Conservation of cofitness between CSW01_12405 and CSW01_04590 in Vibrio cholerae E7946 ATCC 55056

81 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Vibrio cholerae E7946 ATCC 55056 1.0 CSW01_12405 GTP diphosphokinase 1.0 CSW01_04590 transcriptional regulator GcvA 0.46 10
Dickeya dianthicola 67-19 0.67 HGI48_RS17070 GTP diphosphokinase 0.71 HGI48_RS05050 transcriptional regulator GcvA low > 71
Dickeya dadantii 3937 0.67 DDA3937_RS17015 GTP diphosphokinase 0.71 DDA3937_RS05050 transcriptional regulator GcvA low > 74
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.67 GFF4837 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 0.73 GFF4865 Glycine cleavage system transcriptional activator GcvA low > 78
Dickeya dianthicola ME23 0.67 DZA65_RS18145 GTP diphosphokinase 0.71 DZA65_RS05390 transcriptional regulator GcvA low > 75
Klebsiella pneumoniae MKP103 0.67 KDGMDA_03335 GTP diphosphokinase 0.63 KDGMDA_03515 Glycine cleavage system transcriptional activator low > 95
Escherichia coli ECRC101 0.67 MCAODC_10775 relA GTP diphosphokinase 0.72 MCAODC_10645 gcvA glycine cleavage system transcriptional regulator GcvA low > 88
Escherichia coli ECRC98 0.67 JDDGAC_23915 relA GTP diphosphokinase 0.72 JDDGAC_23785 gcvA glycine cleavage system transcriptional regulator GcvA low > 87
Escherichia coli ECRC62 0.67 BNILDI_10630 relA GTP diphosphokinase 0.72 BNILDI_10505 gcvA glycine cleavage system transcriptional regulator GcvA low > 75
Escherichia coli ECRC99 0.67 KEDOAH_07880 relA GTP diphosphokinase 0.72 KEDOAH_08010 gcvA glycine cleavage system transcriptional regulator GcvA
Escherichia coli ECRC100 0.67 OKFHMN_20250 relA GTP diphosphokinase 0.72 OKFHMN_20120 gcvA glycine cleavage system transcriptional regulator GcvA low > 79
Escherichia coli ECOR38 0.67 HEPCGN_19500 relA GTP diphosphokinase 0.72 HEPCGN_19375 gcvA glycine cleavage system transcriptional regulator GcvA low > 88
Escherichia coli HS(pFamp)R (ATCC 700891) 0.67 OHPLBJKB_00947 GTP pyrophosphokinase 0.72 OHPLBJKB_00923 Glycine cleavage system transcriptional activator low > 74
Escherichia coli ECOR27 0.67 NOLOHH_12125 relA GTP diphosphokinase 0.72 NOLOHH_12000 gcvA glycine cleavage system transcriptional regulator GcvA low > 76
Escherichia coli ECRC102 0.67 NIAGMN_18020 relA GTP diphosphokinase 0.72 NIAGMN_17890 gcvA glycine cleavage system transcriptional regulator GcvA low > 80
Escherichia coli Nissle 1917 0.67 ECOLIN_RS15515 GTP diphosphokinase 0.72 ECOLIN_RS15650 glycine cleavage system transcriptional regulator GcvA low > 55
Escherichia coli BW25113 0.67 b2784 relA (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) 0.72 b2808 gcvA DNA-binding transcriptional dual regulator (NCBI) low > 76
Escherichia coli BL21 0.67 ECD_02629 (p)ppGpp synthetase I/GTP pyrophosphokinase 0.72 ECD_02659 glycine cleavage system transcriptional activator; autorepressor 0.39 51
Escherichia fergusonii Becca 0.67 EFB2_01133 GTP pyrophosphokinase 0.72 EFB2_01109 Glycine cleavage system transcriptional activator low > 86
Klebsiella michiganensis M5al 0.67 BWI76_RS22805 GTP diphosphokinase 0.71 BWI76_RS22955 transcriptional regulator GcvA low > 92
Pantoea sp. MT58 0.66 IAI47_04120 GTP diphosphokinase 0.71 IAI47_04025 transcriptional regulator GcvA low > 76
Enterobacter sp. TBS_079 0.66 MPMX20_03653 GTP pyrophosphokinase 0.71 MPMX20_03671 Glycine cleavage system transcriptional activator low > 85
Enterobacter asburiae PDN3 0.66 EX28DRAFT_2864 (p)ppGpp synthetase, RelA/SpoT family 0.71 EX28DRAFT_2883 Transcriptional regulator low > 76
Erwinia tracheiphila HP pepo 2.2 0.66 IJEDHG_17375 relA GTP diphosphokinase 0.71 IJEDHG_17275 gcvA Glycine cleavage system transcriptional activator low > 61
Erwinia tracheiphila SCR3 0.66 LU632_RS06350 relA GTP diphosphokinase 0.71 LU632_RS06255 transcriptional regulator GcvA low > 74
Erwinia amylovora T8 0.66 OLJFJH_09245 GTP diphosphokinase 0.72 OLJFJH_09170 Glycine cleavage system transcriptional activator low > 58
Pantoea agglomerans CFBP13505 P0401 0.66 PagCFBP13505_RS16850 GTP diphosphokinase 0.71 PagCFBP13505_RS16945 transcriptional regulator GcvA low > 74
Rahnella sp. WP5 0.66 EX31_RS07955 GTP diphosphokinase 0.72 EX31_RS13110 transcriptional regulator GcvA low > 89
Pectobacterium carotovorum WPP14 0.66 HER17_RS04115 GTP diphosphokinase 0.71 HER17_RS16415 transcriptional regulator GcvA low > 75
Serratia liquefaciens MT49 0.66 IAI46_03600 GTP diphosphokinase 0.72 IAI46_20340 transcriptional regulator GcvA low > 86
Shewanella amazonensis SB2B 0.57 Sama_1033 GTP diphosphokinase (RefSeq) 0.72 Sama_2429 DNA-binding transcriptional activator GcvA (RefSeq) low > 62
Shewanella sp. ANA-3 0.56 Shewana3_1111 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) 0.71 Shewana3_2894 DNA-binding transcriptional activator GcvA (RefSeq)
Shewanella oneidensis MR-1 0.56 SO3455 relA GTP pyrophosphokinase (NCBI ptt file) 0.70 SO1533 glycine cleavage system transcriptional activator, putative (NCBI ptt file) low > 76
Shewanella loihica PV-4 0.56 Shew_1202 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) 0.71 Shew_2764 DNA-binding transcriptional activator GcvA (RefSeq)
Alteromonas macleodii MIT1002 0.53 MIT1002_00794 GTP pyrophosphokinase 0.65 MIT1002_01520 Gcv operon activator low > 70
Pseudomonas syringae pv. syringae B728a ΔmexB 0.45 Psyr_3695 RelA/SpoT protein 0.29 Psyr_5015 transcriptional regulator, LysR family low > 86
Pseudomonas fluorescens GW456-L13 0.45 PfGW456L13_2035 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.29 PfGW456L13_555 Glycine cleavage system transcriptional activator low > 87
Pseudomonas syringae pv. syringae B728a 0.45 Psyr_3695 RelA/SpoT protein 0.29 Psyr_5015 transcriptional regulator, LysR family low > 86
Pseudomonas fluorescens FW300-N2C3 0.45 AO356_19060 (p)ppGpp synthetase 0.31 AO356_15125 LysR family transcriptional regulator low > 104
Pseudomonas sp. RS175 0.45 PFR28_03223 GTP pyrophosphokinase 0.31 PFR28_04727 Glycine cleavage system transcriptional activator low > 88
Pseudomonas lactucae CFBP13502 0.45 GEMAOFIL_04223 GTP pyrophosphokinase 0.30 GEMAOFIL_02417 Glycine cleavage system transcriptional activator low > 93
Pseudomonas fluorescens FW300-N2E2 0.45 Pf6N2E2_5723 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.37 Pf6N2E2_1560 Glycine cleavage system transcriptional activator GcvA low > 103
Pseudomonas fluorescens FW300-N2E3 0.45 AO353_02710 (p)ppGpp synthetase 0.29 AO353_15505 LysR family transcriptional regulator low > 101
Pseudomonas fluorescens SBW25-INTG 0.45 PFLU_RS22095 GTP diphosphokinase 0.30 PFLU_RS25165 LysR family transcriptional regulator low > 109
Pseudomonas fluorescens SBW25 0.45 PFLU_RS22095 GTP diphosphokinase 0.30 PFLU_RS25165 LysR family transcriptional regulator low > 109
Pseudomonas fluorescens FW300-N1B4 0.45 Pf1N1B4_3508 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.30 Pf1N1B4_1817 Glycine cleavage system transcriptional activator low > 87
Pseudomonas simiae WCS417 0.45 PS417_20150 (p)ppGpp synthetase 0.30 PS417_23350 LysR family transcriptional regulator
Pseudomonas sp. DMC3 0.45 GFF4818 GTP pyrophosphokinase 0.29 GFF687 Glycine cleavage system transcriptional activator low > 89
Pseudomonas putida KT2440 0.45 PP_1656 ATP:GTP 3'-pyrophosphotransferase 0.30 PP_0661 putative Transcriptional regulator AmpR low > 96
Pseudomonas sp. BP01 0.45 JOY50_RS23910 relA GTP diphosphokinase 0.30 JOY50_RS09180 LysR family transcriptional regulator low > 84
Pseudomonas sp. SVBP6 0.45 COO64_RS07325 relA GTP diphosphokinase 0.34 COO64_RS14470 gcvA transcriptional regulator GcvA low > 93
Pseudomonas aeruginosa PA14 0.45 IKLFDK_04200 GTP diphosphokinase 0.31 IKLFDK_23190 LysR family transcriptional regulator low > 100
Pseudomonas sp. S08-1 0.45 OH686_18960 Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase , (p)ppGpp synthetase I 0.31 OH686_11695 Transcriptional regulator, LysR family low > 80
Pseudomonas stutzeri RCH2 0.44 Psest_1640 (p)ppGpp synthetase, RelA/SpoT family 0.30 Psest_2739 Transcriptional regulator low > 67
Pseudomonas segetis P6 0.44 MPMX49_01654 GTP pyrophosphokinase 0.29 MPMX49_00400 Glycine cleavage system transcriptional activator low > 75
Marinobacter adhaerens HP15 0.43 HP15_791 (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA 0.24 HP15_1669 transcriptional regulator, LysR family protein low > 73
Kangiella aquimarina DSM 16071 0.43 B158DRAFT_2277 (p)ppGpp synthetase, RelA/SpoT family 0.53 B158DRAFT_0909 Transcriptional regulator low > 40
Xanthomonas campestris pv. campestris strain 8004 0.39 Xcc-8004.1489.1 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.22 Xcc-8004.1418.1 Glycine cleavage system transcriptional activator
Dyella japonica UNC79MFTsu3.2 0.39 ABZR86_RS19725 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.33 ABZR86_RS20860 transcriptional regulator GcvA low > 74
Rhodanobacter sp. FW510-T8 0.39 OKGIIK_02170 relA GTP diphosphokinase 0.18 OKGIIK_16180 Biotin transporter BioY low > 52
Rhodanobacter denitrificans FW104-10B01 0.38 LRK54_RS12725 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.27 LRK54_RS06630 transcriptional regulator GcvA low > 59
Rhodanobacter denitrificans MT42 0.38 LRK55_RS12430 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.27 LRK55_RS06375 transcriptional regulator GcvA low > 63
Ralstonia solanacearum GMI1000 0.38 RS_RS07930 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.35 RS_RS13815 transcriptional regulator GcvA low > 80
Ralstonia sp. UNC404CL21Col 0.38 ABZR87_RS13745 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.34 ABZR87_RS01495 transcriptional regulator GcvA low > 80
Ralstonia solanacearum PSI07 0.38 RPSI07_RS15685 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.33 RPSI07_RS11375 transcriptional regulator GcvA low > 81
Rhodanobacter sp000427505 FW510-R12 0.38 LRK53_RS15870 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.26 LRK53_RS10360 LysR substrate-binding domain-containing protein low > 59
Dechlorosoma suillum PS 0.38 Dsui_2816 (p)ppGpp synthetase, RelA/SpoT family 0.27 Dsui_2033 transcriptional regulator low > 51
Ralstonia solanacearum UW163 0.38 UW163_RS15115 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.32 UW163_RS22635 transcriptional regulator GcvA
Ralstonia solanacearum IBSBF1503 0.38 RALBFv3_RS01805 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.32 RALBFv3_RS22095 transcriptional regulator GcvA low > 76
Paraburkholderia sabiae LMG 24235 0.37 QEN71_RS05265 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.32 QEN71_RS01310 transcriptional regulator GcvA low > 153
Cupriavidus basilensis FW507-4G11 0.37 RR42_RS06585 GTP pyrophosphokinase 0.31 RR42_RS34190 LysR family transcriptional regulator low > 128
Lysobacter sp. OAE881 0.36 ABIE51_RS05170 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.26 ABIE51_RS00605 LysR substrate-binding domain-containing protein low > 62
Paraburkholderia graminis OAS925 0.35 ABIE53_002905 GTP pyrophosphokinase 0.37 ABIE53_001336 LysR family glycine cleavage system transcriptional activator low > 113
Paraburkholderia bryophila 376MFSha3.1 0.35 H281DRAFT_04499 GTP pyrophosphokinase 0.31 H281DRAFT_02051 LysR family transcriptional regulator, glycine cleavage system transcriptional activator low > 103
Herbaspirillum seropedicae SmR1 0.35 HSERO_RS09855 GTP pyrophosphokinase 0.28 HSERO_RS07925 LysR family transcriptional regulator low > 78
Acinetobacter baumannii LAC-4 0.35 RR41_RS16080 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.24 RR41_RS15665 LysR family transcriptional regulator low > 55
Burkholderia phytofirmans PsJN 0.35 BPHYT_RS13655 GTP pyrophosphokinase 0.34 BPHYT_RS11810 LysR family transcriptional regulator low > 109
Acinetobacter radioresistens SK82 0.35 MPMX26_00539 GTP pyrophosphokinase 0.27 MPMX26_01927 Glycine cleavage system transcriptional activator
Acidovorax sp. GW101-3H11 0.34 Ac3H11_362 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.28 Ac3H11_902 Glycine cleavage system transcriptional activator
Castellaniella sp019104865 MT123 0.34 ABCV34_RS08440 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.27 ABCV34_RS01790 LysR substrate-binding domain-containing protein low > 48
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF4925 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.28 GFF4407 Glycine cleavage system transcriptional activator low > 90
Variovorax sp. SCN45 0.32 GFF403 Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.32 GFF1355 Transcriptional regulator, LysR family low > 127

Not shown: 6 genomes with orthologs for CSW01_12405 only; 19 genomes with orthologs for CSW01_04590 only