Conservation of cofitness between BT0650 and BT0790 in Bacteroides thetaiotaomicron VPI-5482

85 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Bacteroides thetaiotaomicron VPI-5482 1.0 BT0650 thiamine biosynthesis protein ThiC (NCBI ptt file) 1.0 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.56 2
Bacteroides ovatus ATCC 8483 0.98 BACOVA_02358 thiamine biosynthesis protein ThiC 0.85 BACOVA_02530 phosphomethylpyrimidine kinase 0.95 1
Bacteroides stercoris CC31F 0.92 HMPREF1181_RS14685 phosphomethylpyrimidine synthase ThiC 0.58 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 56
Phocaeicola vulgatus CL09T03C04 0.87 HMPREF1058_RS03280 phosphomethylpyrimidine synthase ThiC 0.58 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.96 1
Phocaeicola dorei CL03T12C01 0.86 ABI39_RS17760 phosphomethylpyrimidine synthase ThiC 0.57 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.89 2
Parabacteroides merdae CL09T00C40 0.72 HMPREF1078_RS03485 phosphomethylpyrimidine synthase ThiC 0.48 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 61
Pontibacter actiniarum KMM 6156, DSM 19842 0.69 CA264_20435 phosphomethylpyrimidine synthase ThiC 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.80 2
Mucilaginibacter yixingensis YX-36 DSM 26809 0.68 ABZR88_RS08840 phosphomethylpyrimidine synthase ThiC 0.40 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 2
Echinicola vietnamensis KMM 6221, DSM 17526 0.67 Echvi_3567 thiamine biosynthesis protein ThiC 0.44 Echvi_0215 phosphomethylpyrimidine kinase low > 79
Pedobacter sp. GW460-11-11-14-LB5 0.66 CA265_RS20165 phosphomethylpyrimidine synthase ThiC 0.43 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 88
Herbaspirillum seropedicae SmR1 0.65 HSERO_RS02120 phosphomethylpyrimidine synthase ThiC 0.24 HSERO_RS02135 phosphomethylpyrimidine kinase 0.94 1
Acinetobacter radioresistens SK82 0.65 MPMX26_00180 Phosphomethylpyrimidine synthase 0.23 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase — —
Dechlorosoma suillum PS 0.65 Dsui_0422 thiamine biosynthesis protein ThiC 0.27 Dsui_0662 phosphomethylpyrimidine kinase — —
Dyella japonica UNC79MFTsu3.2 0.65 ABZR86_RS17230 phosphomethylpyrimidine synthase ThiC 0.30 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Rhodanobacter sp. FW510-T8 0.64 OKGIIK_16965 thiC phosphomethylpyrimidine synthase ThiC 0.24 OKGIIK_03835 Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 52
Dickeya dadantii 3937 0.64 DDA3937_RS01175 phosphomethylpyrimidine synthase ThiC 0.34 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.88 6
Paraburkholderia bryophila 376MFSha3.1 0.64 H281DRAFT_00395 hydroxymethylpyrimidine synthase 0.33 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase — —
Pectobacterium carotovorum WPP14 0.64 HER17_RS20380 phosphomethylpyrimidine synthase ThiC 0.36 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.96 1
Pseudomonas sp. S08-1 0.64 OH686_15885 phosphomethylpyrimidine synthase 0.23 OH686_09185 Hydroxymethylpyrimidine phosphate kinase ThiD low > 80
Pseudomonas putida KT2440 0.64 PP_4922 Phosphomethylpyrimidine synthase 0.26 PP_4782 Phosphomethylpyrimidine kinase 0.83 3
Pseudomonas stutzeri RCH2 0.64 Psest_0477 thiamine biosynthesis protein ThiC 0.23 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.65 5
Paraburkholderia graminis OAS925 0.64 ABIE53_002857 phosphomethylpyrimidine synthase 0.32 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase — —
Paraburkholderia sabiae LMG 24235 0.64 QEN71_RS05480 phosphomethylpyrimidine synthase ThiC 0.33 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Castellaniella sp019104865 MT123 0.64 ABCV34_RS10825 phosphomethylpyrimidine synthase ThiC 0.37 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Burkholderia phytofirmans PsJN 0.64 BPHYT_RS13220 phosphomethylpyrimidine synthase 0.34 BPHYT_RS12250 phosphomethylpyrimidine kinase — —
Ralstonia sp. UNC404CL21Col 0.64 ABZR87_RS04785 phosphomethylpyrimidine synthase ThiC 0.35 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Dickeya dianthicola ME23 0.64 DZA65_RS01215 phosphomethylpyrimidine synthase ThiC 0.33 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 3
Escherichia coli ECRC62 0.63 BNILDI_06005 thiC phosphomethylpyrimidine synthase ThiC 0.35 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Cupriavidus basilensis FW507-4G11 0.63 RR42_RS01290 thiamine biosynthesis protein ThiC 0.33 RR42_RS01370 phosphomethylpyrimidine kinase — —
Escherichia coli BW25113 0.63 b3994 thiC thiamine biosynthesis protein ThiC (NCBI) 0.35 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.92 4
Escherichia coli HS(pFamp)R (ATCC 700891) 0.63 OHPLBJKB_04056 Phosphomethylpyrimidine synthase 0.35 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 73
Escherichia coli ECOR27 0.63 NOLOHH_05520 thiC phosphomethylpyrimidine synthase ThiC 0.35 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 57
Escherichia coli ECRC101 0.63 OKFHMN_13375 thiC phosphomethylpyrimidine synthase ThiC 0.35 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Rahnella sp. WP5 0.63 EX31_RS16815 phosphomethylpyrimidine synthase ThiC 0.35 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 89
Pseudomonas fluorescens FW300-N2E2 0.63 Pf6N2E2_3644 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.20 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.41 16
Escherichia coli ECRC99 0.63 KEDOAH_14785 thiC phosphomethylpyrimidine synthase ThiC 0.35 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia fergusonii Becca 0.63 EFB2_04617 Phosphomethylpyrimidine synthase 0.35 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase low > 86
Escherichia coli ECOR38 0.63 HEPCGN_12010 thiC phosphomethylpyrimidine synthase ThiC 0.35 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 85
Serratia liquefaciens MT49 0.63 IAI46_01320 phosphomethylpyrimidine synthase ThiC 0.36 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 86
Escherichia coli ECRC102 0.63 NIAGMN_11125 thiC phosphomethylpyrimidine synthase ThiC 0.35 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Pseudomonas simiae WCS417 0.63 PS417_02355 thiamine biosynthesis protein ThiC 0.25 PS417_24600 hydrogenase 0.63 2
Escherichia coli Nissle 1917 0.63 ECOLIN_RS23040 phosphomethylpyrimidine synthase ThiC 0.35 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC101 0.63 MCAODC_03875 thiC phosphomethylpyrimidine synthase ThiC 0.35 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Escherichia coli ECRC98 0.63 JDDGAC_17000 thiC phosphomethylpyrimidine synthase ThiC 0.35 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Pantoea sp. MT58 0.63 IAI47_18085 phosphomethylpyrimidine synthase ThiC 0.33 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 37
Ralstonia solanacearum GMI1000 0.63 RS_RS00555 phosphomethylpyrimidine synthase 0.35 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Dickeya dianthicola 67-19 0.63 HGI48_RS01170 phosphomethylpyrimidine synthase ThiC 0.33 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 27
Pseudomonas fluorescens FW300-N2C3 0.63 AO356_08810 thiamine biosynthesis protein ThiC 0.24 AO356_15435 hydrogenase 0.43 6
Ralstonia solanacearum PSI07 0.63 RPSI07_RS23420 phosphomethylpyrimidine synthase ThiC 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Pseudomonas fluorescens SBW25 0.63 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.25 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.88 2
Pseudomonas fluorescens SBW25-INTG 0.63 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.25 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.92 1
Escherichia coli BL21 0.63 ECD_03871 phosphomethylpyrimidine synthase 0.36 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase low > 60
Ralstonia solanacearum UW163 0.63 UW163_RS03640 phosphomethylpyrimidine synthase ThiC 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Ralstonia solanacearum IBSBF1503 0.63 RALBFv3_RS09940 phosphomethylpyrimidine synthase ThiC 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.63 Psyr_0544 hydroxymethylpyrimidine synthase 0.23 Psyr_4340 phosphomethylpyrimidine kinase, putative low > 86
Pseudomonas syringae pv. syringae B728a 0.63 Psyr_0544 hydroxymethylpyrimidine synthase 0.23 Psyr_4340 phosphomethylpyrimidine kinase, putative low > 86
Pseudomonas sp. RS175 0.63 PFR28_05091 Phosphomethylpyrimidine synthase 0.21 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.95 2
Enterobacter asburiae PDN3 0.63 EX28DRAFT_4536 phosphomethylpyrimidine synthase 0.35 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.54 50
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.63 GFF4198 Thiamin biosynthesis protein ThiC 0.34 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) low > 78
Pseudomonas fluorescens GW456-L13 0.63 PfGW456L13_187 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.24 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.51 13
Enterobacter sp. TBS_079 0.63 MPMX20_00217 Phosphomethylpyrimidine synthase 0.36 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.56 3
Pseudomonas fluorescens FW300-N2E3 0.63 AO353_13010 thiamine biosynthesis protein ThiC 0.25 AO353_06350 hydrogenase 0.77 1
Pseudomonas fluorescens FW300-N1B4 0.63 Pf1N1B4_1447 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.21 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.55 5
Magnetospirillum magneticum AMB-1 0.63 AMB_RS01125 phosphomethylpyrimidine synthase 0.32 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Erwinia tracheiphila SCR3 0.63 LU632_RS00970 thiC phosphomethylpyrimidine synthase ThiC 0.34 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 74
Agrobacterium fabrum C58 0.63 Atu2569 thiamine biosynthesis protein 0.37 Atu3290 phosphomethylpyrimidine kinase 0.95 1
Phaeobacter inhibens DSM 17395 0.62 PGA1_c09110 thiamine biosynthesis protein ThiC 0.19 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.90 4
Lysobacter sp. OAE881 0.62 ABIE51_RS17515 phosphomethylpyrimidine synthase ThiC 0.27 ABIE51_RS07970 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Sinorhizobium meliloti 1021 0.62 SM_b20615 thiamine biosynthesis protein ThiC 0.37 SM_b20962 phoshomethylpyrimidine kinase low > 103
Dinoroseobacter shibae DFL-12 0.62 Dshi_4080 thiamine biosynthesis protein ThiC (RefSeq) 0.27 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) — —
Klebsiella michiganensis M5al 0.62 BWI76_RS01555 phosphomethylpyrimidine synthase ThiC 0.35 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.38 43
Xanthomonas campestris pv. campestris strain 8004 0.62 Xcc-8004.1066.1 hypothetical protein 0.29 Xcc-8004.3091.1 hypothetical protein 0.73 8
Azospirillum brasilense Sp245 0.62 AZOBR_RS07940 phosphomethylpyrimidine synthase 0.33 AZOBR_RS07045 phosphomethylpyrimidine kinase — —
Acidovorax sp. GW101-3H11 0.61 Ac3H11_2027 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.41 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) — —
Brevundimonas sp. GW460-12-10-14-LB2 0.61 A4249_RS15715 phosphomethylpyrimidine synthase ThiC 0.30 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Vibrio cholerae E7946 ATCC 55056 0.61 CSW01_00335 phosphomethylpyrimidine synthase 0.37 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase low > 62
Caulobacter crescentus NA1000 Δfur 0.61 CCNA_02109 thiamine biosynthesis protein thiC 0.35 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase — —
Caulobacter crescentus NA1000 0.61 CCNA_02109 thiamine biosynthesis protein thiC 0.35 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.60 GFF4626 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.41 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) low > 90
Sphingomonas koreensis DSMZ 15582 0.60 Ga0059261_2424 hydroxymethylpyrimidine synthase 0.24 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Azospirillum sp. SherDot2 0.60 MPMX19_00336 Phosphomethylpyrimidine synthase 0.30 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase — —
Variovorax sp. OAS795 0.59 ABID97_RS25235 phosphomethylpyrimidine synthase ThiC 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Rhodopseudomonas palustris CGA009 0.58 TX73_018540 phosphomethylpyrimidine synthase ThiC 0.32 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Bosea sp. OAE506 0.57 ABIE41_RS02770 phosphomethylpyrimidine synthase ThiC 0.39 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase — —
Rhodospirillum rubrum S1H 0.57 Rru_A2008 Thiamine biosynthesis protein ThiC (NCBI) 0.37 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) — —
Mycobacterium tuberculosis H37Rv 0.49 Rv0423c Probable thiamine biosynthesis protein ThiC 0.28 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) — —

Not shown: 8 genomes with orthologs for BT0650 only; 6 genomes with orthologs for BT0790 only