Conservation of cofitness between CSW01_01015 and CSW01_00850 in Vibrio cholerae E7946 ATCC 55056

87 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Vibrio cholerae E7946 ATCC 55056 1.0 CSW01_01015 DNA helicase II 1.0 CSW01_00850 multidrug resistance protein 0.73 13
Escherichia coli BW25113 0.71 b3813 uvrD DNA-dependent ATPase I and helicase II (NCBI) 0.24 b2470 acrD aminoglycoside/multidrug efflux system (NCBI) low > 76
Escherichia coli ECOR27 0.71 NOLOHH_06540 uvrD DNA helicase II 0.24 NOLOHH_13650 acrD multidrug efflux RND transporter permease AcrD low > 76
Escherichia coli ECRC62 0.71 BNILDI_04995 uvrD DNA helicase II 0.24 BNILDI_12460 acrD multidrug efflux RND transporter permease AcrD low > 75
Escherichia coli ECRC102 0.71 NIAGMN_12165 uvrD DNA helicase II 0.24 NIAGMN_19740 acrD multidrug efflux RND transporter permease AcrD low > 80
Escherichia fergusonii Becca 0.71 EFB2_04824 DNA helicase II 0.24 EFB2_01418 Multidrug efflux pump subunit AcrB low > 86
Escherichia coli ECRC98 0.71 JDDGAC_18035 uvrD DNA helicase II 0.24 JDDGAC_25915 acrD multidrug efflux RND transporter permease AcrD low > 87
Escherichia coli ECRC101 0.71 MCAODC_04915 uvrD DNA helicase II 0.24 MCAODC_12500 acrD multidrug efflux RND transporter permease AcrD low > 87
Escherichia coli HS(pFamp)R (ATCC 700891) 0.71 OHPLBJKB_04237 DNA helicase II 0.24 OHPLBJKB_01261 Multidrug efflux pump subunit AcrB low > 74
Klebsiella michiganensis M5al 0.71 BWI76_RS01220 DNA-dependent helicase II 0.24 BWI76_RS06775 multidrug efflux RND transporter permease subunit low > 92
Escherichia coli BL21 0.71 ECD_03689 DNA-dependent ATPase I and helicase II 0.24 ECD_02361 aminoglycoside/multidrug efflux system — —
Escherichia coli ECRC100 0.71 OKFHMN_14410 uvrD DNA helicase II 0.24 OKFHMN_21970 acrD multidrug efflux RND transporter permease AcrD low > 79
Escherichia coli Nissle 1917 0.71 ECOLIN_RS21885 DNA helicase II 0.24 ECOLIN_RS14090 multidrug efflux RND transporter permease AcrD low > 55
Escherichia coli ECRC99 0.71 KEDOAH_13740 uvrD DNA helicase II 0.24 KEDOAH_06250 acrD multidrug efflux RND transporter permease AcrD — —
Serratia liquefaciens MT49 0.71 IAI46_00735 DNA helicase II 0.23 IAI46_18690 multidrug efflux RND transporter permease AcrD low > 87
Escherichia coli ECOR38 0.71 HEPCGN_13115 uvrD DNA helicase II 0.24 HEPCGN_21140 acrD multidrug efflux RND transporter permease AcrD low > 88
Klebsiella pneumoniae MKP103 0.71 KDGMDA_09710 DNA helicase II 0.24 KDGMDA_14835 acriflavine resistance protein B low > 95
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.71 GFF241 ATP-dependent DNA helicase UvrD/PcrA 0.24 GFF4246 RND efflux system, inner membrane transporter CmeB low > 78
Enterobacter sp. TBS_079 0.70 MPMX20_04463 DNA helicase II 0.24 MPMX20_01064 Multidrug efflux pump subunit AcrB low > 85
Enterobacter asburiae PDN3 0.70 EX28DRAFT_4482 ATP-dependent DNA helicase UvrD (EC 3.6.1.-) 0.24 EX28DRAFT_2496 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family low > 76
Dickeya dadantii 3937 0.70 DDA3937_RS19880 DNA helicase II 0.23 DDA3937_RS05735 multidrug efflux RND transporter permease subunit low > 74
Dickeya dianthicola ME23 0.70 DZA65_RS21080 DNA helicase II 0.22 DZA65_RS06115 multidrug efflux RND transporter permease subunit low > 75
Dickeya dianthicola 67-19 0.70 HGI48_RS20035 DNA helicase II 0.22 HGI48_RS05790 multidrug efflux RND transporter permease subunit 0.42 68
Pectobacterium carotovorum WPP14 0.70 HER17_RS01360 DNA helicase II 0.23 HER17_RS01560 multidrug efflux RND transporter permease AcrD low > 75
Pantoea sp. MT58 0.69 IAI47_18390 DNA helicase II 0.23 IAI47_05310 multidrug efflux RND transporter permease AcrD low > 76
Pantoea agglomerans CFBP13505 P0401 0.68 PagCFBP13505_RS15370 DNA helicase II 0.23 PagCFBP13505_RS19855 multidrug efflux RND transporter permease AcrD low > 74
Erwinia tracheiphila SCR3 0.68 LU632_RS24125 uvrD DNA helicase II 0.22 LU632_RS18185 efflux RND transporter permease subunit — —
Erwinia tracheiphila HP pepo 2.2 0.68 IJEDHG_08770 uvrD DNA helicase II 0.21 IJEDHG_16580 adeB hydrophobe/amphiphile efflux-1 family RND transporter — —
Rahnella sp. WP5 0.68 EX31_RS15175 DNA helicase II 0.23 EX31_RS22470 multidrug efflux RND transporter permease subunit low > 89
Erwinia amylovora T8 0.68 OLJFJH_06425 DNA helicase II 0.22 OLJFJH_17855 multidrug efflux RND transporter permease subunit AcrB low > 58
Shewanella sp. ANA-3 0.67 Shewana3_0469 uvrD DNA-dependent helicase II (RefSeq) 0.72 Shewana3_0371 acriflavin resistance protein (RefSeq) low > 73
Shewanella amazonensis SB2B 0.66 Sama_0419 uvrD DNA-dependent helicase II (RefSeq) 0.71 Sama_3269 putative multidrug resistance protein (RefSeq) low > 62
Pseudomonas aeruginosa PA14 0.60 IKLFDK_26200 DNA helicase II 0.46 IKLFDK_02225 multidrug efflux RND transporter permease subunit MexW low > 98
Pseudomonas aeruginosa MRSN321 0.60 DY961_RS25505 uvrD;go_function=DNA DNA helicase II 0.46 DY961_RS24615 mexW;inference=COORDINATES multidrug efflux RND transporter permease subunit MexW low > 100
Pseudomonas aeruginosa PUPa3 0.60 DQ20_RS57955 uvrD;go_function=DNA DNA helicase II 0.46 DQ20_RS57065 mexW;inference=COORDINATES multidrug efflux RND transporter permease subunit MexW low > 101
Pseudomonas putida KT2440 0.60 PP_5352 DNA-dependent ATPase I and helicase II, nucleotide Excision Repair Complex 0.46 PP_0906 putative Multidrug efflux RND transporter low > 96
Pseudomonas sp. BP01 0.60 JOY50_RS08735 uvrD DNA helicase II 0.47 JOY50_RS14955 multidrug efflux RND transporter permease subunit low > 84
Pseudomonas sp. SVBP6 0.60 COO64_RS01845 uvrD DNA helicase II 0.46 COO64_RS12055 multidrug efflux RND transporter permease subunit low > 93
Pseudomonas fluorescens SBW25 0.59 PFLU_RS29900 DNA helicase II 0.47 PFLU_RS24405 multidrug efflux RND transporter permease subunit low > 109
Pseudomonas fluorescens SBW25-INTG 0.59 PFLU_RS29900 DNA helicase II 0.47 PFLU_RS24405 multidrug efflux RND transporter permease subunit low > 109
Pseudomonas orientalis W4I3 0.59 QF045_RS02600 DNA helicase II 0.24 QF045_RS16760 efflux RND transporter permease subunit low > 93
Pseudomonas lactucae CFBP13502 0.59 GEMAOFIL_00116 DNA helicase II 0.23 GEMAOFIL_03223 multidrug efflux RND transporter permease subunit OqxB9 low > 96
Pseudomonas fluorescens FW300-N2E3 0.59 AO353_10055 DNA helicase II 0.46 AO353_04000 acriflavine resistance protein B low > 101
Pseudomonas sp. DMC3 0.59 GFF512 DNA helicase II 0.46 GFF5069 Multidrug efflux pump subunit AcrB low > 89
Pseudomonas sp. S08-1 0.59 OH686_13045 ATP-dependent DNA helicase UvrD/PcrA 0.47 OH686_17360 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) low > 80
Pseudomonas fluorescens GW456-L13 0.59 PfGW456L13_724 ATP-dependent DNA helicase UvrD/PcrA 0.45 PfGW456L13_1771 RND multidrug efflux transporter; Acriflavin resistance protein low > 87
Pseudomonas stutzeri RCH2 0.59 Psest_4098 Superfamily I DNA and RNA helicases 0.45 Psest_1153 Cation/multidrug efflux pump low > 67
Pseudomonas fluorescens FW300-N1B4 0.59 Pf1N1B4_2005 ATP-dependent DNA helicase UvrD/PcrA 0.47 Pf1N1B4_720 RND multidrug efflux transporter; Acriflavin resistance protein low > 87
Pseudomonas fluorescens FW300-N2E2 0.59 Pf6N2E2_4273 ATP-dependent DNA helicase UvrD/PcrA 0.47 Pf6N2E2_5614 RND multidrug efflux transporter; Acriflavin resistance protein low > 103
Pseudomonas fluorescens FW300-N2C3 0.59 AO356_11990 DNA helicase II 0.47 AO356_18440 acriflavine resistance protein B 0.35 41
Pseudomonas sp. RS175 0.59 PFR28_04523 DNA helicase II 0.47 PFR28_03330 Multidrug efflux pump subunit AcrB low > 88
Kangiella aquimarina DSM 16071 0.58 B158DRAFT_0238 Superfamily I DNA and RNA helicases 0.23 B158DRAFT_0733 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family low > 40
Pseudomonas segetis P6 0.58 ACVTMO_RS00885 uvrD DNA helicase II 0.48 ACVTMO_RS18680 multidrug efflux RND transporter permease subunit low > 75
Pseudomonas syringae pv. syringae B728a ΔmexB 0.58 Psyr_5065 ATP-dependent DNA helicase UvrD 0.23 Psyr_2968 Hydrophobe/amphiphile efflux-1 HAE1 low > 86
Pseudomonas syringae pv. syringae B728a 0.58 Psyr_5065 ATP-dependent DNA helicase UvrD 0.23 Psyr_2968 Hydrophobe/amphiphile efflux-1 HAE1 0.36 83
Marinobacter adhaerens HP15 0.56 HP15_3403 UvrD/REP helicase 0.46 HP15_3262 multidrug resistance protein low > 73
Rhodanobacter sp. FW510-T8 0.55 OKGIIK_16775 DNA helicase 0.23 OKGIIK_11990 acrB acriflavine resistance protein B low > 53
Dyella japonica UNC79MFTsu3.2 0.55 ABZR86_RS16965 DNA helicase II 0.23 ABZR86_RS11745 efflux RND transporter permease subunit low > 74
Rhodanobacter denitrificans MT42 0.54 LRK55_RS06595 DNA helicase II 0.23 LRK55_RS11630 efflux RND transporter permease subunit — —
Rhodanobacter denitrificans FW104-10B01 0.54 LRK54_RS06850 DNA helicase II 0.23 LRK54_RS11905 efflux RND transporter permease subunit low > 59
Rhodanobacter sp000427505 FW510-R12 0.53 LRK53_RS01560 UvrD-helicase domain-containing protein 0.22 LRK53_RS07935 multidrug efflux RND transporter permease subunit — —
Methylophilus sp. DMC18 0.48 GFF1664 DNA helicase II 0.24 GFF1649 Efflux pump membrane transporter BepE low > 43
Burkholderia phytofirmans PsJN 0.45 BPHYT_RS13840 DNA-dependent helicase 0.43 BPHYT_RS29560 acriflavine resistance protein B — —
Dechlorosoma suillum PS 0.45 Dsui_1227 DNA/RNA helicase, superfamily I 0.35 Dsui_1555 cation/multidrug efflux pump low > 51
Paraburkholderia graminis OAS925 0.45 ABIE53_002936 DNA helicase-2/ATP-dependent DNA helicase PcrA 0.24 ABIE53_005788 multidrug efflux pump — —
Paraburkholderia bryophila 376MFSha3.1 0.44 H281DRAFT_04469 ATP-dependent DNA helicase UvrD 0.23 H281DRAFT_04170 multidrug efflux pump — —
Paraburkholderia sabiae LMG 24235 0.44 QEN71_RS05110 3'-5' exonuclease 0.43 QEN71_RS26025 efflux RND transporter permease subunit — —
Acidovorax sp. GW101-3H11 0.44 Ac3H11_1660 ATP-dependent DNA helicase UvrD/PcrA 0.34 Ac3H11_482 RND multidrug efflux transporter; Acriflavin resistance protein low > 79
Cupriavidus basilensis FW507-4G11 0.44 RR42_RS15090 DNA helicase 0.22 RR42_RS32420 multidrug efflux RND transporter permease subunit low > 128
Variovorax sp. OAS795 0.44 ABID97_RS09150 UvrD-helicase domain-containing protein 0.22 ABID97_RS17350 efflux RND transporter permease subunit low > 91
Herbaspirillum seropedicae SmR1 0.43 HSERO_RS02160 DNA-dependent helicase 0.23 HSERO_RS23055 multidrug transporter low > 78
Ralstonia sp. UNC404CL21Col 0.43 ABZR87_RS15705 UvrD-helicase domain-containing protein 0.22 ABZR87_RS09795 efflux RND transporter permease subunit low > 80
Variovorax sp. SCN45 0.43 GFF4000 ATP-dependent DNA helicase UvrD/PcrA (EC 3.6.4.12) 0.45 GFF3509 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) => MexI of MexHI-OpmD system low > 127
Hydrogenophaga sp. GW460-11-11-14-LB1 0.42 GFF5598 ATP-dependent DNA helicase UvrD/PcrA 0.34 GFF4261 RND multidrug efflux transporter; Acriflavin resistance protein — —
Ralstonia solanacearum GMI1000 0.42 RS_RS11220 DNA-dependent helicase 0.22 RS_RS00045 multidrug efflux RND transporter permease subunit low > 80
Ralstonia solanacearum IBSBF1503 0.42 RALBFv3_RS03775 DNA-dependent helicase 0.22 RALBFv3_RS09445 multidrug efflux RND transporter permease subunit — —
Ralstonia solanacearum UW163 0.42 UW163_RS09895 DNA-dependent helicase 0.22 UW163_RS04135 multidrug efflux RND transporter permease subunit — —
Ralstonia solanacearum PSI07 0.42 RPSI07_RS13455 DNA-dependent helicase 0.22 RPSI07_RS23905 hydrophobe/amphiphile efflux-1 family RND transporter — —
Castellaniella sp019104865 MT123 0.42 ABCV34_RS05210 UvrD-helicase domain-containing protein 0.20 ABCV34_RS14620 multidrug efflux RND transporter permease subunit low > 48
Azospirillum brasilense Sp245 0.35 AZOBR_RS12445 DNA helicase II 0.49 AZOBR_RS31320 acriflavine resistance protein B low > 97
Bosea sp. OAE506 0.35 ABIE41_RS12730 UvrD-helicase domain-containing protein 0.23 ABIE41_RS01595 efflux RND transporter permease subunit low > 77
Azospirillum sp. SherDot2 0.34 MPMX19_01610 ATP-dependent DNA helicase PcrA 0.48 MPMX19_05610 Efflux pump membrane transporter BepE low > 112
Magnetospirillum magneticum AMB-1 0.34 AMB_RS03725 DNA helicase II 0.48 AMB_RS17260 acriflavine resistance protein B low > 64
Rhodospirillum rubrum S1H 0.32 Rru_A1536 UvrD/REP helicase (NCBI) 0.49 Rru_A3699 Acriflavin resistance protein (NCBI) low > 58
Cellulophaga baltica 18 0.30 M666_RS15390 3'-5' exonuclease 0.23 M666_RS00650 efflux RND transporter permease subunit — —
Synechococcus elongatus PCC 7942 0.29 Synpcc7942_2168 pcrA ATP-dependent DNA helicase, Rep family 0.24 Synpcc7942_2369 acrF Hydrophobe/amphiphile efflux-1 HAE1 low > 38
Desulfovibrio vulgaris Hildenborough JW710 0.19 DVU0156 pcrA ATP-dependent DNA helicase, UvrD/REP family (TIGR) 0.25 DVU0061 multidrug resistance protein, putative (TIGR) low > 55
Desulfovibrio vulgaris Miyazaki F 0.17 DvMF_1967 UvrD/REP helicase (RefSeq) 0.24 DvMF_2163 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family (RefSeq) low > 51

Not shown: 25 genomes with orthologs for CSW01_01015 only; 7 genomes with orthologs for CSW01_00850 only