Conservation of cofitness between BWI76_RS19375 and BWI76_RS21360 in Klebsiella michiganensis M5al

80 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS21360 L-aspartate oxidase 0.26 9
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 NIAGMN_19140 nadB L-aspartate oxidase — —
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 OKFHMN_21370 nadB L-aspartate oxidase 0.84 31
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 KEDOAH_06850 nadB L-aspartate oxidase — —
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 JDDGAC_25035 nadB L-aspartate oxidase low > 86
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 MCAODC_11900 nadB L-aspartate oxidase 0.84 2
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 NOLOHH_13045 nadB L-aspartate oxidase 0.74 22
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.89 b2574 nadB L-aspartate oxidase (NCBI) 0.55 14
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 BNILDI_11845 nadB L-aspartate oxidase 0.82 4
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.89 OHPLBJKB_01133 L-aspartate oxidase low > 73
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.89 ECD_02468 quinolinate synthase, L-aspartate oxidase (B protein) subunit low > 61
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.88 EFB2_01322 L-aspartate oxidase low > 86
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 HEPCGN_20515 nadB L-aspartate oxidase 0.81 27
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.88 ECOLIN_RS14570 L-aspartate oxidase — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.90 MPMX20_03445 L-aspartate oxidase low > 85
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 EX28DRAFT_0071 L-aspartate oxidase (EC 1.4.3.16) 0.64 4
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.87 GFF2106 L-aspartate oxidase (EC 1.4.3.16) low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 HER17_RS05775 L-aspartate oxidase low > 75
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 IAI46_19590 L-aspartate oxidase low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.81 EX31_RS21795 L-aspartate oxidase 0.36 63
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.80 HGI48_RS15855 L-aspartate oxidase 0.78 32
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.80 DDA3937_RS15770 L-aspartate oxidase 0.72 27
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.80 DZA65_RS16935 L-aspartate oxidase 0.81 16
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 IAI47_04845 L-aspartate oxidase low > 76
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 QEN71_RS03070 L-aspartate oxidase — —
Paraburkholderia bryophila 376MFSha3.1 0.54 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase 0.58 H281DRAFT_04069 L-aspartate oxidase — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.58 BPHYT_RS15640 L-aspartate oxidase — —
Paraburkholderia graminis OAS925 0.50 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.58 ABIE53_003292 L-aspartate oxidase — —
Rhizobium sp. OAE497 0.50 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 ABIE40_RS23260 L-aspartate oxidase low > 107
Rhodopseudomonas palustris CGA009 0.48 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.26 TX73_005420 L-aspartate oxidase — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.24 Atu4097 L-aspartate oxidase 0.82 7
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.53 ABCV34_RS03690 L-aspartate oxidase — —
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 HMPREF1078_RS06605 L-aspartate oxidase — —
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.29 SMc02599 L-aspartate oxidase low > 103
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.75 CSW01_12495 L-aspartate oxidase low > 62
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 HMPREF1058_RS11085 L-aspartate oxidase — —
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 ABI39_RS05945 L-aspartate oxidase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.38 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.55 GFF1214 L-aspartate oxidase (EC 1.4.3.16) low > 90
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 HMPREF1181_RS01800 L-aspartate oxidase — —
Rhodospirillum rubrum S1H 0.37 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) 0.25 Rru_A1433 L-aspartate oxidase (NCBI) — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.43 BT3184 L-aspartate oxidase (NCBI ptt file) 0.43 16
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 RS_RS12285 L-aspartate oxidase — —
Azospirillum brasilense Sp245 0.36 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.20 AZOBR_RS18685 L-aspartate oxidase — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 ABZR87_RS00345 L-aspartate oxidase — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 RALBFv3_RS04725 L-aspartate oxidase — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 UW163_RS08945 L-aspartate oxidase — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 RPSI07_RS12660 L-aspartate oxidase — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.53 ABID97_RS07440 L-aspartate oxidase — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.42 BACOVA_02888 L-aspartate oxidase 0.73 31
Bifidobacterium breve UCC2003 0.34 BBR_RS17215 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.28 BBR_RS16725 L-aspartate oxidase low > 34
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.44 CA265_RS21185 L-aspartate oxidase low > 88
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.28 MPMX19_05671 L-aspartate oxidase — —
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.53 Ac3H11_3824 L-aspartate oxidase (EC 1.4.3.16) — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.58 RR42_RS17010 L-aspartate oxidase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.44 ABZR88_RS20645 L-aspartate oxidase — —
Caulobacter crescentus NA1000 Δfur 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.21 CCNA_03007 L-aspartate oxidase — —
Caulobacter crescentus NA1000 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.21 CCNA_03007 L-aspartate oxidase — —
Magnetospirillum magneticum AMB-1 0.30 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.56 AMB_RS19650 L-aspartate oxidase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.20 A4249_RS00630 L-aspartate oxidase — —
Desulfovibrio vulgaris Miyazaki F 0.28 DvMF_1376 phosphomethylpyrimidine kinase (RefSeq) 0.34 DvMF_0526 L-aspartate oxidase (RefSeq) — —
Desulfovibrio vulgaris Hildenborough JW710 0.28 DVU0931 thiD phosphomethylpyrimidine kinase (TIGR) 0.34 DVU1809 nadB L-aspartate oxidase (TIGR) — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.56 Dsui_2452 L-aspartate oxidase — —
Sphingomonas koreensis DSMZ 15582 0.24 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.52 Ga0059261_2248 L-aspartate oxidase (EC 1.4.3.16) — —
Mycobacterium tuberculosis H37Rv 0.24 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.25 Rv1595 Probable L-aspartate oxidase NadB — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.63 PFLU_RS07225 L-aspartate oxidase low > 109
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.63 PFLU_RS07225 L-aspartate oxidase low > 109
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.63 PS417_07115 L-aspartate oxidase low > 88
Synechococcus elongatus PCC 7942 0.23 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.32 Synpcc7942_1881 nadB L-aspartate oxidase low > 38
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.64 PP_1426 L-aspartate oxidase 0.52 26
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.63 PfGW456L13_4517 L-aspartate oxidase (EC 1.4.3.16) low > 87
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.64 AO353_17620 L-aspartate oxidase 0.28 68
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.63 AO356_04580 L-aspartate oxidase low > 104
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.64 Psest_3101 L-aspartate oxidase low > 67
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.64 Psyr_3959 L-aspartate oxidase low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.64 Psyr_3959 L-aspartate oxidase low > 86
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.59 MPMX26_02162 L-aspartate oxidase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.64 PFR28_00689 L-aspartate oxidase 0.40 25
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.63 Pf1N1B4_3322 L-aspartate oxidase (EC 1.4.3.16) low > 87
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.57 HSERO_RS11085 L-aspartate oxidase 0.39 33
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.61 Pf6N2E2_2758 L-aspartate oxidase (EC 1.4.3.16) low > 103
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.22 PGA1_c27800 L-aspartate oxidase NadB low > 62

Not shown: 8 genomes with orthologs for BWI76_RS19375 only; 9 genomes with orthologs for BWI76_RS21360 only