Conservation of cofitness between ECD_02659 and ECD_00414 in Escherichia coli BL21

76 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_02659 glycine cleavage system transcriptional activator; autorepressor 1.0 ECD_00414 multidrug efflux system low > 61
Escherichia coli ECRC101 1.00 MCAODC_10645 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 MCAODC_27425 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 87
Escherichia coli ECRC99 1.00 KEDOAH_08010 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 KEDOAH_19765 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA
Escherichia coli ECRC102 1.00 NIAGMN_17890 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 NIAGMN_06255 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA
Escherichia coli ECRC98 1.00 JDDGAC_23785 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 JDDGAC_11850 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 86
Escherichia coli BW25113 1.00 b2808 gcvA DNA-binding transcriptional dual regulator (NCBI) 1.00 b0463 acrA multidrug efflux system (NCBI) low > 76
Escherichia fergusonii Becca 1.00 EFB2_01109 Glycine cleavage system transcriptional activator 1.00 EFB2_03595 Multidrug efflux pump subunit AcrA low > 86
Escherichia coli ECOR27 1.00 NOLOHH_12000 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 NOLOHH_01135 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 75
Escherichia coli Nissle 1917 1.00 ECOLIN_RS15650 glycine cleavage system transcriptional regulator GcvA 1.00 ECOLIN_RS02755 multidrug efflux RND transporter periplasmic adaptor subunit AcrA
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00923 Glycine cleavage system transcriptional activator 1.00 OHPLBJKB_03211 Multidrug efflux pump subunit AcrA low > 73
Escherichia coli ECRC100 1.00 OKFHMN_20120 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 OKFHMN_08200 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 80
Escherichia coli ECOR38 1.00 HEPCGN_19375 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 HEPCGN_06815 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 87
Escherichia coli ECRC62 1.00 BNILDI_10505 gcvA glycine cleavage system transcriptional regulator GcvA 1.00 BNILDI_22550 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA low > 75
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.99 GFF4865 Glycine cleavage system transcriptional activator GcvA 0.82 GFF4380 Membrane fusion protein of RND family multidrug efflux pump low > 78
Enterobacter asburiae PDN3 0.98 EX28DRAFT_2883 Transcriptional regulator 0.82 EX28DRAFT_2495 RND family efflux transporter, MFP subunit low > 76
Enterobacter sp. TBS_079 0.97 MPMX20_03671 Glycine cleavage system transcriptional activator 0.85 MPMX20_01065 Multidrug efflux pump subunit AcrA low > 85
Klebsiella michiganensis M5al 0.97 BWI76_RS22955 transcriptional regulator GcvA 0.85 BWI76_RS06780 MexE family multidrug efflux RND transporter periplasmic adaptor subunit low > 92
Pantoea sp. MT58 0.93 IAI47_04025 transcriptional regulator GcvA 0.74 IAI47_14510 efflux RND transporter periplasmic adaptor subunit low > 76
Erwinia tracheiphila SCR3 0.93 LU632_RS06255 transcriptional regulator GcvA 0.71 LU632_RS18180 efflux RND transporter periplasmic adaptor subunit
Dickeya dadantii 3937 0.93 DDA3937_RS05050 transcriptional regulator GcvA 0.70 DDA3937_RS05740 efflux RND transporter periplasmic adaptor subunit low > 74
Dickeya dianthicola ME23 0.93 DZA65_RS05390 transcriptional regulator GcvA 0.68 DZA65_RS06120 efflux RND transporter periplasmic adaptor subunit low > 75
Dickeya dianthicola 67-19 0.93 HGI48_RS05050 transcriptional regulator GcvA 0.68 HGI48_RS05795 efflux RND transporter periplasmic adaptor subunit low > 71
Pectobacterium carotovorum WPP14 0.92 HER17_RS16415 transcriptional regulator GcvA 0.69 HER17_RS15735 efflux RND transporter periplasmic adaptor subunit low > 75
Serratia liquefaciens MT49 0.91 IAI46_20340 transcriptional regulator GcvA 0.75 IAI46_05190 multidrug efflux RND transporter periplasmic adaptor subunit SdeX low > 86
Rahnella sp. WP5 0.89 EX31_RS13110 transcriptional regulator GcvA 0.74 EX31_RS22475 efflux RND transporter periplasmic adaptor subunit low > 89
Shewanella oneidensis MR-1 0.70 SO1533 glycine cleavage system transcriptional activator, putative (NCBI ptt file) 0.43 SO4693 multidrug resistance protein, AcrA/AcrE family (NCBI ptt file) low > 76
Shewanella amazonensis SB2B 0.70 Sama_2429 DNA-binding transcriptional activator GcvA (RefSeq) 0.43 Sama_3553 multidrug resistance protein AcrA/AcrE family (RefSeq) low > 62
Shewanella loihica PV-4 0.70 Shew_2764 DNA-binding transcriptional activator GcvA (RefSeq) 0.42 Shew_0031 RND family efflux transporter MFP subunit (RefSeq)
Alteromonas macleodii MIT1002 0.61 MIT1002_01520 Gcv operon activator 0.36 MIT1002_00134 Acriflavine resistance protein A precursor 0.41 32
Kangiella aquimarina DSM 16071 0.54 B158DRAFT_0909 Transcriptional regulator 0.32 B158DRAFT_0734 RND family efflux transporter, MFP subunit low > 40
Azospirillum sp. SherDot2 0.46 MPMX19_01055 Glycine cleavage system transcriptional activator 0.47 MPMX19_05883 Multidrug resistance protein MexA low > 112
Rhodospirillum rubrum S1H 0.39 Rru_A3368 Transcriptional Regulator, LysR family (NCBI) 0.44 Rru_A2050 Secretion protein HlyD (NCBI) low > 58
Azospirillum brasilense Sp245 0.39 AZOBR_RS20105 transcriptional regulator 0.47 AZOBR_RS30180 hemolysin D low > 97
Pseudomonas fluorescens FW300-N2E2 0.38 Pf6N2E2_1560 Glycine cleavage system transcriptional activator GcvA 0.51 Pf6N2E2_2823 Multidrug efflux RND membrane fusion protein MexC low > 103
Paraburkholderia graminis OAS925 0.38 ABIE53_001336 LysR family glycine cleavage system transcriptional activator 0.43 ABIE53_003409 membrane fusion protein (multidrug efflux system) low > 113
Caulobacter crescentus NA1000 0.38 CCNA_01174 LysR-family transcriptional regulator 0.41 CCNA_00851 periplasmic multidrug efflux lipoprotein precursor low > 66
Caulobacter crescentus NA1000 Δfur 0.38 CCNA_01174 LysR-family transcriptional regulator 0.41 CCNA_00851 periplasmic multidrug efflux lipoprotein precursor low > 67
Ralstonia solanacearum GMI1000 0.36 RS_RS13815 transcriptional regulator GcvA 0.46 RS_RS00050 MexE family multidrug efflux RND transporter periplasmic adaptor subunit low > 80
Ralstonia solanacearum IBSBF1503 0.36 RALBFv3_RS22095 transcriptional regulator GcvA 0.45 RALBFv3_RS09450 MexE family multidrug efflux RND transporter periplasmic adaptor subunit low > 76
Ralstonia solanacearum UW163 0.36 UW163_RS22635 transcriptional regulator GcvA 0.45 UW163_RS04130 MexE family multidrug efflux RND transporter periplasmic adaptor subunit
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS01495 transcriptional regulator GcvA 0.44 ABZR87_RS05310 efflux RND transporter periplasmic adaptor subunit low > 80
Ralstonia solanacearum PSI07 0.35 RPSI07_RS11375 transcriptional regulator GcvA 0.46 RPSI07_RS23900 efflux RND transporter periplasmic adaptor subunit low > 81
Burkholderia phytofirmans PsJN 0.34 BPHYT_RS11810 LysR family transcriptional regulator 0.45 BPHYT_RS34600 hemolysin D low > 109
Paraburkholderia bryophila 376MFSha3.1 0.34 H281DRAFT_02051 LysR family transcriptional regulator, glycine cleavage system transcriptional activator 0.46 H281DRAFT_01000 membrane fusion protein, multidrug efflux system low > 103
Paraburkholderia sabiae LMG 24235 0.34 QEN71_RS01310 transcriptional regulator GcvA 0.46 QEN71_RS29870 efflux RND transporter periplasmic adaptor subunit low > 153
Sphingomonas koreensis DSMZ 15582 0.34 Ga0059261_4130 Transcriptional regulator 0.44 Ga0059261_0560 RND family efflux transporter, MFP subunit low > 68
Rhizobium sp. OAE497 0.34 ABIE40_RS01615 transcriptional regulator GcvA 0.43 ABIE40_RS24220 efflux RND transporter periplasmic adaptor subunit low > 107
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS26815 LysR family transcriptional regulator 0.44 RR42_RS32415 hemolysin D low > 128
Bosea sp. OAE506 0.32 ABIE41_RS23870 transcriptional regulator GcvA 0.41 ABIE41_RS01600 efflux RND transporter periplasmic adaptor subunit low > 77
Variovorax sp. SCN45 0.32 GFF1355 Transcriptional regulator, LysR family 0.42 GFF5989 RND efflux system, membrane fusion protein 0.42 30
Pseudomonas fluorescens FW300-N2C3 0.32 AO356_15125 LysR family transcriptional regulator 0.52 AO356_04875 antibiotic transporter low > 104
Acinetobacter radioresistens SK82 0.31 MPMX26_01927 Glycine cleavage system transcriptional activator 0.41 MPMX26_00690 Multidrug efflux pump subunit AcrA
Variovorax sp. OAS795 0.31 ABID97_RS29015 transcriptional regulator GcvA 0.39 ABID97_RS00320 efflux RND transporter periplasmic adaptor subunit low > 91
Pseudomonas putida KT2440 0.31 PP_4107 Transcriptional regulator, LysR family 0.49 PP_1386 Probable efflux pump periplasmic linker TtgA low > 96
Pseudomonas fluorescens FW300-N1B4 0.31 Pf1N1B4_72 Transcriptional regulator, LysR family 0.48 Pf1N1B4_3247 Multidrug efflux RND membrane fusion protein MexC
Pseudomonas simiae WCS417 0.31 PS417_14890 LysR family transcriptional regulator 0.49 PS417_06775 antibiotic transporter low > 88
Acidovorax sp. GW101-3H11 0.31 Ac3H11_902 Glycine cleavage system transcriptional activator 0.35 Ac3H11_4449 RND efflux system, membrane fusion protein CmeA
Pseudomonas fluorescens SBW25-INTG 0.30 PFLU_RS16910 LysR family transcriptional regulator 0.49 PFLU_RS06810 efflux RND transporter periplasmic adaptor subunit low > 109
Pseudomonas fluorescens GW456-L13 0.30 PfGW456L13_4953 Glycine cleavage system transcriptional activator 0.48 PfGW456L13_4580 Multidrug efflux RND membrane fusion protein MexC low > 87
Pseudomonas fluorescens SBW25 0.30 PFLU_RS16910 LysR family transcriptional regulator 0.49 PFLU_RS06810 efflux RND transporter periplasmic adaptor subunit low > 109
Pseudomonas syringae pv. syringae B728a 0.30 Psyr_3521 transcriptional regulator, LysR family 0.50 Psyr_4007 Secretion protein HlyD low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.30 Psyr_3521 transcriptional regulator, LysR family 0.50 Psyr_4007 Secretion protein HlyD low > 86
Pseudomonas sp. S08-1 0.30 OH686_20310 Transcriptional regulator, LysR family 0.50 OH686_16045 Multidrug efflux system, membrane fusion component low > 80
Sinorhizobium meliloti 1021 0.30 SMa0179 LysR family transcriptional regulator 0.39 SMc02868 multidrug efflux system protein low > 103
Pseudomonas fluorescens FW300-N2E3 0.30 AO353_15505 LysR family transcriptional regulator 0.47 AO353_17300 antibiotic transporter low > 101
Desulfovibrio vulgaris Hildenborough JW710 0.30 DVU1402 transcriptional regulator, LysR family (TIGR) 0.45 DVU2817 acrA multidrug resistance protein (TIGR) low > 55
Pseudomonas stutzeri RCH2 0.29 Psest_2739 Transcriptional regulator 0.49 Psest_0309 RND family efflux transporter, MFP subunit low > 67
Pseudomonas sp. RS175 0.29 PFR28_04727 Glycine cleavage system transcriptional activator 0.51 PFR28_00632 putative efflux pump periplasmic linker TtgA low > 88
Rhodanobacter denitrificans FW104-10B01 0.29 LRK54_RS06630 transcriptional regulator GcvA 0.32 LRK54_RS02095 efflux RND transporter periplasmic adaptor subunit low > 59
Rhodanobacter denitrificans MT42 0.29 LRK55_RS06375 transcriptional regulator GcvA 0.32 LRK55_RS01870 efflux RND transporter periplasmic adaptor subunit low > 63
Hydrogenophaga sp. GW460-11-11-14-LB1 0.28 GFF4407 Glycine cleavage system transcriptional activator 0.40 GFF5686 RND efflux system, membrane fusion protein CmeA low > 90
Castellaniella sp019104865 MT123 0.26 ABCV34_RS01790 LysR substrate-binding domain-containing protein 0.33 ABCV34_RS04230 efflux RND transporter periplasmic adaptor subunit low > 48
Xanthomonas campestris pv. campestris strain 8004 0.25 Xcc-8004.1418.1 Glycine cleavage system transcriptional activator 0.48 Xcc-8004.1793.1 RND efflux system, membrane fusion protein CmeA
Lysobacter sp. OAE881 0.24 ABIE51_RS00605 LysR substrate-binding domain-containing protein 0.30 ABIE51_RS17985 efflux RND transporter periplasmic adaptor subunit low > 62
Rhodopseudomonas palustris CGA009 0.22 TX73_013680 LysR substrate-binding domain-containing protein 0.41 TX73_012250 efflux RND transporter periplasmic adaptor subunit low > 86
Rhodanobacter sp. FW510-T8 0.20 OKGIIK_16180 Biotin transporter BioY 0.34 OKGIIK_09165 acrA efflux transporter periplasmic adaptor subunit low > 52
Pedobacter sp. GW460-11-11-14-LB5 0.11 CA265_RS22285 LysR family transcriptional regulator 0.21 CA265_RS23015 efflux transporter periplasmic adaptor subunit low > 88

Not shown: 11 genomes with orthologs for ECD_02659 only; 1 genomes with orthologs for ECD_00414 only