Conservation of cofitness between GFF3058 and GFF2221 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

76 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 1.0 GFF3058 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 1.0 GFF2221 Nitrogen regulation protein NtrB (EC 2.7.13.3) 0.82 19
Escherichia coli ECOR38 0.93 HEPCGN_18540 hemW radical SAM family heme chaperone HemW 0.93 HEPCGN_12735 glnL nitrogen regulation protein NR(II) low > 87
Escherichia coli BW25113 0.93 b2955 yggW coproporphyrinogen III oxidase (NCBI) 0.94 b3869 glnL sensory histidine kinase in two-component regulatory system with GlnG (NCBI) low > 76
Escherichia fergusonii Becca 0.93 EFB2_00947 Heme chaperone HemW 0.93 EFB2_04747 Sensory histidine kinase/phosphatase NtrB low > 86
Enterobacter sp. TBS_079 0.92 MPMX20_03813 Heme chaperone HemW 0.92 MPMX20_04596 Sensory histidine kinase/phosphatase NtrB low > 85
Escherichia coli BL21 0.92 ECD_02785 HemN family putative oxidoreductase 0.94 ECD_03754 sensory histidine kinase in two-component regulatory system with GlnG low > 61
Escherichia coli HS(pFamp)R (ATCC 700891) 0.92 OHPLBJKB_00761 Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR 0.94 OHPLBJKB_04183 Sensory histidine kinase/phosphatase NtrB low > 73
Escherichia coli ECRC98 0.92 JDDGAC_22865 hemW radical SAM family heme chaperone HemW 0.94 JDDGAC_17730 glnL nitrogen regulation protein NR(II) low > 86
Escherichia coli ECRC101 0.92 MCAODC_09755 hemW radical SAM family heme chaperone HemW 0.94 MCAODC_04605 glnL nitrogen regulation protein NR(II) low > 87
Escherichia coli ECRC62 0.92 BNILDI_09685 hemW radical SAM family heme chaperone HemW 0.94 BNILDI_05295 glnL nitrogen regulation protein NR(II) low > 75
Escherichia coli ECRC102 0.92 NIAGMN_17000 hemW radical SAM family heme chaperone HemW 0.94 NIAGMN_11860 glnL nitrogen regulation protein NR(II)
Escherichia coli ECOR27 0.92 NOLOHH_11105 hemW radical SAM family heme chaperone HemW 0.93 NOLOHH_06235 glnL nitrogen regulation protein NR(II) low > 75
Escherichia coli Nissle 1917 0.92 ECOLIN_RS16435 radical SAM family heme chaperone HemW 0.93 ECOLIN_RS22300 nitrogen regulation protein NR(II) low > 55
Escherichia coli ECRC99 0.92 KEDOAH_08905 hemW radical SAM family heme chaperone HemW 0.94 KEDOAH_14045 glnL nitrogen regulation protein NR(II)
Escherichia coli ECRC100 0.92 OKFHMN_19235 hemW radical SAM family heme chaperone HemW 0.94 OKFHMN_14105 glnL nitrogen regulation protein NR(II) low > 80
Enterobacter asburiae PDN3 0.92 EX28DRAFT_2993 putative oxygen-independent coproporphyrinogen III oxidase 0.92 EX28DRAFT_4351 Signal transduction histidine kinase, nitrogen specific low > 76
Klebsiella michiganensis M5al 0.88 BWI76_RS24120 YggW family oxidoreductase 0.94 BWI76_RS00390 two-component system sensor histidine kinase NtrB low > 92
Serratia liquefaciens MT49 0.84 IAI46_21435 radical SAM family heme chaperone HemW 0.88 IAI46_24955 nitrogen regulation protein NR(II) low > 86
Dickeya dadantii 3937 0.83 DDA3937_RS17325 radical SAM family heme chaperone HemW 0.84 DDA3937_RS00130 nitrogen regulation protein NR(II) low > 74
Dickeya dianthicola 67-19 0.83 HGI48_RS17370 radical SAM family heme chaperone HemW 0.84 HGI48_RS21230 nitrogen regulation protein NR(II) low > 71
Dickeya dianthicola ME23 0.83 DZA65_RS18460 radical SAM family heme chaperone HemW 0.84 DZA65_RS22205 nitrogen regulation protein NR(II) low > 75
Pectobacterium carotovorum WPP14 0.83 HER17_RS03785 radical SAM family heme chaperone HemW 0.84 HER17_RS21435 nitrogen regulation protein NR(II) low > 75
Rahnella sp. WP5 0.82 EX31_RS02710 radical SAM family heme chaperone HemW 0.87 EX31_RS15875 nitrogen regulation protein NR(II) low > 89
Pantoea sp. MT58 0.81 IAI47_03580 radical SAM family heme chaperone HemW 0.88 IAI47_00455 nitrogen regulation protein NR(II) low > 76
Erwinia tracheiphila SCR3 0.79 LU632_RS05445 hemW radical SAM family heme chaperone HemW 0.90 LU632_RS22140 glnL nitrogen regulation protein NR(II) low > 74
Vibrio cholerae E7946 ATCC 55056 0.68 CSW01_02425 YggW family oxidoreductase 0.56 CSW01_13860 nitrogen regulation protein NR(II) low > 62
Shewanella loihica PV-4 0.61 Shew_1131 putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) 0.46 Shew_3560 signal transduction histidine kinase, nitrogen specific, NtrB (RefSeq) low > 60
Alteromonas macleodii MIT1002 0.60 MIT1002_00939 Oxygen-independent coproporphyrinogen-III oxidase 1 0.43 MIT1002_03185 Nitrogen regulation protein NR(II) low > 70
Shewanella sp. ANA-3 0.59 Shewana3_1188 putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) 0.48 Shewana3_0259 signal transduction histidine kinase, nitrogen specific, NtrB (RefSeq) low > 73
Shewanella oneidensis MR-1 0.59 SO3359 oxygen-independent coproporphyrinogen III oxidase, putative (NCBI ptt file) 0.47 SO4471 ntrB nitrogen regulation protein (NCBI ptt file) low > 76
Shewanella amazonensis SB2B 0.58 Sama_2483 oxygen-independent coproporphyrinogen III oxidase, putative (RefSeq) 0.46 Sama_3426 nitrogen regulation protein (RefSeq) low > 62
Pseudomonas fluorescens SBW25 0.54 PFLU_RS28405 radical SAM family heme chaperone HemW 0.42 PFLU_RS01690 nitrogen regulation protein NR(II) low > 109
Pseudomonas fluorescens SBW25-INTG 0.54 PFLU_RS28405 radical SAM family heme chaperone HemW 0.42 PFLU_RS01690 nitrogen regulation protein NR(II) low > 109
Pseudomonas fluorescens FW300-N2E2 0.54 Pf6N2E2_4593 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.42 Pf6N2E2_3825 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 103
Pseudomonas simiae WCS417 0.54 PS417_26760 oxidase 0.42 PS417_01640 histidine kinase low > 88
Pseudomonas fluorescens FW300-N2E3 0.54 AO353_08200 coproporphyrinogen III oxidase 0.41 AO353_12150 histidine kinase low > 101
Pseudomonas fluorescens FW300-N1B4 0.54 Pf1N1B4_2334 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.42 Pf1N1B4_1610 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 87
Pseudomonas fluorescens GW456-L13 0.53 PfGW456L13_1003 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.42 PfGW456L13_346 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 87
Pseudomonas sp. S08-1 0.53 OH686_11020 Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW 0.42 OH686_10635 Nitrogen regulation protein NtrB low > 80
Kangiella aquimarina DSM 16071 0.53 B158DRAFT_0201 coproporphyrinogen III oxidase, anaerobic (EC 1.3.99.22) 0.28 B158DRAFT_0715 Signal transduction histidine kinase, nitrogen specific low > 40
Pseudomonas sp. RS175 0.53 PFR28_04249 Heme chaperone HemW 0.42 PFR28_04945 Sensory histidine kinase/phosphatase NtrB low > 88
Pseudomonas stutzeri RCH2 0.52 Psest_0276 putative oxygen-independent coproporphyrinogen III oxidase 0.40 Psest_3931 Signal transduction histidine kinase, nitrogen specific low > 67
Pseudomonas fluorescens FW300-N2C3 0.52 AO356_13390 coproporphyrinogen III oxidase 0.42 AO356_09725 histidine kinase low > 104
Pseudomonas putida KT2440 0.52 PP_5101 coproporphyrinogen/heterocyclic compound oxidase (aerobic) 0.43 PP_5047 two-component system sensory histidine kinase/phosphatase GlnL/GlnG low > 96
Pseudomonas syringae pv. syringae B728a 0.51 Psyr_0471 coproporphyrinogen III oxidase, anaerobic 0.42 Psyr_4821 PAS/PAC sensor signal transduction histidine kinase low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.51 Psyr_0471 coproporphyrinogen III oxidase, anaerobic 0.42 Psyr_4821 PAS/PAC sensor signal transduction histidine kinase low > 86
Xanthomonas campestris pv. campestris strain 8004 0.49 Xcc-8004.1224.1 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.22 Xcc-8004.251.1 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 74
Dechlorosoma suillum PS 0.49 Dsui_0491 putative oxygen-independent coproporphyrinogen III oxidase 0.38 Dsui_1050 signal transduction histidine kinase, nitrogen specific low > 51
Cupriavidus basilensis FW507-4G11 0.48 RR42_RS04880 coproporphyrinogen III oxidase 0.34 RR42_RS12985 histidine kinase low > 128
Paraburkholderia bryophila 376MFSha3.1 0.48 H281DRAFT_04010 oxygen-independent coproporphyrinogen-3 oxidase 0.32 H281DRAFT_00453 two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL low > 103
Paraburkholderia graminis OAS925 0.48 ABIE53_003236 putative oxygen-independent coproporphyrinogen III oxidase 0.33 ABIE53_002805 two-component system nitrogen regulation sensor histidine kinase GlnL low > 113
Dyella japonica UNC79MFTsu3.2 0.48 ABZR86_RS11910 radical SAM family heme chaperone HemW 0.25 ABZR86_RS15510 ATP-binding protein low > 74
Paraburkholderia sabiae LMG 24235 0.48 QEN71_RS03635 radical SAM family heme chaperone HemW 0.32 QEN71_RS05670 nitrogen regulation protein NR(II) low > 153
Burkholderia phytofirmans PsJN 0.48 BPHYT_RS15335 coproporphyrinogen III oxidase 0.32 BPHYT_RS12940 signal transduction histidine kinase low > 109
Lysobacter sp. OAE881 0.47 ABIE51_RS17300 radical SAM family heme chaperone HemW 0.25 ABIE51_RS01365 ATP-binding protein
Rhodanobacter denitrificans MT42 0.47 LRK55_RS11460 radical SAM family heme chaperone HemW 0.21 LRK55_RS07735 ATP-binding protein low > 63
Rhodanobacter denitrificans FW104-10B01 0.47 LRK54_RS11735 radical SAM family heme chaperone HemW 0.22 LRK54_RS07985 ATP-binding protein 0.46 55
Herbaspirillum seropedicae SmR1 0.46 HSERO_RS10665 coproporphyrinogen III oxidase 0.36 HSERO_RS15685 histidine kinase low > 78
Ralstonia solanacearum PSI07 0.46 RPSI07_RS13830 oxygen-independent coproporphyrinogen III oxidase-like protein 0.36 RPSI07_RS17820 PAS domain-containing sensor histidine kinase low > 81
Castellaniella sp019104865 MT123 0.46 ABCV34_RS03525 radical SAM family heme chaperone HemW 0.29 ABCV34_RS03535 nitrogen regulation protein NR(II) low > 48
Ralstonia solanacearum GMI1000 0.45 RS_RS10840 oxygen-independent coproporphyrinogen III oxidase-like protein 0.37 RS_RS06315 PAS domain-containing sensor histidine kinase low > 80
Ralstonia solanacearum UW163 0.45 UW163_RS10365 oxygen-independent coproporphyrinogen III oxidase-like protein 0.36 UW163_RS12995 PAS domain-containing sensor histidine kinase
Ralstonia solanacearum IBSBF1503 0.45 RALBFv3_RS03355 oxygen-independent coproporphyrinogen III oxidase-like protein 0.36 RALBFv3_RS15535 PAS domain-containing sensor histidine kinase
Rhodanobacter sp. FW510-T8 0.45 OKGIIK_12160 hemW radical SAM family heme chaperone HemW 0.24 OKGIIK_14470 PAS domain-containing sensor histidine kinase low > 52
Ralstonia sp. UNC404CL21Col 0.45 ABZR87_RS15265 radical SAM family heme chaperone HemW 0.32 ABZR87_RS11065 nitrogen regulation protein NR(II) low > 80
Hydrogenophaga sp. GW460-11-11-14-LB1 0.44 GFF3256 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.33 GFF5270 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 90
Marinobacter adhaerens HP15 0.44 HP15_280 putative oxygen-independent coproporphyrinogen III oxidase 0.40 HP15_426 signal transduction histidine kinase, nitrogen specific, NtrB low > 73
Acidovorax sp. GW101-3H11 0.42 Ac3H11_3672 Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB 0.34 Ac3H11_4431 Nitrogen regulation protein NtrB (EC 2.7.13.3) low > 79
Acinetobacter radioresistens SK82 0.42 MPMX26_00308 Heme chaperone HemW 0.35 MPMX26_01293 Sensory histidine kinase/phosphatase NtrB low > 36
Azospirillum brasilense Sp245 0.32 AZOBR_RS02195 coproporphyrinogen III oxidase 0.23 AZOBR_RS14425 ATPase low > 97
Azospirillum sp. SherDot2 0.31 MPMX19_02574 Heme chaperone HemW 0.24 MPMX19_01111 Sensory histidine kinase/phosphatase NtrB low > 112
Rhodospirillum rubrum S1H 0.29 Rru_A3639 Putative oxygen-independent coproporphyrinogen III oxidase (NCBI) 0.24 Rru_A1677 Signal transduction histidine kinase, nitrogen specific, NtrB (NCBI) low > 58
Agrobacterium fabrum C58 0.29 Atu0325 oxygen-independent coproporphyrinogen III oxidase 0.22 Atu1445 two component sensor kinase
Bosea sp. OAE506 0.28 ABIE41_RS03305 radical SAM family heme chaperone HemW 0.22 ABIE41_RS16790 ATP-binding protein low > 77
Rhodopseudomonas palustris CGA009 0.28 TX73_001700 radical SAM family heme chaperone HemW 0.22 TX73_013415 nitrogen regulation protein NR(II)
Magnetospirillum magneticum AMB-1 0.27 AMB_RS22770 radical SAM protein 0.24 AMB_RS11945 PAS domain-containing sensor histidine kinase
Sphingomonas koreensis DSMZ 15582 0.26 Ga0059261_2753 putative oxygen-independent coproporphyrinogen III oxidase 0.15 Ga0059261_0139 Signal transduction histidine kinase, nitrogen specific low > 68

Not shown: 10 genomes with orthologs for GFF3058 only; 3 genomes with orthologs for GFF2221 only