Conservation of cofitness between BWI76_RS19375 and BWI76_RS04845 in Klebsiella michiganensis M5al

85 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS04845 nicotinate-nucleotide pyrophosphorylase 0.26 10
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 JDDGAC_14125 nadC carboxylating nicotinate-nucleotide diphosphorylase low > 86
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 NIAGMN_08380 nadC carboxylating nicotinate-nucleotide diphosphorylase — —
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 OKFHMN_10530 nadC carboxylating nicotinate-nucleotide diphosphorylase 0.84 35
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 KEDOAH_17625 nadC carboxylating nicotinate-nucleotide diphosphorylase — —
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 MCAODC_01045 nadC carboxylating nicotinate-nucleotide diphosphorylase 0.84 4
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.82 b0109 nadC nicotinate-nucleotide pyrophosphorylase (NCBI) 0.54 17
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.82 OHPLBJKB_03552 Nicotinate-nucleotide pyrophosphorylase [carboxylating] low > 73
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 NOLOHH_02875 nadC carboxylating nicotinate-nucleotide diphosphorylase 0.68 43
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 BNILDI_08735 nadC carboxylating nicotinate-nucleotide diphosphorylase 0.73 28
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.82 ECD_00108 quinolinate phosphoribosyltransferase low > 61
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.83 EFB2_03940 Nicotinate-nucleotide pyrophosphorylase [carboxylating] low > 86
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 HEPCGN_08510 nadC carboxylating nicotinate-nucleotide diphosphorylase 0.84 18
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 ECOLIN_RS00585 carboxylating nicotinate-nucleotide diphosphorylase — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.84 MPMX20_00800 Nicotinate-nucleotide pyrophosphorylase [carboxylating] low > 85
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 EX28DRAFT_3702 nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) 0.54 39
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.87 GFF130 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.69 HER17_RS03250 carboxylating nicotinate-nucleotide diphosphorylase low > 75
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.72 IAI46_03530 carboxylating nicotinate-nucleotide diphosphorylase low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 EX31_RS03515 carboxylating nicotinate-nucleotide diphosphorylase low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 HGI48_RS17890 carboxylating nicotinate-nucleotide diphosphorylase low > 71
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.69 DDA3937_RS17955 carboxylating nicotinate-nucleotide diphosphorylase 0.73 21
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 DZA65_RS19035 carboxylating nicotinate-nucleotide diphosphorylase 0.83 10
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.67 LU632_RS03040 nadC carboxylating nicotinate-nucleotide diphosphorylase low > 74
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 IAI47_15845 carboxylating nicotinate-nucleotide diphosphorylase low > 76
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 QEN71_RS03065 carboxylating nicotinate-nucleotide diphosphorylase — —
Paraburkholderia bryophila 376MFSha3.1 0.54 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase 0.42 H281DRAFT_04070 nicotinate-nucleotide pyrophosphorylase [carboxylating] — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.42 BPHYT_RS15645 nicotinate-nucleotide pyrophosphorylase — —
Paraburkholderia graminis OAS925 0.50 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.43 ABIE53_003293 nicotinate-nucleotide pyrophosphorylase (carboxylating) — —
Rhizobium sp. OAE497 0.50 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.34 ABIE40_RS23265 carboxylating nicotinate-nucleotide diphosphorylase low > 107
Rhodopseudomonas palustris CGA009 0.48 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.37 TX73_005415 carboxylating nicotinate-nucleotide diphosphorylase — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.33 Atu4096 nicotinate-nucleotide pyrophosphorylase 0.86 4
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 ABCV34_RS03695 carboxylating nicotinate-nucleotide diphosphorylase — —
Bosea sp. OAE506 0.44 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 ABIE41_RS02500 carboxylating nicotinate-nucleotide diphosphorylase — —
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.33 HMPREF1078_RS16725 carboxylating nicotinate-nucleotide diphosphorylase — —
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.27 SMc02598 nicotinate-nucleotide pyrophosphorylase carboxylating protein low > 103
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 CSW01_12265 carboxylating nicotinate-nucleotide diphosphorylase low > 62
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 HMPREF1058_RS15940 carboxylating nicotinate-nucleotide diphosphorylase — —
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 ABI39_RS11900 carboxylating nicotinate-nucleotide diphosphorylase — —
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 HMPREF1181_RS10745 carboxylating nicotinate-nucleotide diphosphorylase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.38 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 GFF1217 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) low > 90
Rhodospirillum rubrum S1H 0.37 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) 0.35 Rru_A1432 Nicotinate-nucleotide pyrophosphorylase (NCBI) — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.30 BT1560 nicotinate-nucleotide pyrophosphorylase (NCBI ptt file) — —
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 RS_RS12290 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 ABZR87_RS00350 carboxylating nicotinate-nucleotide diphosphorylase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.36 Echvi_0215 phosphomethylpyrimidine kinase 0.30 Echvi_1158 nicotinate-nucleotide pyrophosphorylase low > 79
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 RALBFv3_RS04730 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 UW163_RS08940 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 RPSI07_RS12655 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.37 ABID97_RS07410 carboxylating nicotinate-nucleotide diphosphorylase — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.31 BACOVA_04303 nicotinate-nucleotide diphosphorylase (carboxylating) 0.76 14
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 CA265_RS14530 nicotinate-nucleotide diphosphorylase (carboxylating) low > 88
Bifidobacterium breve UCC2003 0.34 BBR_RS17215 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 BBR_RS16720 nicotinate-nucleotide diphosphorylase (carboxylating) low > 34
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.32 MPMX19_05672 putative nicotinate-nucleotide pyrophosphorylase [carboxylating] — —
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 Ac3H11_3838 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.41 RR42_RS17015 nicotinate-nucleotide pyrophosphorylase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 ABZR88_RS15695 carboxylating nicotinate-nucleotide diphosphorylase — —
Caulobacter crescentus NA1000 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.33 CCNA_03009 nicotinate-nucleotide pyrophosphorylase — —
Caulobacter crescentus NA1000 Δfur 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.33 CCNA_03009 nicotinate-nucleotide pyrophosphorylase — —
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.3091.1 hypothetical protein 0.35 Xcc-8004.2009.1 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) low > 74
Fusobacterium nucleatum SB010 0.30 HUW76_10300 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 HUW76_10730 carboxylating nicotinate-nucleotide diphosphorylase low > 35
Magnetospirillum magneticum AMB-1 0.30 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.38 AMB_RS19655 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.46 ABZR86_RS09850 carboxylating nicotinate-nucleotide diphosphorylase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.32 A4249_RS00635 carboxylating nicotinate-nucleotide diphosphorylase — —
Desulfovibrio vulgaris Hildenborough JW710 0.28 DVU0931 thiD phosphomethylpyrimidine kinase (TIGR) 0.29 DVU1807 nadC nicotinate-nucleotide pyrophosphorylase (TIGR) — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.45 Dsui_2901 nicotinate-nucleotide pyrophosphorylase — —
Sphingomonas koreensis DSMZ 15582 0.24 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.29 Ga0059261_0061 nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) — —
Mycobacterium tuberculosis H37Rv 0.24 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.31 Rv1596 Probable nicotinate-nucleotide pyrophosphatase NadC — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.49 PFLU_RS03970 carboxylating nicotinate-nucleotide diphosphorylase 0.73 80
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.49 PFLU_RS03970 carboxylating nicotinate-nucleotide diphosphorylase 0.50 9
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.48 PS417_03925 nicotinate-nucleotide pyrophosphorylase low > 88
Synechococcus elongatus PCC 7942 0.23 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.30 Synpcc7942_0951 nadC nicotinate-nucleotide pyrophosphorylase low > 38
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.49 PP_0787 quinolinate phosphoribosyltransferase (decarboxylating) monomer 0.70 6
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.47 PfGW456L13_5082 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) low > 87
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.49 AO353_05520 nicotinate-nucleotide pyrophosphorylase 0.44 17
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.48 AO356_07370 nicotinate-nucleotide pyrophosphorylase low > 104
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.52 Psest_0718 nicotinate-nucleotide pyrophosphorylase 0.35 12
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.51 Psyr_0815 nicotinate-nucleotide pyrophosphorylase (carboxylating) low > 86
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.51 Psyr_0815 nicotinate-nucleotide pyrophosphorylase (carboxylating) low > 86
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.47 MPMX26_00042 Nicotinate-nucleotide pyrophosphorylase [carboxylating] — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.49 PFR28_00098 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0.66 7
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.31 CA264_16940 nicotinate-nucleotide diphosphorylase (carboxylating) — —
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.48 Pf1N1B4_1153 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) 0.30 20
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.40 HSERO_RS11070 nicotinate-nucleotide pyrophosphorylase 0.37 52
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.47 Pf6N2E2_3346 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) low > 103
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.29 PGA1_c27810 nicotinate-nucleotide pyrophosphorylase low > 62

Not shown: 3 genomes with orthologs for BWI76_RS19375 only; 13 genomes with orthologs for BWI76_RS04845 only