Conservation of cofitness between SMc00450 and SMc02659 in Sinorhizobium meliloti 1021

85 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Sinorhizobium meliloti 1021 1.0 SMc00450 protoheme IX farnesyltransferase 1.0 SMc02659 GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) protein 0.55 7
Rhizobium sp. OAE497 0.69 ABIE40_RS04070 heme o synthase 0.83 ABIE40_RS06050 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 107
Agrobacterium fabrum C58 0.65 Atu0769 protoheme IX farnesyltransferase 0.85 Atu1030 GTP pyrophosphohydrolase/synthetase, RelA/SpoT family low > 89
Bosea sp. OAE506 0.48 ABIE41_RS22955 heme o synthase 0.59 ABIE41_RS19890 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 77
Azospirillum sp. SherDot2 0.47 MPMX19_00886 Protoheme IX farnesyltransferase 0.48 MPMX19_00838 GTP pyrophosphokinase rsh
Azospirillum brasilense Sp245 0.45 AZOBR_RS10580 protoheme IX farnesyltransferase 0.49 AZOBR_RS22045 GTP pyrophosphokinase low > 97
Rhodopseudomonas palustris CGA009 0.45 TX73_004295 heme o synthase 0.58 TX73_013955 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 86
Sphingomonas koreensis DSMZ 15582 0.41 Ga0059261_2005 protoheme IX farnesyltransferase 0.41 Ga0059261_1293 (p)ppGpp synthetase, RelA/SpoT family 0.59 16
Brevundimonas sp. GW460-12-10-14-LB2 0.40 A4249_RS00115 heme o synthase 0.41 A4249_RS05505 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 48
Caulobacter crescentus NA1000 Δfur 0.40 CCNA_03516 protoheme IX farnesyltransferase coxE 0.43 CCNA_01622 Rsh ppGpp hydrolase-synthetase low > 67
Caulobacter crescentus NA1000 0.40 CCNA_03516 protoheme IX farnesyltransferase coxE 0.43 CCNA_01622 Rsh ppGpp hydrolase-synthetase low > 66
Phaeobacter inhibens DSM 17395 0.39 PGA1_c06260 protoheme IX farnesyltransferase CtaB 0.38 PGA1_c01010 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase SpoT
Dinoroseobacter shibae DFL-12 0.38 Dshi_1141 protoheme IX farnesyltransferase (RefSeq) 0.39 Dshi_0194 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) low > 64
Pseudomonas stutzeri RCH2 0.30 Psest_4334 protoheme IX farnesyltransferase 0.31 Psest_3817 (p)ppGpp synthetase, RelA/SpoT family
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.4836.1 Heme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA 0.30 Xcc-8004.1215.1 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS12895 heme o synthase 0.31 ABZR86_RS11850 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Lysobacter sp. OAE881 0.29 ABIE51_RS19165 heme o synthase 0.31 ABIE51_RS17265 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Kangiella aquimarina DSM 16071 0.28 B158DRAFT_0671 protoheme IX farnesyltransferase 0.32 B158DRAFT_0574 (p)ppGpp synthetase, RelA/SpoT family
Alteromonas macleodii MIT1002 0.28 MIT1002_04027 Protoheme IX farnesyltransferase 0.31 MIT1002_00108 Bifunctional (p)ppGpp synthase/hydrolase SpoT low > 70
Variovorax sp. SCN45 0.28 GFF2307 Heme O synthase, protoheme IX farnesyltransferase, COX10-CtaB 0.31 GFF2375 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II
Pseudomonas fluorescens FW300-N1B4 0.28 Pf1N1B4_1862 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone 0.32 Pf1N1B4_2113 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Marinobacter adhaerens HP15 0.28 HP15_3780 protoheme IX farnesyltransferase 0.30 HP15_305 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 73
Hydrogenophaga sp. GW460-11-11-14-LB1 0.27 GFF698 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 0.29 GFF1034 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Variovorax sp. OAS795 0.27 ABID97_RS23915 heme o synthase 0.30 ABID97_RS23670 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Pseudomonas fluorescens GW456-L13 0.27 PfGW456L13_606 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone 0.32 PfGW456L13_780 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Mycobacterium tuberculosis H37Rv 0.27 Rv1451 Probable cytochrome C oxidase assembly factor CtaB 0.29 Rv2583c Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)
Shewanella oneidensis MR-1 0.27 SO4614 ctaB protoheme IX farnesyltransferase (NCBI ptt file) 0.30 SO0359 spoT guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (NCBI ptt file) low > 76
Rhodanobacter sp. FW510-T8 0.27 OKGIIK_16555 cyoE heme o synthase 0.30 OKGIIK_12100 spoT guanosine-3',5'-bis(diphosphate) 3'-diphosphatase
Pseudomonas fluorescens FW300-N2C3 0.27 AO356_11200 protoheme IX farnesyltransferase 0.32 AO356_12480 (p)ppGpp synthetase
Burkholderia phytofirmans PsJN 0.27 BPHYT_RS02690 protoheme IX farnesyltransferase 0.31 BPHYT_RS15305 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 109
Pseudomonas sp. RS175 0.27 PFR28_04683 Protoheme IX farnesyltransferase 0.32 PFR28_04424 Bifunctional (p)ppGpp synthase/hydrolase SpoT
Pseudomonas fluorescens FW300-N2E2 0.26 Pf6N2E2_4106 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone 0.32 Pf6N2E2_4361 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Rhodanobacter denitrificans FW104-10B01 0.26 LRK54_RS07085 heme o synthase 0.30 LRK54_RS11795 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Rhodanobacter denitrificans MT42 0.26 LRK55_RS06825 heme o synthase 0.30 LRK55_RS11520 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Shewanella sp. ANA-3 0.26 Shewana3_3998 protoheme IX farnesyltransferase (RefSeq) 0.30 Shewana3_3812 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) low > 73
Paraburkholderia sabiae LMG 24235 0.26 QEN71_RS01545 heme o synthase 0.31 QEN71_RS03665 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 153
Acidovorax sp. GW101-3H11 0.26 Ac3H11_3883 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 0.30 Ac3H11_3664 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)
Ralstonia solanacearum PSI07 0.26 RPSI07_RS22315 protoheme IX farnesyltransferase 0.32 RPSI07_RS13870 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Ralstonia solanacearum IBSBF1503 0.26 RALBFv3_RS10990 protoheme IX farnesyltransferase 0.32 RALBFv3_RS03315 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 76
Ralstonia solanacearum UW163 0.26 UW163_RS02590 protoheme IX farnesyltransferase 0.32 UW163_RS10410 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Paraburkholderia bryophila 376MFSha3.1 0.26 H281DRAFT_01985 protoheme IX farnesyltransferase 0.31 H281DRAFT_04004 (p)ppGpp synthetase I, SpoT/RelA low > 103
Ralstonia sp. UNC404CL21Col 0.26 ABZR87_RS06845 heme o synthase 0.32 ABZR87_RS15225 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 80
Ralstonia solanacearum GMI1000 0.25 RS_RS01830 protoheme IX farnesyltransferase 0.31 RS_RS10800 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Cupriavidus basilensis FW507-4G11 0.25 RR42_RS01920 protoheme IX farnesyltransferase 0.32 RR42_RS04920 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Pseudomonas fluorescens FW300-N2E3 0.25 AO353_10870 protoheme IX farnesyltransferase 0.32 AO353_09280 (p)ppGpp synthetase
Paraburkholderia graminis OAS925 0.25 ABIE53_000683 protoheme IX farnesyltransferase 0.31 ABIE53_003230 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase low > 113
Pseudomonas sp. S08-1 0.25 OH686_12285 protoheme IX farnesyltransferase 0.32 OH686_13550 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase / GTP pyrophosphokinase , (p)ppGpp synthetase II low > 80
Herbaspirillum seropedicae SmR1 0.25 HSERO_RS20745 protoheme IX farnesyltransferase 0.33 HSERO_RS10635 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Pseudomonas fluorescens SBW25 0.24 PFLU_RS00330 protoheme IX farnesyltransferase 0.32 PFLU_RS29510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS00330 protoheme IX farnesyltransferase 0.32 PFLU_RS29510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Shewanella loihica PV-4 0.24 Shew_0117 protoheme IX farnesyltransferase (RefSeq) 0.31 Shew_3499 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) low > 60
Pseudomonas simiae WCS417 0.24 PS417_00340 protoheme IX farnesyltransferase 0.32 PS417_27830 (p)ppGpp synthetase
Castellaniella sp019104865 MT123 0.23 ABCV34_RS13230 heme o synthase 0.32 ABCV34_RS03095 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Pseudomonas putida KT2440 0.23 PP_0110 CyoE like protoheme IX farnesyltransferase 0.32 PP_5302 bifunctional (p)ppGpp synthase/hydrolase
Shewanella amazonensis SB2B 0.23 Sama_3491 protoheme IX farnesyltransferase (RefSeq) 0.31 Sama_0264 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) low > 62
Magnetospirillum magneticum AMB-1 0.21 AMB_RS03800 protoheme IX farnesyltransferase 1 0.47 AMB_RS11400 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Echinicola vietnamensis KMM 6221, DSM 17526 0.19 Echvi_2105 protoheme IX farnesyltransferase 0.25 Echvi_4631 (p)ppGpp synthetase, RelA/SpoT family
Rahnella sp. WP5 0.18 EX31_RS22200 protoheme IX farnesyltransferase 0.31 EX31_RS15810 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 89
Klebsiella michiganensis M5al 0.17 BWI76_RS06475 protoheme IX farnesyltransferase 0.31 BWI76_RS27430 (p)ppGpp synthetase low > 92
Erwinia tracheiphila SCR3 0.17 LU632_RS18395 cyoE heme o synthase 0.31 LU632_RS22200 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Enterobacter sp. TBS_079 0.17 MPMX20_01019 Protoheme IX farnesyltransferase 0.31 MPMX20_00086 Bifunctional (p)ppGpp synthase/hydrolase SpoT low > 85
Enterobacter asburiae PDN3 0.17 EX28DRAFT_2543 protoheme IX farnesyltransferase 0.31 EX28DRAFT_3899 (p)ppGpp synthetase, RelA/SpoT family low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.17 GFF4342 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 0.31 GFF357 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 low > 78
Serratia liquefaciens MT49 0.17 IAI46_04965 protoheme IX farnesyltransferase 0.31 IAI46_24895 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 86
Escherichia coli ECRC101 0.16 MCAODC_27605 cyoE heme o synthase 0.31 MCAODC_06065 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia fergusonii Becca 0.16 EFB2_03629 Protoheme IX farnesyltransferase 0.31 EFB2_00138 Bifunctional (p)ppGpp synthase/hydrolase SpoT low > 86
Escherichia coli ECRC62 0.16 BNILDI_22730 cyoE heme o synthase 0.31 BNILDI_04080 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia coli ECRC99 0.16 KEDOAH_19585 cyoE heme o synthase 0.31 KEDOAH_12590 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Dickeya dianthicola 67-19 0.16 HGI48_RS05640 protoheme IX farnesyltransferase 0.31 HGI48_RS21180 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Dickeya dianthicola ME23 0.16 DZA65_RS05965 protoheme IX farnesyltransferase 0.31 DZA65_RS22150 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia coli ECOR38 0.16 HEPCGN_06995 cyoE heme o synthase 0.31 HEPCGN_14375 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 85
Escherichia coli ECRC101 0.16 OKFHMN_08380 cyoE heme o synthase 0.31 OKFHMN_15555 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia coli HS(pFamp)R (ATCC 700891) 0.16 OHPLBJKB_03245 Protoheme IX farnesyltransferase 0.31 OHPLBJKB_00051 Bifunctional (p)ppGpp synthase/hydrolase SpoT low > 73
Escherichia coli BW25113 0.16 b0428 cyoE protoheme IX farnesyltransferase (NCBI) 0.31 b3650 spoT bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) low > 76
Escherichia coli BL21 0.16 ECD_00379 protoheme IX farnesyltransferase 0.31 ECD_03507 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 60
Escherichia coli Nissle 1917 0.16 ECOLIN_RS02575 heme o synthase 0.31 ECOLIN_RS20790 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 52
Escherichia coli ECRC98 0.16 JDDGAC_12035 cyoE heme o synthase 0.31 JDDGAC_19180 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia coli ECRC102 0.16 NIAGMN_06435 cyoE heme o synthase 0.31 NIAGMN_13315 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Escherichia coli ECOR27 0.16 NOLOHH_01315 cyoE heme o synthase 0.31 NOLOHH_07435 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Pseudomonas syringae pv. syringae B728a ΔmexB 0.16 Psyr_1145 Protoheme IX farnesyltransferase 0.32 Psyr_0209 RelA/SpoT protein
Dickeya dadantii 3937 0.16 DDA3937_RS05595 protoheme IX farnesyltransferase 0.31 DDA3937_RS00180 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Pseudomonas syringae pv. syringae B728a 0.16 Psyr_1145 Protoheme IX farnesyltransferase 0.32 Psyr_0209 RelA/SpoT protein
Pectobacterium carotovorum WPP14 0.16 HER17_RS15895 heme o synthase 0.31 HER17_RS21385 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 75
Pantoea sp. MT58 0.15 IAI47_14700 protoheme IX farnesyltransferase 0.31 IAI47_00510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase low > 76
Pedobacter sp. GW460-11-11-14-LB5 0.15 CA265_RS17805 protoheme IX farnesyltransferase 0.28 CA265_RS14485 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Mucilaginibacter yixingensis YX-36 DSM 26809 0.15 ABZR88_RS03670 heme o synthase 0.28 ABZR88_RS15610 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Not shown: 0 genomes with orthologs for SMc00450 only; 16 genomes with orthologs for SMc02659 only