| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Echinicola vietnamensis KMM 6221, DSM 17526 | 1.0 | Echvi_0628 | | putative oxygen-independent coproporphyrinogen III oxidase | 1.0 | Echvi_2622 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | 0.47 | 18 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.52 | CA264_16765 | | coproporphyrinogen III oxidase | 0.54 | CA264_02615 | | DNA-binding response regulator | low | > 74 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.46 | CA265_RS18155 | | coproporphyrinogen III oxidase | 0.54 | CA265_RS03060 | | DNA-binding response regulator | low | > 88 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.44 | ABZR88_RS03545 | | radical SAM family heme chaperone HemW | 0.56 | ABZR88_RS09450 | | response regulator transcription factor | low | > 71 |
| Bacteroides thetaiotaomicron VPI-5482 | 0.42 | BT2168 | | coproporphyrinogen III oxidase (NCBI ptt file) | 0.46 | BT0990 | | two-component system response regulator (NCBI ptt file) | low | > 81 |
| Bacteroides stercoris CC31F | 0.40 | HMPREF1181_RS06440 | | radical SAM family heme chaperone HemW | 0.44 | HMPREF1181_RS01000 | | response regulator transcription factor | low | > 56 |
| Parabacteroides merdae CL09T00C40 | 0.39 | HMPREF1078_RS11035 | | radical SAM family heme chaperone HemW | 0.45 | HMPREF1078_RS01665 | | response regulator transcription factor | low | > 61 |
| Phocaeicola dorei CL03T12C01 | 0.37 | ABI39_RS00100 | | radical SAM family heme chaperone HemW | 0.44 | ABI39_RS05370 | | response regulator transcription factor | low | > 72 |
| Bacteroides ovatus ATCC 8483 | 0.34 | BACOVA_03177 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.46 | BACOVA_00180 | | response regulator receiver domain protein | low | > 94 |
| Caulobacter crescentus NA1000 | 0.27 | CCNA_00144 | | oxygen-independent coproporphyrinogen-III oxidase | 0.41 | CCNA_01351 | | two-component response regulator protein | low | > 66 |
| Caulobacter crescentus NA1000 Δfur | 0.27 | CCNA_00144 | | oxygen-independent coproporphyrinogen-III oxidase | 0.41 | CCNA_01351 | | two-component response regulator protein | low | > 67 |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.26 | A4249_RS12445 | | radical SAM family heme chaperone HemW | 0.37 | A4249_RS10810 | | response regulator transcription factor | low | > 48 |
| Fusobacterium nucleatum SB010 | 0.26 | HUW76_07285 | | radical SAM family heme chaperone HemW | 0.38 | HUW76_07205 | | response regulator transcription factor | low | > 35 |
| Pseudomonas fluorescens FW300-N2E3 | 0.26 | AO353_08200 | | coproporphyrinogen III oxidase | 0.41 | AO353_00355 | | transcriptional regulator | low | > 101 |
| Pseudomonas syringae pv. syringae B728a | 0.26 | Psyr_0471 | | coproporphyrinogen III oxidase, anaerobic | 0.39 | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | low | > 86 |
| Pseudomonas sp. RS175 | 0.26 | PFR28_04249 | | Heme chaperone HemW | 0.39 | PFR28_01134 | | Transcriptional activator protein CopR | low | > 88 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.26 | Psyr_0471 | | coproporphyrinogen III oxidase, anaerobic | 0.39 | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | low | > 86 |
| Pseudomonas fluorescens FW300-N2E2 | 0.26 | Pf6N2E2_4593 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.39 | Pf6N2E2_2266 | | Copper-sensing two-component system response regulator CusR | low | > 103 |
| Pseudomonas fluorescens FW300-N2C3 | 0.25 | AO356_13390 | | coproporphyrinogen III oxidase | 0.39 | AO356_23125 | | transcriptional regulator | low | > 104 |
| Pseudomonas simiae WCS417 | 0.25 | PS417_26760 | | oxidase | 0.41 | PS417_07685 | | transcriptional regulator | low | > 88 |
| Pseudomonas fluorescens FW300-N1B4 | 0.25 | Pf1N1B4_2334 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.41 | Pf1N1B4_67 | | Copper-sensing two-component system response regulator CusR | — | — |
| Pseudomonas sp. S08-1 | 0.25 | OH686_11020 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW | 0.40 | OH686_22680 | | Copper-sensing two-component system response regulator CusR | low | > 80 |
| Pseudomonas fluorescens SBW25-INTG | 0.25 | PFLU_RS28405 | | radical SAM family heme chaperone HemW | 0.40 | PFLU_RS07760 | | heavy metal response regulator transcription factor | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.25 | PFLU_RS28405 | | radical SAM family heme chaperone HemW | 0.40 | PFLU_RS07760 | | heavy metal response regulator transcription factor | low | > 109 |
| Pseudomonas fluorescens GW456-L13 | 0.25 | PfGW456L13_1003 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.41 | PfGW456L13_4017 | | Copper-sensing two-component system response regulator CusR | low | > 87 |
| Azospirillum brasilense Sp245 | 0.25 | AZOBR_RS02195 | | coproporphyrinogen III oxidase | 0.39 | AZOBR_RS10800 | | XRE family transcriptional regulator | low | > 97 |
| Vibrio cholerae E7946 ATCC 55056 | 0.25 | CSW01_02425 | | YggW family oxidoreductase | 0.39 | CSW01_15165 | | DNA-binding response regulator | low | > 62 |
| Castellaniella sp019104865 MT123 | 0.25 | ABCV34_RS03525 | | radical SAM family heme chaperone HemW | 0.39 | ABCV34_RS03230 | | heavy metal response regulator transcription factor | low | > 48 |
| Synechococcus elongatus PCC 7942 | 0.25 | Synpcc7942_2382 | hemN | coproporphyrinogen III oxidase | 0.39 | Synpcc7942_1404 | | two component transcriptional regulator, winged helix family | — | — |
| Phaeobacter inhibens DSM 17395 | 0.25 | PGA1_c35050 | | oxygen-independent coproporphyrinogen III oxidase HemN | 0.36 | PGA1_c13010 | | two-component system response regulator | low | > 62 |
| Bifidobacterium breve UCC2003 | 0.24 | BBR_RS15235 | | coproporphyrinogen III oxidase | 0.34 | BBR_RS17455 | | DNA-binding response regulator | low | > 34 |
| Dyella japonica UNC79MFTsu3.2 | 0.24 | ABZR86_RS11910 | | radical SAM family heme chaperone HemW | 0.38 | ABZR86_RS12570 | | response regulator transcription factor | low | > 74 |
| Azospirillum sp. SherDot2 | 0.24 | MPMX19_02574 | | Heme chaperone HemW | 0.40 | MPMX19_00794 | | Transcriptional activator protein CopR | low | > 112 |
| Mycobacterium tuberculosis H37Rv | 0.24 | Rv2388c | | Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase) | 0.44 | Rv0981 | | Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) | low | > 58 |
| Escherichia coli Nissle 1917 | 0.23 | ECOLIN_RS16435 | | radical SAM family heme chaperone HemW | 0.44 | ECOLIN_RS03125 | | copper response regulator transcription factor CusR | — | — |
| Dechlorosoma suillum PS | 0.23 | Dsui_0491 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.40 | Dsui_2644 | | heavy metal response regulator | low | > 51 |
| Escherichia fergusonii Becca | 0.23 | EFB2_00947 | | Heme chaperone HemW | 0.44 | EFB2_03523 | | Transcriptional regulatory protein CusR | low | > 86 |
| Escherichia coli ECOR38 | 0.23 | HEPCGN_18540 | hemW | radical SAM family heme chaperone HemW | 0.44 | HEPCGN_00585 | cusR | copper response regulator transcription factor CusR | low | > 85 |
| Klebsiella michiganensis M5al | 0.23 | BWI76_RS24120 | | YggW family oxidoreductase | 0.33 | BWI76_RS18590 | | DNA-binding response regulator | low | > 92 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.23 | GFF3058 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.39 | GFF3273 | | Putative two-component system response regulator YedW | low | > 78 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.23 | Xcc-8004.1224.1 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.34 | Xcc-8004.5008.1 | | Two-component system regulatory protein | — | — |
| Escherichia coli BL21 | 0.23 | ECD_02785 | | HemN family putative oxidoreductase | 0.44 | ECD_00532 | | response regulator in two-component regulatory system with CusS | low | > 60 |
| Serratia liquefaciens MT49 | 0.23 | IAI46_21435 | | radical SAM family heme chaperone HemW | 0.38 | IAI46_16745 | | heavy metal response regulator transcription factor | low | > 86 |
| Escherichia coli ECRC98 | 0.23 | JDDGAC_22865 | hemW | radical SAM family heme chaperone HemW | 0.44 | JDDGAC_11350 | cusR | copper response regulator transcription factor CusR | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.23 | OHPLBJKB_00761 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR | 0.44 | OHPLBJKB_03138 | | Transcriptional regulatory protein CusR | low | > 73 |
| Magnetospirillum magneticum AMB-1 | 0.23 | AMB_RS22770 | | radical SAM protein | 0.37 | AMB_RS14570 | | DNA-binding response regulator | — | — |
| Escherichia coli ECRC101 | 0.23 | MCAODC_09755 | hemW | radical SAM family heme chaperone HemW | 0.44 | MCAODC_26920 | cusR | copper response regulator transcription factor CusR | — | — |
| Escherichia coli ECRC102 | 0.23 | NIAGMN_17000 | hemW | radical SAM family heme chaperone HemW | 0.44 | NIAGMN_05760 | cusR | copper response regulator transcription factor CusR | — | — |
| Escherichia coli ECRC99 | 0.23 | KEDOAH_08905 | hemW | radical SAM family heme chaperone HemW | 0.44 | KEDOAH_20265 | cusR | copper response regulator transcription factor CusR | — | — |
| Escherichia coli BW25113 | 0.23 | b2955 | yggW | coproporphyrinogen III oxidase (NCBI) | 0.44 | b0571 | cusR | DNA-binding response regulator in two-component regulatory system with CusS (NCBI) | low | > 76 |
| Escherichia coli ECRC101 | 0.23 | OKFHMN_19235 | hemW | radical SAM family heme chaperone HemW | 0.44 | OKFHMN_07705 | cusR | copper response regulator transcription factor CusR | — | — |
| Pantoea sp. MT58 | 0.23 | IAI47_03580 | | radical SAM family heme chaperone HemW | 0.33 | IAI47_00340 | | response regulator | low | > 76 |
| Escherichia coli ECRC62 | 0.23 | BNILDI_09685 | hemW | radical SAM family heme chaperone HemW | 0.44 | BNILDI_22095 | cusR | copper response regulator transcription factor CusR | — | — |
| Pseudomonas putida KT2440 | 0.23 | PP_5101 | | coproporphyrinogen/heterocyclic compound oxidase (aerobic) | 0.40 | PP_2158 | | transcriptional activator protein | — | — |
| Escherichia coli ECOR27 | 0.23 | NOLOHH_11105 | hemW | radical SAM family heme chaperone HemW | 0.44 | NOLOHH_24085 | cusR | copper response regulator transcription factor CusR | — | — |
| Lysobacter sp. OAE881 | 0.23 | ABIE51_RS17300 | | radical SAM family heme chaperone HemW | 0.37 | ABIE51_RS04165 | | response regulator transcription factor | low | > 62 |
| Rhodanobacter denitrificans MT42 | 0.23 | LRK55_RS11460 | | radical SAM family heme chaperone HemW | 0.39 | LRK55_RS17060 | | heavy metal response regulator transcription factor | low | > 63 |
| Enterobacter asburiae PDN3 | 0.23 | EX28DRAFT_2993 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.42 | EX28DRAFT_1165 | | heavy metal response regulator | low | > 76 |
| Dickeya dianthicola 67-19 | 0.22 | HGI48_RS17370 | | radical SAM family heme chaperone HemW | 0.42 | HGI48_RS03485 | | heavy metal response regulator transcription factor | low | > 71 |
| Dickeya dadantii 3937 | 0.22 | DDA3937_RS17325 | | radical SAM family heme chaperone HemW | 0.38 | DDA3937_RS01140 | | heavy metal response regulator transcription factor | low | > 74 |
| Enterobacter sp. TBS_079 | 0.22 | MPMX20_03813 | | Heme chaperone HemW | 0.43 | MPMX20_02319 | | Transcriptional regulatory protein CusR | low | > 85 |
| Agrobacterium fabrum C58 | 0.22 | Atu0325 | | oxygen-independent coproporphyrinogen III oxidase | 0.38 | Atu0978 | | two component response regulator | — | — |
| Shewanella oneidensis MR-1 | 0.22 | SO3359 | | oxygen-independent coproporphyrinogen III oxidase, putative (NCBI ptt file) | 0.37 | SO4428 | | DNA-binding response regulator (NCBI ptt file) | low | > 76 |
| Rhizobium sp. OAE497 | 0.22 | ABIE40_RS01625 | | radical SAM family heme chaperone HemW | 0.39 | ABIE40_RS05700 | | response regulator transcription factor | — | — |
| Ralstonia solanacearum PSI07 | 0.22 | RPSI07_RS13830 | | oxygen-independent coproporphyrinogen III oxidase-like protein | 0.42 | RPSI07_RS02355 | | DNA-binding response regulator | low | > 81 |
| Shewanella sp. ANA-3 | 0.22 | Shewana3_1188 | | putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) | 0.41 | Shewana3_4296 | | DNA-binding transcriptional activator CusR (RefSeq) | low | > 73 |
| Erwinia tracheiphila SCR3 | 0.22 | LU632_RS05445 | hemW | radical SAM family heme chaperone HemW | 0.31 | LU632_RS21855 | cpxR | envelope stress response regulator transcription factor CpxR | low | > 74 |
| Pseudomonas stutzeri RCH2 | 0.22 | Psest_0276 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.40 | Psest_1185 | | heavy metal response regulator | low | > 67 |
| Sinorhizobium meliloti 1021 | 0.22 | SMc01147 | | coproporphyrinogen III oxidase | 0.40 | SMc02366 | | transcriptional regulator | low | > 103 |
| Bosea sp. OAE506 | 0.22 | ABIE41_RS03305 | | radical SAM family heme chaperone HemW | 0.40 | ABIE41_RS01150 | | response regulator transcription factor | low | > 77 |
| Rhodanobacter sp. FW510-T8 | 0.22 | OKGIIK_12160 | hemW | radical SAM family heme chaperone HemW | 0.37 | OKGIIK_14885 | ompR | DNA-binding response regulator | low | > 52 |
| Pectobacterium carotovorum WPP14 | 0.22 | HER17_RS03785 | | radical SAM family heme chaperone HemW | 0.38 | HER17_RS13650 | | heavy metal response regulator transcription factor | low | > 75 |
| Alteromonas macleodii MIT1002 | 0.22 | MIT1002_00939 | | Oxygen-independent coproporphyrinogen-III oxidase 1 | 0.38 | MIT1002_00247 | | Transcriptional regulatory protein CusR | low | > 70 |
| Dickeya dianthicola ME23 | 0.22 | DZA65_RS18460 | | radical SAM family heme chaperone HemW | 0.42 | DZA65_RS03595 | | copper/silver response regulator transcription factor SilR | low | > 75 |
| Acidovorax sp. GW101-3H11 | 0.22 | Ac3H11_3672 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.41 | Ac3H11_4210 | | DNA-binding heavy metal response regulator | low | > 79 |
| Cupriavidus basilensis FW507-4G11 | 0.22 | RR42_RS04880 | | coproporphyrinogen III oxidase | 0.41 | RR42_RS31535 | | transcriptional regulator | low | > 128 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.22 | GFF3256 | | Radical SAM family enzyme, similar to coproporphyrinogen III oxidase, oxygen-independent, clustered with nucleoside-triphosphatase RdgB | 0.40 | GFF3258 | | DNA-binding heavy metal response regulator | low | > 90 |
| Herbaspirillum seropedicae SmR1 | 0.21 | HSERO_RS10665 | | coproporphyrinogen III oxidase | 0.40 | HSERO_RS15315 | | transcriptional regulator | low | > 78 |
| Acinetobacter radioresistens SK82 | 0.21 | MPMX26_00308 | | Heme chaperone HemW | 0.41 | MPMX26_01710 | | Transcriptional activator protein CzcR | — | — |
| Variovorax sp. SCN45 | 0.21 | GFF2383 | | Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW | 0.40 | GFF4069 | | DNA-binding heavy metal response regulator | low | > 127 |
| Variovorax sp. OAS795 | 0.21 | ABID97_RS23630 | | radical SAM family heme chaperone HemW | 0.34 | ABID97_RS17265 | | two-component system response regulator OmpR | low | > 91 |
| Shewanella loihica PV-4 | 0.21 | Shew_1131 | | putative oxygen-independent coproporphyrinogen III oxidase (RefSeq) | 0.39 | Shew_3258 | | two component heavy metal response transcriptional regulator (RefSeq) | low | > 60 |
| Shewanella amazonensis SB2B | 0.20 | Sama_2483 | | oxygen-independent coproporphyrinogen III oxidase, putative (RefSeq) | 0.35 | Sama_3534 | | response regulator receiver protein (RefSeq) | — | — |
| Marinobacter adhaerens HP15 | 0.18 | HP15_280 | | putative oxygen-independent coproporphyrinogen III oxidase | 0.41 | HP15_3484 | | DNA-binding response regulator | — | — |
Not shown: 13 genomes with orthologs for Echvi_0628 only; 2 genomes with orthologs for Echvi_2622 only