Conservation of cofitness between BT0409 and BT0201 in Bacteroides thetaiotaomicron VPI-5482

85 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Bacteroides thetaiotaomicron VPI-5482 1.0 BT0409 putative short-chain dehydrogenase (NCBI ptt file) 1.0 BT0201 histidinol dehydrogenase (NCBI ptt file) 0.32 18
Bacteroides ovatus ATCC 8483 0.94 BACOVA_01762 hypothetical protein 0.93 BACOVA_01234 histidinol dehydrogenase low > 94
Phocaeicola dorei CL03T12C01 0.82 ABI39_RS12400 SDR family oxidoreductase 0.79 ABI39_RS11835 histidinol dehydrogenase low > 72
Phocaeicola vulgatus CL09T03C04 0.81 HMPREF1058_RS16480 SDR family oxidoreductase 0.79 HMPREF1058_RS15875 histidinol dehydrogenase low > 67
Bacteroides stercoris CC31F 0.77 HMPREF1181_RS12415 SDR family oxidoreductase 0.81 HMPREF1181_RS04860 histidinol dehydrogenase low > 56
Kangiella aquimarina DSM 16071 0.53 B158DRAFT_0585 Short-chain alcohol dehydrogenase of unknown specificity 0.27 B158DRAFT_2293 histidinol dehydrogenase low > 40
Pedobacter sp. GW460-11-11-14-LB5 0.53 CA265_RS15110 NAD(P)-dependent oxidoreductase 0.54 CA265_RS03635 histidinol dehydrogenase low > 88
Mucilaginibacter yixingensis YX-36 DSM 26809 0.51 ABZR88_RS15830 SDR family NAD(P)-dependent oxidoreductase 0.52 ABZR88_RS06880 histidinol dehydrogenase — —
Desulfovibrio vulgaris Hildenborough JW710 0.49 DVU1784 oxidoreductase, short-chain dehydrogenase/reductase family (TIGR) 0.33 DVU0796 hisD histidinol dehydrogenase (TIGR) low > 55
Pontibacter actiniarum KMM 6156, DSM 19842 0.47 CA264_00460 NAD(P)-dependent oxidoreductase 0.60 CA264_05030 histidinol dehydrogenase low > 74
Rhodospirillum rubrum S1H 0.47 Rru_A2127 Serine 3-dehydrogenase (NCBI) 0.32 Rru_A2771 Histidinol dehydrogenase (NCBI) low > 58
Rahnella sp. WP5 0.46 EX31_RS07075 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.49 EX31_RS11440 histidinol dehydrogenase low > 89
Echinicola vietnamensis KMM 6221, DSM 17526 0.46 Echvi_1820 Short-chain alcohol dehydrogenase of unknown specificity 0.60 Echvi_2459 histidinol dehydrogenase low > 79
Pseudomonas syringae pv. syringae B728a ΔmexB 0.45 Psyr_0602 Short-chain dehydrogenase/reductase SDR 0.30 Psyr_4133 histidinol dehydrogenase low > 86
Pseudomonas syringae pv. syringae B728a 0.45 Psyr_0602 Short-chain dehydrogenase/reductase SDR 0.30 Psyr_4133 histidinol dehydrogenase low > 86
Pseudomonas stutzeri RCH2 0.45 Psest_0101 Short-chain alcohol dehydrogenase of unknown specificity 0.30 Psest_3298 histidinol dehydrogenase low > 67
Pectobacterium carotovorum WPP14 0.45 HER17_RS10705 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.49 HER17_RS12230 histidinol dehydrogenase low > 75
Pseudomonas fluorescens GW456-L13 0.45 PfGW456L13_117 Oxidoreductase, short chain dehydrogenase/reductase family 0.29 PfGW456L13_5000 Histidinol dehydrogenase (EC 1.1.1.23) low > 87
Erwinia tracheiphila SCR3 0.45 LU632_RS11720 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.51 LU632_RS08945 hisD histidinol dehydrogenase low > 74
Pseudomonas fluorescens FW300-N2E3 0.44 AO353_13380 hypothetical protein 0.29 AO353_05110 histidinol dehydrogenase low > 101
Pseudomonas fluorescens FW300-N1B4 0.44 Pf1N1B4_1376 Oxidoreductase, short chain dehydrogenase/reductase family 0.30 Pf1N1B4_1066 Histidinol dehydrogenase (EC 1.1.1.23) — —
Serratia liquefaciens MT49 0.44 IAI46_11720 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.51 IAI46_08210 histidinol dehydrogenase low > 86
Dickeya dianthicola 67-19 0.44 HGI48_RS10690 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.49 HGI48_RS09745 histidinol dehydrogenase low > 71
Dickeya dianthicola ME23 0.44 DZA65_RS11160 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.49 DZA65_RS10055 histidinol dehydrogenase low > 75
Pseudomonas fluorescens FW300-N2E2 0.44 Pf6N2E2_3575 Oxidoreductase, short chain dehydrogenase/reductase family 0.30 Pf6N2E2_3252 Histidinol dehydrogenase (EC 1.1.1.23) low > 103
Pseudomonas fluorescens FW300-N2C3 0.44 AO356_08475 hypothetical protein 0.29 AO356_06965 histidinol dehydrogenase low > 104
Pseudomonas sp. RS175 0.44 PFR28_05158 Sulfoacetaldehyde reductase 0.30 PFR28_00187 Histidinol dehydrogenase low > 88
Paraburkholderia bryophila 376MFSha3.1 0.43 H281DRAFT_04724 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase 0.30 H281DRAFT_05652 histidinol dehydrogenase — —
Escherichia coli Nissle 1917 0.43 ECOLIN_RS08810 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 ECOLIN_RS11945 histidinol dehydrogenase — —
Pantoea sp. MT58 0.43 IAI47_09805 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.50 IAI47_07090 histidinol dehydrogenase low > 76
Dickeya dadantii 3937 0.43 DDA3937_RS10695 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.50 DDA3937_RS09735 histidinol dehydrogenase low > 74
Escherichia fergusonii Becca 0.43 EFB2_02417 NADP-dependent 3-hydroxy acid dehydrogenase YdfG 0.52 EFB2_01836 Histidinol dehydrogenase low > 86
Escherichia coli ECRC101 0.43 OKFHMN_01015 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 OKFHMN_24515 hisD Histidinol dehydrogenase — —
Escherichia coli BW25113 0.43 b1539 ydfG L-allo-threonine dehydrogenase, NAD(P)-binding (NCBI) 0.53 b2020 hisD histidinol dehydrogenase (NCBI) 0.21 60
Escherichia coli BL21 0.43 ECD_01498 NADP-dependent 3-hydroxy acid dehydrogenase; malonic semialdehyde reductase 0.52 ECD_01922 bifunctional histidinal dehydrogenase/ histidinol dehydrogenase low > 60
Ralstonia solanacearum GMI1000 0.43 RS_RS03675 NAD(P)-dependent oxidoreductase 0.31 RS_RS14790 histidinol dehydrogenase — —
Desulfovibrio vulgaris Miyazaki F 0.43 DvMF_0398 short-chain dehydrogenase/reductase SDR (RefSeq) 0.28 DvMF_2814 hisD histidinol dehydrogenase (RefSeq) low > 51
Escherichia coli ECOR38 0.43 HEPCGN_26930 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 HEPCGN_03220 hisD Histidinol dehydrogenase low > 85
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS26240 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.30 QEN71_RS27865 histidinol dehydrogenase low > 153
Escherichia coli ECRC99 0.43 KEDOAH_27415 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 KEDOAH_03635 hisD Histidinol dehydrogenase — —
Xanthomonas campestris pv. campestris strain 8004 0.43 Xcc-8004.4903.1 Oxidoreductase 0.45 Xcc-8004.2948.1 Histidinol dehydrogenase (EC 1.1.1.23) low > 74
Escherichia coli ECRC62 0.43 BNILDI_17130 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 BNILDI_14740 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC98 0.43 JDDGAC_03525 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 JDDGAC_28625 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC102 0.43 NIAGMN_25160 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 NIAGMN_22460 hisD Histidinol dehydrogenase — —
Escherichia coli ECOR27 0.43 NOLOHH_18640 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 NOLOHH_15830 hisD Histidinol dehydrogenase — —
Escherichia coli ECRC101 0.43 MCAODC_16910 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.52 MCAODC_20425 hisD Histidinol dehydrogenase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.42 OHPLBJKB_02173 NADP-dependent 3-hydroxy acid dehydrogenase YdfG 0.52 OHPLBJKB_01680 Histidinol dehydrogenase low > 73
Burkholderia phytofirmans PsJN 0.42 BPHYT_RS03720 malonic semialdehyde reductase 0.30 BPHYT_RS17710 histidinol dehydrogenase — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.42 GFF2497 3-hydroxypropionate dehydrogenase (EC 1.1.1.298) 0.52 GFF3912 Histidinol dehydrogenase (EC 1.1.1.23) low > 78
Enterobacter sp. TBS_079 0.42 MPMX20_02099 NADP-dependent 3-hydroxy acid dehydrogenase YdfG 0.51 MPMX20_03002 Histidinol dehydrogenase 0.20 64
Ralstonia sp. UNC404CL21Col 0.42 ABZR87_RS08960 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.32 ABZR87_RS02500 histidinol dehydrogenase — —
Ralstonia solanacearum IBSBF1503 0.42 RALBFv3_RS12900 NAD(P)-dependent oxidoreductase 0.32 RALBFv3_RS06845 histidinol dehydrogenase — —
Ralstonia solanacearum UW163 0.42 UW163_RS00665 NAD(P)-dependent oxidoreductase 0.32 UW163_RS06770 histidinol dehydrogenase — —
Pseudomonas putida KT2440 0.42 PP_4862 3-hydroxy acid dehydrogenase, NADP-dependent / malonic semialdehyde reductase 0.29 PP_0966 Histidinol dehydrogenase low > 96
Enterobacter asburiae PDN3 0.42 EX28DRAFT_1450 Short-chain alcohol dehydrogenase of unknown specificity 0.50 EX28DRAFT_0539 histidinol dehydrogenase low > 76
Ralstonia solanacearum PSI07 0.42 RPSI07_RS20325 NAD(P)-dependent oxidoreductase 0.32 RPSI07_RS10390 histidinol dehydrogenase — —
Klebsiella michiganensis M5al 0.42 BWI76_RS07595 putative oxidoreductase 0.50 BWI76_RS18925 histidinol dehydrogenase low > 92
Agrobacterium fabrum C58 0.42 Atu4110 serine dehydrogenase 0.35 Atu0537 histidinol dehydrogenase low > 89
Herbaspirillum seropedicae SmR1 0.41 HSERO_RS06135 malonic semialdehyde reductase 0.31 HSERO_RS20345 histidinol dehydrogenase low > 78
Pseudomonas simiae WCS417 0.41 PS417_02680 hypothetical protein 0.31 PS417_04420 histidinol dehydrogenase low > 88
Pseudomonas fluorescens SBW25-INTG 0.41 PFLU_RS02750 SDR family oxidoreductase 0.32 PFLU_RS04470 histidinol dehydrogenase low > 109
Pseudomonas fluorescens SBW25 0.41 PFLU_RS02750 SDR family oxidoreductase 0.32 PFLU_RS04470 histidinol dehydrogenase low > 109
Rhodanobacter denitrificans MT42 0.39 LRK55_RS08680 SDR family NAD(P)-dependent oxidoreductase 0.44 LRK55_RS01385 histidinol dehydrogenase low > 63
Rhodanobacter denitrificans FW104-10B01 0.39 LRK54_RS09150 SDR family NAD(P)-dependent oxidoreductase 0.43 LRK54_RS01605 histidinol dehydrogenase low > 59
Rhodanobacter sp. FW510-T8 0.39 OKGIIK_15640 NADP-dependent 3-hydroxy acid dehydrogenase 0.44 OKGIIK_04950 hisD histidinol dehydrogenase 0.52 40
Magnetospirillum magneticum AMB-1 0.39 AMB_RS12070 NADP-dependent 3-hydroxy acid dehydrogenase 0.33 AMB_RS16905 histidinol dehydrogenase — —
Castellaniella sp019104865 MT123 0.38 ABCV34_RS03925 SDR family NAD(P)-dependent oxidoreductase 0.29 ABCV34_RS11230 histidinol dehydrogenase low > 48
Azospirillum sp. SherDot2 0.37 MPMX19_02817 Serine 3-dehydrogenase 0.32 MPMX19_05543 Histidinol dehydrogenase — —
Sphingomonas koreensis DSMZ 15582 0.37 Ga0059261_2041 Short-chain alcohol dehydrogenase of unknown specificity 0.32 Ga0059261_1281 histidinol dehydrogenase low > 68
Bosea sp. OAE506 0.34 ABIE41_RS08870 SDR family NAD(P)-dependent oxidoreductase 0.32 ABIE41_RS24015 histidinol dehydrogenase low > 77
Sinorhizobium meliloti 1021 0.33 SMa0320 short chain alcohol dehydrogenase-related dehydrogenase 0.36 SMc02307 histidinol dehydrogenase low > 103
Mycobacterium tuberculosis H37Rv 0.32 Rv0484c Probable short-chain type oxidoreductase 0.30 Rv1599 Probable histidinol dehydrogenase HisD (HDH) — —
Variovorax sp. SCN45 0.31 GFF4612 Short-chain dehydrogenase/reductase SDR 0.32 GFF5345 Histidinol dehydrogenase (EC 1.1.1.23) — —
Acinetobacter radioresistens SK82 0.30 MPMX26_00858 putative oxidoreductase 0.33 MPMX26_02587 Histidinol dehydrogenase low > 36
Variovorax sp. OAS795 0.30 ABID97_RS05845 SDR family oxidoreductase 0.32 ABID97_RS23160 histidinol dehydrogenase — —
Alteromonas macleodii MIT1002 0.29 MIT1002_02336 putative oxidoreductase 0.48 MIT1002_02633 Histidinol dehydrogenase low > 70
Rhizobium sp. OAE497 0.29 ABIE40_RS03905 SDR family oxidoreductase 0.36 ABIE40_RS02725 histidinol dehydrogenase low > 107
Cupriavidus basilensis FW507-4G11 0.29 RR42_RS36075 oxidoreductase 0.33 RR42_RS18915 histidinol dehydrogenase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS03515 SDR family oxidoreductase 0.34 A4249_RS10695 histidinol dehydrogenase low > 48
Lysobacter sp. OAE881 0.28 ABIE51_RS11295 SDR family oxidoreductase 0.45 ABIE51_RS13325 histidinol dehydrogenase low > 62
Vibrio cholerae E7946 ATCC 55056 0.25 CSW01_19375 NAD(P)-dependent oxidoreductase 0.47 CSW01_05750 histidinol dehydrogenase low > 62
Pseudomonas sp. S08-1 0.25 OH686_18360 Short-chain dehydrogenase/reductase SDR 0.31 OH686_08470 Histidinol dehydrogenase low > 80
Shewanella sp. ANA-3 0.23 Shewana3_3687 short-chain dehydrogenase/reductase SDR (RefSeq) 0.49 Shewana3_1853 hisD histidinol dehydrogenase (RefSeq) low > 73
Shewanella oneidensis MR-1 0.22 SO4141 oxidoreductase, short-chain dehydrogenase/reductase family (NCBI ptt file) 0.49 SO2073 hisD histidinol dehydrogenase (NCBI ptt file) low > 76
Phaeobacter inhibens DSM 17395 0.20 PGA1_c08820 putative oxidoreductase 0.34 PGA1_c31190 histidinol dehydrogenase HisD — —
Acidovorax sp. GW101-3H11 0.20 Ac3H11_2710 short-chain dehydrogenase/reductase SDR 0.32 Ac3H11_4724 Histidinol dehydrogenase (EC 1.1.1.23) — —

Not shown: 2 genomes with orthologs for BT0409 only; 16 genomes with orthologs for BT0201 only