Conservation of cofitness between BWI76_RS19375 and BWI76_RS01535 in Klebsiella michiganensis M5al

83 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS01535 thiazole synthase 0.29 6
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 NIAGMN_11145 thiG thiazole synthase — —
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 JDDGAC_17020 thiG thiazole synthase low > 86
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 KEDOAH_14765 thiG thiazole synthase — —
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 OKFHMN_13395 thiG thiazole synthase low > 80
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 MCAODC_03895 thiG thiazole synthase 0.79 13
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 BNILDI_05985 thiG thiazole synthase low > 75
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 NOLOHH_05540 thiG thiazole synthase 0.89 4
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.91 OHPLBJKB_04060 Thiazole synthase low > 73
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.91 b3991 thiG thiamin biosynthesis, thiazole moiety (VIMSS) 0.87 4
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.91 EFB2_04621 Thiazole synthase low > 86
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.91 ECD_03867 thiamine biosynthesis ThiGH complex subunit low > 61
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 HEPCGN_12030 thiG thiazole synthase 0.83 21
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.90 ECOLIN_RS23020 thiazole synthase — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.90 MPMX20_00213 Thiazole synthase low > 85
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.90 EX28DRAFT_4532 Uncharacterized enzyme of thiazole biosynthesis low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.92 GFF4202 Thiazole biosynthesis protein ThiG low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.79 HER17_RS20400 thiazole synthase 0.89 7
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 IAI46_01300 thiazole synthase low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.78 EX31_RS16795 thiazole synthase low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.77 HGI48_RS01150 thiazole synthase low > 71
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.78 DDA3937_RS01155 thiazole synthase 0.80 6
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.77 DZA65_RS01195 thiazole synthase 0.86 5
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.77 LU632_RS00950 thiazole synthase low > 74
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.36 IAI47_20700 thiazole synthase 0.64 8
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.39 QEN71_RS27930 thiazole synthase — —
Paraburkholderia bryophila 376MFSha3.1 0.54 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase 0.37 H281DRAFT_05639 thiazole-phosphate synthase — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.38 BPHYT_RS17775 thiazole synthase — —
Paraburkholderia graminis OAS925 0.50 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.37 ABIE53_003714 thiazole synthase — —
Rhodopseudomonas palustris CGA009 0.48 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 TX73_018530 thiazole synthase — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.34 Atu2566 thiamin biosynthesis ThiG low > 89
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 ABCV34_RS14510 thiazole synthase — —
Bosea sp. OAE506 0.44 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.37 ABIE41_RS20185 thiazole synthase — —
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.32 SM_b20617 thiazole synthase — —
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.69 CSW01_00355 thiazole synthase low > 62
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.63 HMPREF1058_RS03285 thiazole synthase 0.94 4
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.63 ABI39_RS17755 thiazole synthase 0.84 6
Hydrogenophaga sp. GW460-11-11-14-LB1 0.38 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.36 GFF246 Thiazole biosynthesis protein ThiG — —
Dinoroseobacter shibae DFL-12 0.38 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) 0.34 Dshi_0912 thiazole biosynthesis family protein (RefSeq) 0.35 48
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.64 HMPREF1181_RS14680 thiazole synthase low > 56
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.65 BT0651 thiamine biosynthesis protein ThiG (NCBI ptt file) 0.46 3
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.41 RS_RS00535 thiazole synthase — —
Azospirillum brasilense Sp245 0.36 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.40 AZOBR_RS30960 thiazole synthase — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.41 ABZR87_RS04800 thiazole synthase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.36 Echvi_0215 phosphomethylpyrimidine kinase 0.67 Echvi_3564 Uncharacterized enzyme of thiazole biosynthesis 0.25 46
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.41 UW163_RS03655 thiazole synthase — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.41 RALBFv3_RS09925 thiazole synthase — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.41 RPSI07_RS23435 thiazole synthase — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.38 ABID97_RS15315 thiazole synthase — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.65 BACOVA_02359 thiazole biosynthesis protein ThiG 0.87 6
Bifidobacterium breve UCC2003 0.34 BBR_RS17215 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 BBR_RS13965 thiazole synthase low > 34
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.63 CA265_RS20180 thiazole synthase low > 88
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.43 MPMX19_00262 Thiazole synthase — —
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.35 Ac3H11_1059 Thiazole biosynthesis protein ThiG — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.38 RR42_RS01305 thiazole synthase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.63 ABZR88_RS08825 thiazole synthase 0.90 2
Caulobacter crescentus NA1000 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.40 CCNA_01957 thiazole biosynthesis protein ThiG — —
Caulobacter crescentus NA1000 Δfur 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.40 CCNA_01957 thiazole biosynthesis protein ThiG — —
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.3091.1 hypothetical protein 0.43 Xcc-8004.1284.1 Thiazole biosynthesis protein ThiG 0.76 2
Fusobacterium nucleatum SB010 0.30 HUW76_10300 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 HUW76_10275 thiazole synthase low > 35
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 ABZR86_RS11645 thiazole synthase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 A4249_RS07975 thiazole synthase — —
Desulfovibrio vulgaris Miyazaki F 0.28 DvMF_1376 phosphomethylpyrimidine kinase (RefSeq) 0.46 DvMF_0800 thiG thiazole synthase (RefSeq) — —
Desulfovibrio vulgaris Hildenborough JW710 0.28 DVU0931 thiD phosphomethylpyrimidine kinase (TIGR) 0.46 DVU2094 thiG thiG protein (TIGR) — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.40 Dsui_1014 putative enzyme of thiazole biosynthesis — —
Mycobacterium tuberculosis H37Rv 0.24 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.40 Rv0417 Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein) — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.39 PFLU_RS28420 thiazole synthase 0.91 1
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.39 PFLU_RS28420 thiazole synthase 0.95 1
Synechococcus elongatus PCC 7942 0.23 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.47 Synpcc7942_0576 thiG thiazole synthase — —
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.40 PS417_26775 thiazole synthase 0.86 1
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.38 PP_5104 thiazole synthase 0.90 1
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.40 PfGW456L13_1000 Thiazole biosynthesis protein ThiG 0.57 2
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.40 AO353_08215 thiazole synthase 0.64 3
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.39 AO356_13375 thiazole synthase 0.41 2
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.41 Psest_0267 Uncharacterized enzyme of thiazole biosynthesis 0.67 1
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.40 Psyr_4740 thiazole-phosphate synthase 0.93 1
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.40 Psyr_4740 thiazole-phosphate synthase 0.93 1
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.38 MPMX26_01107 Thiazole synthase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.39 PFR28_04252 Thiazole synthase 0.95 1
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.67 CA264_20420 thiazole synthase 0.59 55
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.39 Pf1N1B4_2331 Thiazole biosynthesis protein ThiG 0.40 7
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.39 Pf6N2E2_4590 Thiazole biosynthesis protein ThiG 0.40 3
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.40 HSERO_RS02130 thiazole synthase 0.87 3
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.35 PGA1_c09070 thiazole biosynthesis protein ThiG 0.91 1

Not shown: 5 genomes with orthologs for BWI76_RS19375 only; 11 genomes with orthologs for BWI76_RS01535 only