Conservation of cofitness between PP_4922 and PP_4782 in Pseudomonas putida KT2440

87 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Pseudomonas putida KT2440 1.0 PP_4922 Phosphomethylpyrimidine synthase 1.0 PP_4782 Phosphomethylpyrimidine kinase 0.83 3
Pseudomonas sp. RS175 0.92 PFR28_05091 Phosphomethylpyrimidine synthase 0.84 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.95 2
Pseudomonas fluorescens FW300-N2C3 0.92 AO356_08810 thiamine biosynthesis protein ThiC 0.88 AO356_15435 hydrogenase 0.43 6
Pseudomonas fluorescens FW300-N2E2 0.92 Pf6N2E2_3644 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.78 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.41 16
Pseudomonas fluorescens SBW25 0.92 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.88 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.88 2
Pseudomonas syringae pv. syringae B728a 0.92 Psyr_0544 hydroxymethylpyrimidine synthase 0.85 Psyr_4340 phosphomethylpyrimidine kinase, putative low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.92 Psyr_0544 hydroxymethylpyrimidine synthase 0.85 Psyr_4340 phosphomethylpyrimidine kinase, putative low > 86
Pseudomonas fluorescens GW456-L13 0.92 PfGW456L13_187 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.87 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.51 13
Pseudomonas fluorescens SBW25-INTG 0.92 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.88 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.92 1
Pseudomonas fluorescens FW300-N2E3 0.92 AO353_13010 thiamine biosynthesis protein ThiC 0.87 AO353_06350 hydrogenase 0.77 1
Pseudomonas simiae WCS417 0.91 PS417_02355 thiamine biosynthesis protein ThiC 0.87 PS417_24600 hydrogenase 0.63 2
Pseudomonas fluorescens FW300-N1B4 0.91 Pf1N1B4_1447 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.78 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.55 5
Pseudomonas sp. S08-1 0.91 OH686_15885 phosphomethylpyrimidine synthase 0.82 OH686_09185 Hydroxymethylpyrimidine phosphate kinase ThiD low > 80
Pseudomonas stutzeri RCH2 0.90 Psest_0477 thiamine biosynthesis protein ThiC 0.78 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.65 5
Marinobacter adhaerens HP15 0.83 HP15_453 thiamine biosynthesis protein thiC 0.27 HP15_349 phosphomethylpyrimidine kinase — —
Paraburkholderia sabiae LMG 24235 0.78 QEN71_RS05480 phosphomethylpyrimidine synthase ThiC 0.19 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Herbaspirillum seropedicae SmR1 0.78 HSERO_RS02120 phosphomethylpyrimidine synthase ThiC 0.31 HSERO_RS02135 phosphomethylpyrimidine kinase 0.94 1
Dechlorosoma suillum PS 0.77 Dsui_0422 thiamine biosynthesis protein ThiC 0.40 Dsui_0662 phosphomethylpyrimidine kinase — —
Dyella japonica UNC79MFTsu3.2 0.77 ABZR86_RS17230 phosphomethylpyrimidine synthase ThiC 0.23 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Acinetobacter radioresistens SK82 0.77 MPMX26_00180 Phosphomethylpyrimidine synthase 0.38 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase — —
Paraburkholderia graminis OAS925 0.77 ABIE53_002857 phosphomethylpyrimidine synthase 0.22 ABIE53_001125 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 113
Paraburkholderia bryophila 376MFSha3.1 0.77 H281DRAFT_00395 hydroxymethylpyrimidine synthase 0.22 H281DRAFT_04811 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 103
Burkholderia phytofirmans PsJN 0.77 BPHYT_RS13220 phosphomethylpyrimidine synthase 0.19 BPHYT_RS04205 kinase low > 109
Pontibacter actiniarum KMM 6156, DSM 19842 0.76 CA264_20435 phosphomethylpyrimidine synthase ThiC 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.80 2
Rhodanobacter sp. FW510-T8 0.76 OKGIIK_16965 thiC phosphomethylpyrimidine synthase ThiC 0.22 OKGIIK_03835 Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 52
Lysobacter sp. OAE881 0.75 ABIE51_RS17515 phosphomethylpyrimidine synthase ThiC 0.23 ABIE51_RS07970 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Castellaniella sp019104865 MT123 0.75 ABCV34_RS10825 phosphomethylpyrimidine synthase ThiC 0.22 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.75 ABZR88_RS08840 phosphomethylpyrimidine synthase ThiC 0.24 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 2
Pedobacter sp. GW460-11-11-14-LB5 0.75 CA265_RS20165 phosphomethylpyrimidine synthase ThiC 0.19 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 88
Pectobacterium carotovorum WPP14 0.74 HER17_RS20380 phosphomethylpyrimidine synthase ThiC 0.25 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.96 1
Xanthomonas campestris pv. campestris strain 8004 0.74 Xcc-8004.1066.1 hypothetical protein 0.23 Xcc-8004.3091.1 hypothetical protein 0.73 8
Ralstonia sp. UNC404CL21Col 0.74 ABZR87_RS04785 phosphomethylpyrimidine synthase ThiC 0.24 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.74 Echvi_3567 thiamine biosynthesis protein ThiC 0.24 Echvi_0215 phosphomethylpyrimidine kinase low > 79
Ralstonia solanacearum PSI07 0.74 RPSI07_RS23420 phosphomethylpyrimidine synthase ThiC 0.26 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Ralstonia solanacearum UW163 0.74 UW163_RS03640 phosphomethylpyrimidine synthase ThiC 0.26 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Ralstonia solanacearum IBSBF1503 0.74 RALBFv3_RS09940 phosphomethylpyrimidine synthase ThiC 0.26 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Ralstonia solanacearum GMI1000 0.74 RS_RS00555 phosphomethylpyrimidine synthase 0.26 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Pantoea sp. MT58 0.73 IAI47_18085 phosphomethylpyrimidine synthase ThiC 0.20 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 37
Dickeya dadantii 3937 0.73 DDA3937_RS01175 phosphomethylpyrimidine synthase ThiC 0.23 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.88 6
Cupriavidus basilensis FW507-4G11 0.73 RR42_RS01290 thiamine biosynthesis protein ThiC 0.19 RR42_RS01370 phosphomethylpyrimidine kinase — —
Rahnella sp. WP5 0.73 EX31_RS16815 phosphomethylpyrimidine synthase ThiC 0.23 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 89
Serratia liquefaciens MT49 0.73 IAI46_01320 phosphomethylpyrimidine synthase ThiC 0.24 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 86
Escherichia coli ECRC62 0.72 BNILDI_06005 thiC phosphomethylpyrimidine synthase ThiC 0.24 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECOR27 0.72 NOLOHH_05520 thiC phosphomethylpyrimidine synthase ThiC 0.24 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 57
Escherichia coli BW25113 0.72 b3994 thiC thiamine biosynthesis protein ThiC (NCBI) 0.24 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.92 4
Escherichia coli Nissle 1917 0.72 ECOLIN_RS23040 phosphomethylpyrimidine synthase ThiC 0.23 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.72 OHPLBJKB_04056 Phosphomethylpyrimidine synthase 0.24 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 73
Escherichia fergusonii Becca 0.72 EFB2_04617 Phosphomethylpyrimidine synthase 0.23 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 86
Erwinia tracheiphila SCR3 0.72 LU632_RS00970 thiC phosphomethylpyrimidine synthase ThiC 0.23 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 74
Escherichia coli ECRC102 0.72 NIAGMN_11125 thiC phosphomethylpyrimidine synthase ThiC 0.24 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC98 0.72 JDDGAC_17000 thiC phosphomethylpyrimidine synthase ThiC 0.24 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC101 0.72 MCAODC_03875 thiC phosphomethylpyrimidine synthase ThiC 0.24 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC101 0.72 OKFHMN_13375 thiC phosphomethylpyrimidine synthase ThiC 0.24 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC99 0.72 KEDOAH_14785 thiC phosphomethylpyrimidine synthase ThiC 0.24 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Dickeya dianthicola 67-19 0.72 HGI48_RS01170 phosphomethylpyrimidine synthase ThiC 0.22 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 27
Enterobacter sp. TBS_079 0.72 MPMX20_00217 Phosphomethylpyrimidine synthase 0.24 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.56 3
Dickeya dianthicola ME23 0.72 DZA65_RS01215 phosphomethylpyrimidine synthase ThiC 0.22 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 3
Escherichia coli ECOR38 0.72 HEPCGN_12010 thiC phosphomethylpyrimidine synthase ThiC 0.23 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 85
Escherichia coli BL21 0.72 ECD_03871 phosphomethylpyrimidine synthase 0.24 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase low > 60
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.72 GFF4198 Thiamin biosynthesis protein ThiC 0.23 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) low > 78
Enterobacter asburiae PDN3 0.72 EX28DRAFT_4536 phosphomethylpyrimidine synthase 0.22 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.54 50
Klebsiella michiganensis M5al 0.71 BWI76_RS01555 phosphomethylpyrimidine synthase ThiC 0.24 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.38 43
Vibrio cholerae E7946 ATCC 55056 0.71 CSW01_00335 phosphomethylpyrimidine synthase 0.22 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 62
Magnetospirillum magneticum AMB-1 0.69 AMB_RS01125 phosphomethylpyrimidine synthase 0.22 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Variovorax sp. SCN45 0.69 GFF2000 Phosphomethylpyrimidine synthase ThiC (EC 4.1.99.17) 0.16 GFF2149 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) low > 127
Variovorax sp. OAS795 0.68 ABID97_RS25235 phosphomethylpyrimidine synthase ThiC 0.19 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.68 GFF4626 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.24 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) low > 90
Acidovorax sp. GW101-3H11 0.67 Ac3H11_2027 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.21 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) — —
Phaeobacter inhibens DSM 17395 0.67 PGA1_c09110 thiamine biosynthesis protein ThiC 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.90 4
Azospirillum brasilense Sp245 0.67 AZOBR_RS07940 phosphomethylpyrimidine synthase 0.23 AZOBR_RS07045 phosphomethylpyrimidine kinase — —
Caulobacter crescentus NA1000 0.66 CCNA_02109 thiamine biosynthesis protein thiC 0.23 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase — —
Caulobacter crescentus NA1000 Δfur 0.66 CCNA_02109 thiamine biosynthesis protein thiC 0.23 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase — —
Agrobacterium fabrum C58 0.65 Atu2569 thiamine biosynthesis protein 0.25 Atu3290 phosphomethylpyrimidine kinase 0.95 1
Dinoroseobacter shibae DFL-12 0.65 Dshi_4080 thiamine biosynthesis protein ThiC (RefSeq) 0.18 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) — —
Sinorhizobium meliloti 1021 0.65 SM_b20615 thiamine biosynthesis protein ThiC 0.19 SM_b20962 phoshomethylpyrimidine kinase low > 103
Rhodopseudomonas palustris CGA009 0.65 TX73_018540 phosphomethylpyrimidine synthase ThiC 0.22 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Azospirillum sp. SherDot2 0.64 MPMX19_00336 Phosphomethylpyrimidine synthase 0.21 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase — —
Sphingomonas koreensis DSMZ 15582 0.64 Ga0059261_2424 hydroxymethylpyrimidine synthase 0.21 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Bosea sp. OAE506 0.63 ABIE41_RS02770 phosphomethylpyrimidine synthase ThiC 0.24 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.63 A4249_RS15715 phosphomethylpyrimidine synthase ThiC 0.24 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Rhodospirillum rubrum S1H 0.61 Rru_A2008 Thiamine biosynthesis protein ThiC (NCBI) 0.27 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) — —
Parabacteroides merdae CL09T00C40 0.58 HMPREF1078_RS03485 phosphomethylpyrimidine synthase ThiC 0.26 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 61
Bacteroides ovatus ATCC 8483 0.58 BACOVA_02358 thiamine biosynthesis protein ThiC 0.26 BACOVA_02530 phosphomethylpyrimidine kinase 0.95 1
Bacteroides thetaiotaomicron VPI-5482 0.58 BT0650 thiamine biosynthesis protein ThiC (NCBI ptt file) 0.29 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.56 2
Phocaeicola dorei CL03T12C01 0.58 ABI39_RS17760 phosphomethylpyrimidine synthase ThiC 0.28 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 2
Phocaeicola vulgatus CL09T03C04 0.58 HMPREF1058_RS03280 phosphomethylpyrimidine synthase ThiC 0.27 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.96 1
Bacteroides stercoris CC31F 0.58 HMPREF1181_RS14685 phosphomethylpyrimidine synthase ThiC 0.24 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 56
Mycobacterium tuberculosis H37Rv 0.53 Rv0423c Probable thiamine biosynthesis protein ThiC 0.18 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) — —

Not shown: 6 genomes with orthologs for PP_4922 only; 6 genomes with orthologs for PP_4782 only