| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Pseudomonas simiae WCS417 | 1.0 | PS417_27035 | | FAD-linked oxidase | 1.0 | PS417_23110 | | 2-isopropylmalate synthase | 0.53 | 12 |
| Pseudomonas fluorescens SBW25-INTG | 0.99 | PFLU_RS28690 | | FAD-binding oxidoreductase | 1.00 | PFLU_RS24765 | | 2-isopropylmalate synthase | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.99 | PFLU_RS28690 | | FAD-binding oxidoreductase | 1.00 | PFLU_RS24765 | | 2-isopropylmalate synthase | low | > 109 |
| Pseudomonas orientalis W4I3 | 0.99 | QF045_RS01425 | | FAD-binding oxidoreductase | 0.99 | QF045_RS25330 | | 2-isopropylmalate synthase | low | > 93 |
| Pseudomonas lactucae CFBP13502 | 0.99 | GEMAOFIL_05547 | | putative FAD-linked oxidoreductase | 0.99 | GEMAOFIL_04774 | | 2-isopropylmalate synthase | low | > 96 |
| Pseudomonas fluorescens GW456-L13 | 0.97 | PfGW456L13_944 | | D-2-hydroxyglutarate dehydrogenase | 0.94 | PfGW456L13_4854 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.51 | 31 |
| Pseudomonas fluorescens FW300-N1B4 | 0.97 | Pf1N1B4_2274 | | D-2-hydroxyglutarate dehydrogenase | 0.95 | Pf1N1B4_847 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 87 |
| Pseudomonas fluorescens FW300-N2C3 | 0.97 | AO356_10305 | | FAD-linked oxidase | 0.93 | AO356_06550 | | 2-isopropylmalate synthase | low | > 104 |
| Pseudomonas fluorescens FW300-N2E2 | 0.97 | Pf6N2E2_3933 | | D-2-hydroxyglutarate dehydrogenase | 0.93 | Pf6N2E2_3170 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.55 | 12 |
| Pseudomonas fluorescens FW300-N2E3 | 0.97 | AO353_08505 | | FAD-linked oxidase | 0.94 | AO353_15925 | | 2-isopropylmalate synthase | 0.60 | 5 |
| Pseudomonas sp. DMC3 | 0.96 | GFF273 | | putative FAD-linked oxidoreductase | 0.94 | GFF4332 | | 2-isopropylmalate synthase | 0.58 | 72 |
| Pseudomonas sp. RS175 | 0.96 | PFR28_04841 | | putative FAD-linked oxidoreductase | 0.93 | PFR28_00305 | | 2-isopropylmalate synthase | low | > 88 |
| Pseudomonas stutzeri RCH2 | 0.91 | Psest_3872 | | FAD/FMN-containing dehydrogenases | 0.81 | Psest_1277 | | 2-isopropylmalate synthase, yeast type | 0.31 | 50 |
| Pseudomonas segetis P6 | 0.91 | MPMX49_00576 | | putative FAD-linked oxidoreductase | 0.80 | MPMX49_01526 | | 2-isopropylmalate synthase | 0.80 | 17 |
| Pseudomonas sp. SVBP6 | 0.91 | COO64_RS12645 | | FAD-binding oxidoreductase | 0.91 | COO64_RS04630 | leuA | 2-isopropylmalate synthase | low | > 93 |
| Pseudomonas aeruginosa MRSN321 | 0.90 | DY961_RS21540 | | FAD-binding oxidoreductase | 0.81 | DY961_RS13960 | leuA;go_function=2-isopropylmalate | 2-isopropylmalate synthase | 0.60 | 3 |
| Pseudomonas aeruginosa PUPa3 | 0.90 | DQ20_RS37750 | | FAD-binding oxidoreductase | 0.81 | DQ20_RS43140 | leuA;go_function=2-isopropylmalate | 2-isopropylmalate synthase | 0.46 | 26 |
| Pseudomonas aeruginosa PA14 | 0.90 | IKLFDK_23855 | | FAD-binding oxidoreductase | 0.81 | IKLFDK_19530 | | 2-isopropylmalate synthase | 0.71 | 1 |
| Pseudomonas syringae pv. syringae B728a | 0.90 | Psyr_4851 | | FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal | 0.89 | Psyr_1257 | | 2-isopropylmalate synthase | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.90 | Psyr_4851 | | FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal | 0.89 | Psyr_1257 | | 2-isopropylmalate synthase | low | > 86 |
| Pseudomonas sp. S08-1 | 0.90 | OH686_11285 | | D-2-hydroxyglutarate dehydrogenase | 0.77 | OH686_17570 | | 2-isopropylmalate synthase | low | > 80 |
| Pseudomonas sp. BP01 | 0.88 | JOY50_RS20620 | | FAD-binding oxidoreductase | 0.90 | JOY50_RS11470 | leuA | 2-isopropylmalate synthase | low | > 84 |
| Pseudomonas putida KT2440 | 0.87 | PP_5154 | | putative Oxidoreductase, FAD-binding | 0.91 | PP_1025 | | 2-isopropylmalate synthase | low | > 96 |
| Marinobacter adhaerens HP15 | 0.72 | HP15_2553 | | oxidoreductase, FAD-binding protein | 0.52 | HP15_2055 | | 2-isopropylmalate synthase | — | — |
| Acinetobacter radioresistens SK82 | 0.71 | MPMX26_02772 | | putative FAD-linked oxidoreductase | 0.60 | MPMX26_00404 | | 2-isopropylmalate synthase | 0.75 | 26 |
| Acinetobacter baumannii LAC-4 | 0.70 | RR41_RS01770 | | FAD-binding oxidoreductase | 0.59 | RR41_RS16605 | | 2-isopropylmalate synthase | low | > 55 |
| Rhodanobacter denitrificans MT42 | 0.55 | LRK55_RS02930 | | FAD-binding oxidoreductase | 0.09 | LRK55_RS09985 | | 2-isopropylmalate synthase | low | > 63 |
| Rhodanobacter sp. FW510-T8 | 0.55 | OKGIIK_10050 | glcD | FAD-binding oxidoreductase | 0.09 | OKGIIK_13575 | leuA | 2-isopropylmalate synthase | 0.90 | 16 |
| Rhodanobacter denitrificans FW104-10B01 | 0.55 | LRK54_RS03180 | | FAD-binding oxidoreductase | 0.09 | LRK54_RS10345 | | 2-isopropylmalate synthase | 0.63 | 23 |
| Rhodanobacter sp000427505 FW510-R12 | 0.54 | LRK53_RS06800 | | FAD-binding oxidoreductase | 0.09 | LRK53_RS03120 | | 2-isopropylmalate synthase | 0.49 | 55 |
| Dyella japonica UNC79MFTsu3.2 | 0.53 | ABZR86_RS09630 | | FAD-binding oxidoreductase | 0.09 | ABZR86_RS15970 | | 2-isopropylmalate synthase | 0.90 | 4 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.52 | Xcc-8004.2929.1 | | D-2-hydroxyglutarate dehydrogenase | 0.10 | Xcc-8004.1056.1 | | 2-isopropylmalate synthase (EC 2.3.3.13) | 0.64 | 60 |
| Lysobacter sp. OAE881 | 0.51 | ABIE51_RS13240 | | FAD-binding oxidoreductase | 0.09 | ABIE51_RS17570 | | 2-isopropylmalate synthase | low | > 62 |
| Rhodopseudomonas palustris CGA009 | 0.32 | TX73_005530 | | FAD-binding oxidoreductase | 0.56 | TX73_024250 | | 2-isopropylmalate synthase | low | > 86 |
| Herbaspirillum seropedicae SmR1 | 0.32 | HSERO_RS16560 | | 2-hydroxyacid dehydrogenase | 0.66 | HSERO_RS17185 | | 2-isopropylmalate synthase | low | > 78 |
| Variovorax sp. SCN45 | 0.32 | GFF3000 | | D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.2) | 0.60 | GFF1164 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 127 |
| Variovorax sp. OAS795 | 0.32 | ABID97_RS10060 | | FAD-binding oxidoreductase | 0.59 | ABID97_RS14905 | | 2-isopropylmalate synthase | low | > 91 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.32 | H281DRAFT_04480 | | FAD/FMN-containing dehydrogenase | 0.62 | H281DRAFT_00385 | | 2-isopropylmalate synthase | low | > 103 |
| Burkholderia phytofirmans PsJN | 0.32 | BPHYT_RS13750 | | D-2-hydroxyacid dehydrogenase | 0.63 | BPHYT_RS13280 | | 2-isopropylmalate synthase | low | > 109 |
| Azospirillum sp. SherDot2 | 0.31 | MPMX19_06983 | | putative FAD-linked oxidoreductase | 0.56 | MPMX19_01822 | | 2-isopropylmalate synthase | low | > 112 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.31 | GFF5251 | | D-2-hydroxyglutarate dehydrogenase | 0.61 | GFF4280 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 90 |
| Paraburkholderia sabiae LMG 24235 | 0.31 | QEN71_RS05170 | | FAD-binding oxidoreductase | 0.57 | QEN71_RS01640 | | 2-isopropylmalate synthase | low | > 153 |
| Azospirillum brasilense Sp245 | 0.31 | AZOBR_RS29745 | | 2-hydroxyacid dehydrogenase | 0.55 | AZOBR_RS12155 | | 2-isopropylmalate synthase | low | > 97 |
| Acidovorax sp. GW101-3H11 | 0.31 | Ac3H11_2934 | | D-2-hydroxyglutarate dehydrogenase | 0.54 | Ac3H11_5000 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 79 |
| Castellaniella sp019104865 MT123 | 0.30 | ABCV34_RS09275 | | FAD-binding oxidoreductase | 0.60 | ABCV34_RS12420 | | 2-isopropylmalate synthase | — | — |
| Rhizobium sp. OAE497 | 0.30 | ABIE40_RS21615 | | FAD-binding oxidoreductase | 0.50 | ABIE40_RS13330 | | 2-isopropylmalate synthase | low | > 107 |
| Paraburkholderia graminis OAS925 | 0.30 | ABIE53_002925 | | FAD/FMN-containing dehydrogenase | 0.61 | ABIE53_002867 | | 2-isopropylmalate synthase | low | > 113 |
| Cupriavidus basilensis FW507-4G11 | 0.30 | RR42_RS06435 | | 2-hydroxyacid dehydrogenase | 0.62 | RR42_RS21205 | | 2-isopropylmalate synthase | low | > 128 |
| Sinorhizobium meliloti 1021 | 0.30 | SMa0244 | | Dehydrogenase, FAD-dependent | 0.52 | SMc02717 | | 2-isopropylmalate synthase | low | > 103 |
| Ralstonia sp. UNC404CL21Col | 0.29 | ABZR87_RS13840 | | FAD-binding oxidoreductase | 0.62 | ABZR87_RS22365 | | 2-isopropylmalate synthase | low | > 80 |
| Ralstonia solanacearum GMI1000 | 0.29 | RS_RS07835 | | FAD-binding oxidoreductase | 0.62 | RS_RS18695 | | 2-isopropylmalate synthase 2 | low | > 80 |
| Dechlorosoma suillum PS | 0.29 | Dsui_2542 | | FAD/FMN-dependent dehydrogenase | 0.59 | Dsui_3227 | | 2-isopropylmalate synthase | — | — |
| Xanthobacter sp. DMC5 | 0.29 | GFF1911 | | putative FAD-linked oxidoreductase | 0.09 | GFF2400 | | 2-isopropylmalate synthase | — | — |
| Ralstonia solanacearum PSI07 | 0.29 | RPSI07_RS15590 | | FAD-binding oxidoreductase | 0.63 | RPSI07_RS01320 | | 2-isopropylmalate synthase | low | > 81 |
| Ralstonia solanacearum UW163 | 0.29 | UW163_RS15210 | | FAD-binding oxidoreductase | 0.64 | UW163_RS17345 | | 2-isopropylmalate synthase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.29 | RALBFv3_RS01900 | | FAD-binding oxidoreductase | 0.64 | RALBFv3_RS21840 | | 2-isopropylmalate synthase | low | > 76 |
| Rhodospirillum rubrum S1H | 0.28 | Rru_A0442 | | FAD linked oxidase-like (NCBI) | 0.55 | Rru_A1461 | | 2-isopropylmalate synthase (RefSeq) | — | — |
| Bosea sp. OAE506 | 0.28 | ABIE41_RS22250 | | FAD-binding oxidoreductase | 0.11 | ABIE41_RS13000 | | 2-isopropylmalate synthase | low | > 77 |
| Sphingobium sp. HT1-2 | 0.28 | GFF3483 | | D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.2) | 0.60 | GFF2060 | | 2-isopropylmalate synthase (EC 2.3.3.13) | low | > 95 |
| Magnetospirillum magneticum AMB-1 | 0.27 | AMB_RS18795 | | FAD-binding oxidoreductase | 0.56 | AMB_RS17550 | | 2-isopropylmalate synthase | — | — |
| Agrobacterium fabrum C58 | 0.26 | Atu2739 | | oxidoreductase | 0.53 | Atu2264 | | 2-isopropylmalate synthase | low | > 89 |
| Sphingomonas koreensis DSMZ 15582 | 0.26 | Ga0059261_1572 | | FAD/FMN-containing dehydrogenases | 0.57 | Ga0059261_4031 | | 2-isopropylmalate synthase, yeast type | — | — |
| Caulobacter crescentus NA1000 Δfur | 0.26 | CCNA_03500 | | FAD/FMN-containing dehydrogenase | 0.09 | CCNA_01610 | | 2-isopropylmalate synthase | low | > 67 |
| Caulobacter crescentus NA1000 | 0.26 | CCNA_03500 | | FAD/FMN-containing dehydrogenase | 0.09 | CCNA_01610 | | 2-isopropylmalate synthase | low | > 66 |
| Desulfovibrio vulgaris Miyazaki F | 0.25 | DvMF_1567 | | D-lactate dehydrogenase (cytochrome) (RefSeq) | 0.11 | DvMF_1791 | | 2-isopropylmalate synthase (RefSeq) | low | > 51 |
| Desulfovibrio vulgaris Hildenborough JW710 | 0.24 | DVU0827 | | glycolate oxidase, subunit GlcD, putative (TIGR) | 0.10 | DVU2981 | leuA | 2-isopropylmalate synthase (TIGR) | 0.18 | 40 |
| Dinoroseobacter shibae DFL-12 | 0.24 | Dshi_2076 | | FAD linked oxidase domain protein (RefSeq) | 0.09 | Dshi_0596 | | 2-isopropylmalate synthase (RefSeq) | — | — |
| Phaeobacter inhibens DSM 17395 | 0.23 | PGA1_c06340 | | putative FAD linked oxidase | 0.09 | PGA1_c26470 | | 2-isopropylmalate synthase LeuA | — | — |
| Mycobacterium tuberculosis H37Rv | 0.22 | Rv0161 | | Possible oxidoreductase | 0.51 | Rv3710 | | 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS) | — | — |
| Synechocystis sp000284455 PCC 6803 | 0.20 | SGL_RS13765 | | glycolate oxidase subunit GlcD | 0.09 | SGL_RS12850 | | 2-isopropylmalate synthase | — | — |
| Synechococcus elongatus PCC 7942 | 0.19 | Synpcc7942_0276 | glcD | glycolate oxidase subunit GlcD | 0.09 | Synpcc7942_1410 | leuA | 2-isopropylmalate synthase | — | — |
| Escherichia coli Nissle 1917 | 0.18 | ECOLIN_RS17140 | | glycolate oxidase subunit GlcD | 0.09 | ECOLIN_RS00400 | | 2-isopropylmalate synthase | low | > 55 |
| Escherichia coli BL21 | 0.18 | ECD_02848 | | glycolate oxidase subunit, FAD-linked | 0.09 | ECD_00076 | | 2-isopropylmalate synthase | low | > 61 |
| Escherichia coli ECOR38 | 0.18 | HEPCGN_17995 | glcD | glycolate oxidase subunit GlcD | 0.09 | HEPCGN_08695 | | 2-isopropylmalate synthase | low | > 88 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.18 | OHPLBJKB_00727 | | putative FAD-linked oxidoreductase | 0.09 | OHPLBJKB_03583 | | 2-isopropylmalate synthase | low | > 74 |
| Escherichia fergusonii Becca | 0.18 | EFB2_00835 | | putative FAD-linked oxidoreductase | 0.09 | EFB2_03971 | | 2-isopropylmalate synthase | low | > 86 |
| Escherichia coli BW25113 | 0.18 | b2979 | glcD | glycolate dehydrogenase, putative FAD-linked subunit (from data) | 0.09 | b0074 | leuA | 2-isopropylmalate synthase (NCBI) | low | > 76 |
| Escherichia coli ECOR27 | 0.18 | NOLOHH_10920 | glcD | glycolate oxidase subunit GlcD | 0.09 | NOLOHH_03060 | | 2-isopropylmalate synthase | low | > 76 |
| Escherichia coli ECRC62 | 0.18 | BNILDI_00595 | glcD | glycolate oxidase subunit GlcD | 0.09 | BNILDI_08550 | | 2-isopropylmalate synthase | low | > 75 |
| Escherichia coli ECRC102 | 0.12 | NIAGMN_18090 | ygcU | Uncharacterized FAD-linked oxidoreductase YgcU | 0.09 | NIAGMN_08565 | | 2-isopropylmalate synthase | low | > 80 |
| Escherichia coli ECRC100 | 0.12 | OKFHMN_20320 | ygcU | Uncharacterized FAD-linked oxidoreductase YgcU | 0.09 | OKFHMN_10715 | | 2-isopropylmalate synthase | low | > 79 |
| Escherichia coli ECRC101 | 0.12 | MCAODC_10845 | ygcU | Uncharacterized FAD-linked oxidoreductase YgcU | 0.09 | MCAODC_01230 | | 2-isopropylmalate synthase | low | > 87 |
| Escherichia coli ECRC98 | 0.12 | JDDGAC_23985 | ygcU | Uncharacterized FAD-linked oxidoreductase YgcU | 0.09 | JDDGAC_14310 | | 2-isopropylmalate synthase | low | > 87 |
| Escherichia coli ECRC99 | 0.12 | KEDOAH_07810 | ygcU | Uncharacterized FAD-linked oxidoreductase YgcU | 0.09 | KEDOAH_17440 | | 2-isopropylmalate synthase | — | — |
Not shown: 6 genomes with orthologs for PS417_27035 only; 31 genomes with orthologs for PS417_23110 only