Conservation of cofitness between ECD_03708 and ECD_00074 in Escherichia coli BL21

67 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_03708 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 1.0 ECD_00074 3-isopropylmalate dehydratase large subunit 0.97 6
Escherichia coli Nissle 1917 1.00 ECOLIN_RS21980 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 1.00 ECOLIN_RS00390 3-isopropylmalate dehydratase large subunit 0.97 11
Escherichia fergusonii Becca 1.00 EFB2_04808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 EFB2_03973 3-isopropylmalate dehydratase large subunit low > 86
Escherichia coli BW25113 1.00 b3829 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) 1.00 b0072 leuC isopropylmalate isomerase large subunit (NCBI) 0.63 52
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04222 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 OHPLBJKB_03585 3-isopropylmalate dehydratase large subunit low > 73
Escherichia coli ECOR27 0.99 NOLOHH_06455 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NOLOHH_03070 leuC1 3-isopropylmalate dehydratase large subunit 1 0.93 14
Escherichia coli ECRC62 0.99 BNILDI_05075 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 BNILDI_08540 leuC1 3-isopropylmalate dehydratase large subunit 1 0.99 3
Escherichia coli ECOR38 0.99 HEPCGN_13025 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 HEPCGN_08705 leuC1 3-isopropylmalate dehydratase large subunit 1 0.99 2
Escherichia coli ECRC100 0.99 OKFHMN_14325 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 OKFHMN_10725 leuC1 3-isopropylmalate dehydratase large subunit 1 0.97 34
Escherichia coli ECRC99 0.99 KEDOAH_13825 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 KEDOAH_17430 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli ECRC101 0.99 MCAODC_04830 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 MCAODC_01240 leuC1 3-isopropylmalate dehydratase large subunit 1 0.95 14
Escherichia coli ECRC98 0.99 JDDGAC_17950 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 JDDGAC_14320 leuC1 3-isopropylmalate dehydratase large subunit 1 low > 86
Escherichia coli ECRC102 0.99 NIAGMN_12080 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NIAGMN_08575 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4494 methionine synthase (B12-independent) (EC 2.1.1.14) 0.95 EX28DRAFT_3668 3-isopropylmalate dehydratase, large subunit 0.74 23
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF254 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.94 GFF166 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS01280 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.95 BWI76_RS04670 3-isopropylmalate dehydratase large subunit low > 92
Enterobacter sp. TBS_079 0.94 MPMX20_04451 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.94 MPMX20_00767 3-isopropylmalate dehydratase large subunit 1 0.29 66
Pectobacterium carotovorum WPP14 0.86 HER17_RS20685 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 HER17_RS03075 3-isopropylmalate dehydratase large subunit 0.60 67
Dickeya dadantii 3937 0.85 DDA3937_RS20380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.85 DDA3937_RS18125 3-isopropylmalate dehydratase large subunit 0.51 36
Dickeya dianthicola ME23 0.85 DZA65_RS00875 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.85 DZA65_RS19210 3-isopropylmalate dehydratase large subunit 0.56 10
Dickeya dianthicola 67-19 0.85 HGI48_RS00820 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.85 HGI48_RS18065 3-isopropylmalate dehydratase large subunit low > 71
Erwinia tracheiphila SCR3 0.84 LU632_RS24030 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.79 LU632_RS02870 leuC 3-isopropylmalate dehydratase large subunit low > 74
Serratia liquefaciens MT49 0.84 IAI46_01035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 IAI46_03345 3-isopropylmalate dehydratase large subunit 0.83 5
Rahnella sp. WP5 0.83 EX31_RS14710 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 EX31_RS03690 3-isopropylmalate dehydratase large subunit low > 89
Pantoea sp. MT58 0.83 IAI47_18310 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 IAI47_16010 3-isopropylmalate dehydratase large subunit low > 76
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_5472 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.62 Pf6N2E2_63 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 103
Pseudomonas fluorescens FW300-N1B4 0.62 Pf1N1B4_783 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.62 Pf1N1B4_15 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 87
Pseudomonas sp. RS175 0.61 PFR28_03477 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.62 PFR28_02824 3-isopropylmalate dehydratase large subunit low > 88
Pseudomonas fluorescens FW300-N2E3 0.61 AO353_16215 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.61 AO353_20620 isopropylmalate isomerase low > 101
Pseudomonas fluorescens FW300-N2C3 0.61 AO356_17740 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.62 AO356_21400 isopropylmalate isomerase low > 104
Pseudomonas stutzeri RCH2 0.60 Psest_1452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.63 Psest_2591 3-isopropylmalate dehydratase, large subunit 0.35 49
Vibrio cholerae E7946 ATCC 55056 0.60 CSW01_08575 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.80 CSW01_12605 3-isopropylmalate dehydratase large subunit low > 62
Pseudomonas fluorescens GW456-L13 0.59 PfGW456L13_3767 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.62 PfGW456L13_3948 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 87
Pseudomonas fluorescens SBW25 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 PFLU_RS20580 3-isopropylmalate dehydratase large subunit low > 109
Pseudomonas fluorescens SBW25-INTG 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 PFLU_RS20580 3-isopropylmalate dehydratase large subunit low > 109
Castellaniella sp019104865 MT123 0.59 ABCV34_RS04445 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 ABCV34_RS04290 3-isopropylmalate dehydratase large subunit low > 48
Pseudomonas sp. S08-1 0.59 OH686_20470 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.63 OH686_04480 3-isopropylmalate dehydratase large subunit low > 80
Paraburkholderia sabiae LMG 24235 0.57 QEN71_RS19725 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 QEN71_RS17605 3-isopropylmalate dehydratase large subunit 0.60 30
Azospirillum brasilense Sp245 0.56 AZOBR_RS24275 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 0.67 AZOBR_RS03545 isopropylmalate isomerase low > 97
Ralstonia sp. UNC404CL21Col 0.56 ABZR87_RS20880 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.63 ABZR87_RS14540 3-isopropylmalate dehydratase large subunit low > 80
Ralstonia solanacearum PSI07 0.55 RPSI07_RS02545 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 RPSI07_RS14695 3-isopropylmalate dehydratase large subunit 0.64 49
Ralstonia solanacearum GMI1000 0.55 RS_RS20360 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.62 RS_RS10000 3-isopropylmalate dehydratase large subunit low > 80
Acidovorax sp. GW101-3H11 0.55 Ac3H11_2345 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.59 Ac3H11_1525 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) 0.93 8
Ralstonia solanacearum IBSBF1503 0.55 RALBFv3_RS20320 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 RALBFv3_RS02620 3-isopropylmalate dehydratase large subunit low > 76
Ralstonia solanacearum UW163 0.55 UW163_RS18855 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 UW163_RS11105 3-isopropylmalate dehydratase large subunit — —
Shewanella loihica PV-4 0.55 Shew_2986 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (RefSeq) 0.71 Shew_3470 isopropylmalate isomerase large subunit (RefSeq) low > 60
Shewanella sp. ANA-3 0.55 Shewana3_3469 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.73 Shewana3_3759 isopropylmalate isomerase large subunit (RefSeq) low > 73
Variovorax sp. SCN45 0.55 GFF795 5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase (EC 2.1.1.14) 0.60 GFF3890 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) 0.50 69
Shewanella oneidensis MR-1 0.55 SO0818 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (NCBI ptt file) 0.73 SO4234 leuC 3-isopropylmalate dehydratase, large subunit (NCBI ptt file) 0.96 10
Marinobacter adhaerens HP15 0.54 HP15_457 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.62 HP15_1834 protein containing 3-isopropylmalate dehydratase, large subunit region domain low > 73
Mucilaginibacter yixingensis YX-36 DSM 26809 0.53 ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.58 ABZR88_RS11595 3-isopropylmalate dehydratase large subunit — —
Pedobacter sp. GW460-11-11-14-LB5 0.53 CA265_RS21095 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.57 CA265_RS15830 3-isopropylmalate dehydratase large subunit low > 88
Cupriavidus basilensis FW507-4G11 0.53 RR42_RS30660 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.63 RR42_RS14400 isopropylmalate isomerase 0.78 19
Shewanella amazonensis SB2B 0.53 Sama_2627 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.72 Sama_0337 isopropylmalate isomerase large subunit (RefSeq) 0.98 9
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS26655 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.62 BPHYT_RS33915 isopropylmalate isomerase low > 109
Variovorax sp. OAS795 0.52 ABID97_RS19395 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.60 ABID97_RS08465 3-isopropylmalate dehydratase large subunit — —
Rhodopseudomonas palustris CGA009 0.52 TX73_012380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.62 TX73_001245 3-isopropylmalate dehydratase large subunit — —
Caulobacter crescentus NA1000 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.61 CCNA_00196 3-isopropylmalate dehydratase large subunit 0.97 8
Caulobacter crescentus NA1000 Δfur 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.61 CCNA_00196 3-isopropylmalate dehydratase large subunit low > 67
Echinicola vietnamensis KMM 6221, DSM 17526 0.51 Echvi_2559 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.54 Echvi_2059 3-isopropylmalate dehydratase, large subunit low > 79
Dyella japonica UNC79MFTsu3.2 0.50 ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.51 ABZR86_RS15960 3-isopropylmalate dehydratase large subunit low > 74
Desulfovibrio vulgaris Miyazaki F 0.50 DvMF_2035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.21 DvMF_1792 3-isopropylmalate dehydratase large subunit (RefSeq) low > 51
Desulfovibrio vulgaris Hildenborough JW710 0.49 DVU3371 metE 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (TIGR) 0.21 DVU2982 leuC 3-isopropylmalate dehydratase / (R)-citramalate isomerase, large subunit LeuC (EC 4.2.1.33; EC 4.2.1.35) (from data) low > 55
Rhodanobacter denitrificans MT42 0.49 LRK55_RS11870 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.54 LRK55_RS07105 3-isopropylmalate dehydratase large subunit low > 63
Rhodanobacter denitrificans FW104-10B01 0.49 LRK54_RS12135 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.54 LRK54_RS07375 3-isopropylmalate dehydratase large subunit low > 59
Rhodospirillum rubrum S1H 0.48 Rru_A1718 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (NCBI) 0.67 Rru_A1189 3-isopropylmalate dehydratase large subunit region (NCBI) low > 58
Mycobacterium tuberculosis H37Rv 0.45 Rv1133c Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) 0.60 Rv2988c Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) — —
Bifidobacterium breve UCC2003 0.42 BBR_RS15405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.55 BBR_RS19630 3-isopropylmalate dehydratase large subunit low > 34

Not shown: 0 genomes with orthologs for ECD_03708 only; 35 genomes with orthologs for ECD_00074 only