| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Methanococcus maripaludis S2 | MMP_RS06720 | | response regulator transcription factor | strong | 100 | 100 |
| o | Methanococcus maripaludis JJ | MMJJ_RS07635 | | response regulator transcription factor | strong | 99 | 100 |
| | Dickeya dianthicola ME23 | DZA65_RS04580 | | response regulator transcription factor | insig. | 39 | 98 |
| | Mycobacterium tuberculosis H37Rv | Rv0757 | | Possible two component system response transcriptional positive regulator PhoP | sig. | 37 | 97 |
| | Mycobacterium tuberculosis H37Rv | Rv0981 | | Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) | insig. | 36 | 98 |
| o | Synechococcus elongatus PCC 7942 | Synpcc7942_1817 | ltnA | response regulator receiver domain protein (CheY-like) | insig. | 40 | 99 |
| | Klebsiella michiganensis M5al | BWI76_RS10845 | | DNA-binding response regulator | insig. | 37 | 99 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1083 | phoB | phosphate regulon transcriptional regulator PhoB (TIGR) | no data | 37 | 98 |
| | Rhodospirillum rubrum S1H | Rru_A2929 | | Two component Transcriptional regulator, Winged helix family (NCBI) | cofit | 42 | 97 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09660 | | DNA-binding response regulator | cofit | 39 | 100 |
| | Dickeya dadantii 3937 | DDA3937_RS04715 | | response regulator transcription factor | insig. | 37 | 99 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1110 | | response regulator receiver domain protein (CheY-like) | strong | 34 | 99 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS12065 | | response regulator transcription factor | cofit | 38 | 99 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_1517 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | insig. | 35 | 99 |
| | Azospirillum brasilense Sp245 | AZOBR_RS23980 | | Fis family transcriptional regulator | insig. | 35 | 98 |
| | Pseudomonas stutzeri RCH2 | Psest_3465 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 39 | 98 |
| | Pantoea sp. MT58 | IAI47_21710 | | response regulator transcription factor | insig. | 38 | 100 |
| o | Desulfovibrio vulgaris Miyazaki F | DvMF_2543 | | response regulator receiver protein (RefSeq) | sig. | 38 | 98 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_0882 | | two component transcriptional regulator, winged helix family (RefSeq) | strong | 37 | 98 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS04560 | | response regulator transcription factor | no data | 36 | 98 |
| | Shewanella oneidensis MR-1 | SO2540 | | response regulator (NCBI ptt file) | sig. | 37 | 97 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11235 | | hybrid sensor histidine kinase/response regulator | strong | 38 | 100 |
| | Dechlorosoma suillum PS | Dsui_0863 | | phosphate regulon transcriptional regulatory protein PhoB | insig. | 37 | 97 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS17625 | | EAL domain-containing protein | strong | 40 | 99 |
| | Pseudomonas segetis P6 | MPMX49_03793 | | Transcriptional activator protein CzcR | strong | 39 | 98 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS24585 | | response regulator transcription factor | cofit | 38 | 97 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_02195 | | DNA-binding response regulator | sig. | 38 | 97 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS57035 | | response regulator transcription factor | insig. | 38 | 97 |
| | Azospirillum sp. SherDot2 | MPMX19_03119 | | Transcriptional regulatory protein QseB | insig. | 37 | 98 |
| | Caulobacter crescentus NA1000 | CCNA_01351 | | two-component response regulator protein | cofit | 36 | 97 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_01351 | | two-component response regulator protein | cofit | 36 | 97 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1873 | | two component transcriptional regulator, winged helix family | insig. | 35 | 97 |
| | Shewanella loihica PV-4 | Shew_3258 | | two component heavy metal response transcriptional regulator (RefSeq) | strong | 36 | 98 |
| | Pectobacterium carotovorum WPP14 | HER17_RS07485 | | response regulator | insig. | 36 | 99 |
| | Azospirillum sp. SherDot2 | MPMX19_03749 | | KDP operon transcriptional regulatory protein KdpE | insig. | 33 | 98 |
| o | Lysobacter sp. OAE881 | ABIE51_RS18145 | | response regulator | insig. | 41 | 90 |
| | Rhodospirillum rubrum S1H | Rru_A2406 | | Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) and Response Regulator Receiver modulation (NCBI) | insig. | 41 | 95 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS05520 | | transcriptional regulator | insig. | 40 | 98 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_00227 | | two component transcriptional regulator, winged helix family | insig. | 40 | 98 |
| | Paraburkholderia graminis OAS925 | ABIE53_001354 | | two-component system phosphate regulon response regulator OmpR | insig. | 40 | 98 |
| o | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2417 | | response regulator receiver protein | insig. | 40 | 96 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS00150 | | DNA-binding response regulator | insig. | 39 | 99 |
| | Pseudomonas sp. S08-1 | OH686_17340 | | DNA-binding response regulator ColR | insig. | 37 | 98 |
| | Pseudomonas stutzeri RCH2 | Psest_1185 | | heavy metal response regulator | insig. | 35 | 98 |
| | Xanthobacter sp. DMC5 | GFF1990 | | Sensor histidine kinase RcsC | insig. | 33 | 96 |
| | Pseudomonas stutzeri RCH2 | Psest_4301 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | sig. | 43 | 89 |
| | Fusobacterium nucleatum SB010 | HUW76_07205 | | response regulator transcription factor | strong | 38 | 97 |
| | Azospirillum sp. SherDot2 | MPMX19_02587 | | Phosphate regulon transcriptional regulatory protein PhoB | cofit | 36 | 97 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_03275 | | hybrid sensor histidine kinase/response regulator | insig. | 38 | 92 |
| | Dechlorosoma suillum PS | Dsui_1068 | | heavy metal response regulator | cofit | 37 | 98 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS05670 | | response regulator | insig. | 37 | 99 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15805 | | two component system response regulator RpaA | strong | 37 | 100 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_04020 | | XRE family transcriptional regulator | strong | 37 | 98 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS09450 | | response regulator transcription factor | insig. | 35 | 97 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS24850 | | response regulator | insig. | 40 | 98 |
| | Pseudomonas sp. BP01 | JOY50_RS14980 | colR | two-component system response regulator ColR | insig. | 37 | 97 |
| | Pseudomonas putida KT2440 | PP_0901 | | DNA-binding response regulator | strong | 37 | 97 |
| | Enterobacter sp. TBS_079 | MPMX20_02548 | | Phosphate regulon transcriptional regulatory protein PhoB | strong | 36 | 99 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS24430 | | response regulator transcription factor | insig. | 37 | 97 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS24430 | | response regulator transcription factor | sig. | 37 | 97 |
| | Pseudomonas sp. DMC3 | GFF5074 | | Transcriptional activator protein CzcR | cofit | 37 | 97 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_04707 | | Transcriptional activator protein CzcR | cofit | 37 | 97 |
| | Pseudomonas sp. SVBP6 | COO64_RS12030 | colR | two-component system response regulator ColR | insig. | 37 | 97 |
| | Pseudomonas orientalis W4I3 | QF045_RS24960 | | two-component system response regulator ColR | cofit | 37 | 97 |
| | Pseudomonas simiae WCS417 | PS417_22780 | | XRE family transcriptional regulator | strong | 37 | 97 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_4210 | | DNA-binding heavy metal response regulator | insig. | 36 | 98 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_2309 | | Response regulator containing a CheY-like receiver domain and a GGDEF domain | insig. | 38 | 98 |
| | Pseudomonas sp. RS175 | PFR28_03335 | | Transcriptional activator protein CzcR | strong | 36 | 98 |
| | Rahnella sp. WP5 | EX31_RS14320 | | envelope stress response regulator transcription factor CpxR | insig. | 35 | 100 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_4070 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | strong | 37 | 97 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_4070 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | insig. | 37 | 97 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_724 | | DNA-binding response regulator ColR | strong | 36 | 97 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_18415 | | XRE family transcriptional regulator | strong | 36 | 97 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_5609 | | DNA-binding response regulator ColR | strong | 36 | 97 |
| o | Phocaeicola dorei CL03T12C01 | ABI39_RS20590 | | response regulator | insig. | 42 | 99 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1461 | | two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq) | no data | 38 | 90 |
| | Dickeya dadantii 3937 | DDA3937_RS07165 | | response regulator transcription factor | insig. | 37 | 97 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_0095 | rpaA | two component transcriptional regulator, winged helix family | strong | 37 | 98 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS06935 | | phosphate regulon transcriptional regulatory protein PhoB | insig. | 36 | 97 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11370 | | response regulator transcription factor | no data | 36 | 98 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS15940 | | DNA-binding response regulator | no data | 35 | 98 |
| | Pseudomonas sp. S08-1 | OH686_22680 | | Copper-sensing two-component system response regulator CusR | strong | 35 | 98 |
| | Azospirillum brasilense Sp245 | AZOBR_RS01105 | | PhoB family transcriptional regulator | insig. | 34 | 97 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_13900 | | transcriptional regulator | sig. | 39 | 100 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02385 | | response regulator receiver domain protein | insig. | 37 | 100 |
| | Lysobacter sp. OAE881 | ABIE51_RS14220 | | phosphate regulon transcriptional regulator PhoB | insig. | 34 | 100 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS27985 | | response regulator | insig. | 33 | 98 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_26115 | phoB | phosphate response regulator transcription factor PhoB | insig. | 34 | 98 |
| | Erwinia tracheiphila SCR3 | LU632_RS18925 | phoB | phosphate response regulator transcription factor PhoB | insig. | 34 | 98 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS08970 | | phosphate regulon transcriptional regulator PhoB | no data | 36 | 97 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT0682 | | two-component system response regulator (NCBI ptt file) | sig. | 36 | 100 |
| | Agrobacterium fabrum C58 | Atu2418 | | two component sensor kinase | insig. | 36 | 93 |
| | Pseudomonas orientalis W4I3 | QF045_RS19850 | | response regulator | insig. | 35 | 97 |
| | Klebsiella michiganensis M5al | BWI76_RS09490 | | DNA-binding response regulator | sig. | 35 | 99 |
| | Pantoea sp. MT58 | IAI47_14855 | | phosphate response regulator transcription factor PhoB | strong | 35 | 98 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS10295 | | phosphate response regulator transcription factor PhoB | cofit | 35 | 98 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1120 | | DNA-binding heavy metal response regulator | insig. | 35 | 98 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_2416 | srrA | two component transcriptional regulator, winged helix family | sig. | 35 | 98 |
| | Acinetobacter radioresistens SK82 | MPMX26_02625 | | Transcriptional regulatory protein BaeR | cofit | 34 | 99 |
| | Pantoea sp. MT58 | IAI47_00760 | | envelope stress response regulator transcription factor CpxR | strong | 34 | 100 |