| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_19505 | | two-component system sensor histidine kinase/response regulator | insig. | 100 | 100 |
| o | Pseudomonas sp. SVBP6 | COO64_RS21250 | | fused response regulator/phosphatase | insig. | 32 | 98 |
| o | Pseudomonas stutzeri RCH2 | Psest_1725 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 32 | 98 |
| o | Pseudomonas syringae pv. syringae B728a | Psyr_3451 | | Response regulator receiver:ATP-binding region, ATPase-like:Stage II sporulation E | insig. | 33 | 98 |
| o | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3451 | | Response regulator receiver:ATP-binding region, ATPase-like:Stage II sporulation E | insig. | 33 | 98 |
| | Alteromonas macleodii MIT1002 | MIT1002_01320 | | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP | cofit | 34 | 97 |
| | Pseudomonas putida KT2440 | PP_4363 | | Sensor histidine kinase/response regulator | sig. | 31 | 96 |
| | Pseudomonas sp. RS175 | PFR28_00838 | | Sensor histidine kinase RcsC | sig. | 31 | 97 |
| | Pseudomonas protegens RBAN4 | FABNJH_08545 | | Response regulator | insig. | 31 | 98 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2587 | | Serine phosphatase RsbU, regulator of sigma subunit | strong | 31 | 96 |
| | Pseudomonas sp. S08-1 | OH686_02805 | | Serine phosphatase RsbU, regulator of sigma subunit / Serine-protein kinase RsbW | cofit | 30 | 98 |
| | Pseudomonas sp. DMC3 | GFF2455 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 30 | 97 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_18710 | | chemotaxis protein CheY | sig. | 30 | 98 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS00130 | hsbR;inference=COORDINATES | two-component system response regulator HsbR | sig. | 31 | 98 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_17155 | | two-component system response regulator HsbR | sig. | 31 | 98 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS40880 | hsbR;inference=COORDINATES | two-component system response regulator HsbR | insig. | 31 | 98 |
| | Pseudomonas sp. BP01 | JOY50_RS00655 | | fused response regulator/phosphatase | insig. | 30 | 96 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_03805 | | chemotaxis protein CheY | sig. | 30 | 96 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_3610 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 31 | 96 |
| | Marinobacter adhaerens HP15 | HP15_2320 | | response regulator receiver protein | insig. | 30 | 98 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4347 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 30 | 96 |
| | Pseudomonas orientalis W4I3 | QF045_RS21905 | | fused response regulator/phosphatase | cofit | 29 | 98 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_04153 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 29 | 98 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS21745 | | fused response regulator/phosphatase | insig. | 29 | 98 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS21745 | | fused response regulator/phosphatase | sig. | 29 | 98 |
| | Pseudomonas simiae WCS417 | PS417_19775 | | chemotaxis protein CheY | insig. | 29 | 98 |
| | Dechlorosoma suillum PS | Dsui_1715 | | response regulator with CheY-like receiver domain and winged-helix DNA-binding domain | cofit | 29 | 98 |
| | Shewanella sp. ANA-3 | Shewana3_2220 | | response regulator receiver protein (RefSeq) | insig. | 26 | 97 |
| | Shewanella oneidensis MR-1 | SO2119 | | response regulator (NCBI ptt file) | cofit | 27 | 89 |
| | Dechlorosoma suillum PS | Dsui_0331 | | PAS domain S-box | insig. | 32 | 44 |
| | Dechlorosoma suillum PS | Dsui_3287 | | response regulator containing a CheY-like receiver domain and an HD-GYP domain | cofit | 27 | 66 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14285 | | transcriptional regulator | strong | 28 | 57 |
| | Azospirillum sp. SherDot2 | MPMX19_01958 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 28 | 59 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14305 | | transcriptional regulator | cofit | 25 | 64 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS13380 | | fused response regulator/phosphatase | insig. | 22 | 65 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS05675 | | Serine phosphatase RsbU regulator sigma subunit | insig. | 24 | 67 |
| | Shewanella sp. ANA-3 | Shewana3_2013 | | response regulator receiver modulated serine phosphatase (RefSeq) | cofit | 22 | 69 |
| | Azospirillum sp. SherDot2 | MPMX19_00501 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 26 | 59 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_1146 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 24 | 67 |
| | Dechlorosoma suillum PS | Dsui_0331 | | PAS domain S-box | insig. | 30 | 30 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS18385 | | transcriptional regulator | insig. | 24 | 65 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4462 | | Serine phosphatase RsbU, regulator of sigma subunit | insig. | 22 | 64 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS10415 | | SpoIIE family protein phosphatase | insig. | 20 | 67 |
| | Azospirillum brasilense Sp245 | AZOBR_RS12605 | | regulator | insig. | 24 | 67 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03815 | | hybrid sensor histidine kinase/response regulator | cofit | 34 | 24 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS20605 | | response regulator | insig. | 36 | 24 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03320 | | EAL domain-containing protein | insig. | 28 | 33 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c34880 | | putative response regulator | strong | 23 | 62 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS17805 | | HAMP domain-containing protein | cofit | 25 | 51 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS06810 | | response regulator | insig. | 34 | 24 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1058 | | two-component system sensor histidine kinase (NCBI ptt file) | strong | 34 | 24 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_4352 | | Response regulator | insig. | 36 | 25 |
| | Azospirillum sp. SherDot2 | MPMX19_01957 | | Sensor histidine kinase RcsC | insig. | 25 | 66 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04086 | | response regulator receiver domain protein | insig. | 35 | 24 |
| | Dechlorosoma suillum PS | Dsui_3334 | | PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein | cofit | 29 | 32 |
| | Shewanella oneidensis MR-1 | SO4003 | | response regulator (NCBI ptt file) | insig. | 37 | 24 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2391 | | two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) | insig. | 36 | 24 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16180 | | diguanylate cyclase | strong | 36 | 22 |
| | Dinoroseobacter shibae DFL-12 | Dshi_2820 | | response regulator receiver modulated diguanylate cyclase (RefSeq) | sig. | 35 | 21 |
| | Sphingobium sp. HT1-2 | GFF2748 | | Pole remodelling regulatory diguanylate cyclase | cofit | 35 | 22 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS07960 | | response regulator | strong | 36 | 23 |
| | Dechlorosoma suillum PS | Dsui_2240 | | PAS domain S-box | cofit | 35 | 20 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS10050 | | response regulator | insig. | 34 | 22 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS17900 | | serine phosphatase | insig. | 23 | 67 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4663 | | two-component system sensor histidine kinase/response (NCBI ptt file) | strong | 34 | 21 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS06700 | | response regulator | insig. | 33 | 23 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS08350 | | PleD family two-component system response regulator | insig. | 37 | 19 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS00270 | | response regulator | cofit | 34 | 20 |
| | Marinobacter adhaerens HP15 | HP15_1054 | | multi-sensor signal transduction histidine kinase | strong | 30 | 27 |
| | Azospirillum sp. SherDot2 | MPMX19_05016 | | Sensor histidine kinase RcsC | insig. | 32 | 20 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3800 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 37 | 20 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS00410 | | response regulator | strong | 34 | 26 |
| | Caulobacter crescentus NA1000 | CCNA_02546 | | GGDEF/response regulator protein PleD | strong | 34 | 23 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02546 | | GGDEF/response regulator protein PleD | cofit | 34 | 23 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08545 | | response regulator | insig. | 33 | 23 |
| | Caulobacter crescentus NA1000 | CCNA_00760 | | two component sensor histidine kinase | cofit | 33 | 21 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00760 | | two component sensor histidine kinase | cofit | 33 | 21 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS13200 | | transcriptional regulator | insig. | 32 | 24 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF3270 | | Two-component response regulator | insig. | 32 | 25 |
| | Azospirillum sp. SherDot2 | MPMX19_01522 | | Response regulator PleD | insig. | 36 | 22 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1096 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 34 | 23 |
| | Rhodopseudomonas palustris CGA009 | TX73_016195 | | PleD family two-component system response regulator | insig. | 35 | 22 |
| | Dechlorosoma suillum PS | Dsui_0919 | | response regulator containing a CheY-like receiver domain and an HD-GYP domain | insig. | 34 | 24 |
| | Shewanella loihica PV-4 | Shew_2749 | | two component transcriptional regulator (RefSeq) | insig. | 37 | 21 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05479 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 32 | 21 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS15245 | | response regulator | insig. | 27 | 35 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4236 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 37 | 20 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11370 | | response regulator transcription factor | no data | 36 | 21 |
| | Dinoroseobacter shibae DFL-12 | Dshi_3485 | | response regulator receiver modulated serine phosphatase (RefSeq) | sig. | 22 | 67 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS06690 | | response regulator | sig. | 33 | 21 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03646 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 36 | 20 |
| | Dechlorosoma suillum PS | Dsui_2382 | | PAS domain S-box | cofit | 36 | 20 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS08375 | | two-component regulator propeller domain-containing protein | insig. | 35 | 18 |
| | Bifidobacterium breve UCC2003 | BBR_RS17455 | | DNA-binding response regulator | strong | 32 | 26 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04904 | | response regulator receiver domain protein | cofit | 33 | 23 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS16930 | | chemotaxis protein CheY | insig. | 33 | 20 |
| | Alteromonas macleodii MIT1002 | MIT1002_01584 | | Stalked cell differentiation-controlling protein | insig. | 32 | 25 |
| | Agrobacterium fabrum C58 | Atu1297 | | two component response regulator | insig. | 36 | 22 |
| | Bosea sp. OAE506 | ABIE41_RS18170 | | PleD family two-component system response regulator | insig. | 34 | 22 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1453 | rpaB | two component transcriptional regulator, winged helix family | no data | 34 | 21 |
| | Dechlorosoma suillum PS | Dsui_2486 | | diguanylate cyclase (GGDEF) domain-containing protein | cofit | 34 | 23 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS15265 | | EAL domain-containing response regulator | insig. | 26 | 51 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS15265 | | EAL domain-containing response regulator | insig. | 26 | 51 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS36100 | | response regulator | insig. | 33 | 24 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS09000 | | response regulator | insig. | 31 | 20 |
| | Alteromonas macleodii MIT1002 | MIT1002_00763 | | Cyclic di-GMP phosphodiesterase response regulator RpfG | insig. | 34 | 20 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4572 | | PAS domain S-box | insig. | 34 | 21 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_3644 | | Pole remodelling regulatory diguanylate cyclase | insig. | 36 | 20 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS10730 | | response regulator | insig. | 32 | 20 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09310 | | two-component system response regulator | insig. | 31 | 24 |
| | Pseudomonas sp. RS175 | PFR28_04227 | | Sensor histidine kinase RcsC | insig. | 36 | 21 |
| | Pseudomonas sp. S08-1 | OH686_16560 | | Two-component transcriptional response regulator, LuxR family | insig. | 34 | 21 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4111 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | strong | 31 | 26 |
| | Variovorax sp. SCN45 | GFF2488 | | Two-component transcriptional response regulator, LuxR family | insig. | 29 | 25 |
| | Rhodospirillum rubrum S1H | Rru_A2108 | | Multi-sensor Hybrid Histidine Kinase (NCBI) | insig. | 28 | 32 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08895 | | response regulator | insig. | 36 | 20 |
| | Shewanella oneidensis MR-1 | SO0860 | | response regulator (NCBI ptt file) | insig. | 32 | 25 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_4617 | | Signal transduction histidine kinase CheA (EC 2.7.3.-) | strong | 35 | 21 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_0492 | | Response regulator receiver:CheW-like protein:ATP-binding region, ATPase-like:Hpt | insig. | 35 | 20 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_0492 | | Response regulator receiver:CheW-like protein:ATP-binding region, ATPase-like:Hpt | insig. | 35 | 20 |
| | Azospirillum sp. SherDot2 | MPMX19_04555 | | Sensor histidine kinase RcsC | insig. | 29 | 23 |
| | Variovorax sp. OAS795 | ABID97_RS23505 | | response regulator transcription factor | insig. | 29 | 25 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS03625 | | response regulator | insig. | 32 | 22 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_1026 | | Signal transduction histidine kinase CheA (EC 2.7.3.-) | insig. | 35 | 20 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02065 | | response regulator receiver domain protein | insig. | 24 | 43 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS14205 | | response regulator | insig. | 37 | 20 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS31465 | | diguanylate cyclase | insig. | 36 | 23 |
| | Sphingobium sp. HT1-2 | GFF2749 | | Hybrid sensory histidine kinase | cofit | 35 | 20 |
| | Pseudomonas segetis P6 | ACVTMO_RS02300 | | response regulator | insig. | 34 | 23 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_20505 | | Histidine kinase | sig. | 34 | 18 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS02895 | | PAS domain-containing protein | insig. | 34 | 21 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS13580 | | response regulator | strong | 32 | 20 |
| | Shewanella sp. ANA-3 | Shewana3_3334 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 32 | 25 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS20960 | | two-component system response regulator | cofit | 31 | 21 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS00885 | | response regulator | insig. | 28 | 24 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS02130 | | hybrid sensor histidine kinase/response regulator | strong | 31 | 23 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_03275 | | hybrid sensor histidine kinase/response regulator | insig. | 28 | 24 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_08085 | | histidine kinase | strong | 34 | 20 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS12980 | ladS;inference=COORDINATES | hybrid sensor histidine kinase/response regulator LadS | strong | 34 | 18 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS48305 | ladS;inference=COORDINATES | hybrid sensor histidine kinase/response regulator LadS | strong | 34 | 18 |
| | Azospirillum sp. SherDot2 | MPMX19_04589 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 33 | 20 |
| | Pseudomonas sp. S08-1 | OH686_09180 | | Two-component system sensor histidine kinase | strong | 32 | 18 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_13500 | | histidine kinase | sig. | 35 | 20 |
| | Methylophilus sp. DMC18 | GFF1954 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 33 | 22 |
| | Pseudomonas sp. S08-1 | OH686_23615 | | Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY | insig. | 39 | 17 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS18615 | | hypothetical protein | insig. | 34 | 20 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1559 | | Response regulator | strong | 34 | 20 |
| | Pseudomonas sp. DMC3 | GFF194 | | Sensor histidine kinase RcsC | cofit | 34 | 20 |
| | Caulobacter crescentus NA1000 | CCNA_02587 | | PAS-family sensor histidine kinase | cofit | 34 | 20 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02587 | | PAS-family sensor histidine kinase | cofit | 34 | 20 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS10445 | | response regulator | cofit | 33 | 20 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_19685 | | DNA-binding response regulator | insig. | 33 | 21 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS09170 | | response regulator | cofit | 32 | 20 |
| | Caulobacter crescentus NA1000 | CCNA_00632 | | chemotaxis receiver domain protein CheYII | insig. | 32 | 20 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00632 | | chemotaxis receiver domain protein CheYII | cofit | 32 | 20 |
| | Shewanella loihica PV-4 | Shew_3790 | | response regulator receiver modulated diguanylate cyclase (RefSeq) | insig. | 32 | 24 |
| | Azospirillum sp. SherDot2 | MPMX19_01591 | | Sensor histidine kinase RcsC | insig. | 32 | 24 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04993 | | response regulator receiver domain protein | insig. | 32 | 24 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS06370 | | response regulator | insig. | 32 | 20 |
| | Pseudomonas putida KT2440 | PP_1875 | | Sensor histidine kinase/response regulator | sig. | 30 | 20 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS12050 | | response regulator | insig. | 29 | 24 |
| | Rhodopseudomonas palustris CGA009 | TX73_022895 | | ATP-binding protein | sig. | 34 | 21 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_26115 | phoB | phosphate response regulator transcription factor PhoB | insig. | 33 | 21 |
| | Erwinia tracheiphila SCR3 | LU632_RS18925 | phoB | phosphate response regulator transcription factor PhoB | insig. | 33 | 21 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_03092 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | cofit | 32 | 23 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08430 | | response regulator | insig. | 32 | 21 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_2256 | | sensor histidine kinase/response regulator | strong | 29 | 20 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS04660 | | response regulator | cofit | 28 | 22 |
| | Lysobacter sp. OAE881 | ABIE51_RS01400 | | HAMP domain-containing protein | cofit | 36 | 18 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08885 | | response regulator | strong | 34 | 20 |
| | Dechlorosoma suillum PS | Dsui_1554 | | PAS domain S-box | cofit | 32 | 20 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1097 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 32 | 24 |
| | Shewanella oneidensis MR-1 | SO1558 | phoB | phosphate regulon response regulator PhoB (NCBI ptt file) | sig. | 35 | 21 |
| | Pseudomonas protegens RBAN4 | FABNJH_29350 | | histidine kinase | insig. | 34 | 20 |
| | Pseudomonas sp. SVBP6 | COO64_RS13630 | | Hpt domain-containing protein | insig. | 34 | 21 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS11200 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 33 | 24 |
| | Shewanella sp. ANA-3 | Shewana3_3418 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 32 | 25 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_181 | | Two-component response regulator | insig. | 32 | 21 |
| | Cellulophaga baltica 18 | M666_RS11820 | | response regulator | sig. | 31 | 23 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 31 | 24 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 31 | 24 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09315 | | PAS domain S-box protein | cofit | 30 | 20 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS14605 | | response regulator | insig. | 27 | 25 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS18295 | | response regulator | sig. | 27 | 25 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0637 | | Serine phosphatase RsbU, regulator of sigma subunit | strong | 25 | 43 |
| | Shewanella loihica PV-4 | Shew_3199 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 36 | 20 |
| | Lysobacter sp. OAE881 | ABIE51_RS00635 | | hybrid sensor histidine kinase/response regulator | strong | 30 | 24 |
| | Azospirillum sp. SherDot2 | MPMX19_06045 | | putative cyclic di-GMP phosphodiesterase | insig. | 26 | 32 |
| | Shewanella sp. ANA-3 | Shewana3_2879 | | two component transcriptional regulator (RefSeq) | insig. | 35 | 21 |
| | Pseudomonas simiae WCS417 | PS417_13905 | | chemotaxis protein CheY | sig. | 35 | 19 |
| | Rhizobium sp. OAE497 | ABIE40_RS02805 | | response regulator | insig. | 34 | 20 |
| | Acinetobacter radioresistens SK82 | MPMX26_02509 | | Sensor histidine kinase RcsC | cofit | 34 | 20 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS22750 | | response regulator transcription factor | insig. | 33 | 23 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS09670 | | cyclic di-GMP phosphodiesterase | sig. | 33 | 20 |
| | Alteromonas macleodii MIT1002 | MIT1002_01768 | | Cyclic di-GMP phosphodiesterase response regulator RpfG | insig. | 33 | 25 |
| | Alteromonas macleodii MIT1002 | MIT1002_00856 | | Autoinducer 2 sensor kinase/phosphatase LuxQ | cofit | 31 | 22 |
| | Pseudomonas segetis P6 | ACVTMO_RS11310 | | response regulator | cofit | 31 | 20 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_2271 | | Response regulator | insig. | 31 | 25 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_0509 | | PAS:GGDEF | insig. | 31 | 27 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_0509 | | PAS:GGDEF | insig. | 31 | 27 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS11775 | | response regulator | sig. | 29 | 26 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS03955 | | response regulator | insig. | 28 | 20 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS09500 | | response regulator | insig. | 28 | 20 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS12845 | | ATP-binding protein | insig. | 33 | 20 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4235 | | Phosphate regulon transcriptional regulatory protein PhoB (SphR) | insig. | 36 | 21 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS18990 | | response regulator | insig. | 35 | 19 |
| | Pseudomonas orientalis W4I3 | QF045_RS16040 | | response regulator | cofit | 35 | 19 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2373 | | multi-sensor hybrid histidine kinase (RefSeq) | cofit | 34 | 21 |
| | Mycobacterium tuberculosis H37Rv | Rv0757 | | Possible two component system response transcriptional positive regulator PhoP | sig. | 33 | 22 |
| | Rhizobium sp. OAE497 | ABIE40_RS07330 | | PleD family two-component system response regulator | cofit | 33 | 22 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_29680 | | cyclic di-GMP phosphodiesterase | insig. | 33 | 20 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS52375 | | cyclic di-GMP phosphodiesterase | insig. | 33 | 20 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_3687 | | Two-component regulator | insig. | 32 | 26 |
| | Xanthobacter sp. DMC5 | GFF4519 | | Chemotaxis protein CheY | no data | 30 | 20 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_01418 | | Signal transduction histidine kinase | insig. | 29 | 23 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_257 | | sensor histidine kinase/response regulator | strong | 28 | 20 |
| | Dechlorosoma suillum PS | Dsui_2864 | | signal transduction histidine kinase | cofit | 28 | 31 |
| | Pseudomonas sp. SVBP6 | COO64_RS05965 | | response regulator | cofit | 28 | 20 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS18310 | | PAS domain-containing protein | insig. | 40 | 15 |
| | Bosea sp. OAE506 | ABIE41_RS10985 | | response regulator | insig. | 34 | 20 |
| | Lysobacter sp. OAE881 | ABIE51_RS11560 | | two-component system response regulator | strong | 33 | 23 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0046 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | sig. | 32 | 21 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS12370 | | response regulator transcription factor | insig. | 32 | 21 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS12370 | | response regulator transcription factor | insig. | 32 | 21 |
| | Pseudomonas simiae WCS417 | PS417_11585 | | LuxR family transcriptional regulator | insig. | 32 | 21 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c01150 | | transcriptional regulatory protein ChvI | strong | 31 | 24 |
| | Phaeobacter inhibens DSM 17395 | PGA1_262p02260 | | putative two-component sensor histidine kinase/response regulator hybrid protein | sig. | 30 | 20 |
| | Shewanella loihica PV-4 | Shew_0459 | | PAS/PAC sensor hybrid histidine kinase (RefSeq) | strong | 30 | 18 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS15110 | | response regulator | insig. | 28 | 20 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09305 | | two-component system response regulator | insig. | 26 | 40 |
| | Caulobacter crescentus NA1000 | CCNA_02715 | | MASE1-family sensor histidine kinase | strong | 32 | 20 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02715 | | MASE1-family sensor histidine kinase | cofit | 32 | 20 |
| | Pseudomonas sp. DMC3 | GFF2890 | | Sensor histidine kinase RcsC | cofit | 35 | 19 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_01420 | | Histidine kinase | cofit | 34 | 20 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS15320 | | phosphate regulon transcriptional regulatory protein PhoB | insig. | 33 | 21 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS05390 | | response regulator | insig. | 33 | 21 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4182 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 30 | 24 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS05130 | | response regulator | insig. | 27 | 26 |
| | Shewanella amazonensis SB2B | Sama_1074 | | response regulator receiver protein (RefSeq) | insig. | 33 | 21 |
| | Alteromonas macleodii MIT1002 | MIT1002_03504 | | Stalked cell differentiation-controlling protein | insig. | 33 | 23 |
| | Paraburkholderia graminis OAS925 | ABIE53_004362 | | DNA-binding response OmpR family regulator | insig. | 33 | 23 |
| | Ralstonia solanacearum GMI1000 | RS_RS07695 | | phosphate regulon transcriptional regulatory protein PhoB | strong | 33 | 21 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04977 | | response regulator receiver domain protein | cofit | 32 | 24 |
| | Pseudomonas sp. SVBP6 | COO64_RS17585 | | bifunctional diguanylate cyclase/phosphodiesterase | insig. | 31 | 27 |
| | Pseudomonas sp. S08-1 | OH686_22595 | | Sensor histidine kinase/response regulator | cofit | 31 | 20 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4178 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 31 | 24 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS08365 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 30 | 20 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS17625 | | EAL domain-containing protein | strong | 31 | 21 |
| | Variovorax sp. OAS795 | ABID97_RS14620 | | phosphate regulon transcriptional regulator PhoB | insig. | 35 | 24 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS14710 | | response regulator | sig. | 34 | 19 |