanthranilate isomerase |  0.55 |  LRK53_RS16375 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Variovorax sp. SCN45 |  0.24 |  GFF3884 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.68 |  GFF3890 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  — |  — | 
 | Variovorax sp. OAS795 |  0.24 |  ABID97_RS08435 |   |  phosphoribosylanthranilate isomerase |  0.68 |  ABID97_RS08465 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Rhodanobacter sp. FW510-T8 |  0.23 |  OKGIIK_04835 |   |  phosphoribosylanthranilate isomerase |  0.51 |  OKGIIK_13585 |  leuC |  3-isopropylmalate dehydratase large subunit |  low |  > 53 | 
 | Synechocystis sp000284455 PCC 6803 |  0.23 |  SGL_RS12060 |   |  phosphoribosylanthranilate isomerase |  0.51 |  SGL_RS17620 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Rhodanobacter denitrificans FW104-10B01 |  0.23 |  LRK54_RS01695 |   |  phosphoribosylanthranilate isomerase |  0.57 |  LRK54_RS07375 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Rhodanobacter denitrificans MT42 |  0.23 |  LRK55_RS01475 |   |  phosphoribosylanthranilate isomerase |  0.58 |  LRK55_RS07105 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Mucilaginibacter yixingensis YX-36 DSM 26809 |  0.23 |  ABZR88_RS10670 |   |  phosphoribosylanthranilate isomerase |  0.55 |  ABZR88_RS11595 |   |  3-isopropylmalate dehydratase large subunit |  — |  — | 
 | Cellulophaga baltica 18 |  0.22 |  M666_RS09070 |   |  phosphoribosylanthranilate isomerase |  0.52 |  M666_RS15060 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 67 | 
 | Desulfovibrio vulgaris Miyazaki F |  0.22 |  DvMF_1742 |   |  Phosphoribosylanthranilate isomerase (RefSeq) |  0.22 |  DvMF_1792 |   |  3-isopropylmalate dehydratase large subunit (RefSeq) |  0.87 |  5 | 
 | Xanthomonas campestris pv. campestris strain 8004 |  0.22 |  Xcc-8004.1962.1 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.66 |  Xcc-8004.1049.1 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.89 |  4 | 
 | Lysobacter sp. OAE881 |  0.21 |  ABIE51_RS08250 |   |  phosphoribosylanthranilate isomerase |  0.53 |  ABIE51_RS17575 |   |  3-isopropylmalate dehydratase large subunit |  0.80 |  42 | 
 | Echinicola vietnamensis KMM 6221, DSM 17526 |  0.20 |  Echvi_2509 |   |  Phosphoribosylanthranilate isomerase |  0.54 |  Echvi_2059 |   |  3-isopropylmalate dehydratase, large subunit |  — |  — | 
 | Acidovorax sp. GW101-3H11 |  0.19 |  Ac3H11_1533 |   |  Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |  0.66 |  Ac3H11_1525 |   |  3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) |  0.92 |  14 | 
 | Desulfovibrio vulgaris Hildenborough JW710 |  0.17 |  DVU0469 |  trpF-1 |  N-(5-phosphoribosyl)anthranilate isomerase (TIGR) |  0.22 |  DVU2982 |  leuC |  3-isopropylmalate dehydratase / (R)-citramalate isomerase, large subunit LeuC (EC 4.2.1.33; EC 4.2.1.35) (from data) |  0.81 |  24 | 
 | Bifidobacterium breve UCC2003 |  0.15 |  BBR_RS17825 |   |  phosphoribosylanthranilate isomerase |  0.58 |  BBR_RS19630 |   |  3-isopropylmalate dehydratase large subunit |  low |  > 34 | 
Not shown: 2 genomes with orthologs for MPMX19_02207 only; 38 genomes with orthologs for MPMX19_01998 only