| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_19505 | | two-component system sensor histidine kinase/response regulator | insig. | 100 | 100 |
| o | Pseudomonas sp. SVBP6 | COO64_RS21250 | | fused response regulator/phosphatase | insig. | 32 | 98 |
| o | Pseudomonas stutzeri RCH2 | Psest_1725 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 32 | 98 |
| o | Pseudomonas syringae pv. syringae B728a | Psyr_3451 | | Response regulator receiver:ATP-binding region, ATPase-like:Stage II sporulation E | insig. | 33 | 98 |
| o | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3451 | | Response regulator receiver:ATP-binding region, ATPase-like:Stage II sporulation E | insig. | 33 | 98 |
| | Alteromonas macleodii MIT1002 | MIT1002_01320 | | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP | cofit | 34 | 97 |
| | Pseudomonas putida KT2440 | PP_4363 | | Sensor histidine kinase/response regulator | sig. | 31 | 96 |
| | Pseudomonas sp. RS175 | PFR28_00838 | | Sensor histidine kinase RcsC | sig. | 31 | 97 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2587 | | Serine phosphatase RsbU, regulator of sigma subunit | strong | 31 | 96 |
| | Pseudomonas sp. S08-1 | OH686_02805 | | Serine phosphatase RsbU, regulator of sigma subunit / Serine-protein kinase RsbW | cofit | 30 | 98 |
| | Pseudomonas sp. DMC3 | GFF2455 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 30 | 97 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_18710 | | chemotaxis protein CheY | sig. | 30 | 98 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS00130 | hsbR;inference=COORDINATES | two-component system response regulator HsbR | sig. | 31 | 98 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_17155 | | two-component system response regulator HsbR | sig. | 31 | 98 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS40880 | hsbR;inference=COORDINATES | two-component system response regulator HsbR | insig. | 31 | 98 |
| | Pseudomonas sp. BP01 | JOY50_RS00655 | | fused response regulator/phosphatase | insig. | 30 | 96 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_03805 | | chemotaxis protein CheY | sig. | 30 | 96 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_3610 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 31 | 96 |
| | Marinobacter adhaerens HP15 | HP15_2320 | | response regulator receiver protein | insig. | 30 | 98 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4347 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 30 | 96 |
| | Pseudomonas orientalis W4I3 | QF045_RS21905 | | fused response regulator/phosphatase | cofit | 29 | 98 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_04153 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 29 | 98 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS21745 | | fused response regulator/phosphatase | insig. | 29 | 98 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS21745 | | fused response regulator/phosphatase | sig. | 29 | 98 |
| | Pseudomonas simiae WCS417 | PS417_19775 | | chemotaxis protein CheY | insig. | 29 | 98 |
| | Dechlorosoma suillum PS | Dsui_1715 | | response regulator with CheY-like receiver domain and winged-helix DNA-binding domain | cofit | 29 | 98 |
| | Shewanella sp. ANA-3 | Shewana3_2220 | | response regulator receiver protein (RefSeq) | insig. | 26 | 97 |
| | Shewanella oneidensis MR-1 | SO2119 | | response regulator (NCBI ptt file) | cofit | 27 | 89 |
| | Dechlorosoma suillum PS | Dsui_0331 | | PAS domain S-box | insig. | 32 | 44 |
| | Dechlorosoma suillum PS | Dsui_3287 | | response regulator containing a CheY-like receiver domain and an HD-GYP domain | cofit | 27 | 66 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14285 | | transcriptional regulator | strong | 28 | 57 |
| | Azospirillum sp. SherDot2 | MPMX19_01958 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 28 | 59 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14305 | | transcriptional regulator | cofit | 25 | 64 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS13380 | | fused response regulator/phosphatase | insig. | 22 | 65 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS05675 | | Serine phosphatase RsbU regulator sigma subunit | insig. | 24 | 67 |
| | Shewanella sp. ANA-3 | Shewana3_2013 | | response regulator receiver modulated serine phosphatase (RefSeq) | cofit | 22 | 69 |
| | Azospirillum sp. SherDot2 | MPMX19_00501 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 26 | 59 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_1146 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 24 | 67 |
| | Dechlorosoma suillum PS | Dsui_0331 | | PAS domain S-box | insig. | 30 | 30 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS18385 | | transcriptional regulator | insig. | 24 | 65 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4462 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 22 | 64 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS10415 | | SpoIIE family protein phosphatase | insig. | 20 | 67 |
| | Azospirillum brasilense Sp245 | AZOBR_RS12605 | | regulator | insig. | 24 | 67 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03815 | | hybrid sensor histidine kinase/response regulator | cofit | 34 | 24 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS20605 | | response regulator | insig. | 36 | 24 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03320 | | EAL domain-containing protein | insig. | 28 | 33 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c34880 | | putative response regulator | strong | 23 | 62 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS17805 | | HAMP domain-containing protein | cofit | 25 | 51 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS06810 | | response regulator | insig. | 34 | 24 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1058 | | two-component system sensor histidine kinase (NCBI ptt file) | strong | 34 | 24 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_4352 | | Response regulator | insig. | 36 | 25 |
| | Azospirillum sp. SherDot2 | MPMX19_01957 | | Sensor histidine kinase RcsC | insig. | 25 | 66 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04086 | | response regulator receiver domain protein | insig. | 35 | 24 |
| | Dechlorosoma suillum PS | Dsui_3334 | | PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein | cofit | 29 | 32 |
| | Shewanella oneidensis MR-1 | SO4003 | | response regulator (NCBI ptt file) | insig. | 37 | 24 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2391 | | two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) | insig. | 36 | 24 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16180 | | diguanylate cyclase | strong | 36 | 22 |
| | Dinoroseobacter shibae DFL-12 | Dshi_2820 | | response regulator receiver modulated diguanylate cyclase (RefSeq) | sig. | 35 | 21 |
| | Sphingobium sp. HT1-2 | GFF2748 | | Pole remodelling regulatory diguanylate cyclase | cofit | 35 | 22 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS07960 | | response regulator | strong | 36 | 23 |
| | Dechlorosoma suillum PS | Dsui_2240 | | PAS domain S-box | cofit | 35 | 20 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS10050 | | response regulator | insig. | 34 | 22 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS17900 | | serine phosphatase | insig. | 23 | 67 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4663 | | two-component system sensor histidine kinase/response (NCBI ptt file) | strong | 34 | 21 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS06700 | | response regulator | insig. | 33 | 23 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS08350 | | PleD family two-component system response regulator | insig. | 37 | 19 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS00270 | | response regulator | cofit | 34 | 20 |
| | Marinobacter adhaerens HP15 | HP15_1054 | | multi-sensor signal transduction histidine kinase | strong | 30 | 27 |
| | Azospirillum sp. SherDot2 | MPMX19_05016 | | Sensor histidine kinase RcsC | insig. | 32 | 20 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3800 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 37 | 20 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS00410 | | response regulator | strong | 34 | 26 |
| | Caulobacter crescentus NA1000 | CCNA_02546 | | GGDEF/response regulator protein PleD | strong | 34 | 23 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02546 | | GGDEF/response regulator protein PleD | cofit | 34 | 23 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08545 | | response regulator | insig. | 33 | 23 |
| | Caulobacter crescentus NA1000 | CCNA_00760 | | two component sensor histidine kinase | cofit | 33 | 21 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00760 | | two component sensor histidine kinase | cofit | 33 | 21 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS13200 | | transcriptional regulator | insig. | 32 | 24 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF3270 | | Two-component response regulator | insig. | 32 | 25 |
| | Azospirillum sp. SherDot2 | MPMX19_01522 | | Response regulator PleD | insig. | 36 | 22 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1096 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 34 | 23 |
| | Rhodopseudomonas palustris CGA009 | TX73_016195 | | PleD family two-component system response regulator | insig. | 35 | 22 |
| | Dechlorosoma suillum PS | Dsui_0919 | | response regulator containing a CheY-like receiver domain and an HD-GYP domain | insig. | 34 | 24 |
| | Shewanella loihica PV-4 | Shew_2749 | | two component transcriptional regulator (RefSeq) | insig. | 37 | 21 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05479 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 32 | 21 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS15245 | | response regulator | insig. | 27 | 35 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4236 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 37 | 20 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11370 | | response regulator transcription factor | no data | 36 | 21 |
| | Dinoroseobacter shibae DFL-12 | Dshi_3485 | | response regulator receiver modulated serine phosphatase (RefSeq) | sig. | 22 | 67 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS06690 | | response regulator | sig. | 33 | 21 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03646 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 36 | 20 |
| | Dechlorosoma suillum PS | Dsui_2382 | | PAS domain S-box | cofit | 36 | 20 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS08375 | | two-component regulator propeller domain-containing protein | insig. | 35 | 18 |
| | Bifidobacterium breve UCC2003 | BBR_RS17455 | | DNA-binding response regulator | strong | 32 | 26 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04904 | | response regulator receiver domain protein | cofit | 33 | 23 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS16930 | | chemotaxis protein CheY | insig. | 33 | 20 |
| | Alteromonas macleodii MIT1002 | MIT1002_01584 | | Stalked cell differentiation-controlling protein | insig. | 32 | 25 |
| | Agrobacterium fabrum C58 | Atu1297 | | two component response regulator | insig. | 36 | 22 |
| | Bosea sp. OAE506 | ABIE41_RS18170 | | PleD family two-component system response regulator | insig. | 34 | 22 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1453 | rpaB | two component transcriptional regulator, winged helix family | no data | 34 | 21 |
| | Dechlorosoma suillum PS | Dsui_2486 | | diguanylate cyclase (GGDEF) domain-containing protein | cofit | 34 | 23 |