Conservation of cofitness between PGA1_c12150 and PGA1_c26470 in Phaeobacter inhibens DSM 17395

76 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Phaeobacter inhibens DSM 17395 1.0 PGA1_c12150 dihydroorotate dehydrogenase PyrD 1.0 PGA1_c26470 2-isopropylmalate synthase LeuA 0.88 11
Dinoroseobacter shibae DFL-12 0.70 Dshi_0847 Dihydroorotate oxidase (RefSeq) 0.78 Dshi_0596 2-isopropylmalate synthase (RefSeq) 0.79 14
Agrobacterium fabrum C58 0.46 Atu0486 dihydroorotate dehydrogenase 0.12 Atu2264 2-isopropylmalate synthase 0.87 14
Magnetospirillum magneticum AMB-1 0.45 AMB_RS19685 quinone-dependent dihydroorotate dehydrogenase 0.59 AMB_RS17765 2-isopropylmalate synthase — —
Caulobacter crescentus NA1000 0.42 CCNA_00562 dihydroorotate dehydrogenase 0.58 CCNA_01610 2-isopropylmalate synthase low > 66
Caulobacter crescentus NA1000 Δfur 0.42 CCNA_00562 dihydroorotate dehydrogenase 0.58 CCNA_01610 2-isopropylmalate synthase low > 67
Rhodopseudomonas palustris CGA009 0.41 TX73_004110 quinone-dependent dihydroorotate dehydrogenase 0.60 TX73_010545 2-isopropylmalate synthase — —
Bosea sp. OAE506 0.40 ABIE41_RS24065 quinone-dependent dihydroorotate dehydrogenase 0.60 ABIE41_RS13000 2-isopropylmalate synthase low > 77
Pseudomonas stutzeri RCH2 0.38 Psest_1947 dihydroorotate dehydrogenase, subfamily 2 0.51 Psest_1056 2-isopropylmalate synthase, bacterial type low > 67
Acidovorax sp. GW101-3H11 0.37 Ac3H11_4100 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.47 Ac3H11_530 2-isopropylmalate synthase (EC 2.3.3.13) — —
Rhodanobacter sp. FW510-T8 0.37 OKGIIK_09010 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 OKGIIK_13575 leuA 2-isopropylmalate synthase — —
Sphingomonas koreensis DSMZ 15582 0.37 Ga0059261_1468 dihydroorotate oxidase A (EC 1.3.3.1) 0.10 Ga0059261_4031 2-isopropylmalate synthase, yeast type — —
Rhodanobacter denitrificans MT42 0.37 LRK55_RS15740 quinone-dependent dihydroorotate dehydrogenase 0.40 LRK55_RS09985 2-isopropylmalate synthase — —
Rhodanobacter denitrificans FW104-10B01 0.37 LRK54_RS15985 quinone-dependent dihydroorotate dehydrogenase 0.40 LRK54_RS10345 2-isopropylmalate synthase — —
Pseudomonas fluorescens SBW25-INTG 0.36 PFLU_RS22550 quinone-dependent dihydroorotate dehydrogenase 0.10 PFLU_RS24765 2-isopropylmalate synthase — —
Pseudomonas fluorescens SBW25 0.36 PFLU_RS22550 quinone-dependent dihydroorotate dehydrogenase 0.10 PFLU_RS24765 2-isopropylmalate synthase — —
Castellaniella sp019104865 MT123 0.36 ABCV34_RS07790 quinone-dependent dihydroorotate dehydrogenase 0.13 ABCV34_RS12420 2-isopropylmalate synthase — —
Pseudomonas fluorescens GW456-L13 0.36 PfGW456L13_4095 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.10 PfGW456L13_4854 2-isopropylmalate synthase (EC 2.3.3.13) — —
Dyella japonica UNC79MFTsu3.2 0.36 ABZR86_RS07450 quinone-dependent dihydroorotate dehydrogenase 0.42 ABZR86_RS15970 2-isopropylmalate synthase — —
Variovorax sp. SCN45 0.36 GFF960 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) 0.48 GFF1165 2-isopropylmalate synthase (EC 2.3.3.13) — —
Pseudomonas sp. S08-1 0.36 OH686_03120 dihydroorotate dehydrogenase (fumarate) 0.12 OH686_17570 2-isopropylmalate synthase — —
Pseudomonas simiae WCS417 0.36 PS417_20935 dihydroorotate dehydrogenase 0.10 PS417_23110 2-isopropylmalate synthase — —
Shewanella oneidensis MR-1 0.36 SO2592 pyrD dihydroorotate dehydrogenase (NCBI ptt file) 0.39 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) 0.84 32
Hydrogenophaga sp. GW460-11-11-14-LB1 0.36 GFF4211 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.48 GFF4281 2-isopropylmalate synthase (EC 2.3.3.13) low > 90
Pseudomonas fluorescens FW300-N1B4 0.36 Pf1N1B4_3842 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.11 Pf1N1B4_847 2-isopropylmalate synthase (EC 2.3.3.13) — —
Ralstonia solanacearum UW163 0.36 UW163_RS14880 quinone-dependent dihydroorotate dehydrogenase 0.47 UW163_RS10700 2-isopropylmalate synthase — —
Pseudomonas fluorescens FW300-N2E2 0.36 Pf6N2E2_2347 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.11 Pf6N2E2_3170 2-isopropylmalate synthase (EC 2.3.3.13) — —
Shewanella sp. ANA-3 0.36 Shewana3_1786 dihydroorotate dehydrogenase 2 (RefSeq) 0.39 Shewana3_3761 2-isopropylmalate synthase (RefSeq) 0.86 30
Ralstonia solanacearum IBSBF1503 0.36 RALBFv3_RS01570 quinone-dependent dihydroorotate dehydrogenase 0.47 RALBFv3_RS03025 2-isopropylmalate synthase — —
Acinetobacter radioresistens SK82 0.36 MPMX26_01120 Dihydroorotate dehydrogenase (quinone) 0.10 MPMX26_00404 2-isopropylmalate synthase low > 36
Pseudomonas fluorescens FW300-N2C3 0.35 AO356_02610 dihydroorotate dehydrogenase (quinone) 0.11 AO356_06550 2-isopropylmalate synthase — —
Pseudomonas sp. RS175 0.35 PFR28_01054 Dihydroorotate dehydrogenase (quinone) 0.11 PFR28_00305 2-isopropylmalate synthase — —
Alteromonas macleodii MIT1002 0.35 MIT1002_02035 Dihydroorotate dehydrogenase (quinone) 0.40 MIT1002_00949 2-isopropylmalate synthase low > 70
Variovorax sp. OAS795 0.35 ABID97_RS14065 quinone-dependent dihydroorotate dehydrogenase 0.48 ABID97_RS14910 2-isopropylmalate synthase — —
Ralstonia sp. UNC404CL21Col 0.35 ABZR87_RS13360 quinone-dependent dihydroorotate dehydrogenase 0.47 ABZR87_RS14930 2-isopropylmalate synthase — —
Paraburkholderia graminis OAS925 0.35 ABIE53_001954 dihydroorotate dehydrogenase 0.48 ABIE53_001580 2-isopropylmalate synthase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.35 Psyr_2106 dihydroorotate oxidase A 0.10 Psyr_1257 2-isopropylmalate synthase — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS15920 quinone-dependent dihydroorotate dehydrogenase 0.47 RPSI07_RS14285 2-isopropylmalate synthase — —
Pseudomonas syringae pv. syringae B728a 0.35 Psyr_2106 dihydroorotate oxidase A 0.10 Psyr_1257 2-isopropylmalate synthase — —
Ralstonia solanacearum GMI1000 0.35 RS_RS08160 dihydroorotate dehydrogenase (quinone) 0.47 RS_RS10395 2-isopropylmalate synthase — —
Dechlorosoma suillum PS 0.35 Dsui_2978 dihydroorotate dehydrogenase, subfamily 2 0.51 Dsui_3519 2-isopropylmalate synthase, bacterial type — —
Burkholderia phytofirmans PsJN 0.35 BPHYT_RS08565 dihydroorotate dehydrogenase 0.48 BPHYT_RS06570 2-isopropylmalate synthase low > 109
Paraburkholderia sabiae LMG 24235 0.34 QEN71_RS22765 quinone-dependent dihydroorotate dehydrogenase 0.48 QEN71_RS24195 2-isopropylmalate synthase — —
Cupriavidus basilensis FW507-4G11 0.34 RR42_RS07465 dihydroorotate dehydrogenase 0.46 RR42_RS05465 2-isopropylmalate synthase — —
Pseudomonas putida KT2440 0.34 PP_2095 Dihydroorotate dehydrogenase (quinone) 0.11 PP_1025 2-isopropylmalate synthase — —
Dickeya dadantii 3937 0.34 DDA3937_RS12855 quinone-dependent dihydroorotate dehydrogenase 0.41 DDA3937_RS18115 2-isopropylmalate synthase 0.62 40
Paraburkholderia bryophila 376MFSha3.1 0.34 H281DRAFT_00743 dihydroorotate oxidase A 0.48 H281DRAFT_04556 2-isopropylmalate synthase — —
Xanthomonas campestris pv. campestris strain 8004 0.34 Xcc-8004.3032.1 Dihydroorotate dehydrogenase (EC 1.3.3.1) 0.43 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) — —
Vibrio cholerae E7946 ATCC 55056 0.33 CSW01_07490 dihydroorotate dehydrogenase (quinone) 0.40 CSW01_12595 2-isopropylmalate synthase low > 62
Pantoea sp. MT58 0.33 IAI47_12705 quinone-dependent dihydroorotate dehydrogenase 0.40 IAI47_16000 2-isopropylmalate synthase 0.77 40
Klebsiella michiganensis M5al 0.33 BWI76_RS09910 dihydroorotate dehydrogenase (quinone) 0.40 BWI76_RS04680 2-isopropylmalate synthase 0.59 47
Dickeya dianthicola ME23 0.33 DZA65_RS13390 quinone-dependent dihydroorotate dehydrogenase 0.41 DZA65_RS19200 2-isopropylmalate synthase 0.89 5
Pectobacterium carotovorum WPP14 0.33 HER17_RS12005 quinone-dependent dihydroorotate dehydrogenase 0.40 HER17_RS03085 2-isopropylmalate synthase 0.96 18
Shewanella loihica PV-4 0.33 Shew_1810 dihydroorotate dehydrogenase 2 (RefSeq) 0.40 Shew_3472 2-isopropylmalate synthase (RefSeq) 0.74 43
Escherichia fergusonii Becca 0.33 EFB2_03126 Dihydroorotate dehydrogenase (quinone) 0.40 EFB2_03971 2-isopropylmalate synthase low > 86
Escherichia coli Nissle 1917 0.33 ECOLIN_RS04965 quinone-dependent dihydroorotate dehydrogenase 0.40 ECOLIN_RS00400 2-isopropylmalate synthase — —
Shewanella amazonensis SB2B 0.33 Sama_1593 dihydroorotate dehydrogenase 2 (RefSeq) 0.40 Sama_0335 2-isopropylmalate synthase (RefSeq) 0.63 34
Enterobacter sp. TBS_079 0.33 MPMX20_01596 Dihydroorotate dehydrogenase (quinone) 0.40 MPMX20_00769 2-isopropylmalate synthase 0.73 58
Enterobacter asburiae PDN3 0.33 EX28DRAFT_1998 dihydroorotate oxidase A (EC 1.3.3.1) 0.39 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) — —
Escherichia coli ECOR38 0.33 HEPCGN_23225 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 HEPCGN_08695 2-isopropylmalate synthase low > 85
Dickeya dianthicola 67-19 0.33 HGI48_RS12925 quinone-dependent dihydroorotate dehydrogenase 0.41 HGI48_RS18055 2-isopropylmalate synthase 0.79 11
Escherichia coli BW25113 0.33 b0945 pyrD dihydroorotate dehydrogenase (NCBI) 0.40 b0074 leuA 2-isopropylmalate synthase (NCBI) 0.76 53
Escherichia coli BL21 0.33 ECD_00949 dihydro-orotate oxidase, FMN-linked 0.40 ECD_00076 2-isopropylmalate synthase low > 60
Escherichia coli ECOR27 0.33 NOLOHH_21850 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 NOLOHH_03060 2-isopropylmalate synthase low > 57
Escherichia coli ECRC98 0.33 JDDGAC_08905 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 JDDGAC_14310 2-isopropylmalate synthase — —
Escherichia coli ECRC62 0.33 BNILDI_20015 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 BNILDI_08550 2-isopropylmalate synthase — —
Escherichia coli ECRC99 0.33 KEDOAH_22440 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 KEDOAH_17440 2-isopropylmalate synthase — —
Erwinia tracheiphila SCR3 0.33 LU632_RS09955 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 LU632_RS02880 leuA 2-isopropylmalate synthase 0.68 62
Lysobacter sp. OAE881 0.33 ABIE51_RS13725 quinone-dependent dihydroorotate dehydrogenase 0.42 ABIE51_RS17570 2-isopropylmalate synthase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.33 OHPLBJKB_02721 Dihydroorotate dehydrogenase (quinone) 0.40 OHPLBJKB_03583 2-isopropylmalate synthase low > 73
Escherichia coli ECRC101 0.33 OKFHMN_05295 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 OKFHMN_10715 2-isopropylmalate synthase — —
Escherichia coli ECRC101 0.33 MCAODC_24685 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 MCAODC_01230 2-isopropylmalate synthase — —
Escherichia coli ECRC102 0.33 NIAGMN_03015 pyrD quinone-dependent dihydroorotate dehydrogenase 0.40 NIAGMN_08565 2-isopropylmalate synthase — —
Serratia liquefaciens MT49 0.32 IAI46_08805 quinone-dependent dihydroorotate dehydrogenase 0.41 IAI46_03355 2-isopropylmalate synthase 0.67 58
Rahnella sp. WP5 0.32 EX31_RS18095 quinone-dependent dihydroorotate dehydrogenase 0.41 EX31_RS03680 2-isopropylmalate synthase 0.91 50
Synechococcus elongatus PCC 7942 0.30 Synpcc7942_0290 pyrD dihydroorotate dehydrogenase 2 0.42 Synpcc7942_1410 leuA 2-isopropylmalate synthase — —
Bifidobacterium breve UCC2003 0.21 BBR_RS12895 quinone-dependent dihydroorotate dehydrogenase 0.11 BBR_RS11170 2-isopropylmalate synthase low > 34

Not shown: 15 genomes with orthologs for PGA1_c12150 only; 11 genomes with orthologs for PGA1_c26470 only