Conservation of cofitness between BWI76_RS19375 and BWI76_RS01555 in Klebsiella michiganensis M5al

82 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS01555 phosphomethylpyrimidine synthase ThiC 0.38 1
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 NIAGMN_11125 thiC phosphomethylpyrimidine synthase ThiC — —
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 JDDGAC_17000 thiC phosphomethylpyrimidine synthase ThiC low > 86
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 MCAODC_03875 thiC phosphomethylpyrimidine synthase ThiC 0.80 9
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 OKFHMN_13375 thiC phosphomethylpyrimidine synthase ThiC 0.91 9
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 KEDOAH_14785 thiC phosphomethylpyrimidine synthase ThiC — —
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 BNILDI_06005 thiC phosphomethylpyrimidine synthase ThiC 0.78 13
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.93 OHPLBJKB_04056 Phosphomethylpyrimidine synthase low > 73
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 NOLOHH_05520 thiC phosphomethylpyrimidine synthase ThiC 0.94 2
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.93 b3994 thiC thiamine biosynthesis protein ThiC (NCBI) 0.92 1
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.93 ECD_03871 phosphomethylpyrimidine synthase low > 61
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.93 EFB2_04617 Phosphomethylpyrimidine synthase low > 86
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 HEPCGN_12010 thiC phosphomethylpyrimidine synthase ThiC 0.92 1
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.93 ECOLIN_RS23040 phosphomethylpyrimidine synthase ThiC — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.94 MPMX20_00217 Phosphomethylpyrimidine synthase 0.56 3
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.95 EX28DRAFT_4536 phosphomethylpyrimidine synthase 0.54 33
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.93 GFF4198 Thiamin biosynthesis protein ThiC low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.86 HER17_RS20380 phosphomethylpyrimidine synthase ThiC 0.96 1
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.85 IAI46_01320 phosphomethylpyrimidine synthase ThiC low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.86 EX31_RS16815 phosphomethylpyrimidine synthase ThiC low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 HGI48_RS01170 phosphomethylpyrimidine synthase ThiC 0.82 11
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.85 DDA3937_RS01175 phosphomethylpyrimidine synthase ThiC 0.88 2
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.85 DZA65_RS01215 phosphomethylpyrimidine synthase ThiC 0.93 2
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 LU632_RS00970 thiC phosphomethylpyrimidine synthase ThiC low > 74
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 IAI47_18085 phosphomethylpyrimidine synthase ThiC low > 76
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 QEN71_RS05480 phosphomethylpyrimidine synthase ThiC — —
Paraburkholderia bryophila 376MFSha3.1 0.54 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase 0.68 H281DRAFT_00395 hydroxymethylpyrimidine synthase — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.68 BPHYT_RS13220 phosphomethylpyrimidine synthase — —
Paraburkholderia graminis OAS925 0.50 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.68 ABIE53_002857 phosphomethylpyrimidine synthase — —
Rhodopseudomonas palustris CGA009 0.48 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 TX73_018540 phosphomethylpyrimidine synthase ThiC — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.62 Atu2569 thiamine biosynthesis protein 0.95 1
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 ABCV34_RS10825 phosphomethylpyrimidine synthase ThiC — —
Bosea sp. OAE506 0.44 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 ABIE41_RS02770 phosphomethylpyrimidine synthase ThiC — —
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 HMPREF1078_RS03485 phosphomethylpyrimidine synthase ThiC low > 61
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.63 SM_b20615 thiamine biosynthesis protein ThiC low > 103
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 CSW01_00335 phosphomethylpyrimidine synthase low > 62
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.55 HMPREF1058_RS03280 phosphomethylpyrimidine synthase ThiC 0.96 3
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.56 ABI39_RS17760 phosphomethylpyrimidine synthase ThiC 0.89 5
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.55 HMPREF1181_RS14685 phosphomethylpyrimidine synthase ThiC low > 56
Hydrogenophaga sp. GW460-11-11-14-LB1 0.38 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.63 GFF166 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) low > 90
Dinoroseobacter shibae DFL-12 0.38 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) 0.63 Dshi_4080 thiamine biosynthesis protein ThiC (RefSeq) — —
Rhodospirillum rubrum S1H 0.37 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) 0.58 Rru_A2008 Thiamine biosynthesis protein ThiC (NCBI) — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.56 BT0650 thiamine biosynthesis protein ThiC (NCBI ptt file) 0.56 1
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.67 RS_RS00555 phosphomethylpyrimidine synthase — —
Azospirillum brasilense Sp245 0.36 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.64 AZOBR_RS07940 phosphomethylpyrimidine synthase — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 ABZR87_RS04785 phosphomethylpyrimidine synthase ThiC — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.36 Echvi_0215 phosphomethylpyrimidine kinase 0.68 Echvi_3567 thiamine biosynthesis protein ThiC low > 79
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.67 UW163_RS03640 phosphomethylpyrimidine synthase ThiC — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.67 RALBFv3_RS09940 phosphomethylpyrimidine synthase ThiC — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 RPSI07_RS23420 phosphomethylpyrimidine synthase ThiC — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.62 ABID97_RS25235 phosphomethylpyrimidine synthase ThiC — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.55 BACOVA_02358 thiamine biosynthesis protein ThiC 0.95 1
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 CA265_RS20165 phosphomethylpyrimidine synthase ThiC low > 88
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.62 MPMX19_00336 Phosphomethylpyrimidine synthase — —
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.62 Ac3H11_2027 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.66 RR42_RS01290 thiamine biosynthesis protein ThiC — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.69 ABZR88_RS08840 phosphomethylpyrimidine synthase ThiC 0.92 1
Caulobacter crescentus NA1000 Δfur 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.63 CCNA_02109 thiamine biosynthesis protein thiC — —
Caulobacter crescentus NA1000 0.31 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.63 CCNA_02109 thiamine biosynthesis protein thiC — —
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.3091.1 hypothetical protein 0.67 Xcc-8004.1066.1 hypothetical protein 0.73 11
Magnetospirillum magneticum AMB-1 0.30 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.65 AMB_RS01125 phosphomethylpyrimidine synthase — —
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 ABZR86_RS17230 phosphomethylpyrimidine synthase ThiC — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 A4249_RS15715 phosphomethylpyrimidine synthase ThiC — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.68 Dsui_0422 thiamine biosynthesis protein ThiC — —
Sphingomonas koreensis DSMZ 15582 0.24 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 Ga0059261_2424 hydroxymethylpyrimidine synthase — —
Mycobacterium tuberculosis H37Rv 0.24 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.50 Rv0423c Probable thiamine biosynthesis protein ThiC — —
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.70 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.92 3
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.70 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.88 4
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.70 PS417_02355 thiamine biosynthesis protein ThiC 0.63 4
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.71 PP_4922 Phosphomethylpyrimidine synthase 0.83 3
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.70 PfGW456L13_187 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.51 6
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.70 AO353_13010 thiamine biosynthesis protein ThiC 0.77 1
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.70 AO356_08810 thiamine biosynthesis protein ThiC 0.43 1
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.70 Psest_0477 thiamine biosynthesis protein ThiC 0.65 2
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.70 Psyr_0544 hydroxymethylpyrimidine synthase low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.70 Psyr_0544 hydroxymethylpyrimidine synthase low > 86
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.68 MPMX26_00180 Phosphomethylpyrimidine synthase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.71 PFR28_05091 Phosphomethylpyrimidine synthase 0.95 2
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.69 CA264_20435 phosphomethylpyrimidine synthase ThiC 0.80 2
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.70 Pf1N1B4_1447 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.55 1
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.69 HSERO_RS02120 phosphomethylpyrimidine synthase ThiC 0.94 1
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.70 Pf6N2E2_3644 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.41 1
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.63 PGA1_c09110 thiamine biosynthesis protein ThiC 0.90 2

Not shown: 6 genomes with orthologs for BWI76_RS19375 only; 11 genomes with orthologs for BWI76_RS01555 only