Conservation of cofitness between Atu0486 and Atu1140 in Agrobacterium fabrum C58

82 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Agrobacterium fabrum C58 1.0 Atu0486 dihydroorotate dehydrogenase 1.0 Atu1140 phosphoribosyalaminoimidazole-succinocarboxamide synthase 0.88 10
Sinorhizobium meliloti 1021 0.73 SMc02245 dihydroorotate dehydrogenase 2 0.65 SMc00614 phosphoribosylglycinamide formyltransferase 0.89 10
Rhizobium sp. OAE497 0.72 ABIE40_RS02420 quinone-dependent dihydroorotate dehydrogenase 0.66 ABIE40_RS06555 phosphoribosylglycinamide formyltransferase — —
Azospirillum sp. SherDot2 0.45 MPMX19_02083 Dihydroorotate dehydrogenase (quinone) 0.45 MPMX19_01305 Phosphoribosylglycinamide formyltransferase — —
Azospirillum brasilense Sp245 0.45 AZOBR_RS13520 dihydroorotate dehydrogenase 0.47 AZOBR_RS16295 phosphoribosylglycinamide formyltransferase low > 97
Rhodopseudomonas palustris CGA009 0.45 TX73_004110 quinone-dependent dihydroorotate dehydrogenase 0.40 TX73_015790 phosphoribosylglycinamide formyltransferase — —
Phaeobacter inhibens DSM 17395 0.45 PGA1_c12150 dihydroorotate dehydrogenase PyrD 0.40 PGA1_c13270 phosphoribosylglycinamide formyltransferase PurN 0.82 29
Magnetospirillum magneticum AMB-1 0.42 AMB_RS19685 quinone-dependent dihydroorotate dehydrogenase 0.43 AMB_RS14335 phosphoribosylglycinamide formyltransferase — —
Dinoroseobacter shibae DFL-12 0.42 Dshi_0847 Dihydroorotate oxidase (RefSeq) 0.40 Dshi_1888 phosphoribosylglycinamide formyltransferase (RefSeq) 0.78 17
Sphingomonas koreensis DSMZ 15582 0.42 Ga0059261_1468 dihydroorotate oxidase A (EC 1.3.3.1) 0.38 Ga0059261_0229 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent — —
Castellaniella sp019104865 MT123 0.41 ABCV34_RS07790 quinone-dependent dihydroorotate dehydrogenase 0.49 ABCV34_RS05225 phosphoribosylglycinamide formyltransferase — —
Rhodospirillum rubrum S1H 0.41 Rru_A0514 Dihydroorotate dehydrogenase 2 (NCBI) 0.49 Rru_A2168 Phosphoribosylglycinamide formyltransferase (NCBI) — —
Caulobacter crescentus NA1000 Δfur 0.41 CCNA_00562 dihydroorotate dehydrogenase 0.37 CCNA_01774 phosphoribosylglycinamide formyltransferase low > 67
Caulobacter crescentus NA1000 0.41 CCNA_00562 dihydroorotate dehydrogenase 0.37 CCNA_01774 phosphoribosylglycinamide formyltransferase low > 66
Brevundimonas sp. GW460-12-10-14-LB2 0.41 A4249_RS00280 quinone-dependent dihydroorotate dehydrogenase 0.35 A4249_RS08220 phosphoribosylglycinamide formyltransferase — —
Acidovorax sp. GW101-3H11 0.41 Ac3H11_4100 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.41 Ac3H11_1709 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Dyella japonica UNC79MFTsu3.2 0.40 ABZR86_RS07450 quinone-dependent dihydroorotate dehydrogenase 0.36 ABZR86_RS19860 phosphoribosylglycinamide formyltransferase — —
Acinetobacter radioresistens SK82 0.40 MPMX26_01120 Dihydroorotate dehydrogenase (quinone) 0.36 MPMX26_02207 Phosphoribosylglycinamide formyltransferase low > 36
Hydrogenophaga sp. GW460-11-11-14-LB1 0.40 GFF4211 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.41 GFF767 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) low > 90
Pantoea sp. MT58 0.40 IAI47_12705 quinone-dependent dihydroorotate dehydrogenase 0.40 IAI47_05175 phosphoribosylglycinamide formyltransferase low > 76
Paraburkholderia sabiae LMG 24235 0.40 QEN71_RS22765 quinone-dependent dihydroorotate dehydrogenase 0.43 QEN71_RS03040 phosphoribosylglycinamide formyltransferase — —
Pectobacterium carotovorum WPP14 0.39 HER17_RS12005 quinone-dependent dihydroorotate dehydrogenase 0.39 HER17_RS15470 phosphoribosylglycinamide formyltransferase low > 75
Alteromonas macleodii MIT1002 0.39 MIT1002_02035 Dihydroorotate dehydrogenase (quinone) 0.39 MIT1002_02220 Phosphoribosylglycinamide formyltransferase low > 70
Paraburkholderia graminis OAS925 0.39 ABIE53_001954 dihydroorotate dehydrogenase 0.41 ABIE53_003298 phosphoribosylglycinamide formyltransferase-1 — —
Burkholderia phytofirmans PsJN 0.39 BPHYT_RS08565 dihydroorotate dehydrogenase 0.42 BPHYT_RS15670 phosphoribosylglycinamide formyltransferase 0.51 82
Dickeya dadantii 3937 0.39 DDA3937_RS12855 quinone-dependent dihydroorotate dehydrogenase 0.39 DDA3937_RS06020 phosphoribosylglycinamide formyltransferase 0.60 47
Rhodanobacter sp. FW510-T8 0.39 OKGIIK_09010 pyrD quinone-dependent dihydroorotate dehydrogenase 0.37 OKGIIK_02310 purN phosphoribosylglycinamide formyltransferase — —
Pseudomonas stutzeri RCH2 0.39 Psest_1947 dihydroorotate dehydrogenase, subfamily 2 0.39 Psest_1473 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent 0.35 44
Vibrio cholerae E7946 ATCC 55056 0.39 CSW01_07490 dihydroorotate dehydrogenase (quinone) 0.42 CSW01_11355 phosphoribosylglycinamide formyltransferase low > 62
Shewanella sp. ANA-3 0.39 Shewana3_1786 dihydroorotate dehydrogenase 2 (RefSeq) 0.38 Shewana3_2546 purN phosphoribosylglycinamide formyltransferase (RefSeq) low > 73
Pseudomonas putida KT2440 0.39 PP_2095 Dihydroorotate dehydrogenase (quinone) 0.43 PP_1664 phosphoribosylglycinamide formyltransferase 1 — —
Pseudomonas simiae WCS417 0.39 PS417_20935 dihydroorotate dehydrogenase 0.45 PS417_20125 phosphoribosylglycinamide formyltransferase — —
Dickeya dianthicola ME23 0.39 DZA65_RS13390 quinone-dependent dihydroorotate dehydrogenase 0.40 DZA65_RS06415 phosphoribosylglycinamide formyltransferase low > 75
Pseudomonas fluorescens SBW25 0.39 PFLU_RS22550 quinone-dependent dihydroorotate dehydrogenase 0.45 PFLU_RS22070 phosphoribosylglycinamide formyltransferase — —
Pseudomonas fluorescens FW300-N2E3 0.39 AO353_00780 dihydroorotate dehydrogenase (quinone) 0.43 AO353_02685 phosphoribosylglycinamide formyltransferase — —
Pseudomonas fluorescens SBW25-INTG 0.39 PFLU_RS22550 quinone-dependent dihydroorotate dehydrogenase 0.45 PFLU_RS22070 phosphoribosylglycinamide formyltransferase — —
Dechlorosoma suillum PS 0.39 Dsui_2978 dihydroorotate dehydrogenase, subfamily 2 0.46 Dsui_1545 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent — —
Variovorax sp. SCN45 0.39 GFF960 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) 0.41 GFF6047 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Shewanella loihica PV-4 0.39 Shew_1810 dihydroorotate dehydrogenase 2 (RefSeq) 0.39 Shew_1512 phosphoribosylglycinamide formyltransferase (RefSeq) low > 60
Herbaspirillum seropedicae SmR1 0.38 HSERO_RS16155 dihydroorotate dehydrogenase 0.44 HSERO_RS05910 phosphoribosylglycinamide formyltransferase — —
Klebsiella michiganensis M5al 0.38 BWI76_RS09910 dihydroorotate dehydrogenase (quinone) 0.39 BWI76_RS20970 phosphoribosylglycinamide formyltransferase low > 92
Pseudomonas fluorescens FW300-N1B4 0.38 Pf1N1B4_3842 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.42 Pf1N1B4_3697 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Rahnella sp. WP5 0.38 EX31_RS18095 quinone-dependent dihydroorotate dehydrogenase 0.44 EX31_RS22690 phosphoribosylglycinamide formyltransferase low > 89
Rhodanobacter denitrificans MT42 0.38 LRK55_RS15740 quinone-dependent dihydroorotate dehydrogenase 0.37 LRK55_RS12640 phosphoribosylglycinamide formyltransferase — —
Dickeya dianthicola 67-19 0.38 HGI48_RS12925 quinone-dependent dihydroorotate dehydrogenase 0.40 HGI48_RS06065 phosphoribosylglycinamide formyltransferase low > 71
Paraburkholderia bryophila 376MFSha3.1 0.38 H281DRAFT_00743 dihydroorotate oxidase A 0.42 H281DRAFT_04075 formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase — —
Pseudomonas fluorescens GW456-L13 0.38 PfGW456L13_4095 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.39 PfGW456L13_4253 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Serratia liquefaciens MT49 0.38 IAI46_08805 quinone-dependent dihydroorotate dehydrogenase 0.39 IAI46_18890 phosphoribosylglycinamide formyltransferase 0.86 5
Pseudomonas fluorescens FW300-N2C3 0.38 AO356_02610 dihydroorotate dehydrogenase (quinone) 0.43 AO356_19085 phosphoribosylglycinamide formyltransferase — —
Rhodanobacter denitrificans FW104-10B01 0.38 LRK54_RS15985 quinone-dependent dihydroorotate dehydrogenase 0.37 LRK54_RS12940 phosphoribosylglycinamide formyltransferase — —
Shewanella oneidensis MR-1 0.38 SO2592 pyrD dihydroorotate dehydrogenase (NCBI ptt file) 0.39 SO2761 purN phosphoribosylglycinamide formyltransferase (NCBI ptt file) low > 76
Pseudomonas fluorescens FW300-N2E2 0.38 Pf6N2E2_2347 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.42 Pf6N2E2_5728 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Marinobacter adhaerens HP15 0.38 HP15_1377 dihydroorotate dehydrogenase 0.39 HP15_1298 phosphoribosylglycinamide formyltransferase 0.49 41
Escherichia coli Nissle 1917 0.38 ECOLIN_RS04965 quinone-dependent dihydroorotate dehydrogenase 0.40 ECOLIN_RS14195 phosphoribosylglycinamide formyltransferase — —
Pseudomonas sp. RS175 0.38 PFR28_01054 Dihydroorotate dehydrogenase (quinone) 0.42 PFR28_03218 Phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECOR38 0.38 HEPCGN_23225 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 HEPCGN_20970 purN phosphoribosylglycinamide formyltransferase low > 85
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS01570 quinone-dependent dihydroorotate dehydrogenase 0.43 RALBFv3_RS04760 phosphoribosylglycinamide formyltransferase — —
Escherichia fergusonii Becca 0.38 EFB2_03126 Dihydroorotate dehydrogenase (quinone) 0.40 EFB2_01398 Phosphoribosylglycinamide formyltransferase low > 86
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.38 GFF3236 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.41 GFF2168 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) low > 78
Ralstonia solanacearum UW163 0.38 UW163_RS14880 quinone-dependent dihydroorotate dehydrogenase 0.43 UW163_RS08910 phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECRC98 0.37 JDDGAC_08905 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 JDDGAC_25750 purN phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECRC62 0.37 BNILDI_20015 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 BNILDI_12265 purN phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECRC99 0.37 KEDOAH_22440 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 KEDOAH_06415 purN phosphoribosylglycinamide formyltransferase — —
Ralstonia solanacearum PSI07 0.37 RPSI07_RS15920 quinone-dependent dihydroorotate dehydrogenase 0.42 RPSI07_RS12625 phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECRC102 0.37 NIAGMN_03015 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 NIAGMN_19575 purN phosphoribosylglycinamide formyltransferase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.37 OHPLBJKB_02721 Dihydroorotate dehydrogenase (quinone) 0.40 OHPLBJKB_01226 Phosphoribosylglycinamide formyltransferase low > 73
Escherichia coli BW25113 0.37 b0945 pyrD dihydroorotate dehydrogenase (NCBI) 0.40 b2500 purN phosphoribosylglycinamide formyltransferase (NCBI) 0.76 55
Escherichia coli BL21 0.37 ECD_00949 dihydro-orotate oxidase, FMN-linked 0.40 ECD_02392 phosphoribosylglycinamide formyltransferase 1 low > 60
Escherichia coli ECOR27 0.37 NOLOHH_21850 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 NOLOHH_13455 purN phosphoribosylglycinamide formyltransferase low > 57
Escherichia coli ECRC101 0.37 OKFHMN_05295 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 OKFHMN_21805 purN phosphoribosylglycinamide formyltransferase — —
Escherichia coli ECRC101 0.37 MCAODC_24685 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 MCAODC_12335 purN phosphoribosylglycinamide formyltransferase — —
Enterobacter asburiae PDN3 0.37 EX28DRAFT_1998 dihydroorotate oxidase A (EC 1.3.3.1) 0.40 EX28DRAFT_0167 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent — —
Enterobacter sp. TBS_079 0.37 MPMX20_01596 Dihydroorotate dehydrogenase (quinone) 0.40 MPMX20_03355 Phosphoribosylglycinamide formyltransferase low > 85
Ralstonia solanacearum GMI1000 0.37 RS_RS08160 dihydroorotate dehydrogenase (quinone) 0.44 RS_RS12320 phosphoribosylglycinamide formyltransferase — —
Ralstonia sp. UNC404CL21Col 0.37 ABZR87_RS13360 quinone-dependent dihydroorotate dehydrogenase 0.41 ABZR87_RS00380 phosphoribosylglycinamide formyltransferase — —
Cupriavidus basilensis FW507-4G11 0.37 RR42_RS07465 dihydroorotate dehydrogenase 0.39 RR42_RS17050 phosphoribosylglycinamide formyltransferase — —
Kangiella aquimarina DSM 16071 0.36 B158DRAFT_2228 dihydroorotate oxidase A (EC 1.3.3.1) 0.38 B158DRAFT_2384 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent — —
Xanthomonas campestris pv. campestris strain 8004 0.36 Xcc-8004.3032.1 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.31 Xcc-8004.1673.1 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) — —
Erwinia tracheiphila SCR3 0.36 LU632_RS09955 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 LU632_RS08270 purN phosphoribosylglycinamide formyltransferase low > 74
Lysobacter sp. OAE881 0.36 ABIE51_RS13725 quinone-dependent dihydroorotate dehydrogenase 0.32 ABIE51_RS15895 phosphoribosylglycinamide formyltransferase — —
Phocaeicola dorei CL03T12C01 0.08 ABI39_RS17250 dihydroorotate dehydrogenase 0.28 ABI39_RS06315 phosphoribosylglycinamide formyltransferase — —
Phocaeicola vulgatus CL09T03C04 0.08 HMPREF1058_RS03975 dihydroorotate dehydrogenase 0.27 HMPREF1058_RS10780 phosphoribosylglycinamide formyltransferase — —
Parabacteroides merdae CL09T00C40 0.08 HMPREF1078_RS02295 dihydroorotate dehydrogenase 0.29 HMPREF1078_RS07090 phosphoribosylglycinamide formyltransferase — —

Not shown: 15 genomes with orthologs for Atu0486 only; 0 genomes with orthologs for Atu1140 only