Conservation of cofitness between BT0650 and BT1861 in Bacteroides thetaiotaomicron VPI-5482

80 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Bacteroides thetaiotaomicron VPI-5482 1.0 BT0650 thiamine biosynthesis protein ThiC (NCBI ptt file) 1.0 BT1861 2-isopropylmalate synthase (EC 2.3.3.13) (from data) 0.45 20
Bacteroides ovatus ATCC 8483 0.98 BACOVA_02358 thiamine biosynthesis protein ThiC 0.99 BACOVA_04604 2-isopropylmalate synthase 0.76 34
Bacteroides stercoris CC31F 0.92 HMPREF1181_RS14685 phosphomethylpyrimidine synthase ThiC 0.92 HMPREF1181_RS14150 2-isopropylmalate synthase low > 56
Phocaeicola vulgatus CL09T03C04 0.87 HMPREF1058_RS03280 phosphomethylpyrimidine synthase ThiC 0.90 HMPREF1058_RS14545 2-isopropylmalate synthase 0.75 26
Phocaeicola dorei CL03T12C01 0.86 ABI39_RS17760 phosphomethylpyrimidine synthase ThiC 0.90 ABI39_RS10195 2-isopropylmalate synthase 0.58 33
Parabacteroides merdae CL09T00C40 0.72 HMPREF1078_RS03485 phosphomethylpyrimidine synthase ThiC 0.86 HMPREF1078_RS16665 2-isopropylmalate synthase low > 61
Marinobacter adhaerens HP15 0.65 HP15_453 thiamine biosynthesis protein thiC 0.47 HP15_538 2-isopropylmalate synthase low > 73
Acinetobacter radioresistens SK82 0.65 MPMX26_00180 Phosphomethylpyrimidine synthase 0.12 MPMX26_03077 2-isopropylmalate synthase — —
Shewanella loihica PV-4 0.65 Shew_2096 thiamine biosynthesis protein ThiC (RefSeq) 0.47 Shew_3472 2-isopropylmalate synthase (RefSeq) low > 60
Dyella japonica UNC79MFTsu3.2 0.65 ABZR86_RS17230 phosphomethylpyrimidine synthase ThiC 0.42 ABZR86_RS15970 2-isopropylmalate synthase 0.35 43
Dechlorosoma suillum PS 0.65 Dsui_0422 thiamine biosynthesis protein ThiC 0.46 Dsui_3519 2-isopropylmalate synthase, bacterial type — —
Shewanella amazonensis SB2B 0.65 Sama_1860 thiamine biosynthesis protein ThiC (RefSeq) 0.46 Sama_0335 2-isopropylmalate synthase (RefSeq) low > 62
Rhodanobacter sp. FW510-T8 0.64 OKGIIK_16965 thiC phosphomethylpyrimidine synthase ThiC 0.40 OKGIIK_13575 leuA 2-isopropylmalate synthase low > 52
Dickeya dadantii 3937 0.64 DDA3937_RS01175 phosphomethylpyrimidine synthase ThiC 0.47 DDA3937_RS18115 2-isopropylmalate synthase low > 74
Paraburkholderia bryophila 376MFSha3.1 0.64 H281DRAFT_00395 hydroxymethylpyrimidine synthase 0.43 H281DRAFT_04556 2-isopropylmalate synthase low > 103
Pectobacterium carotovorum WPP14 0.64 HER17_RS20380 phosphomethylpyrimidine synthase ThiC 0.47 HER17_RS03085 2-isopropylmalate synthase 0.79 48
Pseudomonas sp. S08-1 0.64 OH686_15885 phosphomethylpyrimidine synthase 0.13 OH686_17570 2-isopropylmalate synthase low > 80
Pseudomonas putida KT2440 0.64 PP_4922 Phosphomethylpyrimidine synthase 0.12 PP_1025 2-isopropylmalate synthase 0.35 60
Pseudomonas stutzeri RCH2 0.64 Psest_0477 thiamine biosynthesis protein ThiC 0.46 Psest_1056 2-isopropylmalate synthase, bacterial type low > 67
Paraburkholderia graminis OAS925 0.64 ABIE53_002857 phosphomethylpyrimidine synthase 0.43 ABIE53_001580 2-isopropylmalate synthase low > 113
Paraburkholderia sabiae LMG 24235 0.64 QEN71_RS05480 phosphomethylpyrimidine synthase ThiC 0.43 QEN71_RS24195 2-isopropylmalate synthase low > 153
Ralstonia sp. UNC404CL21Col 0.64 ABZR87_RS04785 phosphomethylpyrimidine synthase ThiC 0.41 ABZR87_RS14930 2-isopropylmalate synthase low > 80
Dickeya dianthicola ME23 0.64 DZA65_RS01215 phosphomethylpyrimidine synthase ThiC 0.47 DZA65_RS19200 2-isopropylmalate synthase 0.76 30
Castellaniella sp019104865 MT123 0.64 ABCV34_RS10825 phosphomethylpyrimidine synthase ThiC 0.12 ABCV34_RS12420 2-isopropylmalate synthase low > 48
Burkholderia phytofirmans PsJN 0.64 BPHYT_RS13220 phosphomethylpyrimidine synthase 0.43 BPHYT_RS06570 2-isopropylmalate synthase low > 109
Escherichia coli ECRC62 0.63 BNILDI_06005 thiC phosphomethylpyrimidine synthase ThiC 0.46 BNILDI_08550 2-isopropylmalate synthase — —
Escherichia coli BW25113 0.63 b3994 thiC thiamine biosynthesis protein ThiC (NCBI) 0.46 b0074 leuA 2-isopropylmalate synthase (NCBI) low > 76
Cupriavidus basilensis FW507-4G11 0.63 RR42_RS01290 thiamine biosynthesis protein ThiC 0.41 RR42_RS05465 2-isopropylmalate synthase 0.36 117
Escherichia coli HS(pFamp)R (ATCC 700891) 0.63 OHPLBJKB_04056 Phosphomethylpyrimidine synthase 0.46 OHPLBJKB_03583 2-isopropylmalate synthase low > 73
Escherichia coli ECOR27 0.63 NOLOHH_05520 thiC phosphomethylpyrimidine synthase ThiC 0.46 NOLOHH_03060 2-isopropylmalate synthase low > 57
Pseudomonas simiae WCS417 0.63 PS417_02355 thiamine biosynthesis protein ThiC 0.12 PS417_23110 2-isopropylmalate synthase low > 88
Rahnella sp. WP5 0.63 EX31_RS16815 phosphomethylpyrimidine synthase ThiC 0.45 EX31_RS03680 2-isopropylmalate synthase low > 89
Escherichia coli ECRC101 0.63 OKFHMN_13375 thiC phosphomethylpyrimidine synthase ThiC 0.46 OKFHMN_10715 2-isopropylmalate synthase — —
Escherichia coli ECRC98 0.63 JDDGAC_17000 thiC phosphomethylpyrimidine synthase ThiC 0.46 JDDGAC_14310 2-isopropylmalate synthase — —
Escherichia coli ECOR38 0.63 HEPCGN_12010 thiC phosphomethylpyrimidine synthase ThiC 0.46 HEPCGN_08695 2-isopropylmalate synthase low > 85
Escherichia coli ECRC101 0.63 MCAODC_03875 thiC phosphomethylpyrimidine synthase ThiC 0.46 MCAODC_01230 2-isopropylmalate synthase — —
Serratia liquefaciens MT49 0.63 IAI46_01320 phosphomethylpyrimidine synthase ThiC 0.47 IAI46_03355 2-isopropylmalate synthase low > 86
Escherichia coli Nissle 1917 0.63 ECOLIN_RS23040 phosphomethylpyrimidine synthase ThiC 0.46 ECOLIN_RS00400 2-isopropylmalate synthase low > 52
Escherichia coli ECRC102 0.63 NIAGMN_11125 thiC phosphomethylpyrimidine synthase ThiC 0.46 NIAGMN_08565 2-isopropylmalate synthase — —
Pseudomonas fluorescens FW300-N2E2 0.63 Pf6N2E2_3644 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.13 Pf6N2E2_3170 2-isopropylmalate synthase (EC 2.3.3.13) low > 103
Escherichia coli ECRC99 0.63 KEDOAH_14785 thiC phosphomethylpyrimidine synthase ThiC 0.46 KEDOAH_17440 2-isopropylmalate synthase — —
Escherichia fergusonii Becca 0.63 EFB2_04617 Phosphomethylpyrimidine synthase 0.46 EFB2_03971 2-isopropylmalate synthase low > 86
Dickeya dianthicola 67-19 0.63 HGI48_RS01170 phosphomethylpyrimidine synthase ThiC 0.47 HGI48_RS18055 2-isopropylmalate synthase 0.76 56
Pseudomonas fluorescens FW300-N2C3 0.63 AO356_08810 thiamine biosynthesis protein ThiC 0.13 AO356_06550 2-isopropylmalate synthase low > 104
Pantoea sp. MT58 0.63 IAI47_18085 phosphomethylpyrimidine synthase ThiC 0.45 IAI47_16000 2-isopropylmalate synthase low > 76
Ralstonia solanacearum GMI1000 0.63 RS_RS00555 phosphomethylpyrimidine synthase 0.41 RS_RS10395 2-isopropylmalate synthase low > 80
Escherichia coli BL21 0.63 ECD_03871 phosphomethylpyrimidine synthase 0.46 ECD_00076 2-isopropylmalate synthase low > 60
Pseudomonas fluorescens SBW25 0.63 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.12 PFLU_RS24765 2-isopropylmalate synthase low > 109
Pseudomonas fluorescens SBW25-INTG 0.63 PFLU_RS02430 phosphomethylpyrimidine synthase ThiC 0.12 PFLU_RS24765 2-isopropylmalate synthase 0.40 16
Ralstonia solanacearum PSI07 0.63 RPSI07_RS23420 phosphomethylpyrimidine synthase ThiC 0.41 RPSI07_RS14285 2-isopropylmalate synthase low > 81
Ralstonia solanacearum UW163 0.63 UW163_RS03640 phosphomethylpyrimidine synthase ThiC 0.41 UW163_RS10700 2-isopropylmalate synthase — —
Pseudomonas syringae pv. syringae B728a 0.63 Psyr_0544 hydroxymethylpyrimidine synthase 0.12 Psyr_1257 2-isopropylmalate synthase 0.71 7
Ralstonia solanacearum IBSBF1503 0.63 RALBFv3_RS09940 phosphomethylpyrimidine synthase ThiC 0.41 RALBFv3_RS03025 2-isopropylmalate synthase low > 76
Pseudomonas syringae pv. syringae B728a ΔmexB 0.63 Psyr_0544 hydroxymethylpyrimidine synthase 0.12 Psyr_1257 2-isopropylmalate synthase 0.51 8
Pseudomonas sp. RS175 0.63 PFR28_05091 Phosphomethylpyrimidine synthase 0.13 PFR28_00305 2-isopropylmalate synthase low > 88
Alteromonas macleodii MIT1002 0.63 MIT1002_00097 Phosphomethylpyrimidine synthase 0.47 MIT1002_00949 2-isopropylmalate synthase low > 70
Enterobacter asburiae PDN3 0.63 EX28DRAFT_4536 phosphomethylpyrimidine synthase 0.45 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) low > 76
Enterobacter sp. TBS_079 0.63 MPMX20_00217 Phosphomethylpyrimidine synthase 0.44 MPMX20_00769 2-isopropylmalate synthase low > 85
Pseudomonas fluorescens GW456-L13 0.63 PfGW456L13_187 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.12 PfGW456L13_4854 2-isopropylmalate synthase (EC 2.3.3.13) low > 87
Pseudomonas fluorescens FW300-N1B4 0.63 Pf1N1B4_1447 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.12 Pf1N1B4_847 2-isopropylmalate synthase (EC 2.3.3.13) low > 87
Magnetospirillum magneticum AMB-1 0.63 AMB_RS01125 phosphomethylpyrimidine synthase 0.46 AMB_RS17765 2-isopropylmalate synthase — —
Erwinia tracheiphila SCR3 0.63 LU632_RS00970 thiC phosphomethylpyrimidine synthase ThiC 0.45 LU632_RS02880 leuA 2-isopropylmalate synthase low > 74
Agrobacterium fabrum C58 0.63 Atu2569 thiamine biosynthesis protein 0.12 Atu2264 2-isopropylmalate synthase 0.71 25
Phaeobacter inhibens DSM 17395 0.62 PGA1_c09110 thiamine biosynthesis protein ThiC 0.45 PGA1_c26470 2-isopropylmalate synthase LeuA low > 62
Lysobacter sp. OAE881 0.62 ABIE51_RS17515 phosphomethylpyrimidine synthase ThiC 0.40 ABIE51_RS17570 2-isopropylmalate synthase low > 62
Sinorhizobium meliloti 1021 0.62 SM_b20615 thiamine biosynthesis protein ThiC 0.17 SMc02546 alpha-isopropylmalate/homocitrate synthase family transferase low > 103
Shewanella sp. ANA-3 0.62 Shewana3_1936 thiamine biosynthesis protein ThiC (RefSeq) 0.47 Shewana3_3761 2-isopropylmalate synthase (RefSeq) low > 73
Klebsiella michiganensis M5al 0.62 BWI76_RS01555 phosphomethylpyrimidine synthase ThiC 0.46 BWI76_RS04680 2-isopropylmalate synthase 0.34 81
Dinoroseobacter shibae DFL-12 0.62 Dshi_4080 thiamine biosynthesis protein ThiC (RefSeq) 0.42 Dshi_0596 2-isopropylmalate synthase (RefSeq) — —
Xanthomonas campestris pv. campestris strain 8004 0.62 Xcc-8004.1066.1 hypothetical protein 0.40 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) low > 74
Shewanella oneidensis MR-1 0.62 SO2445 thiC thiamin biosynthesis protein ThiC (NCBI ptt file) 0.47 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) low > 76
Acidovorax sp. GW101-3H11 0.61 Ac3H11_2027 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.43 Ac3H11_530 2-isopropylmalate synthase (EC 2.3.3.13) low > 79
Vibrio cholerae E7946 ATCC 55056 0.61 CSW01_00335 phosphomethylpyrimidine synthase 0.48 CSW01_12595 2-isopropylmalate synthase low > 62
Caulobacter crescentus NA1000 Δfur 0.61 CCNA_02109 thiamine biosynthesis protein thiC 0.45 CCNA_01610 2-isopropylmalate synthase low > 67
Caulobacter crescentus NA1000 0.61 CCNA_02109 thiamine biosynthesis protein thiC 0.45 CCNA_01610 2-isopropylmalate synthase low > 66
Hydrogenophaga sp. GW460-11-11-14-LB1 0.60 GFF4626 Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17) 0.43 GFF4281 2-isopropylmalate synthase (EC 2.3.3.13) low > 90
Sphingomonas koreensis DSMZ 15582 0.60 Ga0059261_2424 hydroxymethylpyrimidine synthase 0.11 Ga0059261_4031 2-isopropylmalate synthase, yeast type 0.90 37
Variovorax sp. SCN45 0.59 GFF2000 Phosphomethylpyrimidine synthase ThiC (EC 4.1.99.17) 0.43 GFF1165 2-isopropylmalate synthase (EC 2.3.3.13) low > 127
Variovorax sp. OAS795 0.59 ABID97_RS25235 phosphomethylpyrimidine synthase ThiC 0.43 ABID97_RS14910 2-isopropylmalate synthase low > 91
Rhodopseudomonas palustris CGA009 0.58 TX73_018540 phosphomethylpyrimidine synthase ThiC 0.42 TX73_010545 2-isopropylmalate synthase low > 86
Bosea sp. OAE506 0.57 ABIE41_RS02770 phosphomethylpyrimidine synthase ThiC 0.43 ABIE41_RS13000 2-isopropylmalate synthase low > 77

Not shown: 13 genomes with orthologs for BT0650 only; 9 genomes with orthologs for BT1861 only