| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF5259 | | Fumarylacetoacetase (EC 3.7.1.2) | insig. | 100 | 100 |
| | Mycobacterium tuberculosis H37Rv | Rv0939 | | Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase | insig. | 41 | 93 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1773 | | SoxH protein, homolog | insig. | 25 | 81 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_2023 | | Zn-dependent hydrolases, including glyoxylases | insig. | 28 | 62 |
| | Dinoroseobacter shibae DFL-12 | Dshi_3814 | | beta-lactamase domain protein (RefSeq) | insig. | 25 | 79 |
| | Sinorhizobium meliloti 1021 | SM_b20168 | | hypothetical protein | insig. | 26 | 74 |
| | Lysobacter sp. OAE881 | ABIE51_RS03355 | | MBL fold metallo-hydrolase | insig. | 26 | 73 |
| | Azospirillum brasilense Sp245 | AZOBR_RS24465 | | beta-lactamase | insig. | 29 | 74 |
| | Cellulophaga baltica 18 | M666_RS07725 | | MBL fold metallo-hydrolase | insig. | 26 | 73 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c00420 | | metallo-beta-lactamase-like protein | insig. | 24 | 77 |
| | Ralstonia solanacearum GMI1000 | RS_RS20495 | | MBL fold metallo-hydrolase | insig. | 25 | 71 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS02650 | | MBL fold metallo-hydrolase | insig. | 25 | 71 |
| | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS20210 | | MBL fold hydrolase | sig. | 27 | 61 |
| | Ralstonia solanacearum UW163 | UW163_RS18965 | | MBL fold hydrolase | insig. | 27 | 61 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS20775 | | MBL fold metallo-hydrolase | insig. | 26 | 61 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS22485 | | MBL fold metallo-hydrolase | sig. | 26 | 73 |
| | Ralstonia solanacearum GMI1000 | RS_RS23490 | | MBL fold metallo-hydrolase | no data | 24 | 70 |
| | Ralstonia solanacearum GMI1000 | RS_RS23620 | | MBL fold metallo-hydrolase | no data | 24 | 70 |
| | Variovorax sp. OAS795 | ABID97_RS03975 | | MBL fold metallo-hydrolase | insig. | 23 | 81 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4616 | | SoxH protein, homolog | insig. | 25 | 76 |
| | Variovorax sp. OAS795 | ABID97_RS01790 | | MBL fold metallo-hydrolase | insig. | 23 | 81 |
| | Dinoroseobacter shibae DFL-12 | Dshi_1231 | | beta-lactamase domain protein (RefSeq) | insig. | 28 | 69 |
| | Dinoroseobacter shibae DFL-12 | Dshi_4154 | | beta-lactamase domain protein (RefSeq) | insig. | 26 | 81 |
| | Shewanella amazonensis SB2B | Sama_1415 | | beta-lactamase-like protein (RefSeq) | insig. | 24 | 78 |
| | Azospirillum sp. SherDot2 | MPMX19_00288 | | hypothetical protein | insig. | 23 | 60 |
| | Variovorax sp. SCN45 | GFF5497 | | MBL-fold metallo-hydrolase superfamily | insig. | 25 | 60 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS15865 | | MBL fold metallo-hydrolase | insig. | 24 | 60 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_03781 | | Hydroxyacylglutathione hydrolase | cofit | 25 | 79 |
| | Azospirillum sp. SherDot2 | MPMX19_04301 | | hypothetical protein | insig. | 23 | 71 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS02710 | | Zn-dependent hydrolase | insig. | 24 | 61 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_03753 | | Glyoxylase, beta-lactamase superfamily II | insig. | 22 | 70 |
| | Variovorax sp. SCN45 | GFF5051 | | MBL-fold metallohydrolase SPO0683 | insig. | 22 | 81 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_890 | | Cyclase | insig. | 24 | 61 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS35700 | | beta-lactamase domain-containing protein | insig. | 22 | 72 |
| | Variovorax sp. OAS795 | ABID97_RS26255 | | MBL fold metallo-hydrolase | no data | 24 | 75 |
| | Ralstonia solanacearum UW163 | UW163_RS18325 | | MBL fold metallo-hydrolase | insig. | 23 | 70 |
| | Methylophilus sp. DMC18 | GFF2804 | | hypothetical protein | insig. | 24 | 67 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS13765 | | MBL fold metallo-hydrolase | insig. | 22 | 71 |
| | Dinoroseobacter shibae DFL-12 | Dshi_0471 | | beta-lactamase domain protein (RefSeq) | insig. | 26 | 63 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS13165 | | MBL fold metallo-hydrolase | insig. | 23 | 68 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_28035 | | MBL fold metallo-hydrolase | insig. | 23 | 82 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS14135 | | MBL fold metallo-hydrolase | insig. | 23 | 65 |
| | Variovorax sp. SCN45 | GFF2171 | | MBL-fold metallohydrolase SPO0683 | insig. | 24 | 60 |
| | Paraburkholderia graminis OAS925 | ABIE53_004492 | | glyoxylase-like metal-dependent hydrolase (beta-lactamase superfamily II) | insig. | 24 | 38 |
| | Rhizobium sp. OAE497 | ABIE40_RS12235 | | MBL fold metallo-hydrolase | insig. | 29 | 39 |
| | Azospirillum sp. SherDot2 | MPMX19_02915 | | hypothetical protein | no data | 25 | 79 |
| | Pseudomonas sp. BP01 | JOY50_RS02930 | | quinoprotein relay system zinc metallohydrolase 1 | no data | 24 | 79 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_1384 | | SoxH protein, homolog | insig. | 24 | 65 |
| | Pseudomonas putida KT2440 | PP_2678 | | putative Hydrolase | insig. | 24 | 79 |
| | Pseudomonas stutzeri RCH2 | Psest_2058 | | Zn-dependent hydrolases, including glyoxylases | insig. | 24 | 88 |
| | Paraburkholderia graminis OAS925 | ABIE53_005659 | | alkyl sulfatase BDS1-like metallo-beta-lactamase superfamily hydrolase | insig. | 22 | 80 |
| | Rhodopseudomonas palustris CGA009 | TX73_024290 | | MBL fold metallo-hydrolase | insig. | 23 | 47 |
| | Azospirillum brasilense Sp245 | AZOBR_RS12745 | | beta-lactamase | insig. | 23 | 70 |
| | Pseudomonas simiae WCS417 | PS417_17440 | | beta-lactamase | insig. | 23 | 79 |
| | Alteromonas macleodii MIT1002 | MIT1002_03476 | | Beta-lactamase type II precursor | insig. | 25 | 35 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_3519 | | SoxH protein, homolog | sig. | 25 | 66 |
| | Lysobacter sp. OAE881 | ABIE51_RS01550 | | MBL fold metallo-hydrolase | insig. | 24 | 72 |
| | Pseudomonas sp. RS175 | PFR28_01817 | | Hydroxyacylglutathione hydrolase | insig. | 24 | 78 |
| | Pseudomonas sp. S08-1 | OH686_14940 | | hypothetical protein | insig. | 21 | 73 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS05410 | | beta-lactamase | insig. | 31 | 32 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_4499 | | SoxH protein, homolog | no data | 23 | 70 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF5416 | | SoxH protein, homolog | no data | 23 | 63 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2632 | | Zn-dependent hydrolases, including glyoxylases | strong | 34 | 31 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF5401 | | probable beta lactamase( EC:3.5.2.6 ) | no data | 22 | 81 |
| | Dickeya dianthicola 67-19 | HGI48_RS11925 | | alkyl/aryl-sulfatase | insig. | 23 | 79 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_1333 | | Zn-dependent hydrolases, including glyoxylases | insig. | 22 | 84 |
| | Xanthobacter sp. DMC5 | GFF3806 | | hypothetical protein | insig. | 26 | 73 |
| | Shewanella loihica PV-4 | Shew_1646 | | beta-lactamase domain-containing protein (RefSeq) | insig. | 24 | 54 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c10010 | | putative protein SoxH | insig. | 29 | 38 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02656 | | Glyoxylase, beta-lactamase superfamily II | insig. | 24 | 58 |
| | Mycobacterium tuberculosis H37Rv | Rv1913 | | Conserved hypothetical protein | insig. | 25 | 64 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS16000 | | quinoprotein relay system zinc metallohydrolase 1 | insig. | 21 | 70 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS15105 | | MBL fold metallo-hydrolase | insig. | 28 | 52 |
| | Pectobacterium carotovorum WPP14 | HER17_RS21255 | | MBL fold metallo-hydrolase | insig. | 23 | 79 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1607 | | putative cyclase | cofit | 19 | 60 |
| | Dechlorosoma suillum PS | Dsui_3107 | | Zn-dependent hydrolase, glyoxylase | insig. | 30 | 31 |
| | Serratia liquefaciens MT49 | IAI46_08745 | | MBL fold metallo-hydrolase | insig. | 29 | 31 |
| | Shewanella sp. ANA-3 | Shewana3_2197 | | beta-lactamase domain-containing protein (RefSeq) | insig. | 24 | 41 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_20400 | | Hydroxyacylglutathione hydrolase GloC | cofit | 35 | 23 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04039 | | metallo-beta-lactamase domain protein | strong | 27 | 49 |
| | Erwinia tracheiphila SCR3 | LU632_RS09895 | | MBL fold metallo-hydrolase | insig. | 35 | 23 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS18785 | | MBL fold metallo-hydrolase | strong | 28 | 52 |
| | Pectobacterium carotovorum WPP14 | HER17_RS12035 | | MBL fold metallo-hydrolase | insig. | 26 | 35 |
| | Enterobacter sp. TBS_079 | MPMX20_01585 | | Hydroxyacylglutathione hydrolase GloC | insig. | 28 | 31 |
| | Rahnella sp. WP5 | EX31_RS13295 | | MBL fold metallo-hydrolase | insig. | 23 | 72 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS03825 | | MBL fold metallo-hydrolase | insig. | 33 | 30 |
| | Cellulophaga baltica 18 | M666_RS08355 | | subclass B1 metallo-beta-lactamase | insig. | 28 | 31 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_2009 | | Zn-dependent hydrolases, including glyoxylases | insig. | 28 | 31 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS15120 | | MBL fold metallo-hydrolase | insig. | 24 | 60 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1146 | | putative metallo-beta-lactamase (NCBI ptt file) | strong | 26 | 49 |
| | Escherichia coli BL21 | ECD_00931 | | putative metal-binding enzyme | insig. | 28 | 31 |
| | Escherichia coli BW25113 | b0927 | ycbL | predicted metal-binding enzyme (NCBI) | sig. | 28 | 31 |
| | Shewanella loihica PV-4 | Shew_2269 | | beta-lactamase domain-containing protein (RefSeq) | insig. | 28 | 31 |
| | Klebsiella michiganensis M5al | BWI76_RS09865 | | MBL fold hydrolase | insig. | 28 | 31 |
| | Pantoea sp. MT58 | IAI47_12770 | | MBL fold metallo-hydrolase | sig. | 31 | 31 |