| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_02425 | | YggW family oxidoreductase | 1.0 | CSW01_02845 | | cysteine synthase CysM | 0.54 | 11 |
| Pectobacterium carotovorum WPP14 | 0.69 | HER17_RS03785 | | radical SAM family heme chaperone HemW | 0.68 | HER17_RS17210 | | cysteine synthase CysM | low | > 75 |
| Dickeya dadantii 3937 | 0.68 | DDA3937_RS17325 | | radical SAM family heme chaperone HemW | 0.66 | DDA3937_RS04425 | | cysteine synthase CysM | 0.68 | 50 |
| Dickeya dianthicola 67-19 | 0.68 | HGI48_RS17370 | | radical SAM family heme chaperone HemW | 0.65 | HGI48_RS04400 | | cysteine synthase CysM | 0.40 | 34 |
| Dickeya dianthicola ME23 | 0.68 | DZA65_RS18460 | | radical SAM family heme chaperone HemW | 0.66 | DZA65_RS04315 | | cysteine synthase CysM | low | > 75 |
| Serratia liquefaciens MT49 | 0.68 | IAI46_21435 | | radical SAM family heme chaperone HemW | 0.69 | IAI46_18490 | | cysteine synthase CysM | low | > 86 |
| Escherichia coli ECRC99 | 0.67 | KEDOAH_08905 | hemW | radical SAM family heme chaperone HemW | 0.71 | KEDOAH_06050 | cysM | cysteine synthase B | — | — |
| Escherichia coli ECRC102 | 0.67 | NIAGMN_17000 | hemW | radical SAM family heme chaperone HemW | 0.71 | NIAGMN_19940 | cysM | cysteine synthase B | low | > 80 |
| Escherichia coli ECRC98 | 0.67 | JDDGAC_22865 | hemW | radical SAM family heme chaperone HemW | 0.71 | JDDGAC_26120 | cysM | cysteine synthase B | low | > 87 |
| Escherichia coli ECRC101 | 0.67 | MCAODC_09755 | hemW | radical SAM family heme chaperone HemW | 0.71 | MCAODC_12700 | cysM | cysteine synthase B | low | > 88 |
| Escherichia coli ECRC100 | 0.67 | OKFHMN_19235 | hemW | radical SAM family heme chaperone HemW | 0.71 | OKFHMN_22170 | cysM | cysteine synthase B | low | > 79 |
| Escherichia fergusonii Becca | 0.66 | EFB2_00947 | | Heme chaperone HemW | 0.71 | EFB2_01456 | | Cysteine synthase B | low | > 86 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.66 | OHPLBJKB_00761 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR | 0.71 | OHPLBJKB_01302 | | Cysteine synthase B | low | > 74 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.66 | GFF3058 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.71 | GFF2055 | | Cysteine synthase (EC 2.5.1.47) | low | > 78 |
| Escherichia coli BW25113 | 0.66 | b2955 | yggW | coproporphyrinogen III oxidase (NCBI) | 0.71 | b2421 | cysM | cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) | low | > 76 |
| Escherichia coli BL21 | 0.66 | ECD_02785 | | HemN family putative oxidoreductase | 0.71 | ECD_02321 | | cysteine synthase B (O-acetylserine sulfhydrolase B) | low | > 61 |
| Erwinia tracheiphila HP pepo 2.2 | 0.66 | IJEDHG_03465 | hemW | radical SAM family heme chaperone HemW | 0.64 | IJEDHG_16800 | cysM | cysteine synthase CysM | — | — |
| Escherichia coli ECRC62 | 0.66 | BNILDI_09685 | hemW | radical SAM family heme chaperone HemW | 0.71 | BNILDI_12715 | cysM | cysteine synthase B | low | > 75 |
| Erwinia tracheiphila SCR3 | 0.66 | LU632_RS05445 | hemW | radical SAM family heme chaperone HemW | 0.64 | LU632_RS06675 | cysM | cysteine synthase CysM | low | > 74 |
| Escherichia coli Nissle 1917 | 0.65 | ECOLIN_RS16435 | | radical SAM family heme chaperone HemW | 0.71 | ECOLIN_RS13900 | | cysteine synthase B | — | — |
| Escherichia coli ECOR38 | 0.65 | HEPCGN_18540 | hemW | radical SAM family heme chaperone HemW | 0.71 | HEPCGN_21345 | cysM | cysteine synthase B | low | > 88 |
| Escherichia coli ECOR27 | 0.65 | NOLOHH_11105 | hemW | radical SAM family heme chaperone HemW | 0.71 | NOLOHH_13850 | cysM | cysteine synthase B | low | > 76 |
| Enterobacter sp. TBS_079 | 0.65 | MPMX20_03813 | | Heme chaperone HemW | 0.71 | MPMX20_03313 | | Cysteine synthase B | — | — |
| Enterobacter asburiae PDN3 | 0.65 | EX28DRAFT_2993 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.72 | EX28DRAFT_0209 | | cysteine synthase B | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.65 | PagCFBP13505_RS16115 | | radical SAM family heme chaperone HemW | 0.66 | PagCFBP13505_RS19950 | | cysteine synthase CysM | low | > 74 |
| Pantoea sp. MT58 | 0.65 | IAI47_03580 | | radical SAM family heme chaperone HemW | 0.66 | IAI47_05405 | | cysteine synthase CysM | low | > 76 |
| Klebsiella michiganensis M5al | 0.65 | BWI76_RS24120 | | YggW family oxidoreductase | 0.71 | BWI76_RS20685 | | cysteine synthase B | — | — |
| Klebsiella pneumoniae MKP103 | 0.64 | KDGMDA_04635 | | radical SAM family heme chaperone HemW | 0.72 | KDGMDA_27525 | | cysteine synthase B | low | > 95 |
| Erwinia amylovora T8 | 0.64 | OLJFJH_08515 | | radical SAM family heme chaperone HemW | 0.65 | OLJFJH_10835 | | cysteine synthase CysM | low | > 58 |
| Rahnella sp. WP5 | 0.63 | EX31_RS02710 | | radical SAM family heme chaperone HemW | 0.72 | EX31_RS20205 | | cysteine synthase CysM | low | > 89 |
| Shewanella sp. ANA-3 | 0.59 | Shewana3_1188 | | putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) | 0.82 | Shewana3_3188 | cysM | cysteine synthase B (RefSeq) | low | > 73 |
| Shewanella oneidensis MR-1 | 0.59 | SO3359 | | oxygen-independent coproporphyrinogen III oxidase, putative (NCBI ptt file) | 0.79 | SO3598 | cysM | cysteine synthase B (NCBI ptt file) | low | > 76 |
| Pseudomonas sp. RS175 | 0.54 | PFR28_04249 | | Heme chaperone HemW | 0.74 | PFR28_03225 | | Cysteine synthase B | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.54 | Pf6N2E2_4593 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.74 | Pf6N2E2_5721 | | Cysteine synthase B (EC 2.5.1.47) | — | — |
| Kangiella aquimarina DSM 16071 | 0.54 | B158DRAFT_0201 | | coproporphyrinogen III oxidase, anaerobic (EC 1.3.99.22) | 0.33 | B158DRAFT_1208 | | cystathionine beta-synthase (acetylserine-dependent) (EC 4.2.1.-) | low | > 40 |
| Pseudomonas fluorescens FW300-N2E3 | 0.53 | AO353_08200 | | coproporphyrinogen III oxidase | 0.74 | AO353_02720 | | cysteine synthase | low | > 101 |
| Pseudomonas fluorescens GW456-L13 | 0.53 | PfGW456L13_1003 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.74 | PfGW456L13_2032 | | Cysteine synthase B (EC 2.5.1.47) | low | > 87 |
| Pseudomonas fluorescens SBW25-INTG | 0.53 | PFLU_RS28405 | | radical SAM family heme chaperone HemW | 0.73 | PFLU_RS22105 | | cysteine synthase CysM | low | > 109 |
| Pseudomonas simiae WCS417 | 0.53 | PS417_26760 | | oxidase | 0.72 | PS417_20160 | | cysteine synthase | low | > 88 |
| Pseudomonas fluorescens SBW25 | 0.53 | PFLU_RS28405 | | radical SAM family heme chaperone HemW | 0.73 | PFLU_RS22105 | | cysteine synthase CysM | low | > 109 |
| Pseudomonas fluorescens FW300-N1B4 | 0.53 | Pf1N1B4_2334 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.73 | Pf1N1B4_3506 | | Cysteine synthase B (EC 2.5.1.47) | 0.29 | 77 |
| Pseudomonas sp. DMC3 | 0.53 | GFF216 | | Heme chaperone HemW | 0.73 | GFF4820 | | Cysteine synthase B | low | > 89 |
| Pseudomonas fluorescens FW300-N2C3 | 0.53 | AO356_13390 | | coproporphyrinogen III oxidase | 0.73 | AO356_19050 | | cysteine synthase | low | > 104 |
| Pseudomonas sp. SVBP6 | 0.52 | COO64_RS12965 | hemW | radical SAM family heme chaperone HemW | 0.75 | COO64_RS07335 | cysM | cysteine synthase CysM | low | > 93 |
| Pseudomonas aeruginosa PA14 | 0.51 | IKLFDK_23495 | | radical SAM family heme chaperone HemW | 0.75 | IKLFDK_04190 | | cysteine synthase B | low | > 100 |
| Pseudomonas segetis P6 | 0.51 | MPMX49_00603 | | Heme chaperone HemW | 0.75 | MPMX49_01652 | | Cysteine synthase B | — | — |
| Pseudomonas sp. BP01 | 0.51 | JOY50_RS20875 | hemW | radical SAM family heme chaperone HemW | 0.75 | JOY50_RS23900 | cysM | cysteine synthase CysM | 0.32 | 73 |
| Pseudomonas sp. S08-1 | 0.51 | OH686_11020 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW | 0.74 | OH686_18950 | | cysteine synthase B | — | — |
| Pseudomonas putida KT2440 | 0.51 | PP_5101 | | coproporphyrinogen/heterocyclic compound oxidase (aerobic) | 0.74 | PP_1654 | | cysteine synthase B | low | > 96 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.50 | Psyr_0471 | | coproporphyrinogen III oxidase, anaerobic | 0.72 | Psyr_3697 | | cysteine synthase | — | — |
| Pseudomonas stutzeri RCH2 | 0.50 | Psest_0276 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.76 | Psest_1638 | | cysteine synthase B | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.50 | Psyr_0471 | | coproporphyrinogen III oxidase, anaerobic | 0.72 | Psyr_3697 | | cysteine synthase | — | — |
| Pseudomonas lactucae CFBP13502 | 0.49 | GEMAOFIL_05489 | | Heme chaperone HemW | 0.73 | GEMAOFIL_04225 | | Cysteine synthase B | — | — |
| Xanthomonas campestris pv. campestris strain 8004 | 0.48 | Xcc-8004.1224.1 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.34 | Xcc-8004.1247.1 | | Cysteine synthase (EC 2.5.1.47) | low | > 74 |
| Dyella japonica UNC79MFTsu3.2 | 0.47 | ABZR86_RS11910 | | radical SAM family heme chaperone HemW | 0.33 | ABZR86_RS05875 | | cysteine synthase A | low | > 74 |
| Lysobacter sp. OAE881 | 0.47 | ABIE51_RS17300 | | radical SAM family heme chaperone HemW | 0.35 | ABIE51_RS15860 | | cysteine synthase A | low | > 62 |
| Rhodanobacter denitrificans MT42 | 0.46 | LRK55_RS11460 | | radical SAM family heme chaperone HemW | 0.35 | LRK55_RS00680 | | cysteine synthase A | low | > 63 |
| Rhodanobacter denitrificans FW104-10B01 | 0.46 | LRK54_RS11735 | | radical SAM family heme chaperone HemW | 0.35 | LRK54_RS00905 | | cysteine synthase A | low | > 59 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.45 | H281DRAFT_04010 | | oxygen-independent coproporphyrinogen-3 oxidase | 0.65 | H281DRAFT_03911 | | cysteine synthase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.45 | RR42_RS04880 | | coproporphyrinogen III oxidase | 0.64 | RR42_RS04535 | | cysteine synthase | low | > 128 |
| Burkholderia phytofirmans PsJN | 0.44 | BPHYT_RS15335 | | coproporphyrinogen III oxidase | 0.63 | BPHYT_RS14845 | | cysteine synthase | low | > 109 |
| Herbaspirillum seropedicae SmR1 | 0.44 | HSERO_RS10665 | | coproporphyrinogen III oxidase | 0.64 | HSERO_RS04915 | | cysteine synthase | — | — |
| Dechlorosoma suillum PS | 0.44 | Dsui_0491 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.66 | Dsui_1954 | | cysteine synthase B | — | — |
| Paraburkholderia graminis OAS925 | 0.44 | ABIE53_003236 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.63 | ABIE53_003144 | | cysteine synthase B | low | > 113 |
| Variovorax sp. OAS795 | 0.44 | ABID97_RS23630 | | radical SAM family heme chaperone HemW | 0.66 | ABID97_RS07880 | | cysteine synthase CysM | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.44 | QEN71_RS03635 | | radical SAM family heme chaperone HemW | 0.65 | QEN71_RS04135 | | cysteine synthase CysM | — | — |
| Variovorax sp. SCN45 | 0.44 | GFF2383 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW | 0.67 | GFF6025 | | Cysteine synthase B (EC 2.5.1.47) | — | — |
| Ralstonia solanacearum PSI07 | 0.44 | RPSI07_RS13830 | | oxygen-independent coproporphyrinogen III oxidase-like protein | 0.66 | RPSI07_RS19645 | | cysteine synthase CysM | — | — |
| Marinobacter adhaerens HP15 | 0.43 | HP15_280 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.76 | HP15_789 | | cysteine synthase B | — | — |
| Methylophilus sp. DMC18 | 0.43 | GFF2148 | | Heme chaperone HemW | 0.68 | GFF907 | | Cysteine synthase B | — | — |
| Ralstonia sp. UNC404CL21Col | 0.43 | ABZR87_RS15265 | | radical SAM family heme chaperone HemW | 0.65 | ABZR87_RS09515 | | cysteine synthase CysM | low | > 80 |
| Ralstonia solanacearum GMI1000 | 0.42 | RS_RS10840 | | oxygen-independent coproporphyrinogen III oxidase-like protein | 0.66 | RS_RS04560 | | cysteine synthase CysM | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.42 | RALBFv3_RS03355 | | oxygen-independent coproporphyrinogen III oxidase-like protein | 0.66 | RALBFv3_RS13825 | | cysteine synthase CysM | — | — |
| Ralstonia solanacearum UW163 | 0.42 | UW163_RS10365 | | oxygen-independent coproporphyrinogen III oxidase-like protein | 0.66 | UW163_RS15985 | | cysteine synthase CysM | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.42 | GFF3256 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.66 | GFF709 | | Cysteine synthase B (EC 2.5.1.47) | 0.52 | 58 |
| Acinetobacter baumannii LAC-4 | 0.41 | RR41_RS17015 | | radical SAM family heme chaperone HemW | 0.72 | RR41_RS16095 | | cysteine synthase CysM | — | — |
| Acidovorax sp. GW101-3H11 | 0.41 | Ac3H11_3672 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.66 | Ac3H11_644 | | Cysteine synthase B (EC 2.5.1.47) | — | — |
| Acinetobacter radioresistens SK82 | 0.41 | MPMX26_00308 | | Heme chaperone HemW | 0.74 | MPMX26_00536 | | Cysteine synthase B | — | — |
| Castellaniella sp019104865 MT123 | 0.41 | ABCV34_RS03525 | | radical SAM family heme chaperone HemW | 0.62 | ABCV34_RS07055 | | cysteine synthase CysM | — | — |
| Phaeobacter inhibens DSM 17395 | 0.28 | PGA1_c35050 | | oxygen-independent coproporphyrinogen III oxidase HemN | 0.27 | PGA1_c13950 | | cysteine synthase CysK | — | — |
| Dinoroseobacter shibae DFL-12 | 0.28 | Dshi_3460 | | putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) | 0.28 | Dshi_2314 | | Pyridoxal-5'-phosphate-dependent protein beta subunit (RefSeq) | — | — |
| Caulobacter crescentus NA1000 | 0.26 | CCNA_00144 | | oxygen-independent coproporphyrinogen-III oxidase | 0.31 | CCNA_01493 | | cysteine synthase | low | > 66 |
| Caulobacter crescentus NA1000 Δfur | 0.26 | CCNA_00144 | | oxygen-independent coproporphyrinogen-III oxidase | 0.31 | CCNA_01493 | | cysteine synthase | low | > 67 |
| Fusobacterium nucleatum SB010 | 0.25 | HUW76_07285 | | radical SAM family heme chaperone HemW | 0.30 | HUW76_04155 | | cysteine synthase A | — | — |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.24 | Echvi_0628 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.55 | Echvi_0220 | | cysteine synthase B | — | — |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.22 | CA264_16765 | | coproporphyrinogen III oxidase | 0.57 | CA264_08940 | | cysteine synthase B | low | > 74 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.21 | ABZR88_RS03545 | | radical SAM family heme chaperone HemW | 0.54 | ABZR88_RS13695 | | cysteine synthase CysM | — | — |
| Cellulophaga baltica 18 | 0.20 | M666_RS07265 | | radical SAM family heme chaperone HemW | 0.55 | M666_RS17050 | | cysteine synthase CysM | — | — |
Not shown: 22 genomes with orthologs for CSW01_02425 only; 1 genomes with orthologs for CSW01_02845 only