| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_01845 | | protease modulator HflK | 1.0 | CSW01_07190 | | transcriptional regulator FNR | 0.76 | 2 |
| Shewanella sp. ANA-3 | 0.51 | Shewana3_0599 | | HflK protein (RefSeq) | 0.77 | Shewana3_2115 | | fumarate/nitrate reduction transcriptional regulator (RefSeq) | — | — |
| Shewanella oneidensis MR-1 | 0.50 | SO0605 | hflK | hflK protein (NCBI ptt file) | 0.76 | SO2356 | etrA | electron transport regulator a (NCBI ptt file) | low | > 76 |
| Shewanella loihica PV-4 | 0.50 | Shew_0568 | | HflK protein (RefSeq) | 0.76 | Shew_1993 | | fumarate/nitrate reduction transcriptional regulator (RefSeq) | — | — |
| Escherichia fergusonii Becca | 0.49 | EFB2_04361 | | Modulator of FtsH protease HflK | 0.85 | EFB2_02593 | | Fumarate and nitrate reduction regulatory protein | low | > 86 |
| Escherichia coli Nissle 1917 | 0.49 | ECOLIN_RS24240 | | FtsH protease activity modulator HflK | 0.85 | ECOLIN_RS08005 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 55 |
| Escherichia coli ECOR38 | 0.49 | HEPCGN_10475 | hflK | FtsH protease activity modulator HflK | 0.85 | HEPCGN_25925 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 88 |
| Escherichia coli ECRC102 | 0.48 | NIAGMN_10095 | hflK | FtsH protease activity modulator HflK | 0.85 | NIAGMN_26410 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.48 | OHPLBJKB_03868 | | Modulator of FtsH protease HflK | 0.85 | OHPLBJKB_02348 | | Fumarate and nitrate reduction regulatory protein | low | > 74 |
| Escherichia coli ECRC101 | 0.48 | MCAODC_02760 | hflK | FtsH protease activity modulator HflK | 0.85 | MCAODC_16030 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 88 |
| Escherichia coli ECRC100 | 0.48 | OKFHMN_12245 | hflK | FtsH protease activity modulator HflK | 0.85 | OKFHMN_02240 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 79 |
| Escherichia coli ECOR27 | 0.48 | NOLOHH_04510 | hflK | FtsH protease activity modulator HflK | 0.85 | NOLOHH_19940 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 76 |
| Escherichia coli ECRC98 | 0.48 | JDDGAC_15885 | hflK | FtsH protease activity modulator HflK | 0.85 | JDDGAC_04785 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 87 |
| Escherichia coli ECRC62 | 0.48 | BNILDI_06980 | hflK | FtsH protease activity modulator HflK | 0.85 | BNILDI_18090 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 75 |
| Escherichia coli BW25113 | 0.48 | b4174 | hflK | modulator for HflB protease specific for phage lambda cII repressor (NCBI) | 0.85 | b1334 | fnr | DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) | low | > 76 |
| Klebsiella pneumoniae MKP103 | 0.48 | KDGMDA_11045 | | FtsH protease activity modulator HflK | 0.85 | KDGMDA_21005 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 95 |
| Escherichia coli ECRC99 | 0.48 | KEDOAH_15910 | hflK | FtsH protease activity modulator HflK | 0.85 | KEDOAH_26530 | fnr | fumarate/nitrate reduction transcriptional regulator Fnr | — | — |
| Enterobacter asburiae PDN3 | 0.48 | EX28DRAFT_3371 | | HflK protein | 0.84 | EX28DRAFT_1540 | | cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases | low | > 76 |
| Dickeya dadantii 3937 | 0.48 | DDA3937_RS18600 | | FtsH protease activity modulator HflK | 0.86 | DDA3937_RS10950 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 74 |
| Dickeya dianthicola ME23 | 0.48 | DZA65_RS19670 | | FtsH protease activity modulator HflK | 0.86 | DZA65_RS11360 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 75 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.48 | GFF827 | | HflK protein | 0.85 | GFF2656 | | Fumarate and nitrate reduction regulatory protein | low | > 78 |
| Alteromonas macleodii MIT1002 | 0.48 | MIT1002_03786 | | Modulator of FtsH protease HflK | 0.57 | MIT1002_02137 | | Fumarate and nitrate reduction regulatory protein | low | > 70 |
| Dickeya dianthicola 67-19 | 0.48 | HGI48_RS18535 | | FtsH protease activity modulator HflK | 0.86 | HGI48_RS10900 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 71 |
| Shewanella amazonensis SB2B | 0.47 | Sama_3023 | | hflK protein (RefSeq) | 0.76 | Sama_1799 | | fumarate/nitrate reduction transcriptional regulator (RefSeq) | low | > 62 |
| Pantoea sp. MT58 | 0.47 | IAI47_02600 | | FtsH protease activity modulator HflK | 0.85 | IAI47_09580 | | FNR family transcription factor | low | > 76 |
| Erwinia tracheiphila HP pepo 2.2 | 0.46 | IJEDHG_06855 | hflK | FtsH protease activity modulator HflK | 0.83 | IJEDHG_23150 | crp | transcriptional regulator FNR | — | — |
| Pectobacterium carotovorum WPP14 | 0.46 | HER17_RS02595 | | FtsH protease activity modulator HflK | 0.86 | HER17_RS10525 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 75 |
| Erwinia tracheiphila SCR3 | 0.46 | LU632_RS02065 | hflK | FtsH protease activity modulator HflK | 0.83 | LU632_RS11420 | | FNR family transcription factor | low | > 74 |
| Pantoea agglomerans CFBP13505 P0401 | 0.46 | PagCFBP13505_RS11195 | | FtsH protease activity modulator HflK | 0.86 | PagCFBP13505_RS06575 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 74 |
| Enterobacter sp. TBS_079 | 0.46 | MPMX20_00455 | | Modulator of FtsH protease HflK | 0.85 | MPMX20_02035 | | Fumarate and nitrate reduction regulatory protein | low | > 85 |
| Klebsiella michiganensis M5al | 0.45 | BWI76_RS02545 | | protease modulator HflK | 0.85 | BWI76_RS16185 | | transcriptional regulator FNR | — | — |
| Serratia liquefaciens MT49 | 0.45 | IAI46_01635 | | FtsH protease activity modulator HflK | 0.86 | IAI46_13260 | | FNR family transcription factor | low | > 86 |
| Rahnella sp. WP5 | 0.45 | EX31_RS08810 | | FtsH protease activity modulator HflK | 0.86 | EX31_RS07200 | | FNR family transcription factor | low | > 89 |
| Erwinia amylovora T8 | 0.44 | OLJFJH_02490 | | FtsH protease activity modulator HflK | 0.83 | OLJFJH_13925 | | transcriptional regulator FNR | low | > 58 |
| Marinobacter adhaerens HP15 | 0.37 | HP15_2497 | | HflK | 0.41 | HP15_634 | | transcriptional regulator, Crp/Fnr family | low | > 73 |
| Pseudomonas fluorescens FW300-N1B4 | 0.37 | Pf1N1B4_1410 | | HflK protein | 0.53 | Pf1N1B4_3867 | | Fumarate and nitrate reduction regulatory protein | — | — |
| Pseudomonas fluorescens SBW25 | 0.36 | PFLU_RS02580 | | FtsH protease activity modulator HflK | 0.53 | PFLU_RS22395 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 109 |
| Pseudomonas fluorescens SBW25-INTG | 0.36 | PFLU_RS02580 | | FtsH protease activity modulator HflK | 0.53 | PFLU_RS22395 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 109 |
| Pseudomonas fluorescens FW300-N2C3 | 0.36 | AO356_08645 | | hypothetical protein | 0.53 | AO356_02485 | | transcriptional regulator | low | > 104 |
| Pseudomonas fluorescens FW300-N2E3 | 0.36 | AO353_13155 | | hypothetical protein | 0.53 | AO353_00660 | | transcriptional regulator | low | > 101 |
| Pseudomonas aeruginosa PA14 | 0.36 | IKLFDK_28830 | | FtsH protease activity modulator HflK | 0.53 | IKLFDK_07375 | | transcriptional regulator Anr | — | — |
| Pseudomonas segetis P6 | 0.36 | MPMX49_04151 | | Modulator of FtsH protease HflK | 0.54 | MPMX49_02303 | | Transcriptional activator protein Anr | low | > 75 |
| Pseudomonas sp. RS175 | 0.36 | PFR28_05123 | | Modulator of FtsH protease HflK | 0.53 | PFR28_01079 | | Transcriptional activator protein Anr | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.35 | Psyr_0574 | | protease FtsH subunit HflK | 0.54 | Psyr_3425 | | Cyclic nucleotide-binding:Bacterial regulatory protein, Crp | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.35 | Psyr_0574 | | protease FtsH subunit HflK | 0.54 | Psyr_3425 | | Cyclic nucleotide-binding:Bacterial regulatory protein, Crp | — | — |
| Pseudomonas sp. DMC3 | 0.35 | GFF3222 | | Modulator of FtsH protease HflK | 0.54 | GFF711 | | Transcriptional activator protein Anr | — | — |
| Dechlorosoma suillum PS | 0.35 | Dsui_3135 | | HflK protein | 0.40 | Dsui_1646 | | cAMP-binding protein | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.35 | Pf6N2E2_3612 | | HflK protein | 0.53 | Pf6N2E2_2323 | | Fumarate and nitrate reduction regulatory protein | low | > 103 |
| Pseudomonas simiae WCS417 | 0.35 | PS417_02500 | | membrane protein | 0.53 | PS417_20785 | | transcriptional regulator | — | — |
| Pseudomonas lactucae CFBP13502 | 0.35 | GEMAOFIL_00738 | | Modulator of FtsH protease HflK | 0.53 | GEMAOFIL_04302 | | Transcriptional activator protein Anr | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.35 | PfGW456L13_152 | | HflK protein | 0.54 | PfGW456L13_4071 | | Fumarate and nitrate reduction regulatory protein | low | > 87 |
| Ralstonia solanacearum PSI07 | 0.34 | RPSI07_RS18065 | | FtsH protease activity modulator HflK | 0.38 | RPSI07_RS17705 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 81 |
| Pseudomonas sp. SVBP6 | 0.34 | COO64_RS17910 | hflK | FtsH protease activity modulator HflK | 0.52 | COO64_RS18640 | fnrA | Crp/Fnr family transcriptional regulator FnrA | low | > 93 |
| Pseudomonas sp. S08-1 | 0.34 | OH686_09460 | | HflK protein | 0.53 | OH686_02245 | | Fumarate and nitrate reduction regulatory protein | low | > 80 |
| Pseudomonas putida KT2440 | 0.34 | PP_4892 | | integral membrane ATP-dependent zinc metallopeptidase / HflK-HflC complex | 0.52 | PP_4265 | | DNA-binding transcriptional dual regulator | low | > 96 |
| Pseudomonas stutzeri RCH2 | 0.34 | Psest_0685 | | HflK protein | 0.53 | Psest_2538 | | cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases | — | — |
| Pseudomonas sp. BP01 | 0.34 | JOY50_RS17240 | hflK | FtsH protease activity modulator HflK | 0.52 | JOY50_RS00125 | fnrA | Crp/Fnr family transcriptional regulator FnrA | low | > 84 |
| Castellaniella sp019104865 MT123 | 0.33 | ABCV34_RS02660 | | FtsH protease activity modulator HflK | 0.34 | ABCV34_RS06835 | | helix-turn-helix domain-containing protein | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.33 | RALBFv3_RS15310 | | FtsH protease activity modulator HflK | 0.38 | RALBFv3_RS15650 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 76 |
| Ralstonia solanacearum UW163 | 0.33 | UW163_RS12775 | | FtsH protease activity modulator HflK | 0.38 | UW163_RS13110 | | fumarate/nitrate reduction transcriptional regulator Fnr | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.33 | GFF4856 | | HflK protein | 0.39 | GFF4142 | | transcriptional regulator, Crp/Fnr family | low | > 90 |
| Variovorax sp. SCN45 | 0.33 | GFF1002 | | HflK protein | 0.22 | GFF6947 | | transcriptional regulator, Crp/Fnr family | low | > 127 |
| Methylophilus sp. DMC18 | 0.32 | GFF1223 | | hypothetical protein | 0.38 | GFF1089 | | Transcriptional activator protein Anr | low | > 43 |
| Cupriavidus basilensis FW507-4G11 | 0.32 | RR42_RS13105 | | membrane protein | 0.40 | RR42_RS12875 | | transcriptional regulator | — | — |
| Ralstonia sp. UNC404CL21Col | 0.32 | ABZR87_RS10950 | | FtsH protease activity modulator HflK | 0.39 | ABZR87_RS11180 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 80 |
| Herbaspirillum seropedicae SmR1 | 0.31 | HSERO_RS14765 | | membrane protein | 0.41 | HSERO_RS16020 | | transcriptional regulator | — | — |
| Ralstonia solanacearum GMI1000 | 0.31 | RS_RS06120 | | FtsH protease activity modulator HflK | 0.38 | RS_RS06430 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 80 |
| Kangiella aquimarina DSM 16071 | 0.31 | B158DRAFT_1954 | | protease FtsH subunit HflK | 0.56 | B158DRAFT_1982 | | cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases | low | > 40 |
| Acidovorax sp. GW101-3H11 | 0.31 | Ac3H11_1801 | | HflK protein | 0.38 | Ac3H11_975 | | transcriptional regulator, Crp/Fnr family | — | — |
| Rhodanobacter sp. FW510-T8 | 0.29 | OKGIIK_06640 | hflK | FtsH protease activity modulator HflK | 0.37 | OKGIIK_00820 | | CRP-like protein Clp | low | > 52 |
| Rhodanobacter sp000427505 FW510-R12 | 0.28 | LRK53_RS09535 | | FtsH protease activity modulator HflK | 0.35 | LRK53_RS14515 | | cyclic nucleotide-binding domain-containing protein | low | > 59 |
| Rhodanobacter denitrificans FW104-10B01 | 0.28 | LRK54_RS00620 | | FtsH protease activity modulator HflK | 0.35 | LRK54_RS05830 | | helix-turn-helix domain-containing protein | low | > 59 |
| Rhodanobacter denitrificans MT42 | 0.28 | LRK55_RS00390 | | FtsH protease activity modulator HflK | 0.35 | LRK55_RS05585 | | helix-turn-helix domain-containing protein | low | > 63 |
| Dyella japonica UNC79MFTsu3.2 | 0.27 | ABZR86_RS08355 | | FtsH protease activity modulator HflK | 0.25 | ABZR86_RS04345 | | cyclic nucleotide-binding domain-containing protein | low | > 74 |
| Rhodospirillum rubrum S1H | 0.26 | Rru_A2203 | | HflK (NCBI) | 0.22 | Rru_A3322 | | Transcriptional Regulator, Crp/Fnr family (NCBI) | — | — |
| Magnetospirillum magneticum AMB-1 | 0.25 | AMB_RS17650 | | FtsH protease activity modulator HflK | 0.22 | AMB_RS22105 | | transcriptional regulator | — | — |
| Dinoroseobacter shibae DFL-12 | 0.25 | Dshi_2736 | | HflK protein (RefSeq) | 0.15 | Dshi_0660 | | transcriptional regulator, Crp/Fnr family (RefSeq) | low | > 64 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.25 | Xcc-8004.3955.1 | | HflK protein | 0.22 | Xcc-8004.2952.1 | | transcriptional regulator, Crp/Fnr family | low | > 74 |
| Lysobacter sp. OAE881 | 0.24 | ABIE51_RS06550 | | FtsH protease activity modulator HflK | 0.37 | ABIE51_RS03805 | | fumarate/nitrate reduction transcriptional regulator Fnr | low | > 62 |
| Azospirillum sp. SherDot2 | 0.23 | MPMX19_01251 | | Modulator of FtsH protease HflK | 0.26 | MPMX19_00212 | | Nitrogen fixation regulation protein FixK | — | — |
| Agrobacterium fabrum C58 | 0.22 | Atu2045 | | HFLK protein | 0.19 | Atu1602 | | transcriptional activator, Crp family | low | > 89 |
Not shown: 6 genomes with orthologs for CSW01_01845 only; 12 genomes with orthologs for CSW01_07190 only