Conservation of cofitness between ECD_03871 and ECD_03752 in Escherichia coli BL21

84 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_03871 phosphomethylpyrimidine synthase 1.0 ECD_03752 coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent low > 61
Escherichia coli ECRC99 0.99 KEDOAH_14785 thiC phosphomethylpyrimidine synthase ThiC 1.00 KEDOAH_14030 hemN oxygen-independent coproporphyrinogen III oxidase
Escherichia coli ECRC101 0.99 MCAODC_03875 thiC phosphomethylpyrimidine synthase ThiC 1.00 MCAODC_04620 hemN oxygen-independent coproporphyrinogen III oxidase low > 87
Escherichia coli ECRC100 0.99 OKFHMN_13375 thiC phosphomethylpyrimidine synthase ThiC 1.00 OKFHMN_14120 hemN oxygen-independent coproporphyrinogen III oxidase low > 80
Escherichia coli ECRC102 0.99 NIAGMN_11125 thiC phosphomethylpyrimidine synthase ThiC 1.00 NIAGMN_11875 hemN oxygen-independent coproporphyrinogen III oxidase
Escherichia coli ECRC98 0.99 JDDGAC_17000 thiC phosphomethylpyrimidine synthase ThiC 1.00 JDDGAC_17745 hemN oxygen-independent coproporphyrinogen III oxidase low > 86
Escherichia coli ECOR27 0.99 NOLOHH_05520 thiC phosphomethylpyrimidine synthase ThiC 1.00 NOLOHH_06250 hemN oxygen-independent coproporphyrinogen III oxidase low > 75
Escherichia coli BW25113 0.99 b3994 thiC thiamine biosynthesis protein ThiC (NCBI) 1.00 b3867 hemN O2-independent coproporphyrinogen III oxidase (VIMSS) low > 76
Escherichia coli ECRC62 0.99 BNILDI_06005 thiC phosphomethylpyrimidine synthase ThiC 1.00 BNILDI_05280 hemN oxygen-independent coproporphyrinogen III oxidase low > 75
Escherichia coli Nissle 1917 0.99 ECOLIN_RS23040 phosphomethylpyrimidine synthase ThiC 0.99 ECOLIN_RS22285 oxygen-independent coproporphyrinogen III oxidase low > 55
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_04056 Phosphomethylpyrimidine synthase 1.00 OHPLBJKB_04186 Oxygen-independent coproporphyrinogen III oxidase low > 73
Escherichia coli ECOR38 0.99 HEPCGN_12010 thiC phosphomethylpyrimidine synthase ThiC 0.99 HEPCGN_12755 hemN oxygen-independent coproporphyrinogen III oxidase low > 87
Escherichia fergusonii Becca 0.99 EFB2_04617 Phosphomethylpyrimidine synthase 0.99 EFB2_04750 Oxygen-independent coproporphyrinogen III oxidase low > 86
Enterobacter sp. TBS_079 0.95 MPMX20_00217 Phosphomethylpyrimidine synthase 0.93 MPMX20_04598 Oxygen-independent coproporphyrinogen III oxidase low > 85
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4536 phosphomethylpyrimidine synthase 0.93 EX28DRAFT_4348 oxygen-independent coproporphyrinogen III oxidase low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.95 GFF4198 Thiamin biosynthesis protein ThiC 0.93 GFF2219 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) 0.38 5
Klebsiella michiganensis M5al 0.93 BWI76_RS01555 phosphomethylpyrimidine synthase ThiC 0.90 BWI76_RS00380 oxygen-independent coproporphyrinogen III oxidase low > 92
Pectobacterium carotovorum WPP14 0.87 HER17_RS20380 phosphomethylpyrimidine synthase ThiC 0.83 HER17_RS21450 oxygen-independent coproporphyrinogen III oxidase low > 75
Rahnella sp. WP5 0.86 EX31_RS16815 phosphomethylpyrimidine synthase ThiC 0.79 EX31_RS15885 oxygen-independent coproporphyrinogen III oxidase low > 89
Dickeya dianthicola ME23 0.85 DZA65_RS01215 phosphomethylpyrimidine synthase ThiC 0.80 DZA65_RS22220 oxygen-independent coproporphyrinogen III oxidase low > 75
Dickeya dadantii 3937 0.85 DDA3937_RS01175 phosphomethylpyrimidine synthase ThiC 0.79 DDA3937_RS00120 oxygen-independent coproporphyrinogen III oxidase low > 74
Serratia liquefaciens MT49 0.84 IAI46_01320 phosphomethylpyrimidine synthase ThiC 0.82 IAI46_24970 oxygen-independent coproporphyrinogen III oxidase low > 86
Dickeya dianthicola 67-19 0.84 HGI48_RS01170 phosphomethylpyrimidine synthase ThiC 0.79 HGI48_RS21245 oxygen-independent coproporphyrinogen III oxidase low > 71
Pantoea sp. MT58 0.84 IAI47_18085 phosphomethylpyrimidine synthase ThiC 0.76 IAI47_00445 oxygen-independent coproporphyrinogen III oxidase low > 76
Erwinia tracheiphila SCR3 0.83 LU632_RS00970 thiC phosphomethylpyrimidine synthase ThiC 0.70 LU632_RS22115 hemN oxygen-independent coproporphyrinogen III oxidase low > 74
Shewanella loihica PV-4 0.77 Shew_2096 thiamine biosynthesis protein ThiC (RefSeq) 0.66 Shew_3720 coproporphyrinogen III oxidase (RefSeq) low > 60
Shewanella amazonensis SB2B 0.77 Sama_1860 thiamine biosynthesis protein ThiC (RefSeq) 0.66 Sama_0086 coproporphyrinogen III oxidase (RefSeq) low > 62
Shewanella oneidensis MR-1 0.75 SO2445 thiC thiamin biosynthesis protein ThiC (NCBI ptt file) 0.67 SO4730 hemN oxygen-independent coproporphyrinogen III oxidase (NCBI ptt file) low > 76
Alteromonas macleodii MIT1002 0.75 MIT1002_00097 Phosphomethylpyrimidine synthase 0.45 MIT1002_02323 Oxygen-independent coproporphyrinogen-III oxidase low > 70
Shewanella sp. ANA-3 0.74 Shewana3_1936 thiamine biosynthesis protein ThiC (RefSeq) 0.66 Shewana3_4116 coproporphyrinogen III oxidase (RefSeq) low > 73
Vibrio cholerae E7946 ATCC 55056 0.74 CSW01_00335 phosphomethylpyrimidine synthase 0.71 CSW01_00590 oxygen-independent coproporphyrinogen III oxidase low > 62
Pseudomonas sp. RS175 0.72 PFR28_05091 Phosphomethylpyrimidine synthase 0.49 PFR28_01080 Oxygen-independent coproporphyrinogen III oxidase low > 88
Pseudomonas putida KT2440 0.71 PP_4922 Phosphomethylpyrimidine synthase 0.48 PP_4264 oxygen-independent coproporphyrinogen III dehydrogenase low > 96
Pseudomonas fluorescens GW456-L13 0.71 PfGW456L13_187 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.49 PfGW456L13_4070 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) 0.34 27
Pseudomonas sp. S08-1 0.71 OH686_15885 phosphomethylpyrimidine synthase 0.48 OH686_02235 oxygen-independent coproporphyrinogen III oxidase low > 80
Pseudomonas fluorescens FW300-N2E2 0.71 Pf6N2E2_3644 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.48 Pf6N2E2_2321 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 103
Pseudomonas syringae pv. syringae B728a 0.71 Psyr_0544 hydroxymethylpyrimidine synthase 0.48 Psyr_3423 coproporphyrinogen III oxidase, anaerobic low > 86
Pseudomonas fluorescens FW300-N2C3 0.71 AO356_08810 thiamine biosynthesis protein ThiC 0.48 AO356_02480 coproporphyrinogen III oxidase low > 104
Pseudomonas syringae pv. syringae B728a ΔmexB 0.71 Psyr_0544 hydroxymethylpyrimidine synthase 0.48 Psyr_3423 coproporphyrinogen III oxidase, anaerobic low > 86
Pseudomonas fluorescens SBW25-INTG 0.71 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.49 PFLU_RS22385 oxygen-independent coproporphyrinogen III oxidase low > 109
Pseudomonas fluorescens SBW25 0.71 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.49 PFLU_RS22385 oxygen-independent coproporphyrinogen III oxidase low > 109
Pseudomonas fluorescens FW300-N2E3 0.71 AO353_13010 thiamine biosynthesis protein ThiC 0.48 AO353_00655 coproporphyrinogen III oxidase low > 101
Pseudomonas fluorescens FW300-N1B4 0.71 Pf1N1B4_1447 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.48 Pf1N1B4_3868 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 87
Pseudomonas simiae WCS417 0.71 PS417_02355 thiamine biosynthesis protein ThiC 0.49 PS417_20775 coproporphyrinogen III oxidase low > 88
Pseudomonas stutzeri RCH2 0.71 Psest_0477 thiamine biosynthesis protein ThiC 0.47 Psest_2537 oxygen-independent coproporphyrinogen III oxidase low > 67
Marinobacter adhaerens HP15 0.70 HP15_453 thiamine biosynthesis protein thiC 0.49 HP15_2953 oxygen-independent coproporphyrinogen III oxidase low > 73
Pontibacter actiniarum KMM 6156, DSM 19842 0.70 CA264_20435 phosphomethylpyrimidine synthase ThiC 0.32 CA264_03125 oxygen-independent coproporphyrinogen III oxidase low > 74
Mucilaginibacter yixingensis YX-36 DSM 26809 0.70 ABZR88_RS08840 phosphomethylpyrimidine synthase ThiC 0.31 ABZR88_RS05615 oxygen-independent coproporphyrinogen III oxidase low > 71
Herbaspirillum seropedicae SmR1 0.69 HSERO_RS02120 phosphomethylpyrimidine synthase ThiC 0.47 HSERO_RS16075 coproporphyrinogen III oxidase low > 78
Dyella japonica UNC79MFTsu3.2 0.69 ABZR86_RS17230 phosphomethylpyrimidine synthase ThiC 0.45 ABZR86_RS04455 oxygen-independent coproporphyrinogen III oxidase low > 74
Echinicola vietnamensis KMM 6221, DSM 17526 0.69 Echvi_3567 thiamine biosynthesis protein ThiC 0.30 Echvi_4019 oxygen-independent coproporphyrinogen III oxidase low > 79
Castellaniella sp019104865 MT123 0.69 ABCV34_RS10825 phosphomethylpyrimidine synthase ThiC 0.44 ABCV34_RS06465 oxygen-independent coproporphyrinogen III oxidase low > 48
Paraburkholderia sabiae LMG 24235 0.69 QEN71_RS05480 phosphomethylpyrimidine synthase ThiC 0.47 QEN71_RS03200 oxygen-independent coproporphyrinogen III oxidase low > 153
Paraburkholderia bryophila 376MFSha3.1 0.69 H281DRAFT_00395 hydroxymethylpyrimidine synthase 0.45 H281DRAFT_04040 oxygen-independent coproporphyrinogen-3 oxidase low > 103
Dechlorosoma suillum PS 0.69 Dsui_0422 thiamine biosynthesis protein ThiC 0.46 Dsui_1647 oxygen-independent coproporphyrinogen III oxidase
Burkholderia phytofirmans PsJN 0.68 BPHYT_RS13220 phosphomethylpyrimidine synthase 0.47 BPHYT_RS15490 coproporphyrinogen III oxidase low > 109
Rhodanobacter sp. FW510-T8 0.68 OKGIIK_16965 thiC phosphomethylpyrimidine synthase ThiC 0.44 OKGIIK_00800 hemN oxygen-independent coproporphyrinogen III oxidase low > 52
Paraburkholderia graminis OAS925 0.68 ABIE53_002857 phosphomethylpyrimidine synthase 0.46 ABIE53_003264 oxygen-independent coproporphyrinogen-3 oxidase low > 113
Pedobacter sp. GW460-11-11-14-LB5 0.68 CA265_RS20165 phosphomethylpyrimidine synthase ThiC 0.31 CA265_RS01360 oxygen-independent coproporphyrinogen III oxidase low > 88
Ralstonia sp. UNC404CL21Col 0.68 ABZR87_RS04785 phosphomethylpyrimidine synthase ThiC 0.46 ABZR87_RS03910 oxygen-independent coproporphyrinogen III oxidase low > 80
Lysobacter sp. OAE881 0.68 ABIE51_RS17515 phosphomethylpyrimidine synthase ThiC 0.45 ABIE51_RS03875 oxygen-independent coproporphyrinogen III oxidase low > 62
Ralstonia solanacearum IBSBF1503 0.68 RALBFv3_RS09940 phosphomethylpyrimidine synthase ThiC 0.46 RALBFv3_RS08600 oxygen-independent coproporphyrinogen III oxidase low > 76
Ralstonia solanacearum UW163 0.68 UW163_RS03640 phosphomethylpyrimidine synthase ThiC 0.46 UW163_RS05010 oxygen-independent coproporphyrinogen III oxidase
Ralstonia solanacearum GMI1000 0.68 RS_RS00555 phosphomethylpyrimidine synthase 0.46 RS_RS16455 oxygen-independent coproporphyrinogen III oxidase low > 80
Ralstonia solanacearum PSI07 0.68 RPSI07_RS23420 phosphomethylpyrimidine synthase ThiC 0.46 RPSI07_RS08635 oxygen-independent coproporphyrinogen III oxidase low > 81
Xanthomonas campestris pv. campestris strain 8004 0.67 Xcc-8004.1066.1 hypothetical protein 0.40 Xcc-8004.2605.1 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 74
Kangiella aquimarina DSM 16071 0.67 B158DRAFT_0295 hydroxymethylpyrimidine synthase 0.53 B158DRAFT_1981 coproporphyrinogen III oxidase, anaerobic (EC 1.3.99.22) low > 40
Cupriavidus basilensis FW507-4G11 0.67 RR42_RS01290 thiamine biosynthesis protein ThiC 0.44 RR42_RS20025 coproporphyrinogen III oxidase low > 128
Magnetospirillum magneticum AMB-1 0.65 AMB_RS01125 phosphomethylpyrimidine synthase 0.33 AMB_RS13570 oxygen-independent coproporphyrinogen III oxidase
Azospirillum brasilense Sp245 0.65 AZOBR_RS07940 phosphomethylpyrimidine synthase 0.33 AZOBR_RS03710 coproporphyrinogen III oxidase low > 97
Hydrogenophaga sp. GW460-11-11-14-LB1 0.64 GFF166 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.46 GFF4143 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 90
Phaeobacter inhibens DSM 17395 0.64 PGA1_c09110 thiamine biosynthesis protein ThiC 0.30 PGA1_c00360 oxygen-independent coproporphyrinogen III oxidase HemN low > 62
Dinoroseobacter shibae DFL-12 0.64 Dshi_4080 thiamine biosynthesis protein ThiC (RefSeq) 0.34 Dshi_0541 oxygen-independent coproporphyrinogen III oxidase (RefSeq)
Caulobacter crescentus NA1000 0.63 CCNA_02109 thiamine biosynthesis protein thiC 0.27 CCNA_01477 oxygen-independent coproporphyrinogen-III oxidase hemN low > 66
Caulobacter crescentus NA1000 Δfur 0.63 CCNA_02109 thiamine biosynthesis protein thiC 0.27 CCNA_01477 oxygen-independent coproporphyrinogen-III oxidase hemN low > 67
Variovorax sp. SCN45 0.63 GFF2000 Phosphomethylpyrimidine synthase ThiC (EC 4.1.99.17) 0.43 GFF6957 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 127
Agrobacterium fabrum C58 0.63 Atu2569 thiamine biosynthesis protein 0.32 Atu1601 oxygen-independent coproporphyrinogen III oxidase low > 89
Sinorhizobium meliloti 1021 0.63 SM_b20615 thiamine biosynthesis protein ThiC 0.32 SMa1266 coproporphyrinogen III oxidase low > 103
Azospirillum sp. SherDot2 0.63 MPMX19_00336 Phosphomethylpyrimidine synthase 0.34 MPMX19_02313 Oxygen-independent coproporphyrinogen III oxidase low > 112
Variovorax sp. OAS795 0.63 ABID97_RS25235 phosphomethylpyrimidine synthase ThiC 0.45 ABID97_RS16190 oxygen-independent coproporphyrinogen III oxidase low > 91
Acidovorax sp. GW101-3H11 0.63 Ac3H11_2027 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.47 Ac3H11_976 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) low > 79
Rhodopseudomonas palustris CGA009 0.60 TX73_018540 phosphomethylpyrimidine synthase ThiC 0.33 TX73_008565 oxygen-independent coproporphyrinogen III oxidase
Bosea sp. OAE506 0.60 ABIE41_RS02770 phosphomethylpyrimidine synthase ThiC 0.34 ABIE41_RS12085 oxygen-independent coproporphyrinogen III oxidase low > 77
Rhodospirillum rubrum S1H 0.58 Rru_A2008 Thiamine biosynthesis protein ThiC (NCBI) 0.34 Rru_A2504 Oxygen-independent coproporphyrinogen III oxidase HemN (NCBI)
Parabacteroides merdae CL09T00C40 0.57 HMPREF1078_RS03485 phosphomethylpyrimidine synthase ThiC 0.32 HMPREF1078_RS13395 oxygen-independent coproporphyrinogen III oxidase low > 61

Not shown: 9 genomes with orthologs for ECD_03871 only; 3 genomes with orthologs for ECD_03752 only