Conservation of cofitness between CSW01_13675 and CSW01_11730 in Vibrio cholerae E7946 ATCC 55056

83 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Vibrio cholerae E7946 ATCC 55056 1.0 CSW01_13675 bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase 1.0 CSW01_11730 2-dehydropantoate 2-reductase 0.67 20
Klebsiella pneumoniae MKP103 0.76 KDGMDA_08125 bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 KDGMDA_14500 2-dehydropantoate 2-reductase low > 95
Klebsiella michiganensis M5al 0.76 BWI76_RS27430 (p)ppGpp synthetase 0.34 BWI76_RS06405 2-dehydropantoate 2-reductase low > 92
Escherichia fergusonii Becca 0.76 EFB2_00138 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.35 EFB2_03632 2-dehydropantoate 2-reductase low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 0.76 OHPLBJKB_00051 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.35 OHPLBJKB_03251 2-dehydropantoate 2-reductase low > 74
Escherichia coli Nissle 1917 0.76 ECOLIN_RS20790 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.34 ECOLIN_RS02560 2-dehydropantoate 2-reductase low > 55
Escherichia coli BW25113 0.76 b3650 spoT bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) 0.35 b0425 panE 2-dehydropantoate 2-reductase (NCBI) low > 76
Escherichia coli ECRC62 0.76 BNILDI_04080 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 BNILDI_22760 panE 2-dehydropantoate 2-reductase low > 75
Escherichia coli ECRC100 0.76 OKFHMN_15555 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 OKFHMN_08395 panE 2-dehydropantoate 2-reductase low > 79
Escherichia coli ECRC102 0.76 NIAGMN_13315 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 NIAGMN_06450 panE 2-dehydropantoate 2-reductase low > 80
Escherichia coli ECRC98 0.76 JDDGAC_19180 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 JDDGAC_12050 panE 2-dehydropantoate 2-reductase low > 87
Escherichia coli ECRC101 0.76 MCAODC_06065 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 MCAODC_27620 panE 2-dehydropantoate 2-reductase low > 87
Escherichia coli ECRC99 0.76 KEDOAH_12590 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 KEDOAH_19570 panE 2-dehydropantoate 2-reductase
Escherichia coli ECOR38 0.76 HEPCGN_14375 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 HEPCGN_07025 panE 2-dehydropantoate 2-reductase low > 88
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.76 GFF357 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 0.30 GFF4336 2-dehydropantoate 2-reductase (EC 1.1.1.169) low > 78
Escherichia coli ECOR27 0.76 NOLOHH_07435 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 NOLOHH_01345 panE 2-dehydropantoate 2-reductase low > 76
Escherichia coli BL21 0.75 ECD_03507 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 ECD_00373 2-dehydropantoate reductase, NADPH-specific low > 61
Enterobacter sp. TBS_079 0.75 MPMX20_00086 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.36 MPMX20_01016 2-dehydropantoate 2-reductase low > 85
Pantoea agglomerans CFBP13505 P0401 0.75 PagCFBP13505_RS18835 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 PagCFBP13505_RS10480 2-dehydropantoate 2-reductase low > 74
Enterobacter asburiae PDN3 0.75 EX28DRAFT_3899 (p)ppGpp synthetase, RelA/SpoT family 0.35 EX28DRAFT_2546 2-dehydropantoate 2-reductase low > 76
Dickeya dianthicola ME23 0.75 DZA65_RS22150 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.34 DZA65_RS05940 2-dehydropantoate 2-reductase
Rahnella sp. WP5 0.75 EX31_RS15810 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.38 EX31_RS22180 2-dehydropantoate 2-reductase low > 89
Erwinia tracheiphila SCR3 0.75 LU632_RS22200 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 LU632_RS18455 panE 2-dehydropantoate 2-reductase low > 73
Erwinia amylovora T8 0.75 OLJFJH_05560 bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 OLJFJH_18040 2-dehydropantoate 2-reductase low > 58
Dickeya dianthicola 67-19 0.75 HGI48_RS21180 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.33 HGI48_RS05615 2-dehydropantoate 2-reductase
Pantoea sp. MT58 0.75 IAI47_00510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 IAI47_14715 2-dehydropantoate 2-reductase low > 76
Serratia liquefaciens MT49 0.75 IAI46_24895 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.35 IAI46_04950 2-dehydropantoate 2-reductase low > 87
Erwinia tracheiphila HP pepo 2.2 0.75 IJEDHG_08355 spoT bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 IJEDHG_16335 panE 2-dehydropantoate 2-reductase low > 61
Pectobacterium carotovorum WPP14 0.74 HER17_RS21385 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.34 HER17_RS15910 2-dehydropantoate 2-reductase low > 75
Dickeya dadantii 3937 0.74 DDA3937_RS00180 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.32 DDA3937_RS05555 2-dehydropantoate 2-reductase
Shewanella oneidensis MR-1 0.71 SO0359 spoT guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (NCBI ptt file) 0.31 SO3817 panE 2-dehydropantoate 2-reductase (NCBI ptt file) low > 76
Shewanella sp. ANA-3 0.71 Shewana3_3812 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) 0.32 Shewana3_0780 2-dehydropantoate 2-reductase (RefSeq) low > 73
Shewanella amazonensis SB2B 0.71 Sama_0264 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) 0.27 Sama_2559 2-dehydropantoate 2-reductase (RefSeq)
Shewanella loihica PV-4 0.70 Shew_3499 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (RefSeq) 0.31 Shew_2895 2-dehydropantoate 2-reductase (RefSeq) 0.46 18
Alteromonas macleodii MIT1002 0.61 MIT1002_00108 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.28 MIT1002_01217 2-dehydropantoate 2-reductase low > 70
Pseudomonas segetis P6 0.55 ACVTMO_RS00180 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.23 ACVTMO_RS18755 putative 2-dehydropantoate 2-reductase
Pseudomonas syringae pv. syringae B728a 0.55 Psyr_0209 RelA/SpoT protein 0.25 Psyr_4088 ketopantoate reductase
Pseudomonas syringae pv. syringae B728a ΔmexB 0.55 Psyr_0209 RelA/SpoT protein 0.25 Psyr_4088 ketopantoate reductase
Pseudomonas aeruginosa PA14 0.54 IKLFDK_26765 bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.24 IKLFDK_02110 putative 2-dehydropantoate 2-reductase
Pseudomonas aeruginosa PUPa3 0.54 DQ20_RS49545 spoT;go_function=GTP bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.25 DQ20_RS56950 putative 2-dehydropantoate 2-reductase
Pseudomonas aeruginosa MRSN321 0.54 DY961_RS12580 spoT;go_function=GTP bifunctional GTP diphosphokinase/guanosine-3' 5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.24 DY961_RS24500 putative 2-dehydropantoate 2-reductase
Pseudomonas sp. S08-1 0.54 OH686_13550 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase / GTP pyrophosphokinase , (p)ppGpp synthetase II 0.23 OH686_08220 2-dehydropantoate 2-reductase low > 80
Pseudomonas fluorescens FW300-N2E2 0.54 Pf6N2E2_4361 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.24 Pf6N2E2_5521 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Pseudomonas sp. RS175 0.54 PFR28_04424 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.24 PFR28_03426 2-dehydropantoate 2-reductase
Pseudomonas sp. BP01 0.54 JOY50_RS08985 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.23 JOY50_RS15040 putative 2-dehydropantoate 2-reductase low > 84
Pseudomonas putida KT2440 0.54 PP_5302 bifunctional (p)ppGpp synthase/hydrolase 0.24 PP_1351 putative 2-dehydropantoate 2-reductase
Pseudomonas fluorescens FW300-N2C3 0.54 AO356_12480 (p)ppGpp synthetase 0.24 AO356_17955 2-dehydropantoate 2-reductase
Pseudomonas sp. DMC3 0.54 GFF419 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.22 GFF5199 2-dehydropantoate 2-reductase
Pseudomonas fluorescens GW456-L13 0.54 PfGW456L13_780 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.22 PfGW456L13_1839 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Pseudomonas fluorescens FW300-N1B4 0.54 Pf1N1B4_2113 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.22 Pf1N1B4_651 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Pseudomonas fluorescens FW300-N2E3 0.54 AO353_09280 (p)ppGpp synthetase 0.23 AO353_03645 2-dehydropantoate 2-reductase
Pseudomonas sp. SVBP6 0.54 COO64_RS01555 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.27 COO64_RS11970 putative 2-dehydropantoate 2-reductase
Pseudomonas stutzeri RCH2 0.53 Psest_3817 (p)ppGpp synthetase, RelA/SpoT family 0.27 Psest_1140 2-dehydropantoate 2-reductase
Pseudomonas fluorescens SBW25-INTG 0.53 PFLU_RS29510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.21 PFLU_RS24155 putative 2-dehydropantoate 2-reductase
Pseudomonas simiae WCS417 0.53 PS417_27830 (p)ppGpp synthetase 0.22 PS417_22515 2-dehydropantoate 2-reductase
Pseudomonas fluorescens SBW25 0.53 PFLU_RS29510 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.21 PFLU_RS24155 putative 2-dehydropantoate 2-reductase
Pseudomonas orientalis W4I3 0.53 QF045_RS02185 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 0.22 QF045_RS24680 putative 2-dehydropantoate 2-reductase
Pseudomonas lactucae CFBP13502 0.53 GEMAOFIL_00034 Bifunctional (p)ppGpp synthase/hydrolase SpoT 0.21 GEMAOFIL_04655 2-dehydropantoate 2-reductase
Marinobacter adhaerens HP15 0.50 HP15_305 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.24 HP15_1312 2-dehydropantoate 2-reductase low > 73
Rhodanobacter denitrificans MT42 0.49 LRK55_RS11520 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.09 LRK55_RS02820 2-dehydropantoate 2-reductase
Rhodanobacter denitrificans FW104-10B01 0.49 LRK54_RS11795 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.09 LRK54_RS03070 2-dehydropantoate 2-reductase
Rhodanobacter sp. FW510-T8 0.49 OKGIIK_12100 spoT guanosine-3',5'-bis(diphosphate) 3'-diphosphatase 0.09 OKGIIK_09940 panE 2-dehydropantoate 2-reductase
Herbaspirillum seropedicae SmR1 0.46 HSERO_RS10635 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.20 HSERO_RS09230 2-dehydropantoate 2-reductase
Burkholderia phytofirmans PsJN 0.45 BPHYT_RS15305 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.14 BPHYT_RS27355 2-dehydropantoate 2-reductase low > 109
Paraburkholderia bryophila 376MFSha3.1 0.45 H281DRAFT_04004 (p)ppGpp synthetase I, SpoT/RelA 0.15 H281DRAFT_01683 ketopantoate reductase (EC 1.1.1.169) low > 103
Paraburkholderia graminis OAS925 0.45 ABIE53_003230 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.11 ABIE53_006287 2-dehydropantoate 2-reductase low > 113
Paraburkholderia sabiae LMG 24235 0.45 QEN71_RS03665 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.19 QEN71_RS38425 ketopantoate reductase family protein low > 153
Ralstonia solanacearum UW163 0.44 UW163_RS10410 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.08 UW163_RS03340 2-dehydropantoate 2-reductase
Ralstonia solanacearum IBSBF1503 0.44 RALBFv3_RS03315 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.08 RALBFv3_RS10240 2-dehydropantoate 2-reductase low > 76
Ralstonia sp. UNC404CL21Col 0.44 ABZR87_RS15225 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.16 ABZR87_RS15450 2-dehydropantoate 2-reductase low > 80
Cupriavidus basilensis FW507-4G11 0.44 RR42_RS04920 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.14 RR42_RS32960 2-dehydropantoate 2-reductase
Ralstonia solanacearum GMI1000 0.43 RS_RS10800 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.09 RS_RS00860 2-dehydropantoate 2-reductase
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF1034 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.09 GFF1821 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Variovorax sp. SCN45 0.41 GFF2375 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II 0.19 GFF3590 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Acidovorax sp. GW101-3H11 0.41 Ac3H11_3664 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.18 Ac3H11_2346 2-dehydropantoate 2-reductase (EC 1.1.1.169)
Variovorax sp. OAS795 0.40 ABID97_RS23670 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.18 ABID97_RS00870 2-dehydropantoate 2-reductase
Azospirillum brasilense Sp245 0.38 AZOBR_RS22045 GTP pyrophosphokinase 0.09 AZOBR_RS12955 2-dehydropantoate 2-reductase
Magnetospirillum magneticum AMB-1 0.35 AMB_RS11400 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.09 AMB_RS10015 2-dehydropantoate 2-reductase
Rhodospirillum rubrum S1H 0.35 Rru_A1856 (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA (NCBI) 0.09 Rru_A3518 2-dehydropantoate 2-reductase (NCBI)
Rhodopseudomonas palustris CGA009 0.33 TX73_013955 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.21 TX73_023700 2-dehydropantoate 2-reductase low > 86
Caulobacter crescentus NA1000 0.33 CCNA_01622 Rsh ppGpp hydrolase-synthetase 0.10 CCNA_00262 ketopantoate reductase panE/ApbA family protein low > 66
Caulobacter crescentus NA1000 Δfur 0.33 CCNA_01622 Rsh ppGpp hydrolase-synthetase 0.10 CCNA_00262 ketopantoate reductase panE/ApbA family protein low > 67
Bosea sp. OAE506 0.31 ABIE41_RS19890 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.20 ABIE41_RS11280 2-dehydropantoate 2-reductase low > 77
Pontibacter actiniarum KMM 6156, DSM 19842 0.30 CA264_01425 RelA/SpoT family protein 0.11 CA264_06150 hypothetical protein low > 74

Not shown: 36 genomes with orthologs for CSW01_13675 only; 2 genomes with orthologs for CSW01_11730 only