Homologs of Rv2847c from Mycobacterium tuberculosis H37Rv

Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase
SEED: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
KEGG: uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase

Top 100 hits from BLASTp (E < 0.01)

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Orth Species Gene Name Description Fitness %Id Cov
  Mycobacterium tuberculosis H37Rv Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase no data 100 100
o Pseudomonas fluorescens SBW25 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase strong 35 95
o Pseudomonas fluorescens SBW25-INTG PFLU_RS18505 uroporphyrinogen-III C-methyltransferase strong 35 95
o Pseudomonas fluorescens FW300-N2E3 AO353_27625 sirohydrochlorin ferrochelatase no data 35 95
o Pseudomonas fluorescens FW300-N2E2 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) strong 35 95
o Pseudomonas fluorescens FW300-N1B4 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) strong 35 95
o Pseudomonas sp. RS175 PFR28_02603 Siroheme synthase strong 35 95
o Pseudomonas fluorescens FW300-N2C3 AO356_22200 sirohydrochlorin ferrochelatase strong 35 95
o Pseudomonas simiae WCS417 PS417_16465 sirohydrochlorin ferrochelatase strong 34 95
o Pseudomonas fluorescens GW456-L13 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) strong 34 95
o Alteromonas macleodii MIT1002 MIT1002_00665 Siroheme synthase no data 32 94
o Pseudomonas syringae pv. syringae B728a Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase strong 33 95
o Pseudomonas syringae pv. syringae B728a ΔmexB Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase cofit 33 95
o Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) insig. 32 95
o Enterobacter asburiae PDN3 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase insig. 32 95
o Pectobacterium carotovorum WPP14 HER17_RS01835 siroheme synthase CysG insig. 33 97
o Escherichia coli BL21 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase insig. 31 95
o Escherichia fergusonii Becca EFB2_00454 Siroheme synthase insig. 31 95
o Escherichia coli ECOR38 HEPCGN_16010 cysG siroheme synthase CysG cofit 31 95
o Escherichia coli HS(pFamp)R (ATCC 700891) OHPLBJKB_00334 Siroheme synthase insig. 31 95
o Escherichia coli Nissle 1917 ECOLIN_RS19285 siroheme synthase CysG insig. 31 95
o Escherichia coli BW25113 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) strong 31 95
o Escherichia coli ECOR27 NOLOHH_08980 cysG siroheme synthase CysG cofit 31 95
o Escherichia coli ECRC101 OKFHMN_17180 cysG siroheme synthase CysG insig. 31 95
o Escherichia coli ECRC101 MCAODC_07710 cysG siroheme synthase CysG insig. 31 95
o Escherichia coli ECRC102 NIAGMN_14950 cysG siroheme synthase CysG insig. 31 95
o Escherichia coli ECRC62 BNILDI_02540 cysG siroheme synthase CysG insig. 31 95
o Escherichia coli ECRC98 JDDGAC_20810 cysG siroheme synthase CysG no data 31 95
o Escherichia coli ECRC99 KEDOAH_10960 cysG siroheme synthase CysG no data 31 95
o Kangiella aquimarina DSM 16071 B158DRAFT_2163 uroporphyrin-III C-methyltransferase insig. 31 96
  Desulfovibrio vulgaris Hildenborough JW710 DVU0734 cysG-1 uroporphyrinogen III synthase/methyltransferase (TIGR) no data 44 58
o Castellaniella sp019104865 MT123 ABCV34_RS00210 siroheme synthase CysG strong 35 95
o Acinetobacter radioresistens SK82 MPMX26_00706 Siroheme synthase no data 32 97
  Desulfovibrio vulgaris Miyazaki F DvMF_2767 uroporphyrin-III C-methyltransferase (RefSeq) no data 43 58
o Pseudomonas stutzeri RCH2 Psest_2037 uroporphyrin-III C-methyltransferase strong 33 95
o Dickeya dianthicola 67-19 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase cofit 34 97
o Pseudomonas putida KT2440 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase strong 33 92
o Dickeya dianthicola ME23 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase strong 34 95
o Serratia liquefaciens MT49 IAI46_03710 uroporphyrinogen-III C-methyltransferase cofit 34 95
  Fusobacterium nucleatum SB010 HUW76_06215 uroporphyrinogen-III C-methyltransferase cofit 38 60
o Rhodanobacter sp. FW510-T8 OKGIIK_05980 cysG siroheme synthase CysG insig. 34 95
o Pseudomonas sp. S08-1 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase strong 33 92
o Erwinia tracheiphila SCR3 LU632_RS06420 cysG siroheme synthase CysG strong 32 94
o Dickeya dadantii 3937 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase strong 33 95
o Rahnella sp. WP5 EX31_RS04680 uroporphyrinogen-III C-methyltransferase insig. 31 95
  Marinobacter adhaerens HP15 HP15_1815 siroheme synthase strong 41 59
  Methanococcus maripaludis JJ MMJJ_RS00130 uroporphyrinogen-III C-methyltransferase no data 41 58
  Methanococcus maripaludis S2 MMP_RS05005 uroporphyrinogen-III C-methyltransferase no data 41 58
  Rahnella sp. WP5 EX31_RS09100 uroporphyrinogen-III C-methyltransferase insig. 40 59
o Klebsiella michiganensis M5al BWI76_RS22705 siroheme synthase sig. 31 94
  Rhizobium sp. OAE497 ABIE40_RS11110 uroporphyrinogen-III C-methyltransferase insig. 43 59
  Synechococcus elongatus PCC 7942 Synpcc7942_2610 cobA uroporphyrin-III C-methyltransferase no data 43 60
  Pectobacterium carotovorum WPP14 HER17_RS07340 uroporphyrinogen-III C-methyltransferase insig. 40 59
  Pantoea sp. MT58 IAI47_11160 uroporphyrinogen-III C-methyltransferase strong 41 58
  Dickeya dianthicola 67-19 HGI48_RS14080 uroporphyrinogen-III C-methyltransferase insig. 39 60
  Pantoea sp. MT58 IAI47_04175 uroporphyrinogen-III C-methyltransferase strong 32 96
  Magnetospirillum magneticum AMB-1 AMB_RS17015 uroporphyrinogen-III C-methyltransferase no data 40 61
o Xanthomonas campestris pv. campestris strain 8004 Xcc-8004.1248.1 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) strong 33 97
  Dickeya dadantii 3937 DDA3937_RS14080 uroporphyrinogen-III C-methyltransferase sig. 38 60
  Klebsiella michiganensis M5al BWI76_RS26055 siroheme synthase strong 31 95
  Azospirillum sp. SherDot2 MPMX19_05563 Uroporphyrinogen-III C-methyltransferase no data 45 59
  Dechlorosoma suillum PS Dsui_3319 uroporphyrin-III C-methyltransferase strong 44 59
  Dickeya dianthicola ME23 DZA65_RS14740 uroporphyrinogen-III C-methyltransferase insig. 39 60
  Pontibacter actiniarum KMM 6156, DSM 19842 CA264_02520 uroporphyrinogen-III C-methyltransferase strong 40 58
  Pseudomonas stutzeri RCH2 Psest_0810 uroporphyrin-III C-methyltransferase strong 40 60
  Shewanella loihica PV-4 Shew_0672 uroporphyrin-III C-methyltransferase (RefSeq) cofit 40 59
  Pectobacterium carotovorum WPP14 HER17_RS04280 siroheme synthase CysG cofit 42 59
  Magnetospirillum magneticum AMB-1 AMB_RS07085 uroporphyrinogen-III C-methyltransferase insig. 42 58
  Pseudomonas fluorescens FW300-N2C3 AO356_25030 uroporphyrin-III methyltransferase insig. 41 60
  Dechlorosoma suillum PS Dsui_2969 uroporphyrin-III C-methyltransferase cofit 40 60
  Castellaniella sp019104865 MT123 ABCV34_RS06895 uroporphyrinogen-III C-methyltransferase insig. 42 59
  Shewanella amazonensis SB2B Sama_2892 uroporphyrin-III C-methyltransferase (RefSeq) strong 40 59
  Pseudomonas fluorescens FW300-N2E2 Pf6N2E2_696 Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) insig. 40 60
  Serratia liquefaciens MT49 IAI46_23670 uroporphyrinogen-III C-methyltransferase insig. 40 59
  Enterobacter sp. TBS_079 MPMX20_04271 Siroheme synthase sig. 38 59
o Dyella japonica UNC79MFTsu3.2 ABZR86_RS05880 siroheme synthase CysG strong 43 59
  Sinorhizobium meliloti 1021 SMc04284 uroporphyrin-III C-methyltransferase no data 41 59
  Echinicola vietnamensis KMM 6221, DSM 17526 Echvi_0980 uroporphyrin-III C-methyltransferase strong 39 58
  Lysobacter sp. OAE881 ABIE51_RS15855 siroheme synthase CysG strong 39 59
  Pseudomonas fluorescens FW300-N2E3 AO353_21925 uroporphyrin-III methyltransferase insig. 40 60
  Sphingomonas koreensis DSMZ 15582 Ga0059261_1496 uroporphyrin-III C-methyltransferase strong 42 59
  Pseudomonas sp. RS175 PFR28_02239 Siroheme synthase insig. 40 62
  Enterobacter asburiae PDN3 EX28DRAFT_2849 uroporphyrin-III C-methyltransferase strong 31 94
  Rahnella sp. WP5 EX31_RS07885 uroporphyrinogen-III C-methyltransferase cofit 40 65
  Bosea sp. OAE506 ABIE41_RS15910 siroheme synthase CysG no data 38 58
  Enterobacter sp. TBS_079 MPMX20_03639 Siroheme synthase insig. 31 95
  Agrobacterium fabrum C58 Atu2794 uroporphyrin-III C-methyltransferase insig. 38 61
  Shewanella sp. ANA-3 Shewana3_0862 uroporphyrinogen-III C-methyltransferase (RefSeq) strong 38 59
  Azospirillum brasilense Sp245 AZOBR_RS10135 uroporphyrin-III methyltransferase insig. 42 60
  Vibrio cholerae E7946 ATCC 55056 CSW01_12965 uroporphyrinogen-III C-methyltransferase insig. 40 62
  Caulobacter crescentus NA1000 CCNA_01175 uroporphyrin-III C-methyltransferase strong 41 60
  Caulobacter crescentus NA1000 Δfur CCNA_01175 uroporphyrin-III C-methyltransferase cofit 41 60
  Pseudomonas fluorescens FW300-N1B4 Pf1N1B4_5773 Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) no data 39 60
  Pseudomonas putida KT2440 PP_2090 Uroporphyrinogen-III C-methyltransferase sig. 39 59
  Rhodospirillum rubrum S1H Rru_A3362 Uroporphyrin-III C-methyltransferase-like (NCBI) sig. 42 60
  Shewanella oneidensis MR-1 SO3728 cobA uroporphyrin-III C-methyltransferase (NCBI ptt file) strong 39 59
  Pedobacter sp. GW460-11-11-14-LB5 CA265_RS04100 uroporphyrinogen-III C-methyltransferase strong 37 58
  Rhodopseudomonas palustris CGA009 TX73_021850 siroheme synthase CysG cofit 41 59
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF3661 Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) insig. 40 59
  Mucilaginibacter yixingensis YX-36 DSM 26809 ABZR88_RS16905 uroporphyrinogen-III C-methyltransferase no data 36 60